Foresite Capital Management V, LLC
In its 13F for Q4 2025 (holdings as of December 31, 2025, filed February 17, 2026), Foresite Capital Management V, LLC reported 7 stock positions worth $164.4 million. Its top holding was Alumis (ALMS) at 34.3% of the portfolio, followed by CG Oncology (CGON, 25.4%) and Disc Medicine (IRON, 14.4%). Compared with Q3 2025, it opened 1 new position. The biggest buy was a new position in Natera (NTRA).
- Most Recent 13F
- Q2 2026
- Location
- WEST HOLLYWOOD, CA
- CIK
- 0001792206
- Portfolio Value
- $164.4M (Q4 2025)
- SEC Filing
- 0001104659-26-015410 ↗ filed Feb 17, 2026
Holdings Value
Holdings 7 stocks · $164.4M
| ALMS Alumis Inc. | 34.31% | 5,779,348 | $56.4M | No change |
| CGON CG Oncology Inc. | 25.36% | 1,004,050 | $41.7M | No change |
| IRON Disc Medicine Inc. | 14.45% | 299,069 | $23.7M | No change |
| NTRA Natera Inc. | 9.39% | 67,356 | $15.4M | New |
| LYEL Lyell Immunopharma Inc. | 8.93% | 477,078 | $14.7M | No change |
| HIMS Hims & Hers Health Inc. | 5.39% | 273,151 | $8.9M | No change |
| MAZE Maze Therapeutics Inc. | 2.17% | 86,291 | $3.6M | No change |
Portfolio Sells Q3 2025 → Q4 2025
| None this quarter. | |||
Portfolio Buys Q3 2025 → Q4 2025
| NTRA Natera Inc. | New | 9.39% | +9.39 |
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 9 | $362.2M | ALMS, CGON, IRON, HIMS, PHVS |
| Q1 2026 | 9 | $271.0M | ALMS, CGON, IRON, HIMS, EIKN |
| Q4 2025 | 7 | $164.4M | ALMS, CGON, IRON, NTRA, LYEL |
| Q3 2025 | 6 | $108.7M | CGON, ALMS, IRON, HIMS, LYEL |
| Q2 2025 | 6 | $80.7M | CGON, ALMS, IRON, HIMS, MAZE |
| Q1 2025 | 6 | $87.6M | ALMS, CGON, IRON, HIMS, LYEL |
| Q4 2024 | 6 | $120.2M | ALMS, HIMS, CGON, IRON, CGEM |
| Q3 2024 | 5 | $143.9M | ALMS, HIMS, CGON, IRON, CGEM |
| Q2 2024 | 5 | $156.6M | ALMS, HIMS, CGON, IRON, CGEM |
| Q1 2024 | 5 | $106.5M | HIMS, CGON, IRON, KNTE, 23ANDME HOLDING CO |