Pivotal bioVenture Partners Investment Advisor LLC

In its 13F for Q3 2025 (holdings as of September 30, 2025, filed November 13, 2025), Pivotal bioVenture Partners Investment Advisor LLC reported 10 stock positions worth $173.0 million. Its top holding was Vaxcyte (PCVX) at 28.6% of the portfolio, followed by Oculis (OCS, 23.4%) and Arcutis Biotherapeutics (ARQT, 23.1%). Compared with Q2 2025, it opened 1 new position, sold out of 3 and added to 2. The biggest buy was a new position in Immunome (IMNM) and the biggest sale an exit from Inozyme Pharma (INZY).

Most Recent 13F
Q2 2026
Location
SAN FRANCISCO, CA
CIK
0001844645
Portfolio Value
$173.0M (Q3 2025)
SEC Filing
0001012975-25-000748 ↗ filed Nov 13, 2025

Holdings Value

0$100.0M$200.0M$300.0M$400.0M Q1 2024: $155.6M Q1 2024 Q2 2024: $130.1M Q2 2024 Q3 2024: $168.5M Q3 2024 Q4 2024: $148.1M Q4 2024 Q1 2025: $123.6M Q1 2025 Q2 2025: $161.3M Q2 2025 Q3 2025: $173.0M $173.0M Q3 2025 Q4 2025: $258.7M Q4 2025 Q1 2026: $279.8M Q1 2026 Q2 2026: $307.8M Q2 2026

Holdings 10 stocks · $173.0M
PCVX Vaxcyte Inc. 28.58% 1,372,425 $49.4M Add +5.2%
OCS Oculis Holding AG 23.38% 2,300,774 $40.4M No change
ARQT Arcutis Biotherapeutics Inc. 23.11% 2,120,508 $40.0M No change
ZBIO Zenas Biopharma Inc. 10.00% 779,045 $17.3M No change
TRVI Trevi Therapeutics Inc. 6.65% 1,256,782 $11.5M Add +9.7%
IMNM Immunome Inc. 3.40% 502,512 $5.9M New
BIOA Bioage Labs Inc. 2.22% 653,374 $3.8M No change
RXRX Recursion Pharmaceuticals-A 1.68% 595,518 $2.9M No change
RLYB Rallybio Corp. 0.69% 2,404,644 $1.2M No change
BOLT Bolt Biotherapeutics Inc. 0.29% 94,573 $503K No change

Portfolio Sells Q2 2025 → Q3 2025
INZY Inozyme Pharma Inc. Sold out 0.00% −11.14
VIGL Vigil Neuroscience Inc. Sold out 0.00% −2.76
IOBTQ Io Biotech Inc. Sold out 0.00% −0.74

Portfolio Buys Q2 2025 → Q3 2025
IMNM Immunome Inc. New 3.40% +3.40
TRVI Trevi Therapeutics Inc. Add +9.7% 6.65% +2.76
PCVX Vaxcyte Inc. Add +5.2% 28.58% +2.28

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 13$307.8MPCVX, ARQT, TRVI, AVLN, EVMN
Q1 2026 13$279.8MPCVX, OCS, EVMN, ARQT, TRVI
Q4 2025 12$258.7MPCVX, OCS, ARQT, EVMN, ZBIO
Q3 2025 10$173.0MPCVX, OCS, ARQT, ZBIO, TRVI
Q2 2025 12$161.3MOCS, PCVX, ARQT, INZY, ZBIO
Q1 2025 11$123.6MOCS, ARQT, PCVX, ZBIO, INZY
Q4 2024 11$148.1MPCVX, OCS, ARQT, INZY, ZBIO
Q3 2024 11$168.5MPCVX, INZY, ARQT, OCS, ZBIO
Q2 2024 10$130.1MPCVX, INZY, OCS, ARQT, EXAI
Q1 2024 11$155.6MPCVX, INZY, ARQT, OCS, FUSN