SR One Capital Management, LP

In its 13F for Q3 2024 (holdings as of September 30, 2024, filed November 13, 2024), SR One Capital Management, LP reported 11 stock positions worth $498.7 million. Its top holding was Arcellx (ACLX) at 39.3% of the portfolio, followed by Zenas Biopharma (ZBIO, 16.7%) and Ars Pharmaceuticals (SPRY, 11.7%). Compared with Q2 2024, it opened 2 new positions and added to 1. The biggest buy was a new position in Zenas Biopharma (ZBIO).

Most Recent 13F
Q2 2026
Location
Redwood City, CA
CIK
0001910264
Portfolio Value
$498.7M (Q3 2024)
SEC Filing
0000950123-24-011277 ↗ filed Nov 13, 2024

Holdings Value

0$500.0M$1.0B$1.5B Q1 2024: $364.1M Q1 2024 Q2 2024: $319.4M Q2 2024 Q3 2024: $498.7M $498.7M Q3 2024 Q4 2024: $410.1M Q4 2024 Q1 2025: $389.3M Q1 2025 Q2 2025: $461.4M Q2 2025 Q3 2025: $691.4M Q3 2025 Q4 2025: $706.4M Q4 2025 Q1 2026: $915.4M Q1 2026 Q2 2026: $1.0B Q2 2026

Holdings 11 stocks · $498.7M
ACLX Arcellx Inc. 39.29% 2,346,630 $196.0M No change
ZBIO Zenas Biopharma Inc. 16.66% 4,911,539 $83.1M New
SPRY Ars Pharmaceuticals Inc. 11.67% 4,012,903 $58.2M No change
CRSP Crispr Therapeutics AG 9.88% 1,048,951 $49.3M No change
DSGN Design Therapeutics Inc. 7.04% 6,526,476 $35.1M No change
MLYS Mineralys Therapeutics Inc. 4.90% 2,016,822 $24.4M No change
ALMS Alumis Inc. 4.20% 1,959,896 $20.9M No change
NKTX Nkarta Inc. 3.02% 3,333,333 $15.1M No change
ORKA Oruka Therapeutics Inc. 1.84% 375,330 $9.2M New
ENGN Engene Holdings Inc. 0.99% 747,750 $4.9M Add +49.5%
KALA Kala Bio Inc. 0.51% 443,661 $2.5M No change

Portfolio Sells Q2 2024 → Q3 2024
None this quarter.

Portfolio Buys Q2 2024 → Q3 2024
ZBIO Zenas Biopharma Inc. New 16.66% +16.66
ORKA Oruka Therapeutics Inc. New 1.84% +1.84
ENGN Engene Holdings Inc. Add +49.5% 0.99% −0.49

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 15$1.0BMANE, ZBIO, CRSP, AVLN, DSGN
Q1 2026 14$915.4MACLX, MANE, ZBIO, CRSP, DSGN
Q4 2025 13$706.4MZBIO, ACLX, CRSP, DSGN, MLYS
Q3 2025 12$691.4MACLX, CRSP, ZBIO, MLYS, ORIC
Q2 2025 13$461.4MACLX, SPRY, CRSP, ZBIO, ORIC
Q1 2025 12$389.3MACLX, SPRY, MLYS, ZBIO, CRSP
Q4 2024 11$410.1MACLX, SPRY, CRSP, DSGN, ZBIO
Q3 2024 11$498.7MACLX, ZBIO, SPRY, CRSP, DSGN
Q2 2024 9$319.4MACLX, CRSP, SPRY, ALMS, MLYS
Q1 2024 6$364.1MACLX, CRSP, SPRY, NKTX, DSGN