| MPM Bioimpact LLC | 6.68% | New | 4,835,872 | $86.5M |
| EcoR1 Capital, LLC | 3.69% | New | 4,824,469 | $86.3M |
| Blue Owl Capital Holdings LP | 15.29% | New | 3,161,348 | $56.6M |
| Wellington Management Group LLP | 0.01% | New | 2,317,044 | $41.5M |
| T. Rowe Price Investment Management, Inc. | 0.03% | New | 2,123,812 | $38.0M |
| BlackRock, Inc. | 0.00% | New | 2,112,127 | $37.8M |
| RTW Investments, LP | 0.28% | New | 1,592,043 | $28.5M |
| T. Rowe Price Associates Inc. | 0.00% | New | 1,564,196 | $28.0M |
| Ra Capital Management, L.P. | 0.29% | New | 1,503,084 | $26.9M |
| Janus Henderson Group PLC | 0.01% | New | 1,454,267 | $26.0M |
| Baker Bros. Advisors LP | 0.10% | New | 996,351 | $17.8M |
| Octagon Capital Advisors LP | 1.90% | New | 960,847 | $17.2M |
| Merck & Co., Inc. | 4.88% | New | 952,844 | $17.0M |
| Vanguard Capital Management LLC | 0.00% | — | 833,913 | $14.9M |
| Eventide Asset Management, LLC | 0.15% | New | 507,000 | $9.1M |
| Geode Capital Management, LLC | 0.00% | New | 491,936 | $8.8M |
| Avidity Partners Management LP | 1.70% | New | 468,566 | $8.4M |
| State Street Corp. | 0.00% | New | 428,253 | $7.7M |
| a16z Capital Management, L.L.C. | 0.58% | New | 415,000 | $7.4M |
| FMR LLC | 0.00% | New | 386,379 | $6.9M |
| UBS Group AG | 0.00% | New | 353,263 | $6.3M |
| ArrowMark Colorado Holdings LLC | 0.16% | New | 329,471 | $5.9M |
| Alyeska Investment Group, L.P. | 0.01% | New | 290,000 | $5.2M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 162,017 | $2.9M |
| Driehaus Capital Management LLC | 0.02% | New | 150,000 | $2.7M |
| Northern Trust Corp. | 0.00% | New | 149,476 | $2.7M |
| Vanguard Fiduciary Trust Co. | 0.00% | — | 127,395 | $2.3M |
| Vanguard Portfolio Management LLC | 0.00% | — | 120,322 | $2.2M |
| Ameriprise Financial Inc. | 0.00% | New | 102,925 | $1.8M |
| TD Asset Management Inc | 0.00% | New | 100,962 | $1.8M |
| Laurion Capital Management LP | 0.18% | New | 100,000 | $1.8M |
| Soros Fund Management | 0.03% | New | 100,000 | $1.8M |
| Woodline Partners LP | 0.01% | New | 100,000 | $1.8M |
| Citadel Advisors | 0.00% | New | 75,000 | $1.3M |
| Bank of America Corp. | 0.00% | New | 69,926 | $1.3M |
| Manufacturers Life Insurance Company, The | 0.00% | New | 46,993 | $841K |
| Bank of New York Mellon Corp | 0.00% | New | 42,901 | $767K |
| Morgan Stanley | 0.00% | New | 30,723 | $550K |
| Goldman Sachs Group Inc. | 0.00% | New | 30,163 | $540K |
| Readystate Asset Management LP | 0.06% | New | 30,000 | $537K |
| Seven Grand Managers, LLC | 0.03% | New | 25,000 | $447K |
| Ghisallo Capital Management LLC | 0.01% | New | 25,000 | $447K |
| Nuveen, LLC | 0.00% | New | 24,468 | $438K |
| Rhumbline Advisers | 0.00% | New | 21,033 | $376K |
| D. E. Shaw & Co. | 0.00% | New | 17,062 | $305K |
| Zimmer Partners, LP | 0.01% | New | 15,000 | $268K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | New | 14,185 | $254K |
| Deutsche Bank AG | 0.00% | New | 14,080 | $252K |
| XTX Topco Ltd | 0.00% | New | 13,990 | $250K |
| Invesco Ltd. | 0.00% | New | 12,113 | $217K |
| MetLife Investment Management, LLC | 0.00% | New | 11,637 | $208K |
| Barclays PLC | 0.00% | New | 9,724 | $174K |
| Vanguard Global Advisers, LLC | 0.00% | — | 9,689 | $173K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 9,651 | $173K |
| JPMorgan Chase & Co. | 0.00% | New | 8,355 | $138K |
| Wells Fargo & Company | 0.00% | New | 7,611 | $136K |
| PNC Financial Services Group, Inc. | 0.00% | New | 6,948 | $124K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | New | 5,530 | $99K |
| BNP Paribas Financial Markets | 0.00% | New | 4,480 | $80K |
| STRS Ohio | 0.00% | New | 3,600 | $64K |
| New York State Common Retirement Fund | 0.00% | New | 3,200 | $57K |
| Legal & General Group Plc | 0.00% | New | 1,826 | $33K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 1,683 | $30K |
| Russell Investments Group, Ltd. | 0.00% | New | 1,551 | $28K |
| Citigroup Inc. | 0.00% | New | 1,019 | $18K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 1,009 | $18K |
| Salem Investment Counselors Inc. | 0.00% | New | 1,000 | $18K |
| Sterling Capital Management LLC | 0.00% | New | 393 | $7K |
| Cwm, LLC | 0.00% | New | 21 | $376 |