Castle BiosciencesCSTL
13F holders, Q4 2025 (December 31)195holders +22
37new positions
17sold out
7famous investors
$38.89avg. 13F price*
At the end of Q4 2025, 195 institutions reported holding Castle Biosciences Inc. (CSTL) in their 13F filings, up 22 from Q3 2025. 37 opened new positions and 17 sold out. The largest holders were BlackRock, Inc. ($120.8M), Vanguard Group Inc. ($85.6M) and RTW Investments, LP ($82.3M). 7 famous investors held it, including Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Castle Biosciences Inc.
- CUSIP
- 14843C105
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 37 | $115.7M |
| Exits | 17 | $9.7M |
All 13F filers, Q3 2025 → Q4 2025: 4,954,032 shares bought and 4,262,142 shares sold, net +691,890 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 195 holders
| BlackRock, Inc. | 0.00% | Reduce -2.6% | 3,105,246 | $120.8M |
| Vanguard Group Inc. | 0.00% | Add +1.3% | 2,199,829 | $85.6M |
| RTW Investments, LP | 0.82% | New | 2,115,237 | $82.3M |
| Principal Financial Group Inc. | 0.04% | Add +0.7% | 1,807,644 | $70.3M |
| Portolan Capital Management, LLC | 3.60% | Add +14.2% | 1,729,463 | $67.3M |
| Dimensional Fund Advisors LP | 0.01% | Reduce -22.4% | 1,143,799 | $44.5M |
| Summit Partners Public Asset Management, LLC | 1.16% | Add +164.7% | 1,058,725 | $41.2M |
| State Street Corp. | 0.00% | Add +1.7% | 736,454 | $28.6M |
| Geode Capital Management, LLC | 0.00% | Add +2.3% | 714,913 | $27.8M |
| AIGH Capital Management LLC | 7.18% | Reduce -11.7% | 624,719 | $24.3M |
| Allianz Asset Management GmbH | 0.03% | Reduce -4.0% | 622,299 | $24.2M |
| Palisade Capital Management, LP | 0.73% | Reduce -11.1% | 567,777 | $22.1M |
| Wasatch Advisors LP | 0.12% | Reduce -19.7% | 537,241 | $20.9M |
| Nuveen, LLC | 0.01% | Reduce -45.2% | 524,681 | $20.4M |
| Schroder Investment Management Group | 0.01% | Reduce -0.6% | 492,161 | $19.3M |
| Renaissance Technologies | 0.03% | Reduce -12.3% | 493,100 | $19.2M |
| Acadian Asset Management LLC | 0.02% | Reduce -13.6% | 390,406 | $15.2M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.04% | Add +15.7% | 388,491 | $15.1M |
| Citadel Advisors | 0.01% | Add +46.0% | 366,356 | $14.3M |
| Millennium Management | 0.01% | Reduce -46.3% | 308,914 | $12.0M |
| Eventide Asset Management, LLC | 0.19% | New | 305,000 | $11.9M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -16.8% | 287,235 | $11.2M |
| Kornitzer Capital Management Inc. | 0.22% | Reduce -3.8% | 267,733 | $10.4M |
| Bank of America Corp. | 0.00% | Reduce -16.6% | 263,019 | $10.2M |
| Northern Trust Corp. | 0.00% | Reduce -7.1% | 262,243 | $10.2M |
| Advisors Capital Management, LLC | 0.12% | Reduce -1.4% | 250,677 | $9.8M |
| Bridgeway Capital Management, LLC | 0.20% | Add +39.4% | 246,920 | $9.6M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +1.8% | 242,535 | $9.4M |
| Qube Research & Technologies Ltd | 0.01% | Add +6.6% | 235,518 | $9.2M |
| New York State Common Retirement Fund | 0.01% | Add +1.3% | 233,046 | $9.1M |
| Wellington Management Group LLP | 0.00% | New | 218,560 | $8.5M |
| Silvercrest Asset Management Group LLC | 0.05% | Reduce -44.3% | 205,002 | $8.0M |
| Morgan Stanley | 0.00% | Reduce -24.5% | 203,577 | $7.9M |
| Braidwell LP | 0.26% | Reduce -78.5% | 177,183 | $6.9M |
| Jane Street Group, LLC | 0.01% | Add +637.0% | 168,646 | $6.6M |
| Tudor Investment Corporation | 0.04% | Add +95.7% | 167,178 | $6.5M |
| D. E. Shaw & Co. | 0.01% | Add +72.5% | 159,709 | $6.2M |
| Allspring Global Investments Holdings, LLC | 0.01% | Add +1.7% | 159,171 | $6.1M |
| Parkman Healthcare Partners LLC | 0.56% | Reduce -68.3% | 150,558 | $5.9M |
| BNP Paribas Financial Markets | 0.00% | Add +7.2% | 150,011 | $5.8M |
| UBS Group AG | 0.00% | Reduce -51.3% | 141,873 | $5.5M |
| Invesco Ltd. | 0.00% | Add +142.6% | 135,461 | $5.3M |
| Empowered Funds, LLC | 0.08% | Add +24.2% | 121,920 | $4.7M |
| Point72 Asset Management | 0.01% | Reduce -64.5% | 119,458 | $4.6M |
| JPMorgan Chase & Co. | 0.00% | Add +224.1% | 90,032 | $3.5M |
| Bank of New York Mellon Corp | 0.00% | Reduce -7.5% | 86,984 | $3.4M |
| Two Sigma Investments, LP | 0.01% | Add +227.1% | 84,066 | $3.3M |
| Franklin Resources Inc. | 0.00% | Reduce -19.2% | 80,603 | $3.1M |
| Birchview Capital, LP | 1.84% | Reduce -27.1% | 80,600 | $3.1M |
| American Century Companies Inc. | 0.00% | Reduce -5.8% | 77,768 | $3.0M |
| Orion Porfolio Solutions, LLC | 0.02% | Reduce -2.2% | 74,653 | $2.9M |
| Informed Momentum Co LLC | 0.32% | New | 74,138 | $2.9M |
| Barclays PLC | 0.00% | Reduce -1.3% | 72,149 | $2.8M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Add +21.2% | 69,628 | $2.7M |
| Trexquant Investment LP | 0.02% | Reduce -63.8% | 64,605 | $2.5M |
| AQR Capital Management | 0.00% | Add +25.6% | 63,881 | $2.5M |
| Envestnet Asset Management Inc. | 0.00% | Reduce -7.4% | 61,966 | $2.4M |
| Swiss National Bank | 0.00% | Add +2.3% | 57,300 | $2.2M |
| Squarepoint Ops LLC | 0.00% | New | 55,118 | $2.1M |
| HRT Financial LP | 0.01% | Add +0.9% | 47,654 | $1.9M |
| Panagora Asset Management Inc. | 0.01% | Add +115.0% | 45,995 | $1.8M |
| FMR LLC | 0.00% | Add +48.1% | 42,286 | $1.6M |
| Sei Investments Co. | 0.00% | Add +48.4% | 39,727 | $1.5M |
| Rhumbline Advisers | 0.00% | Reduce -12.1% | 38,468 | $1.5M |
| Mackenzie Financial Corp. | 0.00% | Add +54.2% | 37,317 | $1.5M |
| Osaic Holdings, Inc. | 0.00% | Add +8822.5% | 36,404 | $1.4M |
| Ameriprise Financial Inc. | 0.00% | Reduce -86.2% | 35,368 | $1.4M |
| Wells Fargo & Company | 0.00% | Add +42.7% | 34,212 | $1.3M |
| T. Rowe Price Associates Inc. | 0.00% | Add +4.7% | 34,138 | $1.3M |
| Citigroup Inc. | 0.00% | Add +662.9% | 32,422 | $1.3M |
| Two Sigma Advisers, LP | 0.00% | Add +202.0% | 29,899 | $1.2M |
| Legal & General Group Plc | 0.00% | Reduce -14.8% | 29,735 | $1.2M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Reduce -1.8% | 29,357 | $1.1M |
| Perkins Capital Management Inc. | 0.87% | Reduce -0.4% | 28,045 | $1.1M |
| California State Teachers Retirement System | 0.00% | Add +12.6% | 27,725 | $1.1M |
| Alliancebernstein L.P. | 0.00% | Reduce -24.3% | 25,270 | $983K |
| Truist Financial Corp. | 0.00% | Add +1.1% | 23,628 | $919K |
| Engineers Gate Manager LP | 0.01% | Reduce -50.6% | 22,949 | $893K |
| Caxton Associates LLP | 0.02% | New | 22,464 | $874K |
| Deutsche Bank AG | 0.00% | Add +34.5% | 22,384 | $871K |
| XTX Topco Ltd | 0.02% | New | 22,125 | $861K |
| Fox Run Management, L.L.C. | 0.13% | Add +58.4% | 21,884 | $851K |
| Schonfeld Strategic Advisors LLC | 0.00% | Reduce -75.5% | 21,476 | $835K |
| SG Americas Securities, LLC | 0.00% | Add +62.8% | 21,262 | $827K |
| HSBC Holdings PLC | 0.00% | Reduce -41.4% | 19,486 | $760K |
| Algert Global LLC | 0.01% | Reduce -67.2% | 18,978 | $738K |
| SummitTX Capital, L.P. | 0.02% | Reduce -61.3% | 17,410 | $677K |
| AlphaQuest LLC | 0.04% | Add +17.7% | 17,116 | $666K |
| Verition Fund Management LLC | 0.00% | Add +7.5% | 16,811 | $654K |
| First Bank & Trust | 0.11% | Reduce -15.6% | 16,706 | $650K |
| Creative Planning | 0.00% | Reduce -0.8% | 16,141 | $628K |
| MetLife Investment Management, LLC | 0.00% | No change | 15,881 | $618K |
| Janus Henderson Group PLC | 0.00% | Add +64.6% | 15,037 | $585K |
| Los Angeles Capital Management LLC | 0.00% | Reduce -2.0% | 23,631 | $572K |
| Parallel Advisors, LLC | 0.01% | Reduce -21.4% | 13,986 | $544K |
| Oak Harvest Investment Services | 0.06% | Reduce -20.1% | 13,485 | $525K |
| Harbor Capital Advisors, Inc. | 0.04% | Add +2.0% | 13,432 | $523K |
| Y-Intercept (Hong Kong) Ltd | 0.01% | New | 13,246 | $515K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -0.4% | 13,223 | $514K |
| Counterpoint Mutual Funds LLC | 0.04% | New | 12,952 | $504K |
"% of holder's portfolio" is CSTL's weight in each manager's 13F, not the share of Castle Biosciences Inc. the manager owns.