| HRTG Gpe, LLC | 16.26% | New | 16,917,034 | $403.5M |
| FMR LLC | 0.01% | New | 8,909,066 | $212.5M |
| Perceptive Advisors LLC | 3.04% | New | 8,200,662 | $195.6M |
| T. Rowe Price Investment Management, Inc. | 0.07% | New | 4,207,130 | $100.3M |
| Capital Research Global Investors | 0.01% | New | 3,598,942 | $85.8M |
| JPMorgan Chase & Co. | 0.00% | New | 1,790,734 | $46.4M |
| Alliancebernstein L.P. | 0.01% | New | 1,534,837 | $36.6M |
| Liberty Mutual Group Asset Management Inc. | 2.49% | New | 1,196,411 | $28.5M |
| Jennison Associates LLC | 0.01% | New | 903,575 | $21.6M |
| Paradigm Biocapital Advisors LP | 0.40% | New | 900,000 | $21.5M |
| Jupiter Topco LLC | 0.01% | — | 749,703 | $17.7M |
| T. Rowe Price Associates Inc. | 0.00% | New | 658,787 | $15.7M |
| Massachusetts Financial Services Co. | 0.00% | New | 650,000 | $15.5M |
| Goldman Sachs Group Inc. | 0.00% | New | 644,969 | $15.4M |
| Deep Track Capital, LP | 0.21% | New | 600,000 | $14.3M |
| Woodline Partners LP | 0.03% | New | 413,980 | $9.9M |
| Franklin Resources Inc. | 0.00% | New | 400,021 | $9.5M |
| Montanova Capital, LLC | 0.20% | New | 400,000 | $9.5M |
| Bank of New York Mellon Corp | 0.00% | New | 377,758 | $9.0M |
| Catalio Capital Management, LP | 1.40% | New | 312,500 | $7.5M |
| Principal Financial Group Inc. | 0.00% | New | 300,000 | $7.2M |
| Braidwell LP | 0.27% | New | 300,000 | $7.2M |
| Eventide Asset Management, LLC | 0.10% | New | 300,000 | $7.2M |
| UBS Group AG | 0.00% | New | 267,760 | $6.4M |
| Peregrine Capital Management LLC | 0.18% | New | 229,776 | $5.5M |
| Millennium Management | 0.00% | New | 223,065 | $5.3M |
| Integral Health Asset Management, LLC | 0.20% | New | 200,000 | $4.8M |
| Seven Grand Managers, LLC | 0.19% | New | 200,000 | $4.8M |
| Driehaus Capital Management LLC | 0.03% | New | 199,612 | $4.8M |
| HRT Financial LP | 0.01% | New | 156,242 | $3.7M |
| Ameriprise Financial Inc. | 0.00% | New | 149,474 | $3.6M |
| Vanguard Capital Management LLC | 0.00% | New | 130,826 | $3.1M |
| Citadel Advisors | 0.00% | New | 120,000 | $2.9M |
| Jane Street Group, LLC | 0.00% | New | 109,849 | $2.6M |
| Raymond James Financial Inc. | 0.00% | New | 102,521 | $2.4M |
| Nomura Asset Management International Inc. | 0.00% | New | 74,233 | $1.8M |
| Marshall Wace, LLP | 0.00% | New | 66,821 | $1.6M |
| Morgan Stanley | 0.00% | New | 65,388 | $1.6M |
| TD Asset Management Inc | 0.00% | New | 55,814 | $1.3M |
| Bank of America Corp. | 0.00% | New | 53,782 | $1.3M |
| Casdin Capital, LLC | 0.06% | New | 50,000 | $1.2M |
| Ghisallo Capital Management LLC | 0.03% | New | 50,000 | $1.2M |
| Geode Capital Management, LLC | 0.00% | New | 44,482 | $1.1M |
| Monashee Investment Management LLC | 2.46% | New | 42,693 | $1.0M |
| Sei Investments Co. | 0.00% | New | 40,126 | $957K |
| Shay Capital LLC | 0.10% | New | 38,500 | $918K |
| Burkehill Global Management, LP | 0.03% | New | 30,000 | $716K |
| Alyeska Investment Group, L.P. | 0.00% | New | 30,000 | $716K |
| Vanguard Fiduciary Trust Co. | 0.00% | New | 19,801 | $472K |
| Hudson Bay Capital Management LP | 0.00% | New | 18,960 | $452K |
| Oxford Asset Management LLP | 0.22% | New | 18,378 | $438K |
| Vanguard Portfolio Management LLC | 0.00% | New | 18,249 | $435K |
| Virtu Financial LLC | 0.01% | New | 15,114 | $360K |
| Scientech Research LLC | 0.29% | New | 15,030 | $358K |
| Soros Fund Management | 0.01% | New | 15,000 | $358K |
| D. E. Shaw & Co. | 0.00% | New | 15,000 | $358K |
| XTX Topco Ltd | 0.00% | New | 13,490 | $322K |
| Two Sigma Investments, LP | 0.00% | New | 12,500 | $298K |
| Point72 Asset Management | 0.00% | New | 12,386 | $295K |
| Commonwealth Equity Services, LLC | 0.00% | New | 11,355 | $271K |
| Mariner, LLC | 0.00% | New | 10,879 | $259K |
| Squarepoint Ops LLC | 0.00% | New | 10,368 | $247K |
| DAFNA Capital Management LLC | 0.02% | New | 5,000 | $119K |
| Legal & General Group Plc | 0.00% | New | 5,000 | $119K |
| Vanguard Global Advisers, LLC | 0.00% | New | 1,124 | $27K |
| Wells Fargo & Company | 0.00% | New | 350 | $8K |
| FNY Investment Advisers, LLC | 0.00% | New | 100 | $2K |
| SBI Securities Co., Ltd. | 0.00% | New | 24 | $572 |
| Strategic Wealth Partners, Ltd. | 0.00% | New | 5 | $119 |