| FMR LLC | 0.03% | New | 15,167,808 | $412.9M |
| Alphabet Inc. | 8.56% | New | 4,961,744 | $135.1M |
| MIC Capital Management UK LLP | 25.18% | New | 4,539,540 | $123.6M |
| Venrock Adviser, LLC | 8.69% | New | 3,750,662 | $102.1M |
| Janus Henderson Group PLC | 0.04% | New | 2,905,462 | $81.3M |
| T. Rowe Price Investment Management, Inc. | 0.05% | New | 2,893,009 | $78.7M |
| Wellington Management Group LLP | 0.01% | New | 2,401,991 | $65.4M |
| Alpha Wave Global, LP | 28.91% | New | 2,384,050 | $64.9M |
| BlackRock, Inc. | 0.00% | New | 1,814,353 | $49.4M |
| Viking Global Investors | 0.14% | New | 1,616,612 | $44.0M |
| T. Rowe Price Associates Inc. | 0.01% | New | 1,557,487 | $42.4M |
| Vanguard Group Inc. | 0.00% | New | 1,467,011 | $39.9M |
| Alliancebernstein L.P. | 0.01% | New | 1,202,952 | $32.7M |
| Paradigm Biocapital Advisors LP | 1.49% | New | 1,191,462 | $32.4M |
| Deep Track Capital, LP | 0.96% | New | 1,094,408 | $29.8M |
| Ra Capital Management, L.P. | 0.31% | New | 675,525 | $18.4M |
| Deerfield Management Company, L.P. | 0.31% | New | 500,000 | $13.6M |
| Massachusetts Financial Services Co. | 0.00% | New | 481,679 | $13.1M |
| Geode Capital Management, LLC | 0.00% | New | 434,647 | $11.8M |
| Cormorant Asset Management, LP | 0.82% | New | 400,000 | $10.9M |
| Jennison Associates LLC | 0.01% | New | 355,567 | $9.7M |
| Woodline Partners LP | 0.05% | New | 300,217 | $8.2M |
| American Century Companies Inc. | 0.00% | New | 286,207 | $7.8M |
| Eventide Asset Management, LLC | 0.14% | New | 250,000 | $6.8M |
| State Street Corp. | 0.00% | New | 248,648 | $6.8M |
| Braidwell LP | 0.25% | New | 175,000 | $4.8M |
| Ikarian Capital, LLC | 1.33% | New | 150,000 | $4.1M |
| Siren, L.L.C. | 0.23% | New | 150,000 | $4.1M |
| Norges Bank | 0.00% | New | 127,442 | $3.5M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 125,282 | $3.4M |
| Northern Trust Corp. | 0.00% | New | 122,319 | $3.3M |
| Silverarc Capital Management, LLC | 0.64% | New | 112,759 | $3.1M |
| UBS Group AG | 0.00% | New | 105,275 | $2.9M |
| TD Asset Management Inc | 0.00% | New | 76,824 | $2.1M |
| Millennium Management | 0.00% | New | 73,698 | $2.0M |
| EcoR1 Capital, LLC | 0.08% | New | 50,000 | $1.4M |
| Citadel Advisors | 0.00% | New | 48,495 | $1.3M |
| Boothbay Fund Management, LLC | 0.05% | New | 48,105 | $1.3M |
| Morgan Stanley | 0.00% | New | 45,468 | $1.2M |
| Sofinnova Investments, Inc. | 0.08% | New | 36,800 | $1.0M |
| Bank of New York Mellon Corp | 0.00% | New | 32,494 | $884K |
| Schonfeld Strategic Advisors LLC | 0.00% | New | 21,395 | $582K |
| Goldman Sachs Group Inc. | 0.00% | New | 20,856 | $568K |
| Nuveen, LLC | 0.00% | — | 20,317 | $553K |
| Barclays PLC | 0.00% | New | 19,888 | $541K |
| Susquehanna International Group, LLP | 0.00% | New | 19,112 | $520K |
| Rhumbline Advisers | 0.00% | New | 19,105 | $520K |
| Prudential Financial Inc. | 0.00% | New | 14,900 | $406K |
| Deutsche Bank AG | 0.00% | New | 13,740 | $374K |
| Citigroup Inc. | 0.00% | New | 10,851 | $295K |
| Bank of America Corp. | 0.00% | New | 10,606 | $289K |
| Ameriprise Financial Inc. | 0.00% | New | 10,022 | $273K |
| Invesco Ltd. | 0.00% | New | 9,974 | $271K |
| SummitTX Capital, L.P. | 0.01% | — | 9,523 | $259K |
| MetLife Investment Management, LLC | 0.00% | New | 9,342 | $254K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 9,126 | $248K |
| Wells Fargo & Company | 0.00% | New | 8,193 | $223K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 8,154 | $222K |
| Squarepoint Ops LLC | 0.00% | New | 7,835 | $213K |
| Corebridge Financial, Inc. | 0.00% | New | 7,556 | $206K |
| JPMorgan Chase & Co. | 0.00% | New | 7,295 | $199K |
| New York State Common Retirement Fund | 0.00% | New | 4,800 | $131K |
| SG Americas Securities, LLC | 0.00% | New | 4,647 | $126K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | New | 3,237 | $88K |
| STRS Ohio | 0.00% | New | 2,800 | $76K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 1,573 | $43K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 1,560 | $42K |
| Legal & General Group Plc | 0.00% | New | 1,533 | $42K |
| California State Teachers Retirement System | 0.00% | New | 1,139 | $31K |
| BNP Paribas Financial Markets | 0.00% | New | 800 | $22K |
| Osaic Holdings, Inc. | 0.00% | New | 650 | $18K |
| Amalgamated Bank | 0.00% | New | 532 | $14K |
| Salem Investment Counselors Inc. | 0.00% | New | 200 | $5K |
| SBI Securities Co., Ltd. | 0.00% | New | 152 | $4K |
| Sterling Capital Management LLC | 0.00% | New | 126 | $3K |
| Royal Bank of Canada | 0.00% | New | 71 | $2K |
| Arax Advisory Partners | 0.00% | New | 30 | $817 |
| Jones Financial Companies LLLP | 0.00% | New | 25 | $700 |
| PNC Financial Services Group, Inc. | 0.00% | New | 17 | $463 |
| Nisa Investment Advisors, LLC | 0.00% | New | 9 | $245 |