| Ra Capital Management, L.P. | 6.89% | New | 28,933,371 | $791.9M |
| FMR LLC | 0.01% | New | 10,292,735 | $281.7M |
| ARCH Venture Management, LLC | 15.95% | New | 6,412,780 | $175.5M |
| venBio Partners LLC | 27.75% | New | 5,266,697 | $144.1M |
| Alphabet Inc. | 0.14% | New | 4,919,498 | $134.6M |
| Nextech Invest Ltd. | 6.06% | New | 4,663,176 | $127.6M |
| Cormorant Asset Management, LP | 6.47% | New | 4,615,612 | $126.3M |
| Regeneron Pharmaceuticals, Inc. | 64.35% | New | 4,166,666 | $114.0M |
| Siren, L.L.C. | 1.66% | New | 2,992,259 | $81.9M |
| Farallon Capital Management, L.L.C. | 0.38% | New | 2,368,200 | $64.8M |
| Jupiter Topco LLC | 0.03% | — | 2,296,547 | $62.7M |
| Frazier Life Sciences Management, L.P. | 1.15% | New | 1,920,805 | $52.6M |
| Deerfield Management Company, L.P. | 0.64% | New | 1,880,704 | $51.5M |
| General Catalyst Group Management, LLC | 23.24% | New | 1,600,937 | $43.8M |
| General Atlantic, L.P. | 1.45% | New | 1,538,461 | $42.1M |
| Soleus Capital Management, L.P. | 1.38% | New | 1,465,070 | $40.1M |
| Vanguard Portfolio Management LLC | 0.00% | New | 1,302,479 | $35.6M |
| Vanguard Capital Management LLC | 0.00% | New | 1,156,962 | $31.7M |
| JPMorgan Chase & Co. | 0.00% | New | 1,042,772 | $30.4M |
| Foresite Capital Management VI LLC | 4.26% | New | 999,044 | $27.3M |
| Catalio Capital Management, LP | 4.24% | New | 824,043 | $22.6M |
| Alliancebernstein L.P. | 0.01% | New | 810,279 | $22.2M |
| T. Rowe Price Associates Inc. | 0.00% | New | 751,947 | $20.6M |
| Casdin Capital, LLC | 0.88% | New | 645,690 | $17.7M |
| Venrock Adviser, LLC | 0.52% | New | 625,000 | $17.1M |
| Rock Springs Capital Management LP | 0.77% | New | 578,028 | $15.8M |
| Samsara Biocapital, LLC | 1.25% | New | 556,044 | $15.2M |
| Logos Global Management LP | 0.62% | New | 525,000 | $14.4M |
| Bellevue Group AG | 0.29% | New | 500,000 | $13.7M |
| Baker Bros. Advisors LP | 0.07% | New | 500,000 | $13.7M |
| Marshall Wace, LLP | 0.01% | New | 445,359 | $12.2M |
| Franklin Resources Inc. | 0.00% | New | 381,487 | $10.4M |
| ICONIQ Capital, LLC | 0.28% | New | 350,000 | $9.6M |
| Massachusetts Financial Services Co. | 0.00% | New | 295,962 | $8.1M |
| Kynam Capital Management, LP | 0.38% | New | 250,000 | $6.8M |
| Federated Hermes, Inc. | 0.01% | New | 246,200 | $6.7M |
| Ameriprise Financial Inc. | 0.00% | New | 174,773 | $4.8M |
| Driehaus Capital Management LLC | 0.02% | New | 100,000 | $2.7M |
| Geode Capital Management, LLC | 0.00% | New | 99,358 | $2.7M |
| TD Asset Management Inc | 0.00% | New | 76,982 | $2.1M |
| Squarepoint Ops LLC | 0.00% | New | 48,484 | $1.3M |
| Tudor Investment Corporation | 0.01% | New | 44,045 | $1.2M |
| UBS Group AG | 0.00% | New | 38,698 | $1.1M |
| WINTON GROUP Ltd | 0.03% | New | 34,900 | $955K |
| Vanguard Fiduciary Trust Co. | 0.00% | New | 27,800 | $761K |
| Balyasny Asset Management L.P. | 0.00% | New | 24,264 | $664K |
| Hudson Bay Capital Management LP | 0.00% | New | 22,690 | $621K |
| Brevan Howard Capital Management LP | 0.01% | New | 22,565 | $618K |
| Ghisallo Capital Management LLC | 0.01% | New | 20,000 | $547K |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0.00% | New | 19,200 | $526K |
| Vanguard Personalized Indexing Management, LLC | 0.00% | New | 11,729 | $321K |
| Seven Grand Managers, LLC | 0.01% | New | 10,000 | $274K |
| Burkehill Global Management, LP | 0.01% | New | 10,000 | $274K |
| Alyeska Investment Group, L.P. | 0.00% | New | 10,000 | $274K |
| ExodusPoint Capital Management, LP | 0.00% | New | 9,691 | $265K |
| Scientech Research LLC | 0.21% | New | 9,564 | $262K |
| Two Sigma Investments, LP | 0.00% | New | 8,741 | $239K |
| Goldman Sachs Group Inc. | 0.00% | New | 8,253 | $226K |
| Persistent Asset Partners Ltd | 0.04% | New | 4,130 | $113K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 2,070 | $57K |
| Citigroup Inc. | 0.00% | New | 1,869 | $51K |
| China Universal Asset Management Co., Ltd. | 0.00% | New | 1,600 | $44K |
| Wells Fargo & Company | 0.00% | New | 1,152 | $32K |
| Osaic Holdings, Inc. | 0.00% | New | 920 | $25K |
| Parallel Advisors, LLC | 0.00% | New | 550 | $15K |
| Rialto Wealth Management, LLC | 0.00% | New | 508 | $14K |
| Longaeva Partners L.P. | 0.00% | New | 500 | $14K |
| Bell Investment Advisors, Inc | 0.00% | New | 451 | $12K |
| EverSource Wealth Advisors, LLC | 0.00% | New | 261 | $7K |
| Morgan Stanley | 0.00% | New | 200 | $5K |
| Atlantic Union Bankshares Corp | 0.00% | New | 180 | $5K |
| Jones Financial Companies LLLP | 0.00% | New | 103 | $3K |
| Allworth Financial LP | 0.00% | New | 100 | $3K |
| Fifth Third Bancorp | 0.00% | New | 60 | $2K |
| Physician Wealth Advisors, Inc. | 0.00% | New | 59 | $2K |
| North Star Investment Management Corp. | 0.00% | New | 52 | $1K |
| Avion Wealth | 0.00% | New | 69 | $1K |
| Cornerstone Financial Management LLC | 0.00% | New | 29 | $794 |
| Bogart Wealth, LLC | 0.00% | New | 19 | $520 |