72 Investment Holdings, LLC

In its 13F for Q4 2025 (holdings as of December 31, 2025, filed February 17, 2026), 72 Investment Holdings, LLC reported 5 stock positions worth $50.6 million. Its top holding was Praxis Precision Medicines I (PRAX) at 38.4% of the portfolio, followed by Lenz Therapeutics (LENZ, 32.2%) and Alto Neuroscience (ANRO, 23.5%). Its holdings were unchanged from Q3 2025.

Most Recent 13F
Q2 2026
Location
STAMFORD, CT
CIK
0001832749
Portfolio Value
$50.6M (Q4 2025)
SEC Filing
0000902664-26-001106 ↗ filed Feb 17, 2026

Holdings Value

0$20.0M$40.0M$60.0M$80.0M Q1 2024: $67.1M Q1 2024 Q2 2024: $39.8M Q2 2024 Q3 2024: $46.5M Q3 2024 Q4 2024: $49.1M Q4 2024 Q1 2025: $35.6M Q1 2025 Q2 2025: $38.3M Q2 2025 Q3 2025: $67.9M Q3 2025 Q4 2025: $50.6M $50.6M Q4 2025 Q1 2026: $49.6M Q1 2026 Q2 2026: $50.0M Q2 2026

Holdings 5 stocks · $50.6M
PRAX Praxis Precision Medicines I 38.42% 65,933 $19.4M No change
LENZ Lenz Therapeutics Inc. 32.20% 1,017,751 $16.3M No change
ANRO Alto Neuroscience Inc. 23.50% 667,778 $11.9M No change
KRRO Korro Bio Inc. 4.38% 276,831 $2.2M No change
CRBU Caribou Biosciences Inc. 1.49% 474,067 $754K No change

Portfolio Sells Q3 2025 → Q4 2025
None this quarter.

Portfolio Buys Q3 2025 → Q4 2025
None this quarter.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 5$50.0MPRAX, ANRO, LENZ, KRRO, CRBU
Q1 2026 5$49.6MPRAX, ANRO, LENZ, KRRO, CRBU
Q4 2025 5$50.6MPRAX, LENZ, ANRO, KRRO, CRBU
Q3 2025 5$67.9MLENZ, KRRO, PRAX, ANRO, CRBU
Q2 2025 6$38.3MLENZ, KRRO, PRAX, ANRO, CRBU
Q1 2025 6$35.6MLENZ, KRRO, PRAX, ANRO, CRBU
Q4 2024 7$49.1MLENZ, KRRO, PRAX, ANRO, CRBU
Q3 2024 7$46.5MLENZ, KRRO, ANRO, PRAX, CRBU
Q2 2024 7$39.8MLENZ, KRRO, ANRO, PRAX, TSBX
Q1 2024 7$67.1MKRRO, LENZ, ANRO, PRAX, CRBU