Blue Water Life Science Advisors, LP

In its 13F for Q4 2025 (holdings as of December 31, 2025, filed February 17, 2026), Blue Water Life Science Advisors, LP reported 9 stock positions worth $159.3 million. Its top holding was Guardant Health (GH) at 22.8% of the portfolio, followed by Natera (NTRA, 20.3%) and Adaptive Biotechnologies (ADPT, 18.0%). Compared with Q3 2025, it opened 2 new positions, added to 2 and reduced 2. The biggest buy was a new position in Twist Bioscience (TWST) and the biggest sale Adaptive Biotechnologies (ADPT, shares −18%).

Most Recent 13F
Q2 2026
Location
LARKSPUR, CA
CIK
0001789778
Portfolio Value
$159.3M (Q4 2025)
SEC Filing
0001420506-26-000497 ↗ filed Feb 17, 2026

Holdings Value

0$50.0M$100.0M$150.0M$200.0M Q1 2024: $106.3M Q1 2024 Q2 2024: $102.8M Q2 2024 Q3 2024: $113.7M Q3 2024 Q4 2024: $112.9M Q4 2024 Q1 2025: $100.9M Q1 2025 Q2 2025: $126.3M Q2 2025 Q3 2025: $109.6M Q3 2025 Q4 2025: $159.3M $159.3M Q4 2025 Q1 2026: $124.7M Q1 2026 Q2 2026: $158.8M Q2 2026

Holdings 9 stocks · $159.3M
GH Guardant Health Inc. 22.76% 355,047 $36.3M Reduce -12.5%
NTRA Natera Inc. 20.34% 141,494 $32.4M No change
ADPT Adaptive Biotechnologies 17.99% 1,765,145 $28.7M Reduce -17.7%
PSNL Personalis Inc. 8.37% 1,676,300 $13.3M No change
QTRX Quanterix Corp. 8.35% 2,092,147 $13.3M Add +118.4%
TWST Twist Bioscience Corp. 7.63% 383,000 $12.1M New
CDNA Caredx Inc. 6.03% 510,000 $9.6M No change
GRAL Grail Inc. 5.32% 99,000 $8.5M New
TEM Tempus AI Inc. Class A 3.20% 86,412 $5.1M Add +19.3%

Portfolio Sells Q3 2025 → Q4 2025
ADPT Adaptive Biotechnologies Reduce -17.7% 17.99% −11.29
GH Guardant Health Inc. Reduce -12.5% 22.76% −0.36

Portfolio Buys Q3 2025 → Q4 2025
TWST Twist Bioscience Corp. New 7.63% +7.63
GRAL Grail Inc. New 5.32% +5.32
QTRX Quanterix Corp. Add +118.4% 8.35% +3.61
TEM Tempus AI Inc. Class A Add +19.3% 3.20% −2.13

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 9$158.8MCDNA, TXG, PSNL, ADPT, GH
Q1 2026 10$124.7MTXG, GH, CDNA, ADPT, TWST
Q4 2025 9$159.3MGH, NTRA, ADPT, PSNL, QTRX
Q3 2025 7$109.6MADPT, GH, NTRA, PSNL, CDNA
Q2 2025 8$126.3MNTRA, ADPT, GH, CDNA, TXG
Q1 2025 7$100.9MGH, NTRA, ADPT, CDNA, AKYA
Q4 2024 9$112.9MNTRA, GH, CDNA, ADPT, AKYA
Q3 2024 8$113.7MNTRA, CDNA, EXAS, AKYA, ADPT
Q2 2024 8$102.8MNTRA, GH, AKYA, CDNA, TXG
Q1 2024 8$106.3MNTRA, AKYA, GH, TXG, QTRX