Foresite Capital Management IV, LLC
In its 13F for Q1 2026 (holdings as of March 31, 2026, filed May 15, 2026), Foresite Capital Management IV, LLC reported 8 stock positions worth $237.1 million. Its top holding was Pharvaris (PHVS) at 56.9% of the portfolio, followed by Cytokinetics (CYTK, 14.0%) and Eikon Therapeutics (EIKN, 8.7%). Compared with Q4 2025, it opened 1 new position, added to 1 and reduced 1. The biggest buy was a new position in Eikon Therapeutics (EIKN) and the biggest sale Maze Therapeutics (MAZE, shares −70%).
- Most Recent 13F
- Q2 2026
- Location
- WEST HOLLYWOOD, CA
- CIK
- 0001704132
- Portfolio Value
- $237.1M (Q1 2026)
- SEC Filing
- 0001104659-26-062462 ↗ filed May 15, 2026
Holdings Value
Holdings 8 stocks · $237.1M
| PHVS Pharvaris NV | 56.94% | 4,778,581 | $135.0M | No change |
| CYTK Cytokinetics Inc. | 13.99% | 503,295 | $33.2M | Add +9.8% |
| EIKN Eikon Therapeutics Inc. | 8.67% | 1,943,682 | $20.6M | New |
| LYEL Lyell Immunopharma Inc. | 6.77% | 800,399 | $16.1M | No change |
| RLAY Relay Therapeutics Inc. | 4.20% | 1,000,000 | $9.9M | No change |
| XENE Xenon Pharmaceuticals Inc. | 3.92% | 160,000 | $9.3M | No change |
| ALEC Alector Inc. | 3.53% | 3,887,200 | $8.4M | No change |
| MAZE Maze Therapeutics Inc. | 1.98% | 156,901 | $4.7M | Reduce -70.0% |
Portfolio Sells Q4 2025 → Q1 2026
| MAZE Maze Therapeutics Inc. | Reduce -70.0% | 1.98% | −7.45 |
Portfolio Buys Q4 2025 → Q1 2026
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 6 | $290.2M | PHVS, CYTK, EIKN, RLAY, XENE |
| Q1 2026 | 8 | $237.1M | PHVS, CYTK, EIKN, LYEL, RLAY |
| Q4 2025 | 7 | $229.7M | PHVS, CYTK, LYEL, MAZE, RLAY |
| Q3 2025 | 6 | $182.6M | PHVS, CYTK, MAZE, LYEL, XENE |
| Q2 2025 | 6 | $123.8M | PHVS, MAZE, LYEL, XENE, KURA |
| Q1 2025 | 5 | $111.1M | PHVS, MAZE, LYEL, KURA, RLAY |
| Q4 2024 | 4 | $108.8M | PHVS, KURA, LYEL, RLAY |
| Q3 2024 | 5 | $153.0M | PHVS, KURA, SNDX, LYEL, RLAY |
| Q2 2024 | 4 | $148.8M | PHVS, KURA, SNDX, LYEL |
| Q1 2024 | 5 | $197.9M | PHVS, KURA, KNTE, SNDX, LYEL |