Matrix Capital Management Company, LP

In its 13F for Q4 2025 (holdings as of December 31, 2025, filed February 13, 2026), Matrix Capital Management Company, LP reported 2 stock positions worth $57.6 million. Its top holding was Aura Biosciences (AURA) at 65.5% of the portfolio, followed by Maze Therapeutics (MAZE, 34.5%). Compared with Q3 2025, it sold out of 1 and reduced 1. The biggest sale was an exit from Zentalis Pharmaceuticals (ZNTL).

Most Recent 13F
Q2 2026
Location
Portsmouth, NH
CIK
0001410830
Portfolio Value
$57.6M (Q4 2025)
SEC Filing
0001172661-26-000728 ↗ filed Feb 13, 2026

Holdings Value

0$5.0B$10.0B$15.0B Q1 2024: $10.8B Q1 2024 Q2 2024: $13.1B Q2 2024 Q3 2024: $2.1B Q3 2024 Q4 2024: $2.2B Q4 2024 Q1 2025: $347.2M Q1 2025 Q2 2025: $222.8M Q2 2025 Q3 2025: $106.7M Q3 2025 Q4 2025: $57.6M $57.6M Q4 2025 Q1 2026: $46.3M Q1 2026 Q2 2026: $0 Q2 2026

Holdings 2 stocks · $57.6M

AURA Aura Biosciences Inc. 65.48% 6,922,870 $37.7M No change
MAZE Maze Therapeutics Inc. 34.52% 480,000 $19.9M Reduce -71.0%

Portfolio Sells Q3 2025 → Q4 2025

ZNTL Zentalis Pharmaceuticals Inc. Sold out 0.00% −19.75
MAZE Maze Therapeutics Inc. Reduce -71.0% 34.52% −5.66

Portfolio Buys Q3 2025 → Q4 2025

None this quarter.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 0$0
Q1 2026 1$46.3MAURA
Q4 2025 2$57.6MAURA, MAZE
Q3 2025 3$106.7MMAZE, AURA, ZNTL
Q2 2025 4$222.8MGFS, AURA, MAZE, ZNTL
Q1 2025 4$347.2MGFS, AURA, MAZE, ZNTL
Q4 2024 5$2.2BALTR, GFS, PRM, AURA, ZNTL
Q3 2024 7$2.1BALTR, GFS, PRM, AURA, ZNTL
Q2 2024 23$13.1BNVDA, QCOM, TDG, ALTR, MRVL
Q1 2024 23$10.8BNVDA, TDG, QCOM, ALTR, MRVL