Sofinnova Investments, Inc.
In its 13F for Q2 2024 (holdings as of June 30, 2024, filed August 9, 2024), Sofinnova Investments, Inc. reported 71 stock positions worth $1.6 billion. Its top holding was Natera (NTRA) at 10.6% of the portfolio, followed by Vera Therapeutics (VERA, 6.4%) and Ascendis Pharma A/S (ASND, 6.3%). Compared with Q1 2024, it opened 16 new positions, sold out of 11, added to 31 and reduced 14. The biggest buy was a new position in Edwards Lifesciences (EW) and the biggest sale an exit from Merck (MRK).
- Most Recent 13F
- Q2 2026
- Location
- Menlo Park, CA
- CIK
- 0001631134
- Portfolio Value
- $1.6B (Q2 2024)
- SEC Filing
- 0001104659-24-087771 ↗ filed Aug 9, 2024
Holdings Value
Holdings 71 stocks · $1.6B
| NTRA Natera Inc. | 10.59% | 1,550,280 | $167.9M | No change |
| VERA Vera Therapeutics Inc. | 6.37% | 2,793,987 | $101.1M | No change |
| ASND Ascendis Pharma A/S | 6.31% | 734,284 | $100.1M | Reduce -2.6% |
| NVO Novo-Nordisk A/S-Spons ADR | 5.85% | 649,541 | $92.7M | Add +6.2% |
| EW Edwards Lifesciences Corp. | 4.22% | 724,225 | $66.9M | New |
| SYK Stryker Corp. | 4.14% | 193,084 | $65.7M | New |
| AZN Astrazeneca PLC-Spons ADR | 3.94% | 801,417 | $62.5M | Add +34.3% |
| DYN Dyne Therapeutics Inc. | 3.62% | 1,625,703 | $57.4M | Reduce -16.1% |
| ALGN Align Technology Inc. | 3.33% | 218,524 | $52.8M | Add +128.9% |
| RAPP Rapport Therapeutics Inc. | 2.86% | 1,951,562 | $45.4M | New |
| SNDX Syndax Pharmaceuticals Inc. | 2.79% | 2,153,669 | $44.2M | Add +33.9% |
| ELAN Elanco Animal Health Inc. | 2.61% | 2,864,250 | $41.3M | Add +12.1% |
| IDYA Ideaya Biosciences Inc. | 2.55% | 1,151,528 | $40.4M | Add +47.3% |
| ISRG Intuitive Surgical Inc. | 2.45% | 87,217 | $38.8M | Reduce -38.1% |
| ALNY Alnylam Pharmaceuticals Inc. | 2.27% | 147,929 | $35.9M | Add +43.6% |
| TGTX TG Therapeutics Inc. | 2.09% | 1,861,277 | $33.1M | Reduce -6.2% |
| AVBP Arrivent Biopharma Inc. | 1.98% | 1,696,752 | $31.5M | No change |
| IDXX Idexx Laboratories Inc. | 1.96% | 63,862 | $31.1M | Reduce -15.1% |
| SRPT Sarepta Therapeutics Inc. | 1.95% | 195,852 | $30.9M | Reduce -13.9% |
| YMAB Y-Mabs Therapeutics Inc. | 1.67% | 2,194,278 | $26.5M | No change |
| AXSM Axsome Therapeutics Inc. | 1.57% | 310,198 | $25.0M | New |
| COGT Cogent Biosciences Inc. | 1.47% | 2,773,286 | $23.4M | Add +15.5% |
| SLNO Soleno Therapeutics Inc. | 1.43% | 554,359 | $22.6M | Add +267.7% |
| SVRA Savara Inc. | 1.36% | 5,358,918 | $21.6M | Add +128.3% |
| CLDX Celldex Therapeutics Inc. | 1.28% | 547,707 | $20.3M | Reduce -31.7% |
| ROIV Roivant Sciences Ltd. | 1.25% | 1,868,412 | $19.7M | Add +86.5% |
| ESTA Establishment Labs Holdings | 1.23% | 429,244 | $19.5M | Add +204.1% |
| INZY Inozyme Pharma Inc. | 1.20% | 4,280,308 | $19.1M | No change |
| RVMD Revolution Medicines Inc. | 1.11% | 455,099 | $17.7M | New |
| KURA Kura Oncology Inc. | 1.07% | 825,243 | $17.0M | Add +64.4% |
| INSM Insmed Inc. | 0.96% | 227,747 | $15.3M | New |
| BSX Boston Scientific Corp. | 0.83% | 171,080 | $13.2M | Reduce -51.6% |
| MDGL Madrigal Pharmaceuticals Inc. | 0.78% | 44,417 | $12.4M | Add +133.4% |
| PODD Insulet Corp. | 0.78% | 60,967 | $12.3M | Reduce -72.3% |
| PHVS Pharvaris NV | 0.71% | 601,534 | $11.3M | Add +2.9% |
| AXONICS INC | 0.64% | 150,490 | $10.1M | Add +0.7% |
| IMTX Immatics NV | 0.58% | 796,704 | $9.3M | Reduce -63.2% |
| CABA Cabaletta Bio Inc. | 0.58% | 1,220,400 | $9.1M | Add +184.0% |
| PEPG Pepgen Inc. | 0.56% | 561,128 | $9.0M | Add +11.4% |
| EWTX Edgewise Therapeutics Inc. | 0.54% | 475,691 | $8.6M | New |
| IMNM Immunome Inc. | 0.50% | 655,680 | $7.9M | Add +10.3% |
| EXAS Exact Sciences Corp. | 0.48% | 181,828 | $7.7M | Reduce -20.8% |
| NARI Inari Medical Inc. | 0.47% | 155,838 | $7.5M | Add +1425.4% |
| DXCM Dexcom Inc. | 0.44% | 61,494 | $7.0M | New |
| INBX Inhibrx Biosciences Inc. | 0.41% | 463,315 | $6.6M | Add +42.3% |
| ACHV Achieve Life Sciences Inc. | 0.41% | 1,388,372 | $6.5M | Reduce -8.6% |
| WAT Waters Corp. | 0.40% | 21,804 | $6.3M | New |
| AEROVATE THERAPEUTICS INC | 0.39% | 3,758,686 | $6.2M | No change |
| FDMT 4D Molecular Therapeutics Inc. | 0.36% | 271,155 | $5.7M | Add +36.8% |
| MRNS Marinus Pharmaceuticals Inc. | 0.31% | 4,151,576 | $4.9M | Add +196.3% |
| NXTC Nextcure Inc. | 0.27% | 2,671,856 | $4.2M | No change |
| ERAS Erasca Inc. | 0.25% | 1,699,528 | $4.0M | New |
| PAHC Phibro Animal Health Corp. Class A | 0.25% | 237,009 | $4.0M | New |
| BAX Baxter International Inc. | 0.25% | 117,769 | $3.9M | Add +488.8% |
| AVTR Avantor Inc. | 0.19% | 141,045 | $3.0M | Reduce -39.3% |
| TFX Teleflex Inc. | 0.18% | 13,649 | $2.9M | Add +12.4% |
| MASI Masimo Corp. | 0.16% | 20,161 | $2.5M | Add +0.8% |
| BOLT Bolt Biotherapeutics Inc. | 0.13% | 2,754,437 | $2.1M | No change |
| INSP Inspire Medical Systems Inc. | 0.08% | 10,000 | $1.3M | Add +23.5% |
| IRON Disc Medicine Inc. | 0.08% | 29,256 | $1.3M | Add +373.9% |
| CATX Perspective Therapeutics Inc. | 0.08% | 132,089 | $1.3M | New |
| ZBH Zimmer Biomet Holdings Inc. | 0.07% | 10,630 | $1.2M | New |
| LIVN Livanova PLC | 0.07% | 20,602 | $1.1M | Add +0.7% |
| RNAM Avidity Biosciences Inc. | 0.06% | 21,425 | $875K | New |
| IKENA ONCOLOGY INC | 0.04% | 382,616 | $631K | No change |
| AMLX Amylyx Pharmaceuticals Inc. | 0.04% | 299,691 | $569K | Reduce -2.3% |
| ATXS Astria Therapeutics Inc. | 0.03% | 60,692 | $552K | New |
| PDSB PDS Biotechnology Corp. | 0.03% | 142,635 | $418K | No change |
| LUNG Pulmonx Corp. | 0.02% | 60,246 | $382K | New |
| KYTX Kyverna Therapeutics Inc. | 0.02% | 47,850 | $359K | Add +378.5% |
| GPCR Structure Therapeutics Inc. | 0.02% | 8,915 | $350K | Add +2.1% |
Options reported separately and not counted above: QQQ puts ($191.6M), EW puts ($46.2M), ABT calls ($40.5M), XBI puts ($23.2M), ISRG puts ($22.2M), ALNY calls ($12.2M), SVRA puts ($605K), AMLX puts ($570K), MRNS calls ($122K).
Other holdings (1): bonds, preferreds, convertibles and warrants · $933K (not counted above)
| Security | Class | Shares / Principal | Value | Change |
|---|---|---|---|---|
| IMTXW Immatics NV -CW | *W EXP 07/01/202 | 348,731 | $933K | Add +10.2% |
Total filed on the 13F, all lines: $1.6B.
Portfolio Sells Q1 2024 → Q2 2024
| MRK Merck & Co. Inc. | Sold out | 0.00% | −5.07 |
| INCY Incyte Corp. | Sold out | 0.00% | −4.46 |
| ARGX Argenx SE - ADR | Sold out | 0.00% | −3.47 |
| PODD Insulet Corp. | Reduce -72.3% | 0.78% | −1.45 |
| SILK Silk Road Medical Inc. | Sold out | 0.00% | −1.29 |
| ISRG Intuitive Surgical Inc. | Reduce -38.1% | 2.45% | −0.87 |
| IMTX Immatics NV | Reduce -63.2% | 0.58% | −0.76 |
| CLDX Celldex Therapeutics Inc. | Reduce -31.7% | 1.28% | −0.71 |
| SWAV Shockwave Medical Inc. | Sold out | 0.00% | −0.67 |
| BSX Boston Scientific Corp. | Reduce -51.6% | 0.83% | −0.60 |
| EXAS Exact Sciences Corp. | Reduce -20.8% | 0.48% | −0.45 |
| IDXX Idexx Laboratories Inc. | Reduce -15.1% | 1.96% | −0.44 |
| ASND Ascendis Pharma A/S | Reduce -2.6% | 6.31% | −0.42 |
| FUSN Fusion Pharmaceuticals Inc. | Sold out | 0.00% | −0.20 |
| AVTR Avantor Inc. | Reduce -39.3% | 0.19% | −0.16 |
| COO The Cooper Cos Inc. | Sold out | 0.00% | −0.13 |
| NUCANA PLC | Sold out | 0.00% | −0.05 |
| CATX Perspective Therapeutics Inc. | Sold out | 0.00% | −0.03 |
| Nucana PLC | Sold out | 0.00% | −0.02 |
| AMLX Amylyx Pharmaceuticals Inc. | Reduce -2.3% | 0.04% | −0.02 |
| MIRM Mirum Pharmaceuticals Inc. | Sold out | 0.00% | −0.00 |
| ACHV Achieve Life Sciences Inc. | Reduce -8.6% | 0.41% | +0.00 |
| SRPT Sarepta Therapeutics Inc. | Reduce -13.9% | 1.95% | +0.21 |
| TGTX TG Therapeutics Inc. | Reduce -6.2% | 2.09% | +0.31 |
| DYN Dyne Therapeutics Inc. | Reduce -16.1% | 3.62% | +0.37 |
Portfolio Buys Q1 2024 → Q2 2024
| EW Edwards Lifesciences Corp. | New | 4.22% | +4.22 |
| SYK Stryker Corp. | New | 4.14% | +4.14 |
| RAPP Rapport Therapeutics Inc. | New | 2.86% | +2.86 |
| AXSM Axsome Therapeutics Inc. | New | 1.57% | +1.57 |
| AZN Astrazeneca PLC-Spons ADR | Add +34.3% | 3.94% | +1.55 |
| ALGN Align Technology Inc. | Add +128.9% | 3.33% | +1.48 |
| ALNY Alnylam Pharmaceuticals Inc. | Add +43.6% | 2.27% | +1.36 |
| NVO Novo-Nordisk A/S-Spons ADR | Add +6.2% | 5.85% | +1.21 |
| RVMD Revolution Medicines Inc. | New | 1.11% | +1.11 |
| SLNO Soleno Therapeutics Inc. | Add +267.7% | 1.43% | +1.05 |
| INSM Insmed Inc. | New | 0.96% | +0.96 |
| ESTA Establishment Labs Holdings | Add +204.1% | 1.23% | +0.81 |
| SVRA Savara Inc. | Add +128.3% | 1.36% | +0.67 |
| ROIV Roivant Sciences Ltd. | Add +86.5% | 1.25% | +0.62 |
| EWTX Edgewise Therapeutics Inc. | New | 0.54% | +0.54 |
| SNDX Syndax Pharmaceuticals Inc. | Add +33.9% | 2.79% | +0.53 |
| IDYA Ideaya Biosciences Inc. | Add +47.3% | 2.55% | +0.52 |
| COGT Cogent Biosciences Inc. | Add +15.5% | 1.47% | +0.52 |
| MDGL Madrigal Pharmaceuticals Inc. | Add +133.4% | 0.78% | +0.48 |
| NARI Inari Medical Inc. | Add +1425.4% | 0.47% | +0.44 |
| DXCM Dexcom Inc. | New | 0.44% | +0.44 |
| KURA Kura Oncology Inc. | Add +64.4% | 1.07% | +0.44 |
| WAT Waters Corp. | New | 0.40% | +0.40 |
| ERAS Erasca Inc. | New | 0.25% | +0.25 |
| PAHC Phibro Animal Health Corp. Class A | New | 0.25% | +0.25 |
| BAX Baxter International Inc. | Add +488.8% | 0.25% | +0.20 |
| ELAN Elanco Animal Health Inc. | Add +12.1% | 2.61% | +0.15 |
| CABA Cabaletta Bio Inc. | Add +184.0% | 0.58% | +0.14 |
| PEPG Pepgen Inc. | Add +11.4% | 0.56% | +0.13 |
| CATX Perspective Therapeutics Inc. | New | 0.08% | +0.08 |
| ZBH Zimmer Biomet Holdings Inc. | New | 0.07% | +0.07 |
| IRON Disc Medicine Inc. | Add +373.9% | 0.08% | +0.06 |
| RNAM Avidity Biosciences Inc. | New | 0.06% | +0.06 |
| ATXS Astria Therapeutics Inc. | New | 0.03% | +0.03 |
| AXONICS INC | Add +0.7% | 0.64% | +0.03 |
| LUNG Pulmonx Corp. | New | 0.02% | +0.02 |
| TFX Teleflex Inc. | Add +12.4% | 0.18% | +0.02 |
| KYTX Kyverna Therapeutics Inc. | Add +378.5% | 0.02% | +0.01 |
| LIVN Livanova PLC | Add +0.7% | 0.07% | +0.00 |
| GPCR Structure Therapeutics Inc. | Add +2.1% | 0.02% | 0.00 |
| MASI Masimo Corp. | Add +0.8% | 0.16% | −0.01 |
| FDMT 4D Molecular Therapeutics Inc. | Add +36.8% | 0.36% | −0.01 |
| INSP Inspire Medical Systems Inc. | Add +23.5% | 0.08% | −0.02 |
| PHVS Pharvaris NV | Add +2.9% | 0.71% | −0.08 |
| IMNM Immunome Inc. | Add +10.3% | 0.50% | −0.37 |
| MRNS Marinus Pharmaceuticals Inc. | Add +196.3% | 0.31% | −0.44 |
| INBX Inhibrx Biosciences Inc. | Add +42.3% | 0.41% | −2.27 |
Options Activity Q1 2024 → Q2 2024
| QQQ Invesco QQQ Trust Series 1 | put | New | 400,000 | $191.6M |
| EW Edwards Lifesciences Corp. | put | New | 500,000 | $46.2M |
| ABT Abbott Laboratories | call | New | 390,200 | $40.5M |
| XBI SS SPDR S&P Biotech ETF | put | Reduce -70.6% | 250,000 | $23.2M |
| ISRG Intuitive Surgical Inc. | put | New | 50,000 | $22.2M |
| ALNY Alnylam Pharmaceuticals Inc. | call | New | 50,000 | $12.2M |
| MRNS Marinus Pharmaceuticals Inc. | put | Sold out | 1,000,000 | $9.0Mbefore exit |
| INSM Insmed Inc. | call | Sold out | 100,000 | $2.7Mbefore exit |
| SVRA Savara Inc. | put | New | 150,000 | $605K |
| MRNS Marinus Pharmaceuticals Inc. | call | Reduce -87.8% | 104,700 | $122K |
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.
Notes & Other Activity Q1 2024 → Q2 2024
| IMTXW Immatics NV -CW | *W EXP 07/01/202 | Add +10.2% | 348,731 | $933K |
Bonds, preferreds, convertibles and warrants; not part of the stock holdings or percentages above.
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 53 | $1.9B | NTRA, VERA, GMAB, JAZZ, RAPP |
| Q1 2026 | 61 | $2.0B | NTRA, BMY, JAZZ, VERA, UTHR |
| Q4 2025 | 60 | $2.3B | NTRA, JAZZ, AZN, VERA, BMY |
| Q3 2025 | 55 | $1.6B | NTRA, GILD, VERA, UTHR, JAZZ |
| Q2 2025 | 55 | $1.5B | NTRA, GILD, LLY, JAZZ, VERA |
| Q1 2025 | 59 | $1.3B | NTRA, SYK, VERA, JAZZ, MDT |
| Q4 2024 | 60 | $1.4B | NTRA, VERA, GILD, ABBV, JAZZ |
| Q3 2024 | 56 | $1.2B | NTRA, VERA, NVO, AZN, IDYA |
| Q2 2024 | 71 | $1.6B | NTRA, VERA, ASND, NVO, EW |
| Q1 2024Amended | 66 | $1.7B | NTRA, VERA, ASND, AEROVATE THERAPEUTICS INC, MRK |