| FMR LLC | 0.01% | New | 5,835,259 | $192.1M |
| Novo Holdings A/S | 7.42% | New | 3,883,289 | $127.8M |
| SR One Capital Management, LP | 10.48% | New | 3,308,649 | $108.9M |
| Perceptive Advisors LLC | 1.37% | New | 2,675,296 | $88.1M |
| Montanova Capital, LLC | 1.73% | New | 2,503,109 | $82.4M |
| NVP Associates, LLC | 22.75% | New | 2,268,404 | $74.7M |
| Wellington Management Group LLP | 0.01% | New | 2,201,986 | $72.5M |
| T. Rowe Price Associates Inc. | 0.01% | New | 1,735,231 | $57.1M |
| Catalio Capital Management, LP | 10.37% | New | 1,675,830 | $55.2M |
| T. Rowe Price Investment Management, Inc. | 0.03% | New | 1,602,745 | $52.8M |
| Eventide Asset Management, LLC | 0.60% | New | 1,375,486 | $45.3M |
| Bellevue Group AG | 0.94% | New | 1,350,000 | $44.4M |
| BlackRock, Inc. | 0.00% | New | 977,264 | $32.2M |
| Pivotal bioVenture Partners Investment Advisor LLC | 10.34% | New | 966,792 | $31.8M |
| Citadel Advisors | 0.02% | New | 959,098 | $31.6M |
| Andera Partners | 14.82% | New | 929,824 | $30.6M |
| Jennison Associates LLC | 0.02% | New | 812,749 | $26.8M |
| Braidwell LP | 1.01% | New | 801,395 | $26.4M |
| TPG GP A, LLC | 0.54% | New | 773,069 | $25.4M |
| Vanguard Capital Management LLC | 0.00% | New | 739,770 | $24.4M |
| Deerfield Management Company, L.P. | 0.30% | New | 731,000 | $24.1M |
| Rock Springs Capital Management LP | 1.07% | New | 662,918 | $21.8M |
| Geode Capital Management, LLC | 0.00% | New | 434,650 | $14.3M |
| Soleus Capital Management, L.P. | 0.48% | New | 419,000 | $13.8M |
| Infinitum Asset Management, LLC | 1.38% | New | 411,378 | $13.5M |
| Baker Bros. Advisors LP | 0.06% | New | 350,000 | $11.5M |
| Franklin Resources Inc. | 0.00% | New | 331,684 | $10.9M |
| Silverarc Capital Management, LLC | 1.21% | New | 330,487 | $10.9M |
| State Street Corp. | 0.00% | New | 318,995 | $10.5M |
| Goldman Sachs Group Inc. | 0.00% | New | 283,854 | $9.3M |
| Federated Hermes, Inc. | 0.01% | New | 160,000 | $5.3M |
| Woodline Partners LP | 0.02% | New | 150,999 | $5.0M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 146,992 | $4.8M |
| ADAR1 Capital Management, LLC | 0.23% | New | 146,447 | $4.8M |
| Northern Trust Corp. | 0.00% | New | 136,394 | $4.5M |
| Stempoint Capital LP | 0.67% | New | 118,000 | $3.9M |
| Vanguard Portfolio Management LLC | 0.00% | New | 117,338 | $3.9M |
| Vanguard Fiduciary Trust Co. | 0.00% | New | 116,763 | $3.8M |
| Acuta Capital Partners, LLC | 2.64% | New | 115,000 | $3.8M |
| Burkehill Global Management, LP | 0.14% | New | 115,000 | $3.8M |
| Moore Capital Management, LP | 0.09% | New | 110,451 | $3.6M |
| Blackstone Inc. | 0.01% | New | 97,985 | $3.2M |
| TD Asset Management Inc | 0.00% | New | 94,636 | $3.1M |
| Seven Grand Managers, LLC | 0.10% | New | 75,000 | $2.5M |
| Ghisallo Capital Management LLC | 0.06% | New | 70,000 | $2.3M |
| Atom Investors LP | 0.20% | New | 68,254 | $2.2M |
| Aberdeen Group plc | 0.00% | New | 67,174 | $2.2M |
| Zimmer Partners, LP | 0.05% | New | 62,500 | $2.1M |
| Avidity Partners Management LP | 0.32% | New | 60,000 | $2.0M |
| LMR Partners LLP | 0.02% | New | 54,323 | $1.8M |
| Ameriprise Financial Inc. | 0.00% | New | 50,045 | $1.6M |
| Freestone Grove Partners LP | 0.01% | New | 50,000 | $1.6M |
| Brevan Howard Capital Management LP | 0.02% | New | 43,001 | $1.4M |
| Bank of New York Mellon Corp | 0.00% | New | 40,140 | $1.3M |
| Shay Capital LLC | 0.15% | New | 40,000 | $1.3M |
| Balyasny Asset Management L.P. | 0.00% | New | 33,975 | $1.1M |
| Nuveen, LLC | 0.00% | New | 29,670 | $977K |
| Davidson Kempner Capital Management LP | 0.02% | New | 23,000 | $757K |
| D. E. Shaw & Co. | 0.00% | New | 23,000 | $757K |
| Rhumbline Advisers | 0.00% | New | 20,502 | $675K |
| Deutsche Bank AG | 0.00% | New | 16,933 | $557K |
| Morgan Stanley | 0.00% | New | 16,906 | $557K |
| Wells Fargo & Company | 0.00% | New | 15,228 | $501K |
| Hudson Bay Capital Management LP | 0.00% | New | 14,180 | $467K |
| Longaeva Partners L.P. | 0.01% | New | 12,500 | $412K |
| UBS Group AG | 0.00% | New | 12,296 | $405K |
| Bank of America Corp. | 0.00% | New | 11,668 | $384K |
| Invesco Ltd. | 0.00% | New | 11,607 | $382K |
| Raymond James Financial Inc. | 0.00% | New | 11,483 | $378K |
| XTX Topco Ltd | 0.00% | New | 10,640 | $350K |
| MetLife Investment Management, LLC | 0.00% | New | 10,308 | $339K |
| Soros Fund Management | 0.01% | New | 10,000 | $329K |
| Virtu Financial LLC | 0.01% | New | 8,792 | $289K |
| Citigroup Inc. | 0.00% | New | 8,035 | $265K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 7,854 | $259K |
| Vanguard Global Advisers, LLC | 0.00% | New | 7,485 | $246K |
| JPMorgan Chase & Co. | 0.00% | New | 7,102 | $220K |
| Two Sigma Investments, LP | 0.00% | New | 6,675 | $220K |
| Sei Investments Co. | 0.00% | New | 6,592 | $217K |
| New York State Common Retirement Fund | 0.00% | New | 6,000 | $198K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | New | 5,052 | $166K |
| Barclays PLC | 0.00% | New | 4,390 | $145K |
| BNP Paribas Financial Markets | 0.00% | New | 3,958 | $130K |
| Legal & General Group Plc | 0.00% | New | 3,504 | $115K |
| STRS Ohio | 0.00% | New | 3,400 | $112K |
| Persistent Asset Partners Ltd | 0.02% | New | 2,064 | $68K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 1,555 | $51K |
| Russell Investments Group, Ltd. | 0.00% | New | 1,369 | $45K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 1,055 | $35K |
| Royal Bank of Canada | 0.00% | New | 588 | $19K |
| Nisa Investment Advisors, LLC | 0.00% | New | 503 | $17K |
| California State Teachers Retirement System | 0.00% | New | 236 | $8K |
| Sterling Capital Management LLC | 0.00% | New | 149 | $5K |