| EQT Fund Management S.a r.l. | 7.59% | New | 4,929,633 | $84.4M |
| Ra Capital Management, L.P. | 0.61% | New | 3,458,770 | $59.2M |
| Pivotal bioVenture Partners Investment Advisor LLC | 12.75% | New | 1,926,943 | $33.0M |
| Andera Partners | 18.39% | — | 1,897,362 | $32.5M |
| Nan Fung Group Holdings Ltd | 22.08% | New | 1,441,032 | $24.7M |
| JPMorgan Chase & Co. | 0.00% | New | 1,308,901 | $22.4M |
| RTW Investments, LP | 0.22% | New | 1,283,671 | $22.0M |
| SymBiosis Capital Partners, LLC | 20.03% | — | 1,280,778 | $21.9M |
| Marshall Wace, LLP | 0.02% | New | 988,200 | $16.9M |
| Eventide Asset Management, LLC | 0.26% | New | 961,525 | $16.5M |
| T. Rowe Price Associates Inc. | 0.00% | New | 782,121 | $13.4M |
| Sectoral Asset Management Inc. | 8.08% | New | 589,005 | $10.1M |
| Verition Fund Management LLC | 0.05% | New | 565,214 | $9.7M |
| Aberdeen Group plc | 0.01% | New | 525,376 | $9.0M |
| Velan Capital Investment Management LP | 5.05% | New | 506,754 | $8.7M |
| Vanguard Group Inc. | 0.00% | New | 502,574 | $8.6M |
| Octagon Capital Advisors LP | 1.07% | New | 500,000 | $8.6M |
| American Century Companies Inc. | 0.00% | New | 417,455 | $7.1M |
| Great Point Partners LLC | 1.80% | New | 325,000 | $5.6M |
| Federated Hermes, Inc. | 0.01% | New | 325,000 | $5.6M |
| NEXTBio Capital Management LP | 2.29% | — | 228,286 | $3.9M |
| Defilade Capital Management, L.P. | 0.50% | — | 215,418 | $3.7M |
| Kynam Capital Management, LP | 0.21% | New | 185,482 | $3.2M |
| ADAR1 Capital Management, LLC | 0.24% | New | 184,062 | $3.2M |
| Monashee Investment Management LLC | 1.85% | New | 183,239 | $3.1M |
| Sphera Funds Management LTD. | 0.59% | New | 166,147 | $2.8M |
| Sofinnova Investments, Inc. | 0.11% | New | 153,320 | $2.6M |
| BlackRock, Inc. | 0.00% | New | 142,440 | $2.4M |
| Integral Health Asset Management, LLC | 0.11% | New | 125,000 | $2.1M |
| MPM Bioimpact LLC | 0.22% | New | 113,022 | $1.9M |
| Geode Capital Management, LLC | 0.00% | New | 109,781 | $1.9M |
| Ameriprise Financial Inc. | 0.00% | New | 104,555 | $1.8M |
| Seven Grand Managers, LLC | 0.10% | New | 75,000 | $1.3M |
| Stempoint Capital LP | 0.20% | New | 68,196 | $1.2M |
| Balyasny Asset Management L.P. | 0.00% | New | 65,000 | $1.1M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 62,704 | $1.1M |
| Goldman Sachs Group Inc. | 0.00% | New | 61,675 | $1.1M |
| Capricorn Fund Managers Ltd | 0.25% | New | 60,000 | $1.0M |
| Citadel Advisors | 0.00% | New | 50,560 | $866K |
| Burkehill Global Management, LP | 0.06% | New | 50,000 | $856K |
| TD Asset Management Inc | 0.00% | New | 44,634 | $764K |
| Point72 Asset Management | 0.00% | New | 34,384 | $589K |
| Tudor Investment Corporation | 0.00% | New | 31,953 | $547K |
| State Street Corp. | 0.00% | New | 31,500 | $539K |
| Qube Research & Technologies Ltd | 0.00% | New | 24,057 | $412K |
| Northern Trust Corp. | 0.00% | New | 22,636 | $388K |
| Two Sigma Investments, LP | 0.00% | New | 21,324 | $365K |
| Oxford Asset Management LLP | 0.12% | New | 19,565 | $335K |
| XTX Topco Ltd | 0.01% | New | 18,778 | $321K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 10,225 | $179K |
| Morgan Stanley | 0.00% | New | 8,346 | $143K |
| UBS Group AG | 0.00% | New | 3,414 | $58K |
| Bank of America Corp. | 0.00% | New | 2,937 | $50K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 2,745 | $47K |
| National Bank of Canada | 0.00% | New | 2,200 | $38K |
| China Universal Asset Management Co., Ltd. | 0.00% | New | 2,000 | $34K |
| Royal Bank of Canada | 0.00% | New | 585 | $10K |
| Legal & General Group Plc | 0.00% | New | 400 | $7K |
| Comerica Bank | 0.00% | New | 20 | $330 |