5AM Venture Management, LLC

In its 13F for Q2 2026 (holdings as of June 30, 2026, filed August 14, 2026), 5AM Venture Management, LLC reported 16 stock positions worth $287.9 million. Its top holding was Maplight Therapeutics (MPLT) at 11.8% of the portfolio, followed by Tyra Biosciences (TYRA, 11.4%) and Entrada Therapeutics (TRDA, 10.4%). Compared with Q1 2026, it sold out of 4 and reduced 1. The biggest sale was an exit from Erasca (ERAS).

Most Recent 13F
Q2 2026
Location
SAN FRANCISCO, CA
CIK
0001799883
Portfolio Value
$287.9M (Q2 2026)
SEC Filing
0001799883-26-000003 ↗ filed Aug 14, 2026

Holdings Value

0$100.0M$200.0M$300.0M$400.0M$500.0M Q1 2024: $446.6M Q1 2024 Q2 2024: $447.1M Q2 2024 Q3 2024: $484.0M Q3 2024 Q4 2024: $419.1M Q4 2024 Q1 2025: $264.4M Q1 2025 Q2 2025: $260.1M Q2 2025 Q3 2025: $273.0M Q3 2025 Q4 2025: $318.1M Q4 2025 Q1 2026: $360.2M Q1 2026 Q2 2026: $287.9M $287.9M Q2 2026

Holdings 16 stocks · $287.9M
MPLT Maplight Therapeutics Inc. 11.83% 950,011 $34.0M No change
TYRA Tyra Biosciences Inc. 11.42% 1,029,298 $32.9M No change
TRDA Entrada Therapeutics Inc. 10.37% 4,056,379 $29.9M No change
PHVS Pharvaris NV 9.58% 797,600 $27.6M No change
CAMP CAMP4 Therapeutics Corp. 8.91% 5,869,091 $25.6M No change
ARTV Artiva Biotherapeutics Inc. 7.93% 2,353,304 $22.8M No change
TECX Tectonic Therapeutic Inc. 7.24% 606,660 $20.9M No change
ZNTL Zentalis Pharmaceuticals Inc. 6.65% 3,947,913 $19.1M No change
CLDX Celldex Therapeutics Inc. 6.43% 497,270 $18.5M No change
EYPT Eyepoint Inc. 5.22% 1,050,000 $15.0M No change
BHVN Biohaven Ltd. 3.82% 738,972 $11.0M No change
SRZN Surrozen Inc. 2.44% 271,250 $7.0M Reduce -30.0%
SKYE Skye Bioscience Inc. 2.33% 9,681,763 $6.7M No change
ALXO Alx Oncology Holdings Inc. 2.20% 3,057,325 $6.3M No change
TARA Protara Therapeutic Inc. 1.82% 1,369,782 $5.2M No change
SLN Silence Therapeutics PLC-ADR 1.82% 476,200 $5.2M No change

Portfolio Sells Q1 2026 → Q2 2026
ERAS Erasca Inc. Sold out 0.00% −15.66
CNTA Centessa Pharmaceuticals Ltd. Sold out 0.00% −6.41
GHRS GH Research PLC Sold out 0.00% −2.24
RLYB Rallybio Corp. Sold out 0.00% −0.73
SRZN Surrozen Inc. Reduce -30.0% 2.44% −0.69

Portfolio Buys Q1 2026 → Q2 2026
None this quarter.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 16$287.9MMPLT, TYRA, TRDA, PHVS, CAMP
Q1 2026 20$360.2MERAS, TRDA, TYRA, CAMP, CNTA
Q4 2025 21$318.1MTRDA, CAMP, TYRA, VRDN, PHVS
Q3 2025 25$273.0MSKYE, TRDA, PHVS, CAMP, CNTA
Q2 2025 29$260.1MSKYE, TRDA, DNTH, ELVN, PHVS
Q1 2025 31$264.4MTRDA, ELVN, DNTH, SKYE, PHVS
Q4 2024 31$419.1MTRDA, ELVN, SKYE, TECX, ARTV
Q3 2024 28$484.0MTRDA, ELVN, SKYE, ARTV, DNTH
Q2 2024 28$447.1MSKYE, TRDA, ELVN, DNTH, CLDX
Q1 2024 26$446.6MELVN, TRDA, DNTH, MRUS, CLDX