Atlas Venture Life Science Advisors, LLC
In its 13F for Q1 2025 (holdings as of March 31, 2025, filed May 14, 2025), Atlas Venture Life Science Advisors, LLC reported 13 stock positions worth $521.8 million. Its top holding was Kymera Therapeutics (KYMR) at 25.7% of the portfolio, followed by Disc Medicine (IRON, 22.7%) and Dyne Therapeutics (DYN, 18.3%). Compared with Q4 2024, it opened 1 new position, sold out of 1, added to 1 and reduced 1. The biggest buy was a new position in Sionna Therapeutics (SION) and the biggest sale an exit from Tectonic Therapeutic (TECX).
- Most Recent 13F
- Q2 2026
- Location
- CAMBRIDGE, MA
- CIK
- 0001917529
- Portfolio Value
- $521.8M (Q1 2025)
- SEC Filing
- 0001104659-25-048527 ↗ filed May 14, 2025
Holdings Value
Holdings 13 stocks · $521.8M
| KYMR Kymera Therapeutics Inc. | 25.69% | 4,896,462 | $134.0M | No change |
| IRON Disc Medicine Inc. | 22.69% | 2,384,456 | $118.4M | Reduce -5.0% |
| DYN Dyne Therapeutics Inc. | 18.30% | 9,130,465 | $95.5M | Add +13.9% |
| DAWN Day One Biopharmaceuticals I | 9.77% | 6,430,257 | $51.0M | No change |
| SION Sionna Therapeutics Inc. | 7.41% | 3,694,020 | $38.6M | New |
| THRD Third Harmonic Bio Inc. | 6.92% | 10,402,286 | $36.1M | No change |
| KRRO Korro Bio Inc. | 3.79% | 1,137,149 | $19.8M | No change |
| VIGL Vigil Neuroscience Inc. | 1.99% | 5,836,874 | $10.4M | No change |
| IKENA ONCOLOGY INC | 1.23% | 5,018,178 | $6.4M | No change |
| AEROVATE THERAPEUTICS INC | 0.87% | 1,799,232 | $4.5M | No change |
| QTTB Q32 Bio Inc. | 0.66% | 2,092,106 | $3.5M | No change |
| GBIO Generation Bio Co. | 0.64% | 8,279,484 | $3.4M | No change |
| SPRO Spero Therapeutics Inc. | 0.04% | 305,255 | $220K | No change |
Portfolio Sells Q4 2024 → Q1 2025
Portfolio Buys Q4 2024 → Q1 2025
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 7 | $881.3M | KYMR, DYN, SION, KLRA, IRON |
| Q1 2026 | 6 | $790.0M | KYMR, DYN, SION, IRON, QTTB |
| Q4 2025 | 8 | $865.2M | KYMR, DYN, SION, IRON, DAWN |
| Q3 2025 | 9 | $752.6M | KYMR, IRON, DYN, SION, KRRO |
| Q2 2025 | 11 | $662.4M | KYMR, IRON, DYN, SION, THRD |
| Q1 2025 | 13 | $521.8M | KYMR, IRON, DYN, DAWN, SION |
| Q4 2024 | 13 | $819.7M | KYMR, DYN, IRON, THRD, DAWN |
| Q3 2024 | 14 | $1.1B | DYN, KYMR, THRD, IRON, QTTB |
| Q2 2024 | 15 | $949.6M | DYN, KYMR, THRD, IRON, DAWN |
| Q1 2024 | 16 | $1.1B | DYN, KYMR, IRON, DAWN, THRD |