Column Group LLC
In its 13F for Q4 2025 (holdings as of December 31, 2025, filed February 13, 2026), Column Group LLC reported 5 stock positions worth $82.8 million. Its top holding was Surrozen (SRZN) at 50.5% of the portfolio, followed by Oric Pharmaceuticals (ORIC, 35.0%) and Tenaya Therapeutics (TNYA, 8.1%). Compared with Q3 2025, it added to 1 and reduced 1. The biggest buy was Surrozen (SRZN, shares +23%) and the biggest sale Rapt Therapeutics (shares −6%).
- Most Recent 13F
- Q2 2026
- Location
- San Francisco, CA
- CIK
- 0001833486
- Portfolio Value
- $82.8M (Q4 2025)
- SEC Filing
- 0001193125-26-051393 ↗ filed Feb 13, 2026
Holdings Value
Holdings 5 stocks · $82.8M
| SRZN Surrozen Inc. | 50.54% | 1,851,350 | $41.8M | Add +23.4% |
| ORIC Oric Pharmaceuticals Inc. | 34.98% | 3,540,777 | $29.0M | No change |
| TNYA Tenaya Therapeutics Inc. | 8.08% | 9,400,290 | $6.7M | No change |
| RAPT THERAPEUTICS INC | 6.39% | 156,270 | $5.3M | Reduce -5.9% |
| RVMD Revolution Medicines Inc. | 0.00% | 46 | $4K | No change |
Portfolio Sells Q3 2025 → Q4 2025
| RAPT THERAPEUTICS INC | Reduce -5.9% | 6.39% | +1.10 |
Portfolio Buys Q3 2025 → Q4 2025
| SRZN Surrozen Inc. | Add +23.4% | 50.54% | +26.66 |
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 3 | $88.1M | SRZN, ORIC, RVMD |
| Q1 2026 | 3 | $100.7M | SRZN, ORIC, RVMD |
| Q4 2025 | 5 | $82.8M | SRZN, ORIC, TNYA, RAPT THERAPEUTICS INC, RVMD |
| Q3 2025 | 5 | $81.0M | ORIC, SRZN, TNYA, RAPT THERAPEUTICS INC, RVMD |
| Q2 2025 | 5 | $65.7M | ORIC, SRZN, RAPT THERAPEUTICS INC, TNYA, RVMD |
| Q1 2025 | 5 | $44.2M | ORIC, SRZN, TNYA, RAPT THERAPEUTICS INC, RVMD |
| Q4 2024 | 5 | $55.7M | ORIC, TNYA, SRZN, RAPT THERAPEUTICS INC, RVMD |
| Q3 2024 | 6 | $69.6M | ORIC, TNYA, SRZN, RAPT THERAPEUTICS INC, SGMT |
| Q2 2024 | 6 | $71.3M | TNYA, ORIC, SRZN, RAPT THERAPEUTICS INC, SGMT |
| Q1 2024 | 7 | $160.5M | TNYA, ORIC, NGM, RAPT THERAPEUTICS INC, SRZN |