DAFNA Capital Management LLC

In its 13F for Q2 2024 (holdings as of June 30, 2024, filed August 14, 2024), DAFNA Capital Management LLC reported 82 stock positions worth $414.1 million. Its top holding was SS SPDR S&P Biotech ETF (XBI) at 10.0% of the portfolio, followed by Stereotaxis (STXS, 6.0%) and Merus (MRUS, 5.8%). Compared with Q1 2024, it opened 14 new positions, sold out of 3, added to 17 and reduced 17. The biggest buy was Merus (MRUS, shares +8%) and the biggest sale Viking Therapeutics (VKTX, shares −3%).

Most Recent 13F
Q2 2026
Location
LOS ANGELES, CA
CIK
0001389933
Portfolio Value
$414.1M (Q2 2024)
SEC Filing
0001389932-24-000016 ↗ filed Aug 14, 2024

Holdings Value

0$200.0M$400.0M$600.0M Q1 2024: $434.7M Q1 2024 Q2 2024: $414.1M $414.1M Q2 2024 Q3 2024: $418.6M Q3 2024 Q4 2024: $389.0M Q4 2024 Q1 2025: $348.0M Q1 2025 Q2 2025: $357.2M Q2 2025 Q3 2025: $399.3M Q3 2025 Q4 2025: $425.1M Q4 2025 Q1 2026: $433.7M Q1 2026 Q2 2026: $524.4M Q2 2026

Holdings 82 stocks · $414.1M
XBI SS SPDR S&P Biotech ETF 9.96% 445,005 $41.3M Add +3.2%
STXS Stereotaxis Inc. 6.01% 13,680,554 $24.9M No change
MRUS Merus NV 5.85% 409,445 $24.2M Add +8.0%
CYTK Cytokinetics Inc. 5.21% 398,100 $21.6M No change
RVMD Revolution Medicines Inc. 4.80% 511,894 $19.9M No change
IDYA Ideaya Biosciences Inc. 3.58% 422,213 $14.8M Reduce -5.4%
ATRC Atricure Inc. 3.51% 639,173 $14.6M Add +135.8%
IBB iShares Biotechnology ETF 3.40% 102,500 $14.1M No change
SNDX Syndax Pharmaceuticals Inc. 3.26% 657,074 $13.5M Reduce -0.4%
BPMC Blueprint Medicines Corp. 2.73% 104,763 $11.3M Reduce -1.9%
ASND Ascendis Pharma A/S 2.67% 80,972 $11.0M Reduce -12.4%
XENE Xenon Pharmaceuticals Inc. 2.58% 273,739 $10.7M No change
VKTX Viking Therapeutics Inc. 2.42% 189,117 $10.0M Reduce -2.6%
NBIX Neurocrine Biosciences Inc. 2.38% 71,615 $9.9M No change
KALV Kalvista Pharmaceuticals Inc. 2.30% 806,973 $9.5M No change
DAWN Day One Biopharmaceuticals I 2.22% 666,463 $9.2M No change
KURA Kura Oncology Inc. 2.11% 423,500 $8.7M Add +2.6%
TNDM Tandem Diabetes Care Inc. 1.99% 204,208 $8.2M Reduce -20.9%
MORF Morphic Holding Inc. 1.91% 231,748 $7.9M No change
URGN Urogen Pharma Ltd. 1.90% 469,000 $7.9M New
BHVN Biohaven Ltd. 1.83% 218,730 $7.6M Add +84.2%
DXCM Dexcom Inc. 1.79% 65,552 $7.4M No change
AXGN Axogen Inc. 1.64% 935,894 $6.8M No change
EWTX Edgewise Therapeutics Inc. 1.26% 290,197 $5.2M Reduce -5.2%
LRMR Larimar Therapeutics Inc. 1.12% 639,974 $4.6M Reduce -2.5%
BCRX Biocryst Pharmaceuticals Inc. 1.05% 704,500 $4.4M Reduce -0.7%
IPSC Century Therapeutics Inc. 1.05% 1,704,232 $4.3M Add +30.4%
ALEC Alector Inc. 1.00% 912,928 $4.1M No change
TSVT 2SEVENTY Bio Inc. 0.98% 1,050,709 $4.0M Reduce -12.7%
RCUS Arcus Biosciences Inc. 0.93% 253,217 $3.9M Add +9.3%
LKFT Lakefront Biotherapeutic-ADR filed as GALAPAGOS NV 0.78% 130,175 $3.2M No change
PODD Insulet Corp. 0.77% 15,900 $3.2M No change
KROS Keros Therapeutics Inc. 0.75% 67,754 $3.1M No change
SLRN Acelyrin Inc. 0.74% 693,609 $3.1M Add +242.4%
ALKS Alkermes PLC 0.70% 120,700 $2.9M New
STOK Stoke Therapeutics Inc. 0.68% 207,427 $2.8M Add +43.0%
ATXS Astria Therapeutics Inc. 0.60% 274,165 $2.5M Add +22.8%
BCYC Bicycle Therapeutics PLC-ADR 0.60% 122,200 $2.5M No change
CATX Perspective Therapeutics Inc. 0.56% 231,634 $2.3M New
ARAY Accuray Inc. 0.54% 1,222,358 $2.2M No change
ITOS Iteos Therapeutics Inc. 0.52% 144,360 $2.1M Add +46.5%
SPRY Ars Pharmaceuticals Inc. 0.49% 239,194 $2.0M No change
MDWD Mediwound Ltd. 0.47% 124,479 $1.9M Reduce -34.0%
BWAY Brainsway Ltd.-ADR 0.44% 297,655 $1.8M No change
INGN Inogen Inc. 0.41% 208,790 $1.7M No change
IMTX Immatics NV 0.41% 145,000 $1.7M No change
RGLS Regulus Therapeutics Inc. 0.39% 895,200 $1.6M Reduce -16.4%
PRQR Proqr Therapeutics NV 0.36% 905,582 $1.5M No change
CMPS Compass Pathways PLC 0.35% 243,210 $1.5M No change
ALLO Allogene Therapeutics Inc. 0.34% 605,100 $1.4M New
MLYS Mineralys Therapeutics Inc. 0.34% 119,000 $1.4M Add +32.2%
AQST Aquestive Therapeutics Inc. 0.33% 530,000 $1.4M Add +6.0%
LCTX Lineage Cell Therapeutics Inc. 0.33% 1,350,708 $1.3M Reduce -1.1%
ANRO Alto Neuroscience Inc. 0.31% 120,000 $1.3M Add +1100.0%
GOSS Gossamer Bio Inc. 0.31% 1,409,262 $1.3M No change
IMVT Immunovant Inc. 0.31% 47,916 $1.3M Add +62.9%
SAGE Sage Therapeutics Inc. 0.30% 116,200 $1.3M New
AUTL Autolus Therapeutics PLC 0.29% 346,667 $1.2M Add +60.0%
CNTA Centessa Pharmaceuticals Ltd. 0.27% 122,882 $1.1M New
TRML Tourmaline Bio Inc. 0.24% 75,982 $977K New
STRO Sutro Biopharma Inc. Com SHS 0.23% 329,579 $966K Reduce -1.4%
PRCT Procept Biorobotics Corp. 0.21% 13,994 $855K Reduce -74.5%
PYPD Polypid Ltd. 0.19% 184,846 $795K Reduce -0.3%
CGEN Compugen Ltd. 0.19% 462,202 $776K Add +7.4%
NYXH Nyxoah SA 0.18% 108,108 $754K New
ACET Adicet Bio Inc. 0.18% 600,000 $726K No change
ACRV Acrivon Therapeutics Inc. 0.17% 121,351 $704K Reduce -7.6%
SYRS Syros Pharmaceuticals Inc. 0.17% 135,850 $701K No change
ADCT Adc Therapeutics SA 0.16% 204,081 $645K New
TERN Terns Pharmaceuticals Inc. 0.14% 86,000 $586K New
STIM Neuronetics Inc. 0.14% 313,717 $565K No change
APRE Aprea Therapeutics Inc. 0.13% 137,174 $558K No change
NGNE Neurogene Inc. 0.10% 11,000 $400K New
MASI Masimo Corp. 0.09% 3,000 $378K No change
ADAPY Adaptimmune Therapeutics-ADR 0.08% 341,064 $333K No change
ORIC Oric Pharmaceuticals Inc. 0.06% 36,000 $255K New
FHTX Foghorn Therapeutics Inc. 0.06% 41,850 $241K New
NVRO Nevro LLC filed as NEVRO CORP 0.06% 28,000 $236K No change
GPCR Structure Therapeutics Inc. 0.05% 5,000 $196K New
KPTI Karyopharm Therapeutics Inc. 0.04% 192,678 $167K No change
SPRO Spero Therapeutics Inc. 0.04% 125,000 $163K No change
CMPX Compass Therapeutics Inc. 0.03% 116,882 $117K No change
Other holdings (1): bonds, preferreds, convertibles and warrants · $4.4M (not counted above)
SecurityClassShares / PrincipalValueChange
ASCENDIS PHARMA A/S (ASND 2.25 04/01/28) NOTE 2.250% 4/0 · principal 4,000,000$4.4MNo change

Total filed on the 13F, all lines: $418.6M.

Portfolio Sells Q1 2024 → Q2 2024
VKTX Viking Therapeutics Inc. Reduce -2.6% 2.42% −1.24
IDYA Ideaya Biosciences Inc. Reduce -5.4% 3.58% −0.93
CATX Perspective Therapeutics Inc. Sold out 0.00% −0.85
ASND Ascendis Pharma A/S Reduce -12.4% 2.67% −0.55
TSVT 2SEVENTY Bio Inc. Reduce -12.7% 0.98% −0.51
PRCT Procept Biorobotics Corp. Reduce -74.5% 0.21% −0.42
BNTX Biontech SE-ADR Sold out 0.00% −0.36
SNDX Syndax Pharmaceuticals Inc. Reduce -0.4% 3.26% −0.35
RGLS Regulus Therapeutics Inc. Reduce -16.4% 0.39% −0.32
STRO Sutro Biopharma Inc. Com SHS Reduce -1.4% 0.23% −0.20
MDWD Mediwound Ltd. Reduce -34.0% 0.47% −0.15
LCTX Lineage Cell Therapeutics Inc. Reduce -1.1% 0.33% −0.14
TNDM Tandem Diabetes Care Inc. Reduce -20.9% 1.99% −0.12
VIGL Vigil Neuroscience Inc. Sold out 0.00% −0.06
ACRV Acrivon Therapeutics Inc. Reduce -7.6% 0.17% −0.05
LRMR Larimar Therapeutics Inc. Reduce -2.5% 1.12% −0.03
EWTX Edgewise Therapeutics Inc. Reduce -5.2% 1.26% −0.02
PYPD Polypid Ltd. Reduce -0.3% 0.19% −0.00
BCRX Biocryst Pharmaceuticals Inc. Reduce -0.7% 1.05% +0.22
BPMC Blueprint Medicines Corp. Reduce -1.9% 2.73% +0.40

Portfolio Buys Q1 2024 → Q2 2024
MRUS Merus NV Add +8.0% 5.85% +1.92
URGN Urogen Pharma Ltd. New 1.90% +1.90
ATRC Atricure Inc. Add +135.8% 3.51% +1.62
ALKS Alkermes PLC New 0.70% +0.70
CATX Perspective Therapeutics Inc. New 0.56% +0.56
XBI SS SPDR S&P Biotech ETF Add +3.2% 9.96% +0.55
SLRN Acelyrin Inc. Add +242.4% 0.74% +0.42
ALLO Allogene Therapeutics Inc. New 0.34% +0.34
BHVN Biohaven Ltd. Add +84.2% 1.83% +0.34
SAGE Sage Therapeutics Inc. New 0.30% +0.30
ANRO Alto Neuroscience Inc. Add +1100.0% 0.31% +0.27
CNTA Centessa Pharmaceuticals Ltd. New 0.27% +0.27
TRML Tourmaline Bio Inc. New 0.24% +0.24
STOK Stoke Therapeutics Inc. Add +43.0% 0.68% +0.23
ITOS Iteos Therapeutics Inc. Add +46.5% 0.52% +0.21
NYXH Nyxoah SA New 0.18% +0.18
ADCT Adc Therapeutics SA New 0.16% +0.16
TERN Terns Pharmaceuticals Inc. New 0.14% +0.14
NGNE Neurogene Inc. New 0.10% +0.10
IMVT Immunovant Inc. Add +62.9% 0.31% +0.09
KURA Kura Oncology Inc. Add +2.6% 2.11% +0.08
MLYS Mineralys Therapeutics Inc. Add +32.2% 0.34% +0.07
ORIC Oric Pharmaceuticals Inc. New 0.06% +0.06
FHTX Foghorn Therapeutics Inc. New 0.06% +0.06
GPCR Structure Therapeutics Inc. New 0.05% +0.05
AUTL Autolus Therapeutics PLC Add +60.0% 0.29% −0.03
CGEN Compugen Ltd. Add +7.4% 0.19% −0.07
RCUS Arcus Biosciences Inc. Add +9.3% 0.93% −0.08
ATXS Astria Therapeutics Inc. Add +22.8% 0.60% −0.12
AQST Aquestive Therapeutics Inc. Add +6.0% 0.33% −0.16
IPSC Century Therapeutics Inc. Add +30.4% 1.05% −0.21

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 88$524.4MRVMD, XBI, CMPS, STXS, NKTR
Q1 2026 82$433.7MRVMD, XBI, STXS, DAWN, ATRC
Q4 2025 76$425.1MRVMD, XBI, STXS, ATRC, CYTK
Q3 2025 74$399.3MSTXS, XBI, RVMD, CYTK, ATRC
Q2 2025 75$357.2MXBI, STXS, RVMD, BPMC, MRUS
Q1 2025 82$348.0MXBI, STXS, RVMD, MRUS, ATRC
Q4 2024 81$389.0MXBI, STXS, RVMD, ATRC, MRUS
Q3 2024 83$418.6MXBI, STXS, RVMD, CYTK, MRUS
Q2 2024 82$414.1MXBI, STXS, MRUS, CYTK, RVMD
Q1 2024 71$434.7MXBI, STXS, CYTK, IDYA, MRUS