TRV GP V, LLC

In its 13F for Q3 2025 (holdings as of September 30, 2025, filed November 13, 2025), TRV GP V, LLC reported 3 stock positions worth $353.5 million. Its top holding was Rapport Therapeutics (RAPP) at 60.0% of the portfolio, followed by Septerna (SEPN, 33.1%) and Maze Therapeutics (MAZE, 7.0%). Compared with Q2 2025, it sold out of 1. The biggest sale was an exit from Cargo Therapeutics (CRGX).

Most Recent 13F
Q2 2026
Location
Boston, MA
CIK
0001990717
Portfolio Value
$353.5M (Q3 2025)
SEC Filing
0001193125-25-280200 ↗ filed Nov 13, 2025

Holdings Value

0$100.0M$200.0M$300.0M$400.0M$500.0M Q4 2024: $294.0M Q4 2024 Q1 2025: $125.1M Q1 2025 Q2 2025: $165.7M Q2 2025 Q3 2025: $353.5M $353.5M Q3 2025 Q4 2025: $429.2M Q4 2025 Q1 2026: $401.0M Q1 2026 Q2 2026: $498.2M Q2 2026

Holdings 3 stocks · $353.5M
RAPP Rapport Therapeutics Inc. 59.95% 7,135,233 $211.9M No change
SEPN Septerna Inc. 33.07% 6,215,591 $116.9M No change
MAZE Maze Therapeutics Inc. 6.97% 950,800 $24.7M No change

Portfolio Sells Q2 2025 → Q3 2025
CRGX Cargo Therapeutics Inc. Sold out 0.00% −4.32

Portfolio Buys Q2 2025 → Q3 2025
None this quarter.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 3$498.2MRAPP, SEPN, MAZE
Q1 2026 3$401.0MRAPP, SEPN, MAZE
Q4 2025 3$429.2MRAPP, SEPN, MAZE
Q3 2025 3$353.5MRAPP, SEPN, MAZE
Q2 2025 4$165.7MRAPP, SEPN, MAZE, CRGX
Q1 2025 4$125.1MRAPP, SEPN, MAZE, CRGX
Q4 2024 3$294.0MSEPN, RAPP, CRGX