AnnexonANNX
13F holders, Q4 2025 (December 31)168holders +24
39new positions
14sold out
6famous investors
$5.02avg. 13F price*
At the end of Q4 2025, 168 institutions reported holding Annexon Inc. (ANNX) in their 13F filings, up 24 from Q3 2025. 39 opened new positions and 14 sold out. The largest holders were FMR LLC ($51.3M), Redmile Group, LLC ($50.5M) and BVF Inc. ($45.8M). 6 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Annexon Inc.
- CUSIP
- 03589W102
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 39 | $61.9M |
| Exits | 14 | $12.1M |
All 13F filers, Q3 2025 → Q4 2025: 43,695,702 shares bought and 8,598,304 shares sold, net +35,097,398 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 168 holders
| FMR LLC | 0.00% | Reduce -7.8% | 10,222,470 | $51.3M |
| Redmile Group, LLC | 3.72% | Add +59.5% | 10,050,644 | $50.5M |
| BVF Inc. | 1.54% | Add +30.4% | 9,128,080 | $45.8M |
| BlackRock, Inc. | 0.00% | Add +13.4% | 8,960,434 | $45.0M |
| Vanguard Group Inc. | 0.00% | Add +32.9% | 7,753,387 | $38.9M |
| Adage Capital Partners Gp, L.L.C. | 0.04% | Add +266.7% | 5,500,000 | $27.6M |
| Bain Capital Life Sciences Investors, LLC | 2.02% | No change | 5,249,069 | $26.4M |
| Bellevue Group AG | 0.49% | No change | 5,157,290 | $25.9M |
| State Street Corp. | 0.00% | Add +126.9% | 4,652,185 | $23.4M |
| Ameriprise Financial Inc. | 0.00% | Add +98.4% | 4,348,782 | $21.8M |
| Woodline Partners LP | 0.08% | Add +51.6% | 4,000,074 | $20.1M |
| Balyasny Asset Management L.P. | 0.03% | Add +154.3% | 3,299,256 | $16.6M |
| Longaeva Partners L.P. | 1.87% | New | 3,100,000 | $15.6M |
| Mak Capital One LLC | 2.00% | New | 2,958,527 | $14.9M |
| Nuveen, LLC | 0.00% | Add +327.1% | 2,915,324 | $14.6M |
| Geode Capital Management, LLC | 0.00% | Add +19.1% | 2,902,896 | $14.6M |
| Morgan Stanley | 0.00% | Reduce -5.7% | 2,856,143 | $14.3M |
| Millennium Management | 0.01% | Add +0.5% | 2,836,857 | $14.2M |
| Opaleye Management Inc. | 1.72% | No change | 2,600,000 | $13.1M |
| Palo Alto Investors LP | 1.67% | New | 2,384,192 | $12.0M |
| Qube Research & Technologies Ltd | 0.02% | Add +315.9% | 2,381,479 | $12.0M |
| Tetragon Partners GP Ltd | 2.15% | Reduce -3.8% | 2,032,455 | $10.2M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -26.5% | 1,768,745 | $8.9M |
| Bank of America Corp. | 0.00% | Add +24.1% | 1,605,581 | $8.1M |
| Sphera Funds Management LTD. | 1.38% | Reduce -26.6% | 1,316,212 | $6.6M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +33.8% | 1,057,060 | $5.3M |
| D. E. Shaw & Co. | 0.00% | New | 1,046,221 | $5.3M |
| J. Goldman & Co LP | 0.19% | Reduce -10.2% | 993,795 | $5.0M |
| Invesco Ltd. | 0.00% | Add +381.5% | 972,449 | $4.9M |
| Massachusetts Financial Services Co. | 0.00% | Reduce -7.8% | 903,439 | $4.5M |
| Acadian Asset Management LLC | 0.01% | Add +61.8% | 861,245 | $4.3M |
| Renaissance Technologies | 0.01% | Add +6.5% | 802,600 | $4.0M |
| Northern Trust Corp. | 0.00% | Add +0.5% | 792,000 | $4.0M |
| AQR Capital Management | 0.00% | Add +35.2% | 776,307 | $3.9M |
| Ishara Investments LP | 4.38% | — | 750,000 | $3.8M |
| Dimensional Fund Advisors LP | 0.00% | Reduce -6.3% | 718,680 | $3.6M |
| Sirios Capital Management L P | 0.44% | Reduce -26.8% | 710,256 | $3.6M |
| Jacobs Levy Equity Management, Inc. | 0.01% | Add +2927.5% | 683,879 | $3.4M |
| Russell Investments Group, Ltd. | 0.00% | Add +3648.7% | 683,016 | $3.4M |
| Mutual of America Capital Management LLC | 0.03% | Reduce -39.8% | 642,038 | $3.2M |
| Kennedy Capital Management LLC | 0.07% | Reduce -0.1% | 639,902 | $3.2M |
| Parkman Healthcare Partners LLC | 0.29% | Add +48.1% | 601,202 | $3.0M |
| Deerfield Management Company, L.P. | 0.04% | No change | 583,913 | $2.9M |
| Wells Fargo & Company | 0.00% | Add +40.1% | 573,748 | $2.9M |
| Deutsche Bank AG | 0.00% | Reduce -62.7% | 560,744 | $2.8M |
| Hennion & Walsh Asset Management, Inc. | 0.09% | Add +12.4% | 534,986 | $2.7M |
| Schonfeld Strategic Advisors LLC | 0.01% | Add +146.4% | 522,846 | $2.6M |
| Marshall Wace, LLP | 0.00% | New | 520,998 | $2.6M |
| Jane Street Group, LLC | 0.00% | Add +134.1% | 513,836 | $2.6M |
| Board of Trustees of The Leland Stanford Junior University | 0.49% | No change | 482,550 | $2.4M |
| T. Rowe Price Associates Inc. | 0.00% | Reduce -8.2% | 445,074 | $2.2M |
| SummitTX Capital, L.P. | 0.07% | Add +81.2% | 438,497 | $2.2M |
| Wellington Management Group LLP | 0.00% | New | 398,077 | $2.0M |
| UBS Group AG | 0.00% | Add +8.9% | 377,104 | $1.9M |
| Point72 Asset Management | 0.00% | Add +312.2% | 371,190 | $1.9M |
| Bank of New York Mellon Corp | 0.00% | Add +17.4% | 361,677 | $1.8M |
| Cinctive Capital Management LP | 0.10% | Add +448.4% | 358,986 | $1.8M |
| Susquehanna Portfolio Strategies, LLC | 0.03% | Add +0.8% | 356,619 | $1.8M |
| Diadema Partners LP | 1.05% | New | 350,000 | $1.8M |
| Two Sigma Investments, LP | 0.00% | Add +18.9% | 332,038 | $1.7M |
| Barclays PLC | 0.00% | Add +96.0% | 289,963 | $1.5M |
| Citadel Advisors | 0.00% | Add +64.3% | 275,294 | $1.4M |
| DAFNA Capital Management LLC | 0.32% | New | 272,812 | $1.4M |
| American Century Companies Inc. | 0.00% | Add +6.1% | 251,158 | $1.3M |
| XTX Topco Ltd | 0.03% | Add +64.6% | 243,313 | $1.2M |
| Ikarian Capital, LLC | 0.15% | New | 230,244 | $1.2M |
| Susquehanna International Group, LLP | 0.00% | Add +22.6% | 185,508 | $931K |
| Ieq Capital, LLC | 0.00% | Add +21.7% | 182,982 | $919K |
| Osaic Holdings, Inc. | 0.00% | No change | 147,375 | $740K |
| Rafferty Asset Management, LLC | 0.00% | New | 141,644 | $711K |
| Alliancebernstein L.P. | 0.00% | No change | 140,740 | $707K |
| Bridgeway Capital Management, LLC | 0.01% | No change | 137,800 | $692K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -1.9% | 130,102 | $655K |
| Rhumbline Advisers | 0.00% | Reduce -4.6% | 126,463 | $635K |
| Brevan Howard Capital Management LP | 0.01% | Add +30.9% | 123,753 | $621K |
| Jump Financial, LLC | 0.01% | New | 122,858 | $617K |
| Caption Management, LLC | 0.03% | New | 119,491 | $600K |
| DNB Asset Management AS | 0.00% | Add +40.0% | 118,324 | $594K |
| J. Safra Sarasin Holding AG | 0.01% | Reduce -47.2% | 117,768 | $591K |
| Persistent Asset Partners Ltd | 0.23% | New | 93,657 | $470K |
| Quarry LP | 0.06% | Reduce -31.8% | 75,000 | $377K |
| Boothbay Fund Management, LLC | 0.01% | New | 64,069 | $322K |
| BNP Paribas Financial Markets | 0.00% | Add +211.9% | 61,572 | $309K |
| Sei Investments Co. | 0.00% | New | 58,259 | $292K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +21.8% | 54,763 | $275K |
| JPMorgan Chase & Co. | 0.00% | Add +14.6% | 53,729 | $270K |
| Virtus Investment Advisers, LLC | 0.07% | Add +27.5% | 53,527 | $269K |
| WINTON GROUP Ltd | 0.01% | New | 53,400 | $268K |
| Profund Advisors LLC | 0.01% | New | 53,008 | $266K |
| Quadrature Capital Ltd | 0.00% | New | 48,573 | $244K |
| ADAR1 Capital Management, LLC | 0.02% | New | 48,000 | $241K |
| TD Asset Management Inc | 0.00% | No change | 46,848 | $235K |
| Allegheny Financial Group | 0.03% | No change | 42,900 | $215K |
| EntryPoint Capital, LLC | 0.08% | Add +114.2% | 42,774 | $215K |
| Intech Investment Management LLC | 0.00% | Add +59.4% | 42,524 | $213K |
| Citizens Financial Group Inc. | 0.00% | No change | 40,000 | $201K |
| MetLife Investment Management, LLC | 0.00% | Reduce -12.5% | 39,059 | $196K |
| Pale Fire Capital SE | 0.03% | New | 38,600 | $194K |
| China Universal Asset Management Co., Ltd. | 0.01% | Add +2.3% | 36,084 | $181K |
| Landing Point Financial Group, LLC | 0.09% | New | 34,900 | $175K |
"% of holder's portfolio" is ANNX's weight in each manager's 13F, not the share of Annexon Inc. the manager owns.