| Eventide Asset Management, LLC | 1.20% | New | 4,928,019 | $60.3M |
| Wellington Management Group LLP | 0.01% | New | 3,901,599 | $47.3M |
| Soleus Capital Management, L.P. | 3.26% | New | 3,395,341 | $41.6M |
| Farallon Capital Management, L.L.C. | 0.22% | New | 3,332,220 | $40.8M |
| RTW Investments, LP | 0.62% | New | 3,299,870 | $40.4M |
| Sands Capital Alternatives, LLC | 9.29% | New | 3,103,782 | $38.0M |
| Omega Fund Management, LLC | 14.36% | New | 1,988,287 | $24.3M |
| Perceptive Advisors LLC | 0.69% | New | 1,593,608 | $19.5M |
| BlackRock, Inc. | 0.00% | New | 1,427,150 | $17.5M |
| Morgan Stanley | 0.00% | New | 1,401,653 | $17.2M |
| Holocene Advisors, LP | 0.04% | New | 1,107,812 | $13.6M |
| Alliancebernstein L.P. | 0.00% | New | 1,097,263 | $13.4M |
| Deerfield Management Company, L.P. | 0.28% | New | 1,016,000 | $12.4M |
| Citadel Advisors | 0.01% | New | 946,350 | $11.6M |
| Driehaus Capital Management LLC | 0.10% | New | 882,277 | $10.8M |
| ArrowMark Colorado Holdings LLC | 0.16% | New | 932,128 | $9.7M |
| Vanguard Group Inc. | 0.00% | New | 709,255 | $8.7M |
| Marshall Wace, LLP | 0.01% | New | 673,658 | $8.2M |
| Janus Henderson Group PLC | 0.00% | New | 665,653 | $7.8M |
| T. Rowe Price Associates Inc. | 0.00% | New | 636,204 | $7.8M |
| Ra Capital Management, L.P. | 0.10% | New | 500,000 | $6.1M |
| Pura Vida Investments, LLC | 38.36% | New | 429,120 | $5.3M |
| Clearbridge Investments, LLC | 0.00% | New | 369,225 | $4.5M |
| Point72 Asset Management | 0.01% | New | 364,329 | $4.5M |
| Geode Capital Management, LLC | 0.00% | New | 306,017 | $3.7M |
| Longaeva Partners L.P. | 2.06% | — | 275,825 | $3.4M |
| Lord, Abbett & Co. LLC | 0.01% | New | 228,160 | $2.8M |
| Jain Global LLC | 0.04% | New | 148,512 | $1.8M |
| Walleye Capital LLC | 0.02% | New | 148,105 | $1.8M |
| Braidwell LP | 0.09% | New | 140,000 | $1.7M |
| Schonfeld Strategic Advisors LLC | 0.01% | New | 137,322 | $1.7M |
| Woodline Partners LP | 0.01% | New | 125,000 | $1.5M |
| UBS Group AG | 0.00% | New | 124,340 | $1.5M |
| Northern Trust Corp. | 0.00% | New | 111,487 | $1.4M |
| State Street Corp. | 0.00% | New | 105,972 | $1.3M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 101,614 | $1.2M |
| Alyeska Investment Group, L.P. | 0.00% | New | 75,000 | $918K |
| Jennison Associates LLC | 0.00% | New | 67,611 | $828K |
| Bellevue Group AG | 0.02% | New | 66,825 | $818K |
| Bank of America Corp. | 0.00% | New | 61,558 | $753K |
| Goldman Sachs Group Inc. | 0.00% | New | 58,422 | $715K |
| Point72 (DIFC) Ltd | 0.07% | New | 57,158 | $700K |
| Ameriprise Financial Inc. | 0.00% | New | 54,025 | $661K |
| Ghisallo Capital Management LLC | 0.06% | New | 50,000 | $612K |
| Balyasny Asset Management L.P. | 0.00% | New | 49,878 | $611K |
| TD Asset Management Inc | 0.00% | New | 39,876 | $488K |
| Evanson Asset Management, LLC | 0.03% | New | 38,772 | $475K |
| Values First Advisors, Inc. | 0.27% | New | 37,585 | $457K |
| Davidson Kempner Capital Management LP | 0.01% | New | 31,000 | $379K |
| Verition Fund Management LLC | 0.00% | New | 27,217 | $333K |
| Soros Fund Management | 0.01% | New | 25,968 | $318K |
| Bank of New York Mellon Corp | 0.00% | New | 25,793 | $316K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 21,353 | $261K |
| Two Sigma Investments, LP | 0.00% | New | 20,751 | $254K |
| Centiva Capital, LP | 0.01% | New | 20,131 | $246K |
| Barclays PLC | 0.00% | New | 17,425 | $213K |
| Nuveen, LLC | 0.00% | — | 17,044 | $209K |
| Invesco Ltd. | 0.00% | New | 16,464 | $202K |
| Susquehanna International Group, LLP | 0.00% | New | 15,904 | $195K |
| Wells Fargo & Company | 0.00% | New | 15,820 | $194K |
| Rhumbline Advisers | 0.00% | New | 12,880 | $158K |
| Oxford Asset Management LLP | 0.07% | New | 12,500 | $153K |
| Deutsche Bank AG | 0.00% | New | 12,079 | $148K |
| Squarepoint Ops LLC | 0.00% | New | 11,976 | $147K |
| LPL Financial LLC | 0.00% | New | 11,817 | $145K |
| Citigroup Inc. | 0.00% | New | 9,339 | $114K |
| MetLife Investment Management, LLC | 0.00% | New | 8,370 | $102K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 7,772 | $95K |
| FMR LLC | 0.00% | New | 6,883 | $84K |
| Corebridge Financial, Inc. | 0.00% | New | 6,485 | $79K |
| JPMorgan Chase & Co. | 0.00% | New | 6,260 | $77K |
| Sandia Investment Management LP | 0.22% | New | 6,000 | $73K |
| Royal Bank of Canada | 0.00% | New | 4,729 | $58K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | New | 2,751 | $34K |
| STRS Ohio | 0.00% | New | 2,400 | $29K |
| New York State Common Retirement Fund | 0.00% | New | 1,700 | $21K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 1,339 | $16K |
| Legal & General Group Plc | 0.00% | New | 1,337 | $16K |
| Steward Partners Investment Advisory, LLC | 0.00% | New | 1,115 | $14K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 1,097 | $13K |
| GPS Wealth Strategies Group, LLC | 0.00% | New | 1,000 | $12K |
| Zimmer Partners, LP | 0.00% | New | 1,000 | $12K |
| Stonebridge Financial Group, LLC | 0.00% | New | 911 | $11K |
| California State Teachers Retirement System | 0.00% | New | 830 | $10K |
| BNP Paribas Financial Markets | 0.00% | New | 720 | $9K |
| PSI Advisors, LLC | 0.00% | New | 682 | $8K |
| Quarry LP | 0.00% | New | 667 | $8K |
| EverSource Wealth Advisors, LLC | 0.00% | New | 644 | $8K |
| MAI Capital Management | 0.00% | New | 625 | $8K |
| CoreCap Advisors, LLC | 0.00% | New | 560 | $7K |
| Amalgamated Bank | 0.00% | New | 456 | $6K |
| Jones Financial Companies LLLP | 0.00% | New | 237 | $3K |
| Rakuten Investment Management, Inc. | 0.00% | — | 215 | $3K |
| Private Trust Co. NA | 0.00% | New | 150 | $2K |
| Osaic Holdings, Inc. | 0.00% | New | 109 | $1K |
| Clearstead Advisors, LLC | 0.00% | New | 90 | $1K |
| Sterling Capital Management LLC | 0.00% | New | 85 | $1K |
| Comerica Bank | 0.00% | New | 74 | $906 |
| PNC Financial Services Group, Inc. | 0.00% | New | 50 | $612 |
| WPG Advisers, LLC | 0.00% | New | 28 | $343 |
| Nisa Investment Advisors, LLC | 0.00% | New | 15 | $184 |
| GAMMA Investing LLC | 0.00% | New | 13 | $159 |