| FMR LLC | 0.01% | New | 4,950,549 | $128.1M |
| TPG GP A, LLC | 1.66% | New | 3,967,422 | $102.7M |
| Red Tree Management, LLC | 37.57% | — | 2,205,661 | $57.1M |
| Yu Fan | 59.41% | New | 1,222,202 | $31.6M |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 64.42% | New | 1,088,101 | $28.2M |
| Ra Capital Management, L.P. | 0.28% | New | 824,582 | $21.3M |
| BlackRock, Inc. | 0.00% | New | 762,212 | $19.7M |
| Vanguard Group Inc. | 0.00% | New | 696,087 | $18.0M |
| Board of Trustees of The Leland Stanford Junior University | 1.38% | New | 623,751 | $16.1M |
| Millennium Management | 0.01% | New | 503,695 | $13.0M |
| Franklin Resources Inc. | 0.00% | New | 481,446 | $12.5M |
| Redmile Group, LLC | 0.79% | New | 435,239 | $11.3M |
| Massachusetts Financial Services Co. | 0.00% | New | 415,361 | $10.7M |
| Federated Hermes, Inc. | 0.02% | New | 372,251 | $9.6M |
| Novo Holdings A/S | 0.52% | New | 328,809 | $8.5M |
| Adage Capital Partners Gp, L.L.C. | 0.01% | New | 318,072 | $8.2M |
| Lord, Abbett & Co. LLC | 0.03% | New | 296,050 | $7.7M |
| Driehaus Capital Management LLC | 0.06% | New | 280,005 | $7.2M |
| Geode Capital Management, LLC | 0.00% | New | 257,070 | $6.7M |
| Deutsche Bank AG | 0.00% | New | 230,787 | $6.0M |
| Braidwell LP | 0.24% | New | 210,000 | $5.4M |
| Citadel Advisors | 0.01% | New | 206,350 | $5.3M |
| Next Century Growth Investors LLC | 0.40% | New | 204,760 | $5.3M |
| Perceptive Advisors LLC | 0.13% | New | 180,546 | $4.7M |
| State Street Corp. | 0.00% | New | 154,988 | $4.0M |
| Captrust Financial Advisors | 0.01% | New | 151,441 | $3.9M |
| RTW Investments, LP | 0.06% | New | 150,000 | $3.9M |
| Alyeska Investment Group, L.P. | 0.01% | New | 125,000 | $3.2M |
| Emerald Advisers, LLC | 0.12% | New | 120,805 | $3.1M |
| Orbimed Advisors LLC | 0.06% | New | 112,500 | $2.9M |
| Northern Trust Corp. | 0.00% | New | 102,828 | $2.7M |
| Woodline Partners LP | 0.02% | New | 100,000 | $2.6M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 96,582 | $2.5M |
| Emerald Mutual Fund Advisers Trust | 0.12% | New | 77,835 | $2.0M |
| ArrowMark Colorado Holdings LLC | 0.03% | New | 75,000 | $1.9M |
| State of Wisconsin Investment Board | 0.00% | New | 69,663 | $1.8M |
| Morgan Stanley | 0.00% | New | 68,701 | $1.8M |
| Goldman Sachs Group Inc. | 0.00% | New | 65,002 | $1.7M |
| Fred Alger Management, LLC | 0.01% | New | 60,761 | $1.6M |
| Walleye Capital LLC | 0.02% | New | 58,800 | $1.5M |
| Renaissance Technologies | 0.00% | New | 41,900 | $1.1M |
| UBS Group AG | 0.00% | New | 35,686 | $924K |
| JPMorgan Chase & Co. | 0.00% | New | 34,013 | $880K |
| Parkman Healthcare Partners LLC | 0.11% | New | 32,002 | $828K |
| Marshall Wace, LLP | 0.00% | New | 31,215 | $808K |
| Soros Fund Management | 0.02% | New | 25,000 | $647K |
| Bank of New York Mellon Corp | 0.00% | New | 24,274 | $628K |
| Verition Fund Management LLC | 0.00% | New | 24,011 | $621K |
| Alliancebernstein L.P. | 0.00% | New | 20,561 | $532K |
| Bank of America Corp. | 0.00% | New | 19,256 | $498K |
| Barclays PLC | 0.00% | New | 19,190 | $497K |
| Norges Bank | 0.00% | New | 16,316 | $422K |
| Nuveen Asset Management, LLC | 0.00% | New | 16,186 | $419K |
| Ameriprise Financial Inc. | 0.00% | New | 14,231 | $368K |
| Rhumbline Advisers | 0.00% | New | 12,353 | $320K |
| Davidson Kempner Capital Management LP | 0.01% | New | 10,000 | $258K |
| Citigroup Inc. | 0.00% | New | 9,742 | $252K |
| Invesco Ltd. | 0.00% | New | 9,728 | $252K |
| MetLife Investment Management, LLC | 0.00% | New | 7,749 | $201K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 6,957 | $180K |
| Wells Fargo & Company | 0.00% | New | 6,434 | $167K |
| Corebridge Financial, Inc. | 0.00% | New | 6,122 | $158K |
| SG Americas Securities, LLC | 0.00% | New | 5,448 | $141K |
| STRS Ohio | 0.00% | New | 2,300 | $60K |
| PNC Financial Services Group, Inc. | 0.00% | New | 1,797 | $47K |
| BNP Paribas Financial Markets | 0.00% | New | 1,667 | $43K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 1,411 | $37K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 1,288 | $33K |
| Legal & General Group Plc | 0.00% | New | 1,247 | $32K |
| California State Teachers Retirement System | 0.00% | New | 914 | $24K |
| Royal Bank of Canada | 0.00% | New | 806 | $21K |
| Amalgamated Bank | 0.00% | New | 420 | $11K |
| Creative Financial Designs Inc. | 0.00% | New | 400 | $10K |
| R Squared Ltd | 0.01% | — | 290 | $8K |
| MCF Advisors LLC | 0.00% | New | 242 | $6K |
| Larson Financial Group LLC | 0.00% | New | 191 | $5K |
| Sterling Capital Management LLC | 0.00% | New | 135 | $3K |
| Steward Partners Investment Advisory, LLC | 0.00% | New | 80 | $2K |