| FMR LLC | 0.00% | New | 4,835,383 | $48.3M |
| Fairmount Funds Management LLC | 4.17% | New | 3,220,368 | $32.2M |
| Venrock Adviser, LLC | 2.41% | New | 3,220,364 | $32.2M |
| Deep Track Capital, LP | 0.81% | New | 2,509,301 | $25.1M |
| Vanguard Group Inc. | 0.00% | New | 1,807,582 | $18.1M |
| Frazier Life Sciences Management, L.P. | 0.71% | New | 1,772,116 | $17.7M |
| BlackRock, Inc. | 0.00% | New | 1,714,348 | $17.1M |
| Versant Venture Management, LLC | 18.56% | New | 1,525,820 | $15.2M |
| RTW Investments, LP | 0.21% | New | 1,449,273 | $14.5M |
| Driehaus Capital Management LLC | 0.10% | New | 1,255,798 | $12.5M |
| Avidity Partners Management LP | 2.26% | New | 1,127,186 | $11.3M |
| Ra Capital Management, L.P. | 0.18% | New | 1,062,326 | $10.6M |
| Soleus Capital Management, L.P. | 0.55% | New | 796,744 | $8.0M |
| Geode Capital Management, LLC | 0.00% | New | 676,431 | $6.8M |
| Logos Global Management LP | 0.83% | New | 625,000 | $6.2M |
| Samsara Biocapital, LLC | 1.09% | New | 531,163 | $5.3M |
| Orbimed Advisors LLC | 0.13% | New | 531,163 | $5.3M |
| Deerfield Management Company, L.P. | 0.11% | New | 531,163 | $5.3M |
| Great Point Partners LLC | 3.23% | New | 498,054 | $5.0M |
| State Street Corp. | 0.00% | New | 318,771 | $3.2M |
| Barclays PLC | 0.00% | New | 274,830 | $2.7M |
| Northern Trust Corp. | 0.00% | New | 228,092 | $2.3M |
| Sofinnova Investments, Inc. | 0.07% | New | 107,391 | $1.1M |
| Woodline Partners LP | 0.01% | New | 106,270 | $1.1M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 103,255 | $1.0M |
| Bank of New York Mellon Corp | 0.00% | New | 78,393 | $783K |
| Affinity Asset Advisors, LLC | 0.10% | New | 65,317 | $653K |
| TCG Crossover Management, LLC | 0.07% | New | 64,023 | $640K |
| Nuveen, LLC | 0.00% | New | 60,128 | $601K |
| Morgan Stanley | 0.00% | New | 49,773 | $497K |
| Rhumbline Advisers | 0.00% | New | 44,570 | $445K |
| Susquehanna International Group, LLP | 0.00% | New | 39,229 | $392K |
| XTX Topco Ltd | 0.01% | New | 25,752 | $257K |
| Deutsche Bank AG | 0.00% | New | 25,614 | $256K |
| Intech Investment Management LLC | 0.00% | New | 22,995 | $230K |
| Quantinno Capital Management LP | 0.00% | New | 21,986 | $220K |
| UBS Group AG | 0.00% | New | 21,038 | $210K |
| Wells Fargo & Company | 0.00% | New | 20,833 | $208K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 17,757 | $177K |
| T. Rowe Price Associates Inc. | 0.00% | New | 16,256 | $163K |
| Deltec Asset Management LLC | 0.03% | New | 15,756 | $157K |
| JPMorgan Chase & Co. | 0.00% | New | 15,367 | $154K |
| Bank of America Corp. | 0.00% | New | 14,350 | $143K |
| Citigroup Inc. | 0.00% | New | 12,143 | $121K |
| Alliancebernstein L.P. | 0.00% | New | 12,054 | $120K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 11,420 | $114K |
| Corient Private Wealth LP | 0.00% | New | 10,133 | $101K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | New | 7,113 | $71K |
| Group One Trading LLC | 0.00% | New | 5,268 | $53K |
| STRS Ohio | 0.00% | New | 4,900 | $49K |
| Royal Bank of Canada | 0.00% | New | 3,691 | $37K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 3,312 | $33K |
| BNP Paribas Financial Markets | 0.00% | New | 3,222 | $32K |
| Russell Investments Group, Ltd. | 0.00% | New | 3,143 | $31K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 3,089 | $31K |
| Legal & General Group Plc | 0.00% | New | 2,954 | $29K |
| Sterling Capital Management LLC | 0.00% | New | 876 | $9K |
| PNC Financial Services Group, Inc. | 0.00% | New | 339 | $3K |
| GAMMA Investing LLC | 0.00% | New | 127 | $1K |
| New York State Common Retirement Fund | 0.00% | New | 122 | $1K |
| Cwm, LLC | 0.00% | New | 120 | $1K |
| Glenmede Investment Management, LP | 0.00% | — | 53 | $529 |
| Rothschild Investment LLC | 0.00% | New | 30 | $300 |
| Farther Finance Advisors, LLC | 0.00% | New | 16 | $160 |
| Principal Securities, Inc. | 0.00% | New | 13 | $130 |
| EverSource Wealth Advisors, LLC | 0.00% | New | 7 | $70 |
| SBI Securities Co., Ltd. | 0.00% | New | 4 | $40 |
| Arax Advisory Partners | 0.00% | New | 3 | $30 |
| Jones Financial Companies LLLP | 0.00% | New | 2 | $18 |
| Assetmark, Inc. | 0.00% | New | 1 | $10 |
| Amalgamated Bank | 0.00% | New | 9 | $0 |
| Capital Advisors, Ltd. LLC | 0.00% | New | 6 | $0 |
| Avion Wealth | 0.00% | New | 7 | $0 |