| ABVX Abivax SA-ADR | 19.24% | 6,007,834 | $800.6M | Reduce -7.3% |
| TNGX Tango Therapeutics Inc. | 6.82% | 9,081,201 | $283.9M | Reduce -13.8% |
| CGON CG Oncology Inc. | 6.27% | 3,670,206 | $260.8M | No change |
| COGT Cogent Biosciences Inc. | 4.52% | 4,854,436 | $187.9M | Reduce -1.9% |
| IMVT Immunovant Inc. | 4.13% | 4,457,988 | $171.8M | No change |
| SYRE Spyre Therapeutics Inc. | 4.06% | 1,900,582 | $168.7M | No change |
| DNTH Dianthus Therapeutics Inc. | 3.93% | 1,676,624 | $163.4M | No change |
| MIRM Mirum Pharmaceuticals Inc. | 2.99% | 1,062,049 | $124.3M | No change |
| ZLAB Zai Lab Ltd.-ADR | 2.80% | 6,137,627 | $116.6M | New |
| AMLX Amylyx Pharmaceuticals Inc. | 2.70% | 6,243,812 | $112.1M | No change |
| GLUE Monte Rosa Therapeutics Inc. | 2.69% | 4,622,151 | $111.9M | No change |
| BCRX Biocryst Pharmaceuticals Inc. | 2.65% | 11,020,968 | $110.2M | No change |
| VOR Vor Biopharma Inc. | 2.51% | 5,673,078 | $104.4M | No change |
| TYRA Tyra Biosciences Inc. | 2.49% | 3,248,980 | $103.8M | No change |
| DYN Dyne Therapeutics Inc. | 2.46% | 4,615,144 | $102.5M | No change |
| IRON Disc Medicine Inc. | 2.36% | 1,341,862 | $98.1M | No change |
| RLAY Relay Therapeutics Inc. | 1.92% | 4,273,356 | $80.0M | No change |
| SVRA Savara Inc. | 1.83% | 12,362,205 | $76.2M | No change |
| AURA Aura Biosciences Inc. | 1.63% | 9,533,333 | $67.7M | New |
| RVMD Revolution Medicines Inc. | 1.53% | 340,899 | $63.8M | Reduce -40.9% |
| TRAX First Tracks Biotherapeutics | 1.40% | 2,895,304 | $58.3M | New |
| KOD Kodiak Sciences Inc. | 1.35% | 1,445,538 | $56.3M | No change |
| AVTX Avalo Therapeutics Inc. | 1.34% | 3,017,120 | $55.8M | Add +308.6% |
| LBRX LB Pharmaceuticals Inc. | 1.13% | 1,447,310 | $47.0M | Reduce -21.3% |
| IPSC Century Therapeutics Inc. | 1.04% | 17,754,430 | $43.4M | No change |
| TECX Tectonic Therapeutic Inc. | 1.00% | 1,204,891 | $41.4M | No change |
| XNCR Xencor Inc. | 0.95% | 2,452,138 | $39.5M | No change |
| SRZN Surrozen Inc. | 0.92% | 1,473,101 | $38.2M | No change |
| EDIT Editas Medicine Inc. | 0.87% | 11,111,111 | $36.0M | New |
| MBX MBX Biosciences Inc. | 0.86% | 650,000 | $35.9M | No change |
| PHVS Pharvaris NV | 0.84% | 1,008,229 | $34.9M | New |
| SLN Silence Therapeutics PLC-ADR | 0.80% | 3,033,560 | $33.3M | No change |
| IFRX Inflarx NV | 0.78% | 14,500,000 | $32.5M | New |
| ALT Altimmune Inc. | 0.73% | 10,000,000 | $30.4M | New |
| JANX Janux Therapeutics Inc. | 0.66% | 1,789,617 | $27.5M | No change |
| CATX Perspective Therapeutics Inc. | 0.65% | 7,915,567 | $27.0M | No change |
| AGMB Agomab Therapeutics NV | 0.64% | 2,053,233 | $26.7M | No change |
| BHVN Biohaven Ltd. | 0.64% | 1,779,952 | $26.5M | Reduce -61.6% |
| AKTS Aktis Oncology Inc. | 0.54% | 696,560 | $22.5M | New |
| ALEC Alector Inc. | 0.48% | 10,000,000 | $20.1M | No change |
| FBRX Forte Biosciences Inc. | 0.47% | 920,000 | $19.6M | New |
| MNPR Monopar Therapeutics Inc. | 0.45% | 203,327 | $18.8M | Add +53.9% |
| OCUL Ocular Therapeutix Inc. | 0.39% | 1,647,752 | $16.2M | No change |
| ADCT Adc Therapeutics SA | 0.29% | 11,390,175 | $12.2M | No change |
| ALXO Alx Oncology Holdings Inc. | 0.28% | 5,655,487 | $11.7M | Reduce -56.5% |
| TRDA Entrada Therapeutics Inc. | 0.19% | 1,060,230 | $7.8M | Reduce -53.6% |
| CGEM Cullinan Therapeutics Inc. | 0.18% | 406,786 | $7.4M | No change |
| ARVN Arvinas Inc. | 0.14% | 707,098 | $5.9M | Reduce -70.4% |
| KRRO Korro Bio Inc. | 0.13% | 416,301 | $5.5M | No change |
| RACC Research Alliance Corp. Class A | 0.13% | 500,000 | $5.3M | New |
| LONA Leonabio Inc. | 0.10% | 464,398 | $4.3M | No change |
| JATT Jatt II Acquisition Corp. | 0.05% | 200,000 | $2.3M | New |
| CNTX Context Therapeutics Inc. | 0.04% | 2,682,696 | $1.5M | No change |
| EIKN Eikon Therapeutics Inc. | 0.01% | 37,902 | $495K | New |