Repare TherapeuticsRPTX
13F holders, Q4 2025 (December 31)At the end of Q4 2025, 46 institutions reported holding Repare Therapeutics Inc. (RPTX) in their 13F filings, up 1 from Q3 2025. 13 opened new positions and 11 sold out. The largest holders were BVF Inc. ($26.9M), Blue Owl Capital Holdings LP ($9.0M) and Orbimed Advisors LLC ($8.6M). 3 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and Steve Cohen (0.0% of Point72 Asset Management's portfolio).
- Company
- Repare Therapeutics Inc.
- CUSIP
- 760273102
- Latest filing quarter
- Q4 2025
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 13 | $5.4M |
| Exits | 11 | $6.8M |
All 13F filers, Q3 2025 → Q4 2025: 3,438,287 shares bought and 4,427,161 shares sold, net −988,874 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 46 holders
| BVF Inc. | 0.90% | No change | 10,333,600 | $26.9M |
| Blue Owl Capital Holdings LP | 2.79% | No change | 3,443,659 | $9.0M |
| Orbimed Advisors LLC | 0.18% | No change | 3,322,488 | $8.6M |
| Redmile Group, LLC | 0.30% | No change | 1,586,174 | $4.1M |
| Rangeley Capital, LLC | 2.93% | Add +99.4% | 1,287,829 | $3.3M |
| Marshall Wace, LLP | 0.00% | New | 1,115,744 | $2.9M |
| Renaissance Technologies | 0.00% | Add +35.5% | 981,360 | $2.6M |
| Acadian Asset Management LLC | 0.00% | Add +8.9% | 618,672 | $1.6M |
| Two Sigma Investments, LP | 0.00% | Add +2942.7% | 333,694 | $868K |
| Jane Street Group, LLC | 0.00% | New | 278,304 | $724K |
| Yakira Capital Management, Inc. | 0.24% | New | 266,601 | $693K |
| Northern Trust Corp. | 0.00% | Reduce -0.7% | 260,311 | $677K |
| Citadel Advisors | 0.00% | Reduce -65.8% | 238,912 | $621K |
| BlackRock, Inc. | 0.00% | Reduce -1.6% | 144,219 | $375K |
| Militia Capital Partners, LP | 0.12% | No change | 119,176 | $310K |
| Equitec Proprietary Markets, LLC | 1.49% | New | 118,375 | $308K |
| XTX Topco Ltd | 0.01% | Add +145.9% | 116,933 | $304K |
| Walleye Capital LLC | 0.00% | New | 106,683 | $277K |
| Bank of Montreal | 0.00% | No change | 104,919 | $273K |
| Two Sigma Advisers, LP | 0.00% | Add +95.7% | 54,200 | $141K |
| Point72 Asset Management | 0.00% | New | 51,252 | $133K |
| HRT Financial LP | 0.00% | New | 42,301 | $109K |
| Quinn Opportunity Partners LLC | 0.00% | No change | 40,000 | $104K |
| FNY Investment Advisers, LLC | 0.03% | New | 35,000 | $91K |
| NewEdge Wealth, LLC | 0.00% | No change | 32,959 | $86K |
| Virtu Financial LLC | 0.00% | New | 15,488 | $40K |
| Squarepoint Ops LLC | 0.00% | Reduce -77.8% | 14,485 | $38K |
| Occudo Quantitative Strategies LP | 0.00% | New | 13,548 | $35K |
| Covestor Ltd | 0.02% | New | 13,627 | $35K |
| HarbourVest Partners LLC | 0.02% | No change | 12,276 | $32K |
| Engineers Gate Manager LP | 0.00% | Add +1.1% | 11,627 | $30K |
| Bank of America Corp. | 0.00% | Reduce -16.5% | 10,737 | $28K |
| StoneX Group Inc. | 0.00% | New | 10,603 | $28K |
| Cibc World Market Inc. | 0.00% | No change | 10,500 | $27K |
| Stifel Financial Corp. | 0.00% | Reduce -87.1% | 10,000 | $26K |
| Federation des caisses Desjardins du Quebec | 0.00% | Add +772.2% | 2,259 | $6K |
| SBI Securities Co., Ltd. | 0.00% | Reduce -0.8% | 1,252 | $3K |
| TD Waterhouse Canada Inc. | 0.00% | No change | 1,250 | $3K |
| Barclays PLC | 0.00% | No change | 530 | $1K |
| Curio Wealth, LLC | 0.00% | New | 500 | $1K |
| Morgan Stanley | 0.00% | Reduce -94.0% | 404 | $1K |
| Royal Bank of Canada | 0.00% | No change | 200 | $1K |
| Jones Financial Companies LLLP | 0.00% | No change | 100 | $260 |
| Steward Partners Investment Advisory, LLC | 0.00% | No change | 11 | $29 |
| JPMorgan Chase & Co. | 0.00% | No change | 4 | $10 |
| BNP Paribas Financial Markets | 0.00% | No change | 1 | $3 |
"% of holder's portfolio" is RPTX's weight in each manager's 13F, not the share of Repare Therapeutics Inc. the manager owns.