| EcoR1 Capital, LLC | 3.17% | New | 3,174,519 | $63.9M |
| TCG Crossover Management, LLC | 1.40% | New | 2,895,304 | $58.3M |
| FMR LLC | 0.00% | New | 2,054,127 | $41.3M |
| Affinity Asset Advisors, LLC | 2.03% | New | 2,032,012 | $40.9M |
| BlackRock, Inc. | 0.00% | New | 1,963,541 | $39.5M |
| Trails Edge Capital Partners, LP | 4.84% | New | 1,514,000 | $30.5M |
| State Street Corp. | 0.00% | New | 1,512,896 | $30.4M |
| Vanguard Capital Management LLC | 0.00% | New | 1,451,909 | $29.2M |
| Jupiter Topco LLC | 0.01% | — | 1,091,464 | $22.0M |
| Vestal Point Capital, LP | 0.48% | New | 1,013,000 | $20.4M |
| Woodline Partners LP | 0.06% | New | 917,176 | $18.5M |
| Sanofi | 3.10% | New | 821,917 | $16.5M |
| Morgan Stanley | 0.00% | New | 781,534 | $15.7M |
| 683 Capital Management, LLC | 1.45% | New | 750,000 | $15.1M |
| Adage Capital Partners Gp, L.L.C. | 0.02% | New | 729,000 | $14.7M |
| Balyasny Asset Management L.P. | 0.03% | New | 714,948 | $14.4M |
| Geode Capital Management, LLC | 0.00% | New | 702,087 | $14.1M |
| Bank of America Corp. | 0.00% | New | 647,962 | $13.0M |
| Stempoint Capital LP | 2.17% | New | 622,723 | $12.5M |
| Palo Alto Investors LP | 1.68% | New | 603,489 | $12.1M |
| Sofinnova Investments, Inc. | 0.61% | New | 565,199 | $11.4M |
| Vanguard Portfolio Management LLC | 0.00% | New | 546,992 | $11.0M |
| Goldman Sachs Group Inc. | 0.00% | New | 487,213 | $9.8M |
| Point72 Asset Management | 0.01% | New | 408,330 | $8.2M |
| UBS Group AG | 0.00% | New | 310,886 | $6.3M |
| Arrowstreet Capital, Limited Partnership | 0.00% | New | 299,500 | $6.0M |
| Federated Hermes, Inc. | 0.01% | New | 290,000 | $5.8M |
| Ally Bridge Group (NY) LLC | 7.37% | New | 284,287 | $5.7M |
| Charles Schwab Investment Management Inc. | 0.00% | New | 256,873 | $5.2M |
| Nantahala Capital Management, LLC | 0.30% | New | 250,000 | $5.0M |
| Granahan Investment Management, LLC | 0.17% | New | 238,304 | $4.8M |
| Apis Capital Advisors, LLC | 0.44% | New | 226,000 | $4.5M |
| Fred Alger Management, LLC | 0.01% | New | 218,400 | $4.4M |
| Northern Trust Corp. | 0.00% | New | 201,096 | $4.0M |
| Ameriprise Financial Inc. | 0.00% | New | 193,183 | $3.9M |
| Vanguard Fiduciary Trust Co. | 0.00% | New | 191,220 | $3.8M |
| Citadel Advisors | 0.00% | New | 168,790 | $3.4M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.01% | New | 164,793 | $3.3M |
| Marshall Wace, LLP | 0.00% | New | 163,851 | $3.3M |
| D. E. Shaw & Co. | 0.00% | New | 128,130 | $2.6M |
| Rockefeller Capital Management L.P. | 0.00% | New | 116,939 | $2.4M |
| Ensign Peak Advisors, Inc | 0.00% | New | 115,978 | $2.3M |
| Jain Global LLC | 0.03% | New | 98,956 | $2.0M |
| Nomura Asset Management International Inc. | 0.00% | New | 93,732 | $1.9M |
| Financial Enhancement Group LLC | 0.18% | New | 74,450 | $1.5M |
| ADAR1 Capital Management, LLC | 0.07% | New | 71,910 | $1.4M |
| Invesco Ltd. | 0.00% | New | 71,014 | $1.4M |
| Bank of New York Mellon Corp | 0.00% | New | 69,813 | $1.4M |
| Norges Bank | 0.00% | — | 69,100 | $1.4M |
| Opaleye Management Inc. | 0.12% | New | 65,000 | $1.3M |
| Quantinno Capital Management LP | 0.00% | New | 62,494 | $1.3M |
| Deutsche Bank AG | 0.00% | New | 62,117 | $1.2M |
| Prudential Financial Inc. | 0.00% | New | 60,940 | $1.2M |
| SummitTX Capital, L.P. | 0.03% | New | 58,843 | $1.2M |
| Wellington Management Group LLP | 0.00% | New | 57,476 | $1.2M |
| Dimensional Fund Advisors LP | 0.00% | New | 57,064 | $1.1M |
| Moody Aldrich Partners LLC | 0.20% | New | 54,316 | $1.1M |
| Fisher Asset Management | 0.00% | New | 51,549 | $1.0M |
| Nuveen, LLC | 0.00% | New | 49,608 | $998K |
| Swiss National Bank | 0.00% | New | 48,900 | $984K |
| J. Goldman & Co LP | 0.03% | New | 46,847 | $943K |
| T. Rowe Price Associates Inc. | 0.00% | New | 45,232 | $911K |
| XTX Topco Ltd | 0.01% | New | 43,000 | $865K |
| Ikarian Capital, LLC | 0.14% | New | 42,775 | $861K |
| Los Angeles Capital Management LLC | 0.00% | New | 36,834 | $741K |
| Alliancebernstein L.P. | 0.00% | New | 36,810 | $741K |
| Wells Fargo & Company | 0.00% | New | 36,204 | $728K |
| Citigroup Inc. | 0.00% | New | 36,199 | $728K |
| CRCM LP | 0.47% | New | 35,340 | $711K |
| Rhumbline Advisers | 0.00% | New | 31,412 | $632K |
| Tema ETFs LLC | 0.02% | New | 30,907 | $622K |
| Tidal Investments LLC | 0.00% | New | 30,907 | $622K |
| Corient Private Wealth LP | 0.00% | New | 30,339 | $610K |
| AQR Capital Management | 0.00% | New | 28,812 | $580K |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | New | 28,129 | $566K |
| Y-Intercept (Hong Kong) Ltd | 0.01% | New | 28,084 | $565K |
| Sphera Funds Management LTD. | 0.08% | New | 27,876 | $561K |
| Martingale Asset Management L P | 0.01% | New | 27,240 | $548K |
| California State Teachers Retirement System | 0.00% | New | 26,291 | $529K |
| Rafferty Asset Management, LLC | 0.00% | New | 25,861 | $520K |
| Jacobs Levy Equity Management, Inc. | 0.00% | New | 25,140 | $506K |
| Susquehanna International Group, LLP | 0.00% | New | 21,129 | $425K |
| VANGUARD ASSET MANAGEMENT, Ltd | 0.00% | New | 20,146 | $405K |
| Credit Agricole S A | 0.00% | New | 20,000 | $402K |
| Virtus Investment Advisers, LLC | 0.09% | New | 18,549 | $373K |
| Qube Research & Technologies Ltd | 0.00% | New | 18,244 | $367K |
| Legal & General Group Plc | 0.00% | New | 17,972 | $362K |
| American Century Companies Inc. | 0.00% | New | 17,253 | $347K |
| Russell Investments Group, Ltd. | 0.00% | New | 16,021 | $322K |
| MetLife Investment Management, LLC | 0.00% | New | 14,201 | $286K |
| Cresset Asset Management, LLC | 0.00% | New | 13,694 | $276K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 13,706 | $266K |
| Boothbay Fund Management, LLC | 0.01% | New | 13,127 | $264K |
| Profund Advisors LLC | 0.01% | New | 13,064 | $263K |
| Victory Capital Management Inc. | 0.00% | New | 12,780 | $257K |
| JPMorgan Chase & Co. | 0.00% | New | 14,887 | $253K |
| Glenmede Trust Co. NA | 0.00% | New | 12,240 | $246K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.00% | New | 11,550 | $232K |
| Manufacturers Life Insurance Company, The | 0.00% | New | 10,786 | $217K |
| Vanguard Global Advisers, LLC | 0.00% | New | 10,577 | $213K |