Zentalis PharmaceuticalsZNTL
13F holders, Q4 2025 (December 31)86holders −13
6new positions
18sold out
7famous investors
$1.35avg. 13F price*
At the end of Q4 2025, 86 institutions reported holding Zentalis Pharmaceuticals Inc. (ZNTL) in their 13F filings, down 13 from Q3 2025. 6 opened new positions and 18 sold out. The largest holders were 5AM Venture Management, LLC ($5.3M), Renaissance Technologies ($3.9M) and Vanguard Group Inc. ($3.9M). 7 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Ken Griffin (0.0% of Citadel Advisors's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Zentalis Pharmaceuticals Inc.
- CUSIP
- 98943L107
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 6 | $529K |
| Exits | 18 | $25.8M |
All 13F filers, Q3 2025 → Q4 2025: 7,895,730 shares bought and 20,425,346 shares sold, net −12,529,616 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 86 holders
| 5AM Venture Management, LLC | 1.68% | Add +705.7% | 3,947,913 | $5.3M |
| Renaissance Technologies | 0.01% | Add +24.0% | 2,883,745 | $3.9M |
| Vanguard Group Inc. | 0.00% | Reduce -1.7% | 2,855,590 | $3.9M |
| Acadian Asset Management LLC | 0.01% | Add +0.1% | 2,849,294 | $3.8M |
| Citadel Advisors | 0.00% | Reduce -5.4% | 1,964,255 | $2.7M |
| D. E. Shaw & Co. | 0.00% | Add +17.9% | 1,660,378 | $2.2M |
| Two Sigma Advisers, LP | 0.00% | Add +1.5% | 1,483,500 | $2.0M |
| Two Sigma Investments, LP | 0.00% | Add +7.9% | 1,471,414 | $2.0M |
| Opaleye Management Inc. | 0.25% | Add +342.6% | 1,400,906 | $1.9M |
| Bank of America Corp. | 0.00% | Reduce -11.7% | 1,367,254 | $1.8M |
| Decheng Capital LLC | 0.24% | No change | 1,323,327 | $1.8M |
| Ishara Investments LP | 2.07% | — | 1,320,000 | $1.8M |
| BlackRock, Inc. | 0.00% | Add +0.0% | 1,249,968 | $1.7M |
| Gsa Capital Partners LLP | 0.14% | Add +8.5% | 1,169,573 | $1.6M |
| Primecap Management Co. | 0.00% | Reduce -0.5% | 957,420 | $1.3M |
| Pfizer Inc | 0.54% | No change | 953,834 | $1.3M |
| Morgan Stanley | 0.00% | Reduce -42.9% | 803,654 | $1.1M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | Add +106.7% | 787,055 | $1.1M |
| UBS Group AG | 0.00% | Add +26.6% | 674,598 | $911K |
| Millennium Management | 0.00% | Reduce -25.4% | 673,129 | $909K |
| Almitas Capital LLC | 0.18% | Add +33.4% | 610,073 | $824K |
| Geode Capital Management, LLC | 0.00% | Reduce -0.0% | 589,105 | $796K |
| XTX Topco Ltd | 0.02% | Add +5.1% | 576,707 | $779K |
| Barclays PLC | 0.00% | Add +252.0% | 568,443 | $767K |
| Woodline Partners LP | 0.00% | No change | 530,582 | $716K |
| Jane Street Group, LLC | 0.00% | Reduce -26.7% | 473,175 | $639K |
| Stonepine Capital Management, LLC | 0.50% | Add +2.2% | 463,700 | $626K |
| Peapod Lane Capital LLC | 0.52% | Reduce -20.6% | 448,861 | $606K |
| BNP Paribas Financial Markets | 0.00% | Add +163.9% | 419,367 | $566K |
| State Street Corp. | 0.00% | No change | 271,790 | $367K |
| Creative Planning | 0.00% | No change | 260,000 | $351K |
| Marshall Wace, LLP | 0.00% | New | 247,788 | $335K |
| FMR LLC | 0.00% | Add +19.7% | 243,308 | $328K |
| Anfield Capital Management, LLC | 0.10% | Add +239.9% | 242,605 | $328K |
| Invesco Ltd. | 0.00% | Add +8.6% | 188,582 | $255K |
| JPMorgan Chase & Co. | 0.00% | Reduce -74.4% | 185,007 | $250K |
| Wealth Enhancement Advisory Services, LLC | 0.00% | Reduce -21.6% | 130,407 | $232K |
| Sei Investments Co. | 0.00% | No change | 167,100 | $226K |
| Quadrature Capital Ltd | 0.00% | Add +126.8% | 137,568 | $186K |
| Quarry LP | 0.03% | Add +21.4% | 132,000 | $178K |
| Opal Capital LLC | 0.04% | — | 72,251 | $173K |
| Jacobs Levy Equity Management, Inc. | 0.00% | Reduce -82.2% | 124,525 | $168K |
| Goldman Sachs Group Inc. | 0.00% | Reduce -65.8% | 118,212 | $160K |
| Walleye Capital LLC | 0.00% | Reduce -8.3% | 110,448 | $149K |
| Squarepoint Ops LLC | 0.00% | Add +405.3% | 107,734 | $145K |
| Point72 Asset Management | 0.00% | New | 100,290 | $135K |
| Dimensional Fund Advisors LP | 0.00% | Reduce -48.0% | 96,263 | $130K |
| Northern Trust Corp. | 0.00% | Reduce -1.3% | 92,871 | $125K |
| Graham Capital Management, L.P. | 0.01% | Reduce -40.3% | 90,910 | $123K |
| Panagora Asset Management Inc. | 0.00% | Reduce -11.5% | 86,640 | $117K |
| ADAR1 Capital Management, LLC | 0.01% | Add +60.0% | 80,000 | $108K |
| RBF Capital, LLC | 0.00% | No change | 80,000 | $108K |
| Bridgeway Capital Management, LLC | 0.00% | No change | 77,300 | $104K |
| 49 Wealth Management, LLC | 0.01% | Add +151.5% | 70,911 | $96K |
| Commonwealth Equity Services, LLC | 0.00% | Add +0.7% | 61,412 | $83K |
| Barr E S & Co. | 0.00% | Add +43.8% | 57,500 | $78K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | No change | 51,061 | $69K |
| Algert Global LLC | 0.00% | No change | 48,496 | $65K |
| AQR Capital Management | 0.00% | Reduce -57.0% | 45,995 | $62K |
| Tudor Investment Corporation | 0.00% | No change | 34,849 | $47K |
| Federated Hermes, Inc. | 0.00% | Reduce -15.9% | 34,574 | $47K |
| Regency Capital Management Inc.\DE | 0.02% | No change | 29,500 | $40K |
| Prudential Financial Inc. | 0.00% | Add +13.7% | 24,550 | $33K |
| Carson Advisory Inc. | 0.02% | Reduce -26.8% | 23,470 | $32K |
| Acorn Wealth Advisors, LLC | 0.01% | No change | 20,000 | $27K |
| Sivia Capital Partners, LLC | 0.01% | New | 20,000 | $27K |
| Raymond James Financial Inc. | 0.00% | Reduce -3.4% | 19,895 | $27K |
| Qube Research & Technologies Ltd | 0.00% | Reduce -69.2% | 17,471 | $24K |
| Birchview Capital, LP | 0.01% | No change | 17,000 | $23K |
| Evergreen Capital Management LLC | 0.00% | No change | 16,915 | $23K |
| American Century Companies Inc. | 0.00% | New | 12,880 | $17K |
| Royal Bank of Canada | 0.00% | Add +2919.0% | 12,740 | $17K |
| Ieq Capital, LLC | 0.00% | Reduce -64.2% | 12,229 | $17K |
| Shay Capital LLC | 0.00% | New | 10,662 | $14K |
| Susquehanna International Group, LLP | 0.00% | Reduce -94.9% | 10,343 | $14K |
| Cwm, LLC | 0.00% | Reduce -34.7% | 8,564 | $12K |
| Highline Wealth Partners LLC | 0.00% | Reduce -58.3% | 5,000 | $7K |
| EverSource Wealth Advisors, LLC | 0.00% | Reduce -36.6% | 1,644 | $2K |
| Wilmington Savings Fund Society, FSB | 0.00% | No change | 1,000 | $1K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 387 | $522 |
| HighMark Wealth Management LLC | 0.00% | No change | 130 | $175 |
| Optiver Holding B.V. | 0.00% | No change | 44 | $59 |
| SBI Securities Co., Ltd. | 0.00% | Reduce -3.6% | 27 | $36 |
| Inspire Investing, LLC | 0.00% | New | 16 | $22 |
| Caitong International Asset Management Co., Ltd | 0.00% | No change | 1 | $1 |
| Covestor Ltd | 0.00% | Reduce -1.9% | 51 | $0 |
"% of holder's portfolio" is ZNTL's weight in each manager's 13F, not the share of Zentalis Pharmaceuticals Inc. the manager owns.