ZymeworksZYME
13F holders, Q3 2025 (September 30)184holders +2
24new positions
22sold out
7famous investors
$17.08avg. 13F price*
At the end of Q3 2025, 184 institutions reported holding Zymeworks Inc. (ZYME) in their 13F filings, up 2 from Q2 2025. 24 opened new positions and 22 sold out. The largest holders were EcoR1 Capital, LLC ($392.3M), Rubric Capital Management LP ($80.5M) and BlackRock, Inc. ($68.1M). 7 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Paul Tudor Jones (0.0% of Tudor Investment Corporation's portfolio).
- Company
- Zymeworks Inc.
- CUSIP
- 98985Y108
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q2 2025 → Q3 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 24 | $16.7M |
| Exits | 22 | $35.4M |
All 13F filers, Q2 2025 → Q3 2025: 5,726,711 shares bought and 7,596,195 shares sold, net −1,869,484 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 184 holders
| EcoR1 Capital, LLC | 18.87% | No change | 22,970,388 | $392.3M |
| Rubric Capital Management LP | 1.08% | No change | 4,710,551 | $80.5M |
| BlackRock, Inc. | 0.00% | Add +5.2% | 3,989,533 | $68.1M |
| Morgan Stanley | 0.00% | Reduce -4.6% | 3,984,585 | $68.1M |
| BVF Inc. | 2.73% | Reduce -8.6% | 3,938,641 | $67.3M |
| Redmile Group, LLC | 6.16% | Reduce -10.7% | 3,705,750 | $63.3M |
| Vanguard Group Inc. | 0.00% | Reduce -12.6% | 2,154,434 | $36.8M |
| Perceptive Advisors LLC | 1.05% | Add +63.9% | 2,090,663 | $35.7M |
| Vestal Point Capital, LP | 1.37% | Add +53.5% | 1,765,000 | $30.1M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.01% | Reduce -30.5% | 1,710,463 | $29.2M |
| Blackstone Inc. | 0.12% | Reduce -2.4% | 1,616,290 | $27.6M |
| Deutsche Bank AG | 0.01% | Add +0.0% | 1,544,898 | $26.4M |
| Assenagon Asset Management S.A. | 0.03% | Add +169.2% | 1,326,774 | $22.7M |
| Dimensional Fund Advisors LP | 0.00% | Reduce -0.1% | 1,190,838 | $20.3M |
| Nextech Invest Ltd. | 2.90% | No change | 1,113,946 | $19.0M |
| Millennium Management | 0.02% | Add +851.6% | 1,104,813 | $18.9M |
| Tang Capital Management LLC | 0.72% | No change | 1,100,000 | $18.8M |
| State Street Corp. | 0.00% | Reduce -0.7% | 1,081,189 | $18.5M |
| Prosight Management, LP | 3.07% | Reduce -42.8% | 749,611 | $12.8M |
| Geode Capital Management, LLC | 0.00% | Reduce -3.8% | 678,636 | $11.6M |
| Nuveen, LLC | 0.00% | Reduce -13.7% | 565,385 | $9.7M |
| Adage Capital Partners Gp, L.L.C. | 0.02% | Add +18.5% | 564,000 | $9.6M |
| Goldman Sachs Group Inc. | 0.00% | Add +3.4% | 443,525 | $7.6M |
| Renaissance Technologies | 0.01% | Reduce -19.1% | 431,700 | $7.4M |
| Jupiter Asset Management Ltd. | 0.05% | Reduce -5.1% | 350,660 | $6.0M |
| Northern Trust Corp. | 0.00% | Reduce -0.4% | 348,253 | $5.9M |
| Granahan Investment Management, LLC | 0.24% | Reduce -9.3% | 345,331 | $5.9M |
| Arrowstreet Capital, Limited Partnership | 0.00% | New | 313,753 | $5.4M |
| Silvercrest Asset Management Group LLC | 0.03% | Reduce -2.8% | 272,797 | $4.7M |
| Qube Research & Technologies Ltd | 0.01% | Add +264.9% | 255,002 | $4.4M |
| Squarepoint Ops LLC | 0.01% | Add +41.4% | 219,948 | $3.8M |
| Hillsdale Investment Management Inc. | 0.11% | Add +5.6% | 216,422 | $3.7M |
| Algert Global LLC | 0.06% | Add +76.0% | 207,926 | $3.6M |
| Samsara Biocapital, LLC | 0.46% | Reduce -33.0% | 207,901 | $3.6M |
| Citadel Advisors | 0.00% | Reduce -16.0% | 206,858 | $3.5M |
| Picton Mahoney Asset Management | 0.05% | Reduce -0.6% | 206,322 | $3.5M |
| Barclays PLC | 0.00% | Add +62.0% | 199,023 | $3.4M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +55.7% | 193,360 | $3.3M |
| Federated Hermes, Inc. | 0.01% | Add +0.3% | 182,847 | $3.1M |
| Wells Fargo & Company | 0.00% | Add +6.1% | 176,634 | $3.0M |
| Wellington Management Group LLP | 0.00% | Reduce -6.6% | 168,685 | $2.9M |
| Schroder Investment Management Group | 0.00% | Reduce -47.0% | 161,486 | $2.8M |
| Man Group plc | 0.01% | Add +348.0% | 158,616 | $2.7M |
| AXA Investment Managers S.A. | 0.01% | — | 158,416 | $2.7M |
| Marshall Wace, LLP | 0.00% | New | 154,858 | $2.6M |
| AQR Capital Management | 0.00% | Reduce -8.1% | 152,632 | $2.6M |
| Kennedy Capital Management LLC | 0.06% | Reduce -0.3% | 146,440 | $2.5M |
| Jane Street Group, LLC | 0.00% | Add +1057.1% | 145,206 | $2.5M |
| Bank of New York Mellon Corp | 0.00% | Add +3.4% | 137,552 | $2.3M |
| D. E. Shaw & Co. | 0.00% | Reduce -50.3% | 126,923 | $2.2M |
| Platinum Investment Management Ltd. | 0.14% | Reduce -47.7% | 124,784 | $2.1M |
| Raymond James Financial Inc. | 0.00% | Reduce -1.3% | 122,868 | $2.1M |
| Citigroup Inc. | 0.00% | Reduce -24.5% | 117,804 | $2.0M |
| Schonfeld Strategic Advisors LLC | 0.01% | New | 107,788 | $1.8M |
| Panagora Asset Management Inc. | 0.01% | Add +216.1% | 106,072 | $1.8M |
| Opaleye Management Inc. | 0.24% | Reduce -52.4% | 100,000 | $1.7M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.01% | New | 96,800 | $1.7M |
| Invesco Ltd. | 0.00% | Add +4.8% | 93,657 | $1.6M |
| Rhumbline Advisers | 0.00% | Reduce -0.2% | 85,902 | $1.5M |
| Tejara Capital Ltd | 0.80% | Reduce -57.5% | 85,163 | $1.5M |
| Susquehanna Portfolio Strategies, LLC | 0.02% | Reduce -1.8% | 84,195 | $1.4M |
| North Growth Management Ltd. | 0.25% | Reduce -15.5% | 82,000 | $1.4M |
| Acuta Capital Partners, LLC | 1.41% | Reduce -4.2% | 80,143 | $1.4M |
| Ameriprise Financial Inc. | 0.00% | New | 75,928 | $1.3M |
| Bank of America Corp. | 0.00% | Reduce -16.6% | 75,327 | $1.3M |
| Swiss National Bank | 0.00% | No change | 73,100 | $1.2M |
| Ikarian Capital, LLC | 0.25% | Add +191.2% | 72,787 | $1.2M |
| Stifel Financial Corp. | 0.00% | Add +4.0% | 72,530 | $1.2M |
| Fisher Asset Management | 0.00% | Reduce -0.0% | 71,974 | $1.2M |
| HRT Financial LP | 0.00% | Add +109.0% | 68,461 | $1.2M |
| Tema ETFs LLC | 0.09% | Add +22.8% | 63,663 | $1.1M |
| NEOS Investment Management LLC | 0.01% | Add +22.8% | 63,663 | $1.1M |
| Royal Bank of Canada | 0.00% | Reduce -20.6% | 57,925 | $989K |
| Russell Investments Group, Ltd. | 0.00% | Add +102.9% | 57,448 | $981K |
| Mackenzie Financial Corp. | 0.00% | Add +164.0% | 56,377 | $963K |
| Engineers Gate Manager LP | 0.01% | Add +197.3% | 56,318 | $962K |
| State of Wisconsin Investment Board | 0.00% | Add +155.4% | 56,274 | $961K |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 0.01% | Add +3.5% | 55,975 | $956K |
| Susquehanna International Group, LLP | 0.00% | Reduce -79.9% | 52,054 | $889K |
| UBS Group AG | 0.00% | Reduce -79.4% | 51,841 | $885K |
| American Century Companies Inc. | 0.00% | Add +63.8% | 51,016 | $871K |
| Alliancebernstein L.P. | 0.00% | No change | 50,030 | $855K |
| O'shaughnessy Asset Management, LLC | 0.00% | Add +1.3% | 41,768 | $713K |
| STRS Ohio | 0.00% | Reduce -11.7% | 40,900 | $699K |
| Tudor Investment Corporation | 0.00% | Add +9.6% | 37,583 | $642K |
| HSBC Holdings PLC | 0.00% | Add +3.0% | 37,600 | $640K |
| Dark Forest Capital Management LP | 0.02% | Reduce -61.7% | 37,167 | $635K |
| Oxford Asset Management LLP | 0.20% | New | 36,359 | $621K |
| California State Teachers Retirement System | 0.00% | Reduce -17.8% | 35,231 | $602K |
| Victory Capital Management Inc. | 0.00% | Reduce -0.3% | 34,510 | $589K |
| JPMorgan Chase & Co. | 0.00% | Reduce -92.3% | 33,884 | $579K |
| Franklin Resources Inc. | 0.00% | New | 33,821 | $578K |
| Prudential Financial Inc. | 0.00% | Reduce -25.7% | 33,390 | $570K |
| MetLife Investment Management, LLC | 0.00% | No change | 33,309 | $569K |
| Boothbay Fund Management, LLC | 0.01% | New | 32,757 | $559K |
| Campbell & CO Investment Adviser LLC | 0.04% | Add +116.8% | 32,493 | $555K |
| Commonwealth Equity Services, LLC | 0.00% | Reduce -2.9% | 31,237 | $534K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Add +112.8% | 30,432 | $520K |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0.00% | Reduce -0.8% | 29,708 | $507K |
| Journey Strategic Wealth LLC | 0.01% | Add +0.0% | 29,050 | $496K |
| Massachusetts Financial Services Co. | 0.00% | Add +7.0% | 29,015 | $496K |
| Simplex Trading, LLC | 0.01% | Add +346.3% | 28,761 | $491K |
| Legal & General Group Plc | 0.00% | Reduce -35.2% | 28,369 | $485K |
| Bank of Montreal | 0.00% | No change | 27,642 | $472K |
| Creative Planning | 0.00% | Add +7.6% | 27,314 | $467K |
| T. Rowe Price Associates Inc. | 0.00% | No change | 26,816 | $459K |
| Ritholtz Wealth Management | 0.01% | Reduce -2.0% | 24,722 | $422K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Reduce -14.6% | 22,945 | $392K |
| Vinva Investment Management Ltd | 0.01% | New | 14,594 | $382K |
| Duncan Williams Asset Management, LLC | 0.11% | No change | 22,095 | $377K |
| DLD Asset Management, LP | 0.14% | New | 20,000 | $342K |
| Janus Henderson Group PLC | 0.00% | No change | 18,200 | $311K |
| PharVision Advisers, LLC | 0.17% | New | 17,790 | $304K |
| Manufacturers Life Insurance Company, The | 0.00% | Reduce -7.8% | 17,574 | $300K |
| Intech Investment Management LLC | 0.00% | Reduce -26.7% | 16,982 | $290K |
| Fox Run Management, L.L.C. | 0.04% | New | 16,145 | $276K |
| BNP Paribas Financial Markets | 0.00% | Add +50.0% | 15,460 | $264K |
| State Board of Administration of Florida Retirement System | 0.00% | No change | 15,340 | $262K |
| Lazard Asset Management LLC | 0.00% | New | 15,308 | $261K |
| Envestnet Asset Management Inc. | 0.00% | Reduce -0.2% | 14,574 | $249K |
| Brevan Howard Capital Management LP | 0.00% | Add +36.6% | 14,518 | $248K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | Add +21.7% | 14,205 | $243K |
| SG Americas Securities, LLC | 0.00% | Add +57.1% | 13,624 | $233K |
| New York State Common Retirement Fund | 0.00% | No change | 13,371 | $228K |
| China Universal Asset Management Co., Ltd. | 0.02% | Reduce -5.9% | 13,176 | $225K |
| Two Sigma Securities, LLC | 0.03% | New | 12,225 | $209K |
| Tower Research Capital LLC (TRC) | 0.01% | Add +128.4% | 11,301 | $193K |
| ProShare Advisors LLC | 0.00% | Reduce -11.6% | 11,201 | $191K |
| Janney Montgomery Scott LLC | 0.00% | Reduce -4.3% | 11,067 | $189K |
| Arizona State Retirement System | 0.00% | Reduce -0.9% | 11,059 | $189K |
| Ewing Morris & Co. Investment Partners Ltd. | 0.08% | New | 10,850 | $185K |
| James Investment Research, Inc. | 0.02% | No change | 10,578 | $181K |
| Northwest & Ethical Investments L.P. | 0.00% | No change | 10,030 | $173K |
| TPG Financial Advisors, LLC | 0.06% | No change | 10,017 | $171K |
| Virtus Investment Advisers, LLC | 0.04% | Add +21.0% | 8,686 | $148K |
| AlphaQuest LLC | 0.01% | Reduce -39.6% | 8,471 | $145K |
| KLP Kapitalforvaltning As | 0.00% | No change | 7,300 | $125K |
| Cwm, LLC | 0.00% | Reduce -18.7% | 6,968 | $119K |
| Group One Trading LLC | 0.00% | Add +6768.0% | 6,868 | $117K |
| Clearstead Advisors, LLC | 0.00% | Add +0.0% | 5,001 | $85K |
| Shell Asset Management Co. | 0.01% | Reduce -54.7% | 4,212 | $72K |
| Ameritas Investment Partners, Inc. | 0.00% | Reduce -25.9% | 4,164 | $71K |
| DekaBank Deutsche Girozentrale | 0.00% | No change | 3,843 | $65K |
| FMR LLC | 0.00% | Add +13.0% | 3,514 | $60K |
| Arax Advisory Partners | 0.00% | New | 2,981 | $51K |
| Quarry LP | 0.01% | New | 2,942 | $50K |
| Mirae Asset Global Investments Co., Ltd. | 0.00% | Add +8.0% | 2,906 | $50K |
| Amalgamated Bank | 0.00% | No change | 1,880 | $32K |
| GF Fund Management Co. LTD. | 0.00% | Reduce -8.3% | 1,617 | $28K |
| Optiver Holding B.V. | 0.00% | New | 1,510 | $26K |
| Nisa Investment Advisors, LLC | 0.00% | No change | 968 | $17K |
| Federation des caisses Desjardins du Quebec | 0.00% | No change | 870 | $15K |
| GAMMA Investing LLC | 0.00% | Reduce -0.6% | 805 | $14K |
| Osaic Holdings, Inc. | 0.00% | Add +15.8% | 775 | $12K |
| National Bank of Canada | 0.00% | Add +16.3% | 549 | $9K |
| Summit Securities Group LLC | 0.00% | New | 472 | $8K |
| Parallel Advisors, LLC | 0.00% | No change | 329 | $6K |
| PNC Financial Services Group, Inc. | 0.00% | Reduce -7.4% | 313 | $5K |
| TD Waterhouse Canada Inc. | 0.00% | No change | 311 | $5K |
| Daiwa Securities Group Inc. | 0.00% | No change | 286 | $5K |
| HighMark Wealth Management LLC | 0.00% | No change | 280 | $5K |
| US Bancorp \de | 0.00% | No change | 248 | $4K |
| Truvestments Capital LLC | 0.00% | Reduce -25.2% | 231 | $4K |
| Comerica Bank | 0.00% | New | 211 | $4K |
| EverSource Wealth Advisors, LLC | 0.00% | Add +0.6% | 182 | $3K |
| Allworth Financial LP | 0.00% | Add +14.8% | 140 | $2K |
| Sterling Capital Management LLC | 0.00% | Add +1.7% | 121 | $2K |
| IFP Advisors, Inc | 0.00% | No change | 96 | $2K |
| Walleye Capital LLC | 0.00% | New | 76 | $1K |
| Kilter Group LLC | 0.00% | No change | 66 | $1K |
| Bare Financial Services, Inc | 0.00% | Add +42.2% | 64 | $1K |
| Farther Finance Advisors, LLC | 0.00% | Add +148.0% | 62 | $1K |
| Covestor Ltd | 0.00% | Add +103.8% | 53 | $1K |
| Bessemer Group Inc. | 0.00% | New | 73 | $1K |
| True Wealth Design, LLC | 0.00% | Add +728.6% | 58 | $991 |
| Rothschild Investment LLC | 0.00% | No change | 55 | $939 |
| Steward Partners Investment Advisory, LLC | 0.00% | No change | 53 | $905 |
| Physician Wealth Advisors, Inc. | 0.00% | No change | 51 | $872 |
| Sunbelt Securities, Inc. | 0.00% | New | 27 | $461 |
| CoreCap Advisors, LLC | 0.00% | No change | 18 | $307 |
| Smartleaf Asset Management LLC | 0.00% | New | 12 | $206 |
| Essential Partners LLC | 0.00% | Reduce -14.3% | 12 | $205 |
| SBI Securities Co., Ltd. | 0.00% | Add +20.0% | 12 | $205 |
| Innovative Advisory Group, LLC | 0.00% | No change | 8 | $137 |
"% of holder's portfolio" is ZYME's weight in each manager's 13F, not the share of Zymeworks Inc. the manager owns.