ZymeworksZYME
13F holders, Q4 2025 (December 31)210holders +26
41new positions
19sold out
7famous investors
$26.33avg. 13F price*
At the end of Q4 2025, 210 institutions reported holding Zymeworks Inc. (ZYME) in their 13F filings, up 26 from Q3 2025. 41 opened new positions and 19 sold out. The largest holders were EcoR1 Capital, LLC ($604.8M), Rubric Capital Management LP ($151.4M) and BlackRock, Inc. ($121.0M). 7 famous investors held it, including Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio), Israel Englander (0.0% of Millennium Management's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Zymeworks Inc.
- CUSIP
- 98985Y108
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q3 2025 → Q4 2025
| Institutions | Total Value | |
|---|---|---|
| New Positions | 41 | $149.1M |
| Exits | 19 | $46.1M |
All 13F filers, Q3 2025 → Q4 2025: 11,635,585 shares bought and 13,803,837 shares sold, net −2,168,252 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 210 holders
| EcoR1 Capital, LLC | 27.72% | No change | 22,970,388 | $604.8M |
| Rubric Capital Management LP | 1.81% | Add +22.1% | 5,750,000 | $151.4M |
| BlackRock, Inc. | 0.00% | Add +15.2% | 4,595,548 | $121.0M |
| BVF Inc. | 3.49% | No change | 3,938,641 | $103.7M |
| Perceptive Advisors LLC | 1.58% | Add +56.0% | 3,261,850 | $85.9M |
| Morgan Stanley | 0.00% | Reduce -34.9% | 2,593,080 | $68.3M |
| Vanguard Group Inc. | 0.00% | Add +8.1% | 2,328,727 | $61.3M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.06% | New | 1,822,048 | $48.0M |
| Siren, L.L.C. | 1.32% | New | 1,680,121 | $44.2M |
| Deutsche Bank AG | 0.01% | Add +3.3% | 1,595,833 | $42.0M |
| Dimensional Fund Advisors LP | 0.01% | Reduce -2.7% | 1,159,215 | $30.5M |
| Nextech Invest Ltd. | 2.84% | No change | 1,113,946 | $29.3M |
| State Street Corp. | 0.00% | Reduce -4.0% | 1,037,642 | $27.3M |
| Capricorn Fund Managers Ltd | 6.49% | New | 1,022,840 | $26.9M |
| Vestal Point Capital, LP | 0.84% | Reduce -51.0% | 865,000 | $22.8M |
| Arrowstreet Capital, Limited Partnership | 0.01% | Add +123.1% | 700,002 | $18.4M |
| Adage Capital Partners Gp, L.L.C. | 0.03% | Add +17.6% | 663,546 | $17.5M |
| Nuveen, LLC | 0.00% | Add +14.7% | 648,326 | $17.1M |
| Geode Capital Management, LLC | 0.00% | Reduce -4.5% | 647,970 | $17.1M |
| Assenagon Asset Management S.A. | 0.03% | Reduce -51.2% | 647,374 | $17.0M |
| FMR LLC | 0.00% | Add +15838.7% | 560,086 | $14.7M |
| Prosight Management, LP | 2.89% | Reduce -29.2% | 530,393 | $14.0M |
| Redmile Group, LLC | 0.95% | Reduce -86.7% | 491,654 | $12.9M |
| Qube Research & Technologies Ltd | 0.02% | Add +86.0% | 474,290 | $12.5M |
| Algert Global LLC | 0.17% | Add +103.8% | 423,646 | $11.2M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -5.3% | 420,207 | $11.1M |
| Millennium Management | 0.01% | Reduce -65.5% | 381,621 | $10.0M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.00% | Reduce -81.3% | 320,261 | $8.4M |
| Northern Trust Corp. | 0.00% | Reduce -11.6% | 307,979 | $8.1M |
| Schonfeld Strategic Advisors LLC | 0.04% | Add +167.7% | 288,571 | $7.6M |
| UBS Group AG | 0.00% | Add +437.9% | 278,854 | $7.3M |
| Invesco Ltd. | 0.00% | Add +175.0% | 257,580 | $6.8M |
| Citadel Advisors | 0.00% | Add +23.4% | 255,351 | $6.7M |
| Picton Mahoney Asset Management | 0.07% | Add +18.6% | 244,798 | $6.4M |
| Hillsdale Investment Management Inc. | 0.17% | Add +9.9% | 237,922 | $6.3M |
| Granahan Investment Management, LLC | 0.25% | Reduce -35.0% | 224,408 | $5.9M |
| SummitTX Capital, L.P. | 0.18% | New | 224,268 | $5.9M |
| D. E. Shaw & Co. | 0.00% | Add +76.3% | 223,786 | $5.9M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +14.3% | 220,909 | $5.8M |
| Renaissance Technologies | 0.01% | Reduce -48.8% | 220,877 | $5.8M |
| Wells Fargo & Company | 0.00% | Add +17.9% | 208,313 | $5.5M |
| Raymond James Financial Inc. | 0.00% | Add +52.8% | 187,685 | $4.9M |
| Silvercrest Asset Management Group LLC | 0.03% | Reduce -33.4% | 181,790 | $4.8M |
| Wellington Management Group LLP | 0.00% | Add +7.7% | 181,705 | $4.8M |
| Susquehanna International Group, LLP | 0.01% | Add +238.3% | 176,088 | $4.6M |
| Federated Hermes, Inc. | 0.01% | Reduce -16.5% | 152,689 | $4.0M |
| Kennedy Capital Management LLC | 0.08% | Reduce -0.6% | 145,534 | $3.8M |
| Bank of New York Mellon Corp | 0.00% | Reduce -6.8% | 128,131 | $3.4M |
| Jupiter Asset Management Ltd. | 0.03% | Reduce -64.2% | 125,506 | $3.3M |
| HRT Financial LP | 0.01% | Add +76.8% | 121,064 | $3.2M |
| Ameriprise Financial Inc. | 0.00% | Add +49.0% | 113,141 | $3.0M |
| Citigroup Inc. | 0.00% | Reduce -5.6% | 111,207 | $2.9M |
| Opaleye Management Inc. | 0.38% | Add +8.9% | 108,929 | $2.9M |
| Platinum Investment Management Ltd. | 0.64% | Reduce -15.7% | 105,184 | $2.8M |
| Trexquant Investment LP | 0.02% | New | 101,274 | $2.7M |
| Soleus Capital Management, L.P. | 0.11% | New | 100,000 | $2.6M |
| Susquehanna Portfolio Strategies, LLC | 0.04% | Add +18.5% | 99,795 | $2.6M |
| Schroder Investment Management Group | 0.00% | Reduce -39.4% | 97,907 | $2.6M |
| XTX Topco Ltd | 0.06% | New | 93,469 | $2.5M |
| AQR Capital Management | 0.00% | Reduce -40.3% | 91,075 | $2.4M |
| Bank of America Corp. | 0.00% | Add +18.9% | 89,524 | $2.4M |
| Kornitzer Capital Management Inc. | 0.05% | New | 88,800 | $2.3M |
| Acuta Capital Partners, LLC | 1.43% | No change | 80,143 | $2.1M |
| Barclays PLC | 0.00% | Reduce -59.8% | 79,966 | $2.1M |
| Panagora Asset Management Inc. | 0.01% | Reduce -26.1% | 78,336 | $2.1M |
| NEOS Investment Management LLC | 0.01% | Add +21.1% | 77,115 | $2.0M |
| Tema ETFs LLC | 0.16% | Add +19.3% | 75,975 | $2.0M |
| Stifel Financial Corp. | 0.00% | Add +4.6% | 75,847 | $2.0M |
| State of Wisconsin Investment Board | 0.00% | Add +34.3% | 75,566 | $2.0M |
| Rhumbline Advisers | 0.00% | Reduce -12.1% | 75,498 | $2.0M |
| Man Group plc | 0.00% | Reduce -52.5% | 75,318 | $2.0M |
| Credit Agricole S A | 0.01% | New | 75,000 | $2.0M |
| Pictet Asset Management Holding SA | 0.00% | New | 73,627 | $2.0M |
| Swiss National Bank | 0.00% | Add +1.5% | 74,200 | $2.0M |
| Jane Street Group, LLC | 0.00% | Reduce -51.5% | 70,445 | $1.9M |
| Fisher Asset Management | 0.00% | Reduce -5.3% | 68,197 | $1.8M |
| Penserra Capital Management LLC | 0.02% | New | 60,146 | $1.6M |
| Franklin Resources Inc. | 0.00% | Add +74.4% | 58,987 | $1.6M |
| American Century Companies Inc. | 0.00% | Add +15.3% | 58,832 | $1.5M |
| Russell Investments Group, Ltd. | 0.00% | Add +1.6% | 58,350 | $1.5M |
| Royal Bank of Canada | 0.00% | Reduce -5.0% | 55,055 | $1.4M |
| Alliancebernstein L.P. | 0.00% | No change | 50,030 | $1.3M |
| Dana Investment Advisors, Inc. | 0.04% | New | 48,318 | $1.3M |
| Simplex Trading, LLC | 0.04% | Add +67.0% | 48,040 | $1.3M |
| Mackenzie Financial Corp. | 0.00% | Reduce -19.4% | 45,460 | $1.2M |
| North Growth Management Ltd. | 0.18% | Reduce -45.1% | 45,000 | $1.2M |
| O'shaughnessy Asset Management, LLC | 0.01% | Add +3.1% | 43,052 | $1.1M |
| Victory Capital Management Inc. | 0.00% | Add +24.3% | 42,905 | $1.1M |
| Envestnet Asset Management Inc. | 0.00% | Add +180.0% | 40,812 | $1.1M |
| California State Teachers Retirement System | 0.00% | Add +7.2% | 37,761 | $994K |
| JPMorgan Chase & Co. | 0.00% | Add +3.3% | 35,008 | $922K |
| Tang Capital Management LLC | 0.04% | Reduce -96.8% | 34,631 | $912K |
| Campbell & CO Investment Adviser LLC | 0.04% | Add +3.4% | 33,588 | $884K |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.00% | Add +7.8% | 32,815 | $864K |
| SBI Okasan Asset Management Co.Ltd. | 0.05% | — | 32,000 | $856K |
| Legal & General Group Plc | 0.00% | Add +13.3% | 32,149 | $846K |
| Two Sigma Advisers, LP | 0.00% | New | 31,415 | $827K |
| Tudor Investment Corporation | 0.00% | Reduce -19.3% | 30,324 | $798K |
| Journey Strategic Wealth LLC | 0.02% | No change | 29,050 | $765K |
| Quantinno Capital Management LP | 0.00% | New | 28,883 | $760K |
"% of holder's portfolio" is ZYME's weight in each manager's 13F, not the share of Zymeworks Inc. the manager owns.