Aquilo Capital Management, LLC

In its 13F for Q2 2024 (holdings as of June 30, 2024, filed August 14, 2024), Aquilo Capital Management, LLC reported 13 stock positions worth $103.7 million. Its top holding was Arrowhead Pharmaceuticals (ARWR) at 22.8% of the portfolio, followed by Blueprint Medicines (BPMC, 11.9%) and Arvinas (ARVN, 11.0%). Compared with Q1 2024, it opened 3 new positions, added to 2 and reduced 6. The biggest buy was a new position in Bicycle Therapeutics PLC-ADR (BCYC) and the biggest sale Sutro Biopharma Inc. Com SHS (STRO, shares −35%).

Most Recent 13F
Q3 2025
Location
SAN FRANCISCO, CA
CIK
0001591986
Portfolio Value
$103.7M (Q2 2024)
SEC Filing
0001591986-24-000006 ↗ filed Aug 14, 2024

Holdings Value

0$50.0M$100.0M$150.0M Q1 2024: $133.4M Q1 2024 Q2 2024: $103.7M $103.7M Q2 2024 Q3 2024: $88.8M Q3 2024 Q4 2024: $58.4M Q4 2024 Q1 2025: $37.1M Q1 2025 Q2 2025: $0 Q2 2025 Q3 2025: $0 Q3 2025

Holdings 13 stocks · $103.7M

ARWR Arrowhead Pharmaceuticals Inc. 22.76% 908,474 $23.6M No change
BPMC Blueprint Medicines Corp. 11.91% 114,600 $12.4M Reduce -37.1%
ARVN Arvinas Inc. 11.00% 428,766 $11.4M Add +5.7%
RGNX Regenxbio Inc. 10.22% 906,248 $10.6M No change
KYMR Kymera Therapeutics Inc. 9.46% 328,743 $9.8M Reduce -15.4%
SLN Silence Therapeutics PLC-ADR 9.16% 500,214 $9.5M Reduce -12.9%
MRUS Merus NV 8.45% 148,109 $8.8M Reduce -41.9%
DTIL Precision Biosciences Inc. 3.58% 381,803 $3.7M Reduce -0.9%
BCYC Bicycle Therapeutics PLC-ADR 3.06% 156,692 $3.2M New
RPTX Repare Therapeutics Inc. 3.04% 956,932 $3.2M Add +51.1%
ACET Adicet Bio Inc. 2.95% 2,531,194 $3.1M New
IMTX Immatics NV 2.24% 200,000 $2.3M New
STRO Sutro Biopharma Inc. Com SHS 2.15% 762,498 $2.2M Reduce -34.6%

Portfolio Sells Q1 2024 → Q2 2024

STRO Sutro Biopharma Inc. Com SHS Reduce -34.6% 2.15% −2.78
KYMR Kymera Therapeutics Inc. Reduce -15.4% 9.46% −2.25
BPMC Blueprint Medicines Corp. Reduce -37.1% 11.91% −1.04
DTIL Precision Biosciences Inc. Reduce -0.9% 3.58% −0.34
MRUS Merus NV Reduce -41.9% 8.45% −0.16
SLN Silence Therapeutics PLC-ADR Reduce -12.9% 9.16% −0.13

Portfolio Buys Q1 2024 → Q2 2024

BCYC Bicycle Therapeutics PLC-ADR New 3.06% +3.06
ACET Adicet Bio Inc. New 2.95% +2.95
IMTX Immatics NV New 2.24% +2.24
RPTX Repare Therapeutics Inc. Add +51.1% 3.04% +0.81
ARVN Arvinas Inc. Add +5.7% 11.00% −1.55

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q3 2025 0$0
Q2 2025 0$0
Q1 2025 12$37.1MBPMC, ARWR, PTGX, KYMR, DTIL
Q4 2024 13$58.4MARWR, BPMC, KYMR, ARVN, BCYC
Q3 2024 13$88.8MARWR, BPMC, KYMR, RGNX, ARVN
Q2 2024 13$103.7MARWR, BPMC, ARVN, RGNX, KYMR
Q1 2024 10$133.4MARWR, RGNX, BPMC, ARVN, KYMR