Aquilo Capital Management, LLC

In its 13F for Q3 2024 (holdings as of September 30, 2024, filed November 14, 2024), Aquilo Capital Management, LLC reported 13 stock positions worth $88.8 million. Its top holding was Arrowhead Pharmaceuticals (ARWR) at 17.4% of the portfolio, followed by Blueprint Medicines (BPMC, 13.0%) and Kymera Therapeutics (KYMR, 11.1%). Compared with Q2 2024, it added to 5 and reduced 5. The biggest buy was Immatics (IMTX, shares +67%) and the biggest sale Arrowhead Pharmaceuticals (ARWR, shares −12%).

Most Recent 13F
Q3 2025
Location
SAN FRANCISCO, CA
CIK
0001591986
Portfolio Value
$88.8M (Q3 2024)
SEC Filing
0001591986-24-000007 ↗ filed Nov 14, 2024

Holdings Value

0$50.0M$100.0M$150.0M Q1 2024: $133.4M Q1 2024 Q2 2024: $103.7M Q2 2024 Q3 2024: $88.8M $88.8M Q3 2024 Q4 2024: $58.4M Q4 2024 Q1 2025: $37.1M Q1 2025 Q2 2025: $0 Q2 2025 Q3 2025: $0 Q3 2025

Holdings 13 stocks · $88.8M

ARWR Arrowhead Pharmaceuticals Inc. 17.35% 795,813 $15.4M Reduce -12.4%
BPMC Blueprint Medicines Corp. 12.97% 124,600 $11.5M Add +8.7%
KYMR Kymera Therapeutics Inc. 11.12% 208,743 $9.9M Reduce -36.5%
RGNX Regenxbio Inc. 10.99% 930,708 $9.8M Add +2.7%
ARVN Arvinas Inc. 10.78% 388,766 $9.6M Reduce -9.3%
MRUS Merus NV 6.63% 117,855 $5.9M Reduce -20.4%
SLN Silence Therapeutics PLC-ADR 6.49% 317,214 $5.8M Reduce -36.6%
BCYC Bicycle Therapeutics PLC-ADR 4.63% 181,911 $4.1M Add +16.1%
IMTX Immatics NV 4.28% 333,502 $3.8M Add +66.8%
ACET Adicet Bio Inc. 4.10% 2,531,194 $3.6M No change
DTIL Precision Biosciences Inc. 3.85% 381,803 $3.4M No change
RPTX Repare Therapeutics Inc. 3.83% 989,364 $3.4M Add +3.4%
STRO Sutro Biopharma Inc. Com SHS 2.97% 762,498 $2.6M No change

Options reported separately and not counted above: SPY puts ($43.0M).

Portfolio Sells Q2 2024 → Q3 2024

ARWR Arrowhead Pharmaceuticals Inc. Reduce -12.4% 17.35% −5.41
SLN Silence Therapeutics PLC-ADR Reduce -36.6% 6.49% −2.67
MRUS Merus NV Reduce -20.4% 6.63% −1.82
ARVN Arvinas Inc. Reduce -9.3% 10.78% −0.23
KYMR Kymera Therapeutics Inc. Reduce -36.5% 11.12% +1.66

Portfolio Buys Q2 2024 → Q3 2024

IMTX Immatics NV Add +66.8% 4.28% +2.04
BCYC Bicycle Therapeutics PLC-ADR Add +16.1% 4.63% +1.58
BPMC Blueprint Medicines Corp. Add +8.7% 12.97% +1.06
RPTX Repare Therapeutics Inc. Add +3.4% 3.83% +0.79
RGNX Regenxbio Inc. Add +2.7% 10.99% +0.77

Options Activity Q2 2024 → Q3 2024

SPY SS SPDR S&P 500 ETF Trust-US put New 75,000 $43.0M

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q3 2025 0$0
Q2 2025 0$0
Q1 2025 12$37.1MBPMC, ARWR, PTGX, KYMR, DTIL
Q4 2024 13$58.4MARWR, BPMC, KYMR, ARVN, BCYC
Q3 2024 13$88.8MARWR, BPMC, KYMR, RGNX, ARVN
Q2 2024 13$103.7MARWR, BPMC, ARVN, RGNX, KYMR
Q1 2024 10$133.4MARWR, RGNX, BPMC, ARVN, KYMR