Avidity Partners Management LP
In its 13F for Q1 2024 (holdings as of March 31, 2024, filed May 15, 2024), Avidity Partners Management LP reported 86 stock positions worth $2.8 billion. Its top holding was Fusion Pharmaceuticals (FUSN) at 4.9% of the portfolio, followed by Boston Scientific (BSX, 4.8%) and Arvinas (ARVN, 4.4%). Compared with Q4 2023, it opened 32 new positions, sold out of 17, added to 17 and reduced 29. The biggest buy was Dianthus Therapeutics (DNTH, shares +123%) and the biggest sale Thermo Fisher Scientific (TMO, shares −80%).
- Most Recent 13F
- Q2 2026
- Location
- DALLAS, TX
- CIK
- 0001791827
- Portfolio Value
- $2.8B (Q1 2024)
- SEC Filing
- 0001791827-24-000004 ↗ filed May 15, 2024
Holdings Value
Holdings 86 stocks · $2.8B
| FUSN Fusion Pharmaceuticals Inc. | 4.93% | 6,500,328 | $138.6M | No change |
| BSX Boston Scientific Corp. | 4.76% | 1,956,000 | $134.0M | Add +3.5% |
| ARVN Arvinas Inc. | 4.38% | 2,985,190 | $123.2M | Add +0.0% |
| ISRG Intuitive Surgical Inc. | 3.21% | 226,000 | $90.2M | Add +165.9% |
| DNTH Dianthus Therapeutics Inc. | 2.90% | 2,717,554 | $81.5M | Add +123.2% |
| ACHC Acadia Healthcare Co. Inc. | 2.83% | 1,005,000 | $79.6M | Reduce -13.1% |
| NBIX Neurocrine Biosciences Inc. | 2.63% | 536,500 | $74.0M | Reduce -18.5% |
| NTRA Natera Inc. | 2.61% | 803,300 | $73.5M | Reduce -27.6% |
| JAZZ Jazz Pharmaceuticals PLC | 2.50% | 584,000 | $70.3M | Add +19.4% |
| AVTR Avantor Inc. | 2.45% | 2,695,000 | $68.9M | Add +27.0% |
| CI The Cigna Group | 2.38% | 184,500 | $67.0M | New |
| MRK Merck & Co. Inc. | 2.35% | 502,000 | $66.2M | New |
| REGN Regeneron Pharmaceuticals | 2.33% | 68,000 | $65.4M | No change |
| CGON CG Oncology Inc. | 2.27% | 1,454,765 | $63.9M | New |
| ILMN Illumina Inc. | 2.27% | 464,100 | $63.7M | New |
| THC Tenet Healthcare Corp. | 2.25% | 601,000 | $63.2M | Reduce -31.0% |
| ALGN Align Technology Inc. | 2.20% | 189,000 | $62.0M | Add +21.3% |
| SNDX Syndax Pharmaceuticals Inc. | 2.04% | 2,412,500 | $57.4M | Reduce -38.9% |
| LLY Eli Lilly & Co. | 1.94% | 70,000 | $54.5M | Reduce -17.6% |
| UTHR United Therapeutics Corp. | 1.77% | 217,000 | $49.8M | Reduce -8.5% |
| ALPN Alpine Immune Sciences Inc. | 1.66% | 1,174,700 | $46.6M | New |
| RARE Ultragenyx Pharmaceutical Inc. | 1.55% | 933,500 | $43.6M | Add +10.5% |
| CVS CVS Health Corp. | 1.54% | 545,000 | $43.5M | Reduce -26.4% |
| SGRY Surgery Partners Inc. | 1.53% | 1,445,000 | $43.1M | Add +23.9% |
| ITCI Intra-Cellular Therapies Inc. | 1.48% | 600,000 | $41.5M | Reduce -15.5% |
| ABBV Abbvie Inc. | 1.47% | 227,000 | $41.3M | Reduce -20.2% |
| BPMC Blueprint Medicines Corp. | 1.44% | 426,000 | $40.4M | Reduce -30.7% |
| LEGN Legend Biotech Corp.-ADR | 1.33% | 668,300 | $37.5M | Reduce -2.4% |
| GPCR Structure Therapeutics Inc. | 1.32% | 864,000 | $37.0M | Reduce -20.0% |
| ALNY Alnylam Pharmaceuticals Inc. | 1.29% | 243,000 | $36.3M | New |
| DHR Danaher Corp. | 1.28% | 143,800 | $35.9M | Reduce -50.4% |
| IDYA Ideaya Biosciences Inc. | 1.25% | 799,700 | $35.1M | Reduce -47.4% |
| AXSM Axsome Therapeutics Inc. | 1.22% | 431,000 | $34.4M | Reduce -6.2% |
| XENE Xenon Pharmaceuticals Inc. | 1.09% | 710,000 | $30.6M | Reduce -13.0% |
| LNTH Lantheus Holdings Inc. | 1.06% | 480,000 | $29.9M | Add +26.3% |
| CRBU Caribou Biosciences Inc. | 1.06% | 5,785,352 | $29.7M | Reduce -9.0% |
| MIRM Mirum Pharmaceuticals Inc. | 1.02% | 1,142,850 | $28.7M | No change |
| RCKT Rocket Pharmaceuticals Inc. | 0.98% | 1,025,000 | $27.6M | Reduce -40.4% |
| RGNX Regenxbio Inc. | 0.97% | 1,300,064 | $27.4M | New |
| APGE Apogee Therapeutics Inc. | 0.91% | 384,893 | $25.6M | New |
| NMRA Neumora Therapeutics Inc. | 0.88% | 1,800,000 | $24.8M | Reduce -9.6% |
| DXCM Dexcom Inc. | 0.87% | 176,900 | $24.5M | New |
| NGNE Neurogene Inc. | 0.84% | 465,237 | $23.7M | Reduce -0.2% |
| JSPR Jasper Therapeutics Inc. | 0.79% | 760,000 | $22.3M | New |
| IMNM Immunome Inc. | 0.77% | 873,891 | $21.6M | Reduce -34.5% |
| TMO Thermo Fisher Scientific Inc. | 0.76% | 36,600 | $21.3M | Reduce -80.0% |
| GKOS Glaukos Corp. | 0.75% | 224,000 | $21.1M | New |
| RVMD Revolution Medicines Inc. | 0.73% | 635,000 | $20.5M | Add +958.3% |
| PCVX Vaxcyte Inc. | 0.69% | 284,000 | $19.4M | Reduce -50.2% |
| IMCR Immunocore Holdings PLC-ADR | 0.66% | 286,400 | $18.6M | Reduce -4.6% |
| PHAT Phathom Pharmaceuticals Inc. | 0.65% | 1,735,000 | $18.4M | Add +0.8% |
| MCK McKesson Corp. | 0.64% | 33,300 | $17.9M | Reduce -61.0% |
| VERA Vera Therapeutics Inc. | 0.59% | 383,500 | $16.5M | New |
| IMVT Immunovant Inc. | 0.58% | 505,000 | $16.3M | Add +106.1% |
| PRVA Privia Health Group Inc. | 0.53% | 764,200 | $15.0M | Reduce -40.6% |
| JANX Janux Therapeutics Inc. | 0.51% | 384,245 | $14.5M | New |
| CYBIN INC | 0.51% | 34,884,000 | $14.4M | New |
| COLL Collegium Pharmaceutical Inc. | 0.50% | 361,400 | $14.0M | Add +0.0% |
| PRME Prime Medicine Inc. | 0.50% | 1,990,000 | $13.9M | New |
| KROS Keros Therapeutics Inc. | 0.49% | 209,700 | $13.9M | New |
| ATXS Astria Therapeutics Inc. | 0.49% | 982,000 | $13.8M | New |
| ACIU Ac Immune SA | 0.47% | 4,470,000 | $13.2M | Add +0.0% |
| KPTI Karyopharm Therapeutics Inc. | 0.45% | 8,298,570 | $12.5M | No change |
| IMUX Immunic Inc. | 0.42% | 8,902,972 | $11.8M | New |
| CYTK Cytokinetics Inc. | 0.41% | 166,000 | $11.6M | New |
| RDNT Radnet Inc. | 0.41% | 238,000 | $11.6M | New |
| ESTA Establishment Labs Holdings | 0.41% | 225,000 | $11.5M | New |
| NAMS Newamsterdam Pharma Co. NV | 0.40% | 475,000 | $11.2M | New |
| ACAD Acadia Pharmaceuticals Inc. | 0.39% | 588,500 | $10.9M | New |
| AZN Astrazeneca PLC-Spons ADR | 0.39% | 160,000 | $10.8M | New |
| SYRS Syros Pharmaceuticals Inc. | 0.32% | 1,673,538 | $9.0M | No change |
| IONS Ionis Pharmaceuticals Inc. | 0.20% | 130,000 | $5.6M | New |
| IPSC Century Therapeutics Inc. | 0.18% | 1,221,555 | $5.1M | Reduce -9.8% |
| KYTX Kyverna Therapeutics Inc. | 0.18% | 202,333 | $5.0M | New |
| EBS Emergent Biosolutions Inc. | 0.17% | 1,908,000 | $4.8M | New |
| KEZAR LIFE SCIENCES INC | 0.16% | 5,026,000 | $4.5M | Add +0.0% |
| BHVN Biohaven Ltd. | 0.15% | 75,000 | $4.1M | Reduce -93.5% |
| ANTX AN2 Therapeutics Inc. | 0.13% | 1,150,000 | $3.7M | Add +0.9% |
| DNA Ginkgo Bioworks Holdings Inc. | 0.12% | 3,000,000 | $3.5M | New |
| XFOR X4 Pharmaceuticals Inc. | 0.12% | 2,413,000 | $3.4M | New |
| COGT Cogent Biosciences Inc. | 0.11% | 445,706 | $3.0M | New |
| PACB Pacific Biosciences of Calif | 0.09% | 675,000 | $2.5M | New |
| SCYX Scynexis Inc. | 0.08% | 1,448,728 | $2.1M | No change |
| KOD Kodiak Sciences Inc. | 0.06% | 300,000 | $1.6M | New |
| HYPR Hyperfine Inc. | 0.04% | 1,188,178 | $1.2M | No change |
| CMAXQ Caremax Inc. | 0.00% | 21,200 | $102K | No change |
Options reported separately and not counted above: ITCI calls ($239.5M), CYTK calls ($42.1M), GPCR calls ($6.4M).
Other holdings (1): bonds, preferreds, convertibles and warrants · $27K (not counted above)
| Security | Class | Shares / Principal | Value | Change |
|---|---|---|---|---|
| NUVB.WS Nuvation Bio Inc. -CW27 | *W EXP 02/10/202 | 89,543 | $27K | No change |
Total filed on the 13F, all lines: $2.8B.
Portfolio Sells Q4 2023 → Q1 2024
| TMO Thermo Fisher Scientific Inc. | Reduce -80.0% | 0.76% | −2.95 |
| KRTX Karuna Therapeutics Inc. | Sold out | 0.00% | −2.49 |
| IMGN Immunogen Inc. | Sold out | 0.00% | −2.07 |
| ZTS Zoetis Inc. | Sold out | 0.00% | −1.81 |
| HUM Humana Inc. | Sold out | 0.00% | −1.75 |
| BHVN Biohaven Ltd. | Reduce -93.5% | 0.15% | −1.73 |
| BDX Becton Dickinson and Co. | Sold out | 0.00% | −1.55 |
| DHR Danaher Corp. | Reduce -50.4% | 1.28% | −1.29 |
| SNDX Syndax Pharmaceuticals Inc. | Reduce -38.9% | 2.04% | −1.22 |
| UNH Unitedhealth Group Inc. | Sold out | 0.00% | −1.18 |
| RCKT Rocket Pharmaceuticals Inc. | Reduce -40.4% | 0.98% | −0.99 |
| MCK McKesson Corp. | Reduce -61.0% | 0.64% | −0.88 |
| ARWR Arrowhead Pharmaceuticals Inc. | Sold out | 0.00% | −0.84 |
| IDYA Ideaya Biosciences Inc. | Reduce -47.4% | 1.25% | −0.82 |
| BPMC Blueprint Medicines Corp. | Reduce -30.7% | 1.44% | −0.73 |
| CRNX Crinetics Pharmaceuticals Inc. | Sold out | 0.00% | −0.72 |
| CVS CVS Health Corp. | Reduce -26.4% | 1.54% | −0.69 |
| NBIX Neurocrine Biosciences Inc. | Reduce -18.5% | 2.63% | −0.69 |
| PCVX Vaxcyte Inc. | Reduce -50.2% | 0.69% | −0.68 |
| ACHC Acadia Healthcare Co. Inc. | Reduce -13.1% | 2.83% | −0.61 |
| PRVA Privia Health Group Inc. | Reduce -40.6% | 0.53% | −0.60 |
| VRNA Verona Pharma Ltd. | Sold out | 0.00% | −0.59 |
| A Agilent Technologies Inc. | Sold out | 0.00% | −0.53 |
| NTLA Intellia Therapeutics Inc. | Sold out | 0.00% | −0.52 |
| ITCI Intra-Cellular Therapies Inc. | Reduce -15.5% | 1.48% | −0.47 |
| ARGX Argenx SE - ADR | Sold out | 0.00% | −0.45 |
| CERE Cerevel Therapeutics Holding | Sold out | 0.00% | −0.45 |
| NMRA Neumora Therapeutics Inc. | Reduce -9.6% | 0.88% | −0.42 |
| GPCR Structure Therapeutics Inc. | Reduce -20.0% | 1.32% | −0.37 |
| XENE Xenon Pharmaceuticals Inc. | Reduce -13.0% | 1.09% | −0.35 |
| CRBU Caribou Biosciences Inc. | Reduce -9.0% | 1.06% | −0.34 |
| TVTX Travere Therapeutics Inc. | Sold out | 0.00% | −0.28 |
| THC Tenet Healthcare Corp. | Reduce -31.0% | 2.25% | −0.27 |
| LEGN Legend Biotech Corp.-ADR | Reduce -2.4% | 1.33% | −0.24 |
| UTHR United Therapeutics Corp. | Reduce -8.5% | 1.77% | −0.22 |
| ABBV Abbvie Inc. | Reduce -20.2% | 1.47% | −0.22 |
| AKRO Akero Therapeutics Inc. | Sold out | 0.00% | −0.21 |
| AXSM Axsome Therapeutics Inc. | Reduce -6.2% | 1.22% | −0.18 |
| IMCR Immunocore Holdings PLC-ADR | Reduce -4.6% | 0.66% | −0.12 |
| CMPX Compass Therapeutics Inc. | Sold out | 0.00% | −0.10 |
| NTRA Natera Inc. | Reduce -27.6% | 2.61% | −0.05 |
| AMLX Amylyx Pharmaceuticals Inc. | Sold out | 0.00% | −0.04 |
| IPSC Century Therapeutics Inc. | Reduce -9.8% | 0.18% | +0.01 |
| LLY Eli Lilly & Co. | Reduce -17.6% | 1.94% | +0.04 |
| IMNM Immunome Inc. | Reduce -34.5% | 0.77% | +0.22 |
| NGNE Neurogene Inc. | Reduce -0.2% | 0.84% | +0.50 |
Portfolio Buys Q4 2023 → Q1 2024
| DNTH Dianthus Therapeutics Inc. | Add +123.2% | 2.90% | +2.41 |
| CI The Cigna Group | New | 2.38% | +2.38 |
| MRK Merck & Co. Inc. | New | 2.35% | +2.35 |
| CGON CG Oncology Inc. | New | 2.27% | +2.27 |
| ILMN Illumina Inc. | New | 2.27% | +2.27 |
| ISRG Intuitive Surgical Inc. | Add +165.9% | 3.21% | +2.11 |
| ALPN Alpine Immune Sciences Inc. | New | 1.66% | +1.66 |
| ALNY Alnylam Pharmaceuticals Inc. | New | 1.29% | +1.29 |
| RGNX Regenxbio Inc. | New | 0.97% | +0.97 |
| APGE Apogee Therapeutics Inc. | New | 0.91% | +0.91 |
| DXCM Dexcom Inc. | New | 0.87% | +0.87 |
| JSPR Jasper Therapeutics Inc. | New | 0.79% | +0.79 |
| GKOS Glaukos Corp. | New | 0.75% | +0.75 |
| RVMD Revolution Medicines Inc. | Add +958.3% | 0.73% | +0.66 |
| AVTR Avantor Inc. | Add +27.0% | 2.45% | +0.60 |
| VERA Vera Therapeutics Inc. | New | 0.59% | +0.59 |
| BSX Boston Scientific Corp. | Add +3.5% | 4.76% | +0.58 |
| ALGN Align Technology Inc. | Add +21.3% | 2.20% | +0.57 |
| JANX Janux Therapeutics Inc. | New | 0.51% | +0.51 |
| CYBIN INC | New | 0.51% | +0.51 |
| PRME Prime Medicine Inc. | New | 0.50% | +0.50 |
| KROS Keros Therapeutics Inc. | New | 0.49% | +0.49 |
| ATXS Astria Therapeutics Inc. | New | 0.49% | +0.49 |
| IMUX Immunic Inc. | New | 0.42% | +0.42 |
| CYTK Cytokinetics Inc. | New | 0.41% | +0.41 |
| RDNT Radnet Inc. | New | 0.41% | +0.41 |
| ESTA Establishment Labs Holdings | New | 0.41% | +0.41 |
| NAMS Newamsterdam Pharma Co. NV | New | 0.40% | +0.40 |
| ACAD Acadia Pharmaceuticals Inc. | New | 0.39% | +0.39 |
| AZN Astrazeneca PLC-Spons ADR | New | 0.39% | +0.39 |
| IONS Ionis Pharmaceuticals Inc. | New | 0.20% | +0.20 |
| JAZZ Jazz Pharmaceuticals PLC | Add +19.4% | 2.50% | +0.20 |
| IMVT Immunovant Inc. | Add +106.1% | 0.58% | +0.19 |
| KYTX Kyverna Therapeutics Inc. | New | 0.18% | +0.18 |
| EBS Emergent Biosolutions Inc. | New | 0.17% | +0.17 |
| LNTH Lantheus Holdings Inc. | Add +26.3% | 1.06% | +0.16 |
| DNA Ginkgo Bioworks Holdings Inc. | New | 0.12% | +0.12 |
| XFOR X4 Pharmaceuticals Inc. | New | 0.12% | +0.12 |
| COGT Cogent Biosciences Inc. | New | 0.11% | +0.11 |
| SGRY Surgery Partners Inc. | Add +23.9% | 1.53% | +0.11 |
| PACB Pacific Biosciences of Calif | New | 0.09% | +0.09 |
| COLL Collegium Pharmaceutical Inc. | Add +0.0% | 0.50% | +0.07 |
| KOD Kodiak Sciences Inc. | New | 0.06% | +0.06 |
| PHAT Phathom Pharmaceuticals Inc. | Add +0.8% | 0.65% | +0.05 |
| RARE Ultragenyx Pharmaceutical Inc. | Add +10.5% | 1.55% | +0.00 |
| KEZAR LIFE SCIENCES INC | Add +0.0% | 0.16% | −0.02 |
| ARVN Arvinas Inc. | Add +0.0% | 4.38% | −0.32 |
| ACIU Ac Immune SA | Add +0.0% | 0.47% | −0.38 |
| ANTX AN2 Therapeutics Inc. | Add +0.9% | 0.13% | −0.76 |
Options Activity Q4 2023 → Q1 2024
| ITCI Intra-Cellular Therapies Inc. | call | New | 600,000 | $239.5M |
| CI The Cigna Group | call | Sold out | 350,000 | $104.8Mbefore exit |
| CYTK Cytokinetics Inc. | call | New | 600,000 | $42.1M |
| GPCR Structure Therapeutics Inc. | call | Reduce -75.0% | 150,000 | $6.4M |
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 45 | $624.4M | DNTH, CGON, ORKA, JBIO, ELVN |
| Q1 2026Amended | 45 | $493.8M | DNTH, CGON, ORKA, CATX, JBIO |
| Q4 2025 | 39 | $346.7M | DNTH, CGON, JBIO, ORKA, TEVA |
| Q3 2025 | 43 | $439.4M | DNTH, CGON, MDT, BSX, ORKA |
| Q2 2025 | 55 | $498.8M | CGON, BSX, NTRA, DNTH, EXAS |
| Q1 2025 | 63 | $484.9M | BSX, DNTH, UNH, CGON, HUM |
| Q4 2024 | 61 | $1.0B | DNTH, BSX, JANX, NTRA, EXAS |
| Q3 2024 | 81 | $2.0B | BSX, DNTH, ISRG, NTRA, CGON |
| Q2 2024 | 84 | $2.4B | ISRG, BSX, NTRA, ARVN, ACHC |
| Q1 2024 | 86 | $2.8B | FUSN, BSX, ARVN, ISRG, DNTH |