Ionis PharmaceuticalsIONS
13F holders, Q2 2026 (June 30)515holders +18
61new positions
46sold out
9famous investors
$79.38avg. 13F price*
At the end of Q2 2026, 515 institutions reported holding Ionis Pharmaceuticals Inc. (IONS) in their 13F filings, up 18 from Q1 2026. 61 opened new positions and 46 sold out. The largest holders were FMR LLC ($2.0B), Capital World Investors ($1.7B) and BlackRock, Inc. ($848.8M). 9 famous investors held it, including Cathie Wood (0.2% of ARK Investment Management's portfolio), Jim Simons / Peter Brown (0.1% of Renaissance Technologies's portfolio) and Joel Greenblatt (0.0% of Gotham Asset Management's portfolio).
- Company
- Ionis Pharmaceuticals Inc.
- CUSIP
- 462222100
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2026 → Q2 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 61 | $169.5M |
| Exits | 46 | $77.2M |
All 13F filers, Q1 2026 → Q2 2026: 18,710,228 shares bought and 11,715,154 shares sold, net +6,995,074 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 515 holders
| FMR LLC | 0.09% | Add +0.3% | 24,631,956 | $2.0B |
| Capital World Investors | 0.20% | Add +2.3% | 21,669,226 | $1.7B |
| BlackRock, Inc. | 0.01% | Add +2.5% | 10,704,660 | $848.8M |
| Vanguard Portfolio Management LLC | 0.03% | Add +0.7% | 7,859,529 | $623.2M |
| Wellington Management Group LLP | 0.10% | Add +19.7% | 7,651,415 | $606.7M |
| Vanguard Capital Management LLC | 0.01% | Add +1.3% | 7,211,497 | $571.8M |
| Two Sigma Investments, LP | 0.39% | Add +6.7% | 6,252,342 | $495.7M |
| Royal Bank of Canada | 0.08% | Add +62.6% | 6,182,479 | $490.2M |
| State Street Corp. | 0.01% | Add +8.5% | 4,334,848 | $343.7M |
| T. Rowe Price Investment Management, Inc. | 0.21% | Reduce -35.7% | 3,959,372 | $313.9M |
| Geode Capital Management, LLC | 0.02% | Reduce -10.1% | 3,584,024 | $294.8M |
| T. Rowe Price Associates Inc. | 0.03% | Add +5.3% | 3,184,500 | $252.5M |
| JPMorgan Chase & Co. | 0.01% | Add +13.0% | 2,671,717 | $216.2M |
| Artisan Partners Limited Partnership | 0.34% | Add +28.3% | 2,640,024 | $209.3M |
| Tweedy, Browne Co LLC | 13.70% | Add +0.2% | 2,280,311 | $180.8M |
| Deep Track Capital, LP | 2.57% | Add +12.8% | 2,200,000 | $174.4M |
| Goldman Sachs Group Inc. | 0.02% | Add +24.1% | 2,109,945 | $167.3M |
| Baker Bros. Advisors LP | 0.82% | No change | 2,047,727 | $162.4M |
| Deerfield Management Company, L.P. | 1.96% | No change | 1,979,669 | $157.0M |
| American Century Companies Inc. | 0.07% | Add +17.0% | 1,947,076 | $154.4M |
| Franklin Resources Inc. | 0.03% | Add +3.1% | 1,623,377 | $128.7M |
| Charles Schwab Investment Management Inc. | 0.02% | Add +1.4% | 1,605,054 | $127.3M |
| Barclays PLC | 0.04% | Add +453.1% | 1,603,136 | $127.1M |
| Pictet Asset Management Holding SA | 0.12% | Add +11.3% | 1,596,998 | $127.0M |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0.02% | Reduce -1.4% | 1,454,672 | $115.3M |
| Polar Capital Holdings Plc | 0.33% | Add +75.3% | 1,454,021 | $115.3M |
| Alyeska Investment Group, L.P. | 0.29% | Add +199.7% | 1,417,916 | $112.4M |
| Nomura Asset Management International Inc. | 0.16% | Add +65.6% | 1,300,392 | $103.1M |
| Morgan Stanley | 0.01% | Add +24.8% | 1,281,444 | $101.6M |
| Invesco Ltd. | 0.01% | Reduce -12.3% | 1,120,707 | $88.9M |
| Vanguard Fiduciary Trust Co. | 0.02% | Add +3.6% | 1,060,845 | $84.1M |
| Bellevue Group AG | 1.62% | Reduce -46.5% | 972,258 | $77.1M |
| Groupama Asset Managment | 0.96% | Add +13.7% | 937,083 | $75.2M |
| Northern Trust Corp. | 0.01% | Add +5.2% | 913,610 | $72.4M |
| Capital International Investors | 0.01% | New | 823,764 | $65.3M |
| Davern Capital Partners, LP | 10.80% | Add +106.4% | 798,709 | $63.3M |
| Bank of America Corp. | 0.00% | Reduce -5.9% | 790,990 | $62.7M |
| Summit Partners Public Asset Management, LLC | 1.62% | Reduce -43.9% | 787,263 | $62.4M |
| GW&K Investment Management, LLC | 0.46% | Reduce -4.2% | 746,966 | $59.2M |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 0.06% | Reduce -19.1% | 734,219 | $58.2M |
| Nuveen, LLC | 0.01% | Add +12.0% | 726,282 | $57.6M |
| Connor, Clark & Lunn Investment Management Ltd. | 0.10% | Reduce -21.7% | 684,236 | $54.3M |
| Eversept Partners, LP | 2.87% | Add +5.2% | 664,684 | $52.7M |
| Voloridge Investment Management, LLC | 0.22% | Reduce -2.6% | 655,454 | $52.0M |
| Massachusetts Financial Services Co. | 0.02% | Reduce -2.1% | 651,816 | $51.7M |
| Neuberger Berman Group LLC | 0.03% | Add +42.9% | 633,533 | $50.2M |
| Arrowstreet Capital, Limited Partnership | 0.02% | Reduce -14.3% | 632,028 | $50.1M |
| UBS Group AG | 0.01% | Reduce -22.7% | 624,874 | $49.5M |
| TimesSquare Capital Management, LLC | 0.72% | Add +122.8% | 614,070 | $48.7M |
| Eventide Asset Management, LLC | 0.61% | No change | 575,000 | $45.6M |
| Perceptive Advisors LLC | 0.70% | Add +12.3% | 566,000 | $44.9M |
| Renaissance Technologies | 0.06% | Add +83.1% | 559,414 | $44.4M |
| Bank of New York Mellon Corp | 0.01% | Add +5.4% | 542,454 | $43.0M |
| Teacher Retirement System of Texas | 0.11% | Reduce -0.3% | 522,317 | $41.4M |
| Boone Capital Management LLC | 9.64% | Add +3.9% | 519,977 | $41.2M |
| Jane Street Group, LLC | 0.03% | Add +162.6% | 503,647 | $39.9M |
| New York State Common Retirement Fund | 0.05% | Add +42.7% | 500,050 | $39.6M |
| BNP Paribas Financial Markets | 0.02% | Reduce -5.2% | 454,649 | $36.0M |
| Candriam S.C.A. | 0.16% | Reduce -8.1% | 445,019 | $35.3M |
| First Trust Advisors LP | 0.02% | Reduce -8.8% | 427,197 | $33.9M |
| Pinnacle Associates Ltd. | 0.36% | Reduce -3.8% | 419,752 | $33.3M |
| Nomura Holdings Inc. | 0.14% | Add +252.6% | 402,192 | $31.9M |
| Handelsbanken Fonder AB | 0.09% | Add +79.2% | 383,211 | $30.4M |
| C WorldWide Group Holding A/S | 0.70% | No change | 366,000 | $29.0M |
| TD Asset Management Inc | 0.02% | Reduce -35.7% | 340,548 | $27.0M |
| Freestone Grove Partners LP | 0.18% | New | 339,967 | $27.0M |
| Qube Research & Technologies Ltd | 0.03% | Add +679.2% | 333,952 | $26.5M |
| Capital Research Global Investors | 0.00% | Add +2.8% | 331,936 | $26.3M |
| Capital Fund Management S.A. | 0.19% | Add +131.8% | 329,554 | $26.1M |
| Alliancebernstein L.P. | 0.01% | Reduce -15.0% | 340,450 | $25.6M |
| Carmignac Gestion | 0.33% | Add +505.7% | 321,000 | $25.5M |
| Privium Fund Management B.V. | 4.66% | Add +10.3% | 319,924 | $25.4M |
| Swiss National Bank | 0.01% | Add +3.5% | 315,000 | $25.0M |
| Jump Financial, LLC | 0.24% | Add +48.2% | 306,330 | $24.3M |
| ARK Investment Management | 0.15% | Add +4.2% | 300,770 | $23.8M |
| Legal & General Group Plc | 0.00% | Add +1.5% | 299,184 | $23.7M |
| D. E. Shaw & Co. | 0.02% | Reduce -30.9% | 297,041 | $23.6M |
| Millennium Management | 0.02% | Reduce -72.5% | 288,872 | $22.9M |
| DAVENPORT & Co LLC | 0.11% | Add +19.2% | 283,960 | $22.5M |
| Aberdeen Group plc | 0.03% | Add +143.7% | 277,400 | $22.0M |
| California Public Employees Retirement System | 0.01% | Add +6.0% | 270,843 | $21.5M |
| Tocqueville Asset Management L.P. | 0.26% | Add +14.6% | 251,215 | $19.9M |
| Raymond James Financial Inc. | 0.01% | Add +0.9% | 237,348 | $18.8M |
| Citadel Advisors | 0.01% | Reduce -74.9% | 236,284 | $18.7M |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0.03% | Add +6.3% | 233,499 | $18.5M |
| Wells Fargo & Company | 0.00% | Add +19.1% | 226,213 | $17.9M |
| Empowered Funds, LLC | 0.09% | Add +116.3% | 223,142 | $17.7M |
| Orion Investment Co | 5.10% | Reduce -2.1% | 220,335 | $17.5M |
| Life Cycle Investment Partners Ltd | 0.08% | New | 219,896 | $17.4M |
| Algert Global LLC | 0.19% | Add +77.5% | 206,853 | $16.4M |
| Stifel Financial Corp. | 0.01% | Add +3.2% | 202,983 | $16.1M |
| Corient Private Wealth LP | 0.02% | Add +0.0% | 196,661 | $15.6M |
| Eagle Health Investments LP | 2.56% | New | 194,577 | $15.4M |
| HSBC Holdings PLC | 0.01% | Add +1.3% | 188,402 | $15.0M |
| Sector Gamma As | 3.26% | Add +11.8% | 189,468 | $15.0M |
| California State Teachers Retirement System | 0.01% | Add +2.5% | 180,949 | $14.3M |
| Polymer Capital Management (HK) LTD | 1.43% | Add +190.7% | 177,897 | $14.1M |
| Deutsche Bank AG | 0.00% | Add +6.1% | 169,614 | $13.4M |
| ADAR1 Capital Management, LLC | 0.62% | Add +3.7% | 166,286 | $13.2M |
| Rhumbline Advisers | 0.01% | Reduce -4.9% | 164,911 | $13.1M |
"% of holder's portfolio" is IONS's weight in each manager's 13F, not the share of Ionis Pharmaceuticals Inc. the manager owns.