| IONS Ionis Pharmaceuticals Inc. | 5.49% | 8,299,514 | $359.8M | Reduce -4.8% |
| ARGX Argenx SE - ADR | 4.87% | 811,016 | $319.3M | Reduce -6.7% |
| NBIX Neurocrine Biosciences Inc. | 4.32% | 2,055,874 | $283.5M | Reduce -15.4% |
| VRTX Vertex Pharmaceuticals Inc. | 4.26% | 668,750 | $279.5M | Reduce -9.2% |
| ISRG Intuitive Surgical Inc. | 4.15% | 682,186 | $272.3M | Reduce -18.0% |
| BSX Boston Scientific Corp. | 3.29% | 3,148,676 | $215.7M | Reduce -0.7% |
| ITCI Intra-Cellular Therapies Inc. | 2.98% | 2,819,482 | $195.1M | Reduce -8.1% |
| MRNA Moderna Inc. | 2.78% | 1,711,089 | $182.3M | Reduce -10.3% |
| DXCM Dexcom Inc. | 2.58% | 1,221,197 | $169.4M | Add +33.5% |
| RVMD Revolution Medicines Inc. | 2.49% | 5,073,600 | $163.5M | Reduce -0.3% |
| ABT Abbott Laboratories | 2.49% | 1,434,183 | $163.0M | Reduce -6.6% |
| SYK Stryker Corp. | 2.45% | 449,340 | $160.8M | Reduce -3.5% |
| MGNX Macrogenics Inc. | 2.24% | 9,965,862 | $146.7M | Add +0.1% |
| ALNY Alnylam Pharmaceuticals Inc. | 2.09% | 918,284 | $137.2M | Add +3.7% |
| INCY Incyte Corp. | 1.87% | 2,153,388 | $122.7M | Reduce -0.1% |
| CLDX Celldex Therapeutics Inc. | 1.79% | 2,796,615 | $117.4M | Add +15.7% |
| AGIO Agios Pharmaceuticals Inc. | 1.79% | 4,006,000 | $117.1M | Reduce -0.1% |
| EW Edwards Lifesciences Corp. | 1.61% | 1,103,136 | $105.4M | Add +8.3% |
| BDX Becton Dickinson and Co. | 1.57% | 415,700 | $102.9M | Add +7.1% |
| ARVN Arvinas Inc. | 1.51% | 2,390,800 | $98.7M | Reduce -4.7% |
| MDT Medtronic PLC | 1.34% | 1,007,000 | $87.8M | Add +3.7% |
| SAGE Sage Therapeutics Inc. | 1.28% | 4,465,544 | $83.7M | Add +27.1% |
| EXAS Exact Sciences Corp. | 1.20% | 1,138,526 | $78.6M | Add +8.7% |
| UNH Unitedhealth Group Inc. | 1.12% | 148,719 | $73.6M | Add +7.7% |
| TNDM Tandem Diabetes Care Inc. | 1.10% | 2,031,888 | $71.9M | Add +2.0% |
| EPIX Essa Pharma Inc. | 1.02% | 7,889,583 | $67.0M | Reduce -0.1% |
| IMCR Immunocore Holdings PLC-ADR | 0.96% | 972,254 | $63.2M | Reduce -0.4% |
| BHVN Biohaven Ltd. | 0.96% | 1,150,000 | $62.9M | Add +7.0% |
| OPCH Option Care Health Inc. | 0.96% | 1,867,263 | $62.6M | Reduce -3.7% |
| CRL Charles River Laboratories | 0.95% | 229,697 | $62.2M | Add +5.5% |
| INSM Insmed Inc. | 0.89% | 2,141,843 | $58.1M | Reduce -6.5% |
| AXSM Axsome Therapeutics Inc. | 0.83% | 685,476 | $54.7M | Add +7.9% |
| BIO Bio-Rad Laboratories-A | 0.83% | 156,618 | $54.2M | Add +11.0% |
| HCA HCA Healthcare Inc. | 0.81% | 159,703 | $53.3M | Add +4.9% |
| ELV Elevance Health Inc. | 0.78% | 98,612 | $51.1M | Reduce -8.5% |
| ALGN Align Technology Inc. | 0.77% | 154,909 | $50.8M | Reduce -2.8% |
| IDXX Idexx Laboratories Inc. | 0.77% | 93,358 | $50.4M | Reduce -0.8% |
| PODD Insulet Corp. | 0.77% | 293,828 | $50.4M | Add +1.4% |
| ACCD Accolade Inc. | 0.77% | 4,804,514 | $50.4M | Add +6.6% |
| RLAY Relay Therapeutics Inc. | 0.75% | 5,926,618 | $49.2M | Reduce -0.2% |
| EVH Evolent Health Inc. Class A | 0.74% | 1,483,096 | $48.6M | Reduce -37.6% |
| HUM Humana Inc. | 0.72% | 135,541 | $47.0M | Add +34.9% |
| INSP Inspire Medical Systems Inc. | 0.71% | 217,694 | $46.8M | Add +1.0% |
| GEHC GE Healthcare Technology | 0.71% | 512,230 | $46.6M | Reduce -4.3% |
| EXEL Exelixis Inc. | 0.69% | 1,903,200 | $45.2M | Reduce -9.7% |
| LLY Eli Lilly & Co. | 0.69% | 57,965 | $45.1M | Add +3.1% |
| PRCT Procept Biorobotics Corp. | 0.67% | 890,114 | $44.0M | Add +0.5% |
| BDTX Black Diamond Therapeutics I | 0.66% | 8,517,839 | $43.2M | Reduce -0.2% |
| CRSP Crispr Therapeutics AG | 0.64% | 619,950 | $42.3M | Reduce -31.1% |
| CDNA Caredx Inc. | 0.64% | 3,934,006 | $41.7M | Reduce -0.5% |
| MOH Molina Healthcare Inc. | 0.63% | 99,883 | $41.0M | Add +9.2% |
| MRK Merck & Co. Inc. | 0.63% | 310,851 | $41.0M | Add +7.1% |
| PEN Penumbra Inc. | 0.62% | 181,158 | $40.4M | Reduce -10.8% |
| COO The Cooper Cos Inc. | 0.61% | 397,373 | $40.3M | Add +15.5% |
| BEAM Beam Therapeutics Inc. | 0.60% | 1,193,121 | $39.4M | Add +71.7% |
| VEEV Veeva Systems Inc. Class A | 0.59% | 168,247 | $39.0M | Reduce -13.7% |
| SRRK Scholar Rock Holding Corp. | 0.59% | 2,165,203 | $38.5M | Reduce -0.2% |
| ZBH Zimmer Biomet Holdings Inc. | 0.57% | 282,217 | $37.2M | Add +0.4% |
| FATE Fate Therapeutics Inc. | 0.54% | 4,839,779 | $35.5M | Reduce -0.2% |
| SWAV Shockwave Medical Inc. | 0.53% | 105,786 | $34.4M | Reduce -15.2% |
| SRPT Sarepta Therapeutics Inc. | 0.50% | 251,521 | $32.6M | Add +6.0% |
| COR Cencora Inc. | 0.49% | 131,504 | $32.0M | Add +4.3% |
| GMED Globus Medical Inc. Class A | 0.47% | 579,898 | $31.1M | Reduce -4.6% |
| CI The Cigna Group | 0.44% | 79,645 | $28.9M | Reduce -10.0% |
| CNC Centene Corp. | 0.43% | 363,100 | $28.5M | Reduce -17.8% |
| BMRN Biomarin Pharmaceutical Inc. | 0.43% | 321,787 | $28.1M | Reduce -1.2% |
| APLS Apellis Pharmaceuticals Inc. | 0.42% | 473,915 | $27.9M | Reduce -42.3% |
| SILK Silk Road Medical Inc. filed as SILK RD MED INC | 0.42% | 1,518,230 | $27.8M | Add +5.8% |
| CSTL Castle Biosciences Inc. | 0.41% | 1,220,085 | $27.0M | Reduce -1.0% |
| TMDX Transmedics Group Inc. | 0.41% | 364,064 | $26.9M | Reduce -29.8% |
| ESPR Esperion Therapeutics Inc. | 0.41% | 9,944,064 | $26.7M | Add +136.5% |
| WVE Wave Life Sciences Ltd. | 0.39% | 4,094,458 | $25.3M | Reduce -8.9% |
| NTRA Natera Inc. | 0.38% | 269,832 | $24.7M | Add +5.2% |
| TMO Thermo Fisher Scientific Inc. | 0.35% | 39,956 | $23.2M | Add +13.1% |
| HOLX Hologic Inc. | 0.34% | 289,969 | $22.6M | Add +0.0% |
| DHR Danaher Corp. | 0.33% | 86,232 | $21.5M | Add +2.3% |
| PRVA Privia Health Group Inc. | 0.32% | 1,059,171 | $20.7M | Add +0.7% |
| HCM Hutchmed China-ADR | 0.30% | 1,154,632 | $19.4M | Add +2.1% |
| SIBN Si-Bone Inc. | 0.28% | 1,139,956 | $18.7M | Add +810.5% |
| VRNA Verona Pharma Ltd. | 0.28% | 1,139,295 | $18.3M | Add +35.6% |
| PACB Pacific Biosciences of Calif | 0.26% | 4,592,251 | $17.2M | Reduce -37.2% |
| STE Steris PLC | 0.25% | 73,434 | $16.5M | New |
| LEGN Legend Biotech Corp.-ADR | 0.25% | 293,270 | $16.4M | Add +45.4% |
| GBIO Generation Bio Co. | 0.24% | 3,861,575 | $15.7M | Add +6.8% |
| ANNX Annexon Inc. | 0.24% | 2,182,290 | $15.6M | New |
| GPCR Structure Therapeutics Inc. | 0.24% | 363,926 | $15.6M | Add +2858.8% |
| NEO Neogenomics Inc. | 0.23% | 946,025 | $14.9M | New |
| ATRC Atricure Inc. | 0.21% | 447,376 | $13.6M | Reduce -45.3% |
| TXG 10X Genomics Inc. Class A | 0.18% | 308,311 | $11.6M | Add +5.2% |
| PHR Phreesia Inc. | 0.16% | 443,341 | $10.6M | Add +5.2% |
| OMCL Omnicell Inc. | 0.10% | 235,372 | $6.9M | Add +5.2% |
| REGN Regeneron Pharmaceuticals | 0.10% | 7,077 | $6.8M | Reduce -33.9% |
| AMGN Amgen Inc. | 0.10% | 22,139 | $6.3M | Reduce -35.3% |
| RMD Resmed Inc. | 0.09% | 30,391 | $6.0M | Add +0.2% |
| ILMN Illumina Inc. | 0.09% | 43,596 | $6.0M | Reduce -3.1% |
| GKOS Glaukos Corp. | 0.08% | 55,926 | $5.3M | New |
| ABBV Abbvie Inc. | 0.08% | 27,593 | $5.0M | Add +310.2% |
| MCK McKesson Corp. | 0.07% | 8,997 | $4.8M | Add +85.4% |
| RXRX Recursion Pharmaceuticals-A | 0.06% | 425,249 | $4.2M | Add +143.6% |
| TDOC Teladoc Health Inc. | 0.06% | 272,798 | $4.1M | Add +5.2% |
| ONC Beone Medicines Ltd.-ADR filed as BEIGENE LTD | 0.06% | 24,929 | $3.9M | Reduce -12.8% |
| DOCS Doximity Inc. Class A | 0.06% | 144,065 | $3.9M | Reduce -45.4% |
| SPY SS SPDR S&P 500 ETF Trust-US | 0.05% | 6,660 | $3.5M | Add +156.2% |
| RDY Dr. Reddy's Laboratories-ADR | 0.05% | 40,896 | $3.0M | Reduce -32.9% |
| GILD Gilead Sciences Inc. | 0.04% | 33,305 | $2.4M | Reduce -35.1% |
| MTEMQ Molecular Templates Inc. | 0.04% | 1,029,820 | $2.3M | No change |
| IQV Iqvia Holdings Inc. | 0.03% | 8,336 | $2.1M | Add +0.9% |
| TEVA Teva Pharmaceutical-SP ADR | 0.03% | 142,213 | $2.0M | New |
| NVRO Nevro LLC filed as NEVRO CORP | 0.03% | 135,235 | $2.0M | Reduce -31.5% |
| CVS CVS Health Corp. | 0.03% | 22,066 | $1.8M | Reduce -30.0% |
| CERT Certara Inc. | 0.03% | 95,924 | $1.7M | Add +5.2% |
| AZN Astrazeneca PLC-Spons ADR | 0.02% | 23,200 | $1.6M | Reduce -55.0% |
| BIIB Biogen Inc. | 0.02% | 6,008 | $1.3M | Reduce -29.2% |
| BMY Bristol-Myers Squibb Co. | 0.02% | 23,436 | $1.3M | New |
| ZTS Zoetis Inc. | 0.02% | 7,510 | $1.3M | Add +29.7% |
| OM Outset Medical Inc. | 0.02% | 572,359 | $1.3M | Reduce -67.5% |
| EHC Encompass Health Corp. | 0.02% | 14,980 | $1.2M | Add +25.9% |
| CYTK Cytokinetics Inc. | 0.02% | 15,640 | $1.1M | Reduce -17.3% |
| GDX Vaneck Gold Miners ETF | 0.02% | 33,000 | $1.0M | No change |
| JNJ Johnson & Johnson | 0.02% | 6,420 | $1.0M | Reduce -77.3% |
| PFE Pfizer Inc. | 0.01% | 33,834 | $939K | Add +48.0% |
| GOOG Alphabet Inc. Class C | 0.01% | 6,000 | $914K | No change |
| PCVX Vaxcyte Inc. | 0.01% | 13,244 | $905K | Reduce -16.2% |
| KRYS Krystal Biotech Inc. | 0.01% | 4,810 | $856K | Reduce -39.9% |
| ALKS Alkermes PLC | 0.01% | 24,144 | $654K | Reduce -53.7% |
| XENE Xenon Pharmaceuticals Inc. | 0.01% | 14,100 | $607K | Reduce -35.9% |
| PTGX Protagonist Therapeutics Inc. | 0.01% | 19,146 | $554K | Reduce -36.2% |
| RYTM Rhythm Pharmaceuticals Inc. | 0.01% | 12,500 | $542K | Reduce -62.0% |
| RCKT Rocket Pharmaceuticals Inc. | 0.01% | 19,700 | $531K | Reduce -6.2% |
| FDMT 4D Molecular Therapeutics Inc. | 0.01% | 15,700 | $500K | New |
| BPMC Blueprint Medicines Corp. | 0.01% | 5,100 | $484K | New |
| CCCC C4 Therapeutics Inc. | 0.01% | 57,600 | $471K | Reduce -7.1% |
| THC Tenet Healthcare Corp. | 0.01% | 4,244 | $446K | Add +193.3% |
| VKTX Viking Therapeutics Inc. | 0.01% | 5,400 | $443K | Reduce -69.1% |
| MRUS Merus NV | 0.01% | 9,800 | $441K | Reduce -56.8% |
| ASTH Astrana Health Inc. | 0.01% | 10,256 | $431K | New |
| GRMN Garmin Ltd. | 0.01% | 2,800 | $417K | New |
| BBIO Bridgebio Pharma Inc. | 0.01% | 12,800 | $396K | Reduce -61.6% |
| VERV Verve Therapeutics Inc. | 0.01% | 29,200 | $388K | Reduce -25.1% |
| AAPL Apple Inc. | 0.01% | 2,200 | $377K | New |
| WST West Pharmaceutical Services | 0.01% | 870 | $344K | New |
| DVAX Dynavax Technologies Corp. | 0.01% | 27,558 | $342K | Reduce -36.2% |
| CAH Cardinal Health Inc. | 0.01% | 3,000 | $336K | Reduce -14.3% |
| VRDN Viridian Therapeutics Inc. | 0.01% | 19,100 | $334K | Reduce -36.3% |
| BCYC Bicycle Therapeutics PLC-ADR | 0.00% | 12,500 | $311K | Reduce -37.5% |
| MDGL Madrigal Pharmaceuticals Inc. | 0.00% | 1,060 | $283K | New |
| AMRX Amneal Pharmaceuticals Inc. | 0.00% | 45,387 | $275K | Add +78.2% |
| ADMA Adma Biologics Inc. | 0.00% | 40,900 | $270K | New |
| SMPL The Simply Good Foods Co. | 0.00% | 7,900 | $269K | New |
| BMEA Biomea Fusion Inc. | 0.00% | 17,800 | $266K | Reduce -28.8% |
| RGNX Regenxbio Inc. | 0.00% | 12,000 | $253K | New |
| MLTX Moonlake Immunotherapeutics | 0.00% | 4,400 | $221K | New |
| BIDU Baidu Inc. - Spon ADR | 0.00% | 2,000 | $211K | New |
| AUTL Autolus Therapeutics PLC | 0.00% | 32,500 | $207K | Reduce -35.0% |
| BAX Baxter International Inc. | 0.00% | 4,200 | $180K | New |
| VTRS Viatris Inc. | 0.00% | 14,515 | $173K | Reduce -19.4% |
| ETNB 89BIO Inc. | 0.00% | 13,700 | $159K | Reduce -32.2% |
| IDYA Ideaya Biosciences Inc. | 0.00% | 3,300 | $145K | New |
| MLYS Mineralys Therapeutics Inc. | 0.00% | 9,200 | $119K | New |
| NVDA Nvidia Corp. | 0.00% | 97 | $88K | Reduce -2.0% |
| QCOM Qualcomm Inc. | 0.00% | 517 | $88K | Add +49.0% |
| ORCL Oracle Corp. | 0.00% | 677 | $85K | Add +49.1% |
| A Agilent Technologies Inc. | 0.00% | 540 | $79K | Add +48.8% |
| MSFT Microsoft Corp. | 0.00% | 180 | $76K | Add +47.5% |
| OABI Omniab Inc. | 0.00% | 11,456 | $62K | New |
| MTD Mettler-Toledo International | 0.00% | 33 | $44K | Add +32.0% |
| LH Laboratory CRP of Amer Hldgs | 0.00% | 148 | $32K | Reduce -97.9% |
| EXAI Exscientia Ltd. | 0.00% | 2,644 | $15K | Add +49.8% |
| IONQ Ionq Inc. | 0.00% | 1,107 | $11K | Add +49.4% |