Howard Hughes Medical Institute
In its 13F for Q3 2025 (holdings as of September 30, 2025, filed November 14, 2025), Howard Hughes Medical Institute reported 500 stock positions worth $170.6 million. Its top holding was SS SPDR S&P 500 ETF Trust-US (SPY) at 92.9% of the portfolio, followed by Nvidia (NVDA, 0.6%) and Microsoft (MSFT, 0.5%). Compared with Q2 2025, it opened 8 new positions, sold out of 9, added to 63 and reduced 141. The biggest buy was Amazon.com (AMZN, shares +2%) and the biggest sale SS SPDR S&P 500 ETF Trust-US (SPY, shares −39%).
- Most Recent 13F
- Q2 2026
- Location
- Chevy Chase, MD
- CIK
- 0000810386
- Portfolio Value
- $170.6M (Q3 2025)
- SEC Filing
- 0001193125-25-281376 ↗ filed Nov 14, 2025
Holdings Value
Holdings 500 stocks · $170.6M
| SPY SS SPDR S&P 500 ETF Trust-US | 92.87% | 237,885 | $158.5M | Reduce -38.7% |
| NVDA Nvidia Corp. | 0.57% | 5,240 | $978K | Reduce -0.8% |
| MSFT Microsoft Corp. | 0.48% | 1,597 | $827K | Reduce -0.9% |
| AAPL Apple Inc. | 0.48% | 3,188 | $812K | Reduce -1.4% |
| AMZN Amazon.com Inc. | 0.27% | 2,084 | $458K | Add +2.2% |
| META Meta Platforms Inc. Class A | 0.20% | 466 | $342K | Reduce -1.5% |
| AVGO Broadcom Inc. | 0.20% | 1,011 | $334K | No change |
| GOOGL Alphabet Inc. Class A | 0.18% | 1,250 | $304K | Reduce -0.8% |
| TSLA Tesla Inc. | 0.16% | 602 | $268K | Add +0.2% |
| GOOG Alphabet Inc. Class C | 0.14% | 1,003 | $244K | Reduce -1.8% |
| BRK.B Berkshire Hathaway Inc. Class B | 0.12% | 394 | $198K | Reduce -0.5% |
| JPM JPMorgan Chase & Co. | 0.11% | 591 | $186K | Reduce -2.3% |
| LLY Eli Lilly & Co. | 0.08% | 170 | $130K | No change |
| V Visa Inc. Class A | 0.07% | 365 | $125K | Reduce -1.9% |
| NFLX Netflix Inc. | 0.06% | 92 | $110K | No change |
| XOM Exxon Mobil Corp. | 0.06% | 916 | $103K | Reduce -2.9% |
| MA Mastercard Inc. Class A | 0.06% | 177 | $101K | Add +0.6% |
| ORCL Oracle Corp. | 0.06% | 355 | $100K | Add +1.4% |
| WMT Walmart Inc. | 0.06% | 942 | $97K | Add +0.5% |
| JNJ Johnson & Johnson | 0.06% | 518 | $96K | Reduce -0.4% |
| PLTR Palantir Technologies Inc. Class A | 0.05% | 488 | $89K | Add +10.7% |
| ABBV Abbvie Inc. | 0.05% | 380 | $88K | Reduce -0.3% |
| COST Costco Wholesale Corp. | 0.05% | 95 | $88K | No change |
| HD Home Depot Inc. | 0.05% | 214 | $87K | No change |
| PG The Procter & Gamble Co. | 0.05% | 504 | $77K | Reduce -0.4% |
| BAC Bank of America Corp. filed as BANK AMERICA CORP | 0.04% | 1,463 | $75K | Add +2.2% |
| GE General Electric filed as GE AEROSPACE | 0.04% | 228 | $69K | Reduce -1.3% |
| UNH Unitedhealth Group Inc. | 0.04% | 195 | $67K | Reduce -1.5% |
| CVX Chevron Corp. | 0.04% | 414 | $64K | Add +14.7% |
| CSCO Cisco Systems Inc. | 0.03% | 851 | $58K | Reduce -1.1% |
| WFC Wells Fargo & Co. | 0.03% | 688 | $58K | Reduce -3.2% |
| AMD Advanced Micro Devices | 0.03% | 349 | $56K | Reduce -0.3% |
| IBM Intl Business Machines Corp. filed as INTERNATIONAL BUSINESS MACHS | 0.03% | 200 | $56K | Add +0.5% |
| KO The Coca-Cola Co. | 0.03% | 832 | $55K | Reduce -0.5% |
| GS Goldman Sachs Group Inc. | 0.03% | 66 | $53K | Reduce -1.5% |
| ABT Abbott Laboratories | 0.03% | 374 | $50K | No change |
| CRM Salesforce Inc. | 0.03% | 206 | $49K | No change |
| CAT Caterpillar Inc. | 0.03% | 101 | $48K | Reduce -1.9% |
| RTX RTX Corp. | 0.03% | 287 | $48K | No change |
| LIN Linde PLC | 0.03% | 101 | $48K | Reduce -1.0% |
| MCD McDonald's Corp. | 0.03% | 154 | $47K | No change |
| MRK Merck & Co. Inc. | 0.03% | 537 | $45K | Reduce -1.6% |
| DIS The Walt Disney Co. filed as DISNEY WALT CO | 0.03% | 387 | $44K | Reduce -0.8% |
| UBER Uber Technologies Inc. | 0.03% | 448 | $44K | Reduce -0.7% |
| T AT&T Inc. | 0.03% | 1,536 | $43K | Reduce -1.4% |
| APP AppLovin Corp. Class A | 0.02% | 58 | $42K | New |
| MS Morgan Stanley | 0.02% | 261 | $41K | Reduce -2.3% |
| PEP Pepsico Inc. | 0.02% | 295 | $41K | Reduce -0.3% |
| INTU Intuit Inc. | 0.02% | 60 | $41K | No change |
| NOW ServiceNow Inc. | 0.02% | 44 | $40K | No change |
| C Citigroup Inc. | 0.02% | 396 | $40K | Reduce -2.2% |
| MU Micron Technology Inc. | 0.02% | 240 | $40K | No change |
| VZ Verizon Communications Inc. | 0.02% | 906 | $40K | Reduce -0.3% |
| TMO Thermo Fisher Scientific Inc. | 0.02% | 82 | $40K | No change |
| AXP American Express Co. | 0.02% | 117 | $39K | Reduce -1.7% |
| QCOM Qualcomm Inc. | 0.02% | 232 | $39K | Reduce -2.9% |
| BKNG Booking Holdings Inc. | 0.02% | 7 | $38K | No change |
| LRCX Lam Research Corp. | 0.02% | 272 | $36K | Reduce -1.8% |
| GEV GE Vernova Inc. | 0.02% | 59 | $36K | No change |
| BLK BlackRock Inc. | 0.02% | 31 | $36K | No change |
| TXN Texas Instruments Inc. | 0.02% | 196 | $36K | No change |
| AMAT Applied Materials Inc. | 0.02% | 173 | $35K | Reduce -1.1% |
| SCHW Schwab (charles) Corp. | 0.02% | 367 | $35K | Reduce -0.3% |
| BA The Boeing Co. | 0.02% | 162 | $35K | No change |
| TJX TJX Companies Inc. filed as TJX COS INC NEW | 0.02% | 240 | $35K | Reduce -0.8% |
| ISRG Intuitive Surgical Inc. | 0.02% | 77 | $34K | No change |
| NEE Nextera Energy Inc. | 0.02% | 443 | $33K | Reduce -0.2% |
| SPGI S&P Global Inc. | 0.02% | 68 | $33K | No change |
| ACN Accenture PLC Class A | 0.02% | 134 | $33K | Reduce -0.7% |
| AMGN Amgen Inc. | 0.02% | 116 | $33K | No change |
| ADBE Adobe Inc. | 0.02% | 92 | $32K | Reduce -2.1% |
| APH Amphenol Corp. Class A | 0.02% | 262 | $32K | Add +0.4% |
| ANET Arista Networks Inc. | 0.02% | 222 | $32K | Reduce -0.5% |
| INTC Intel Corp. | 0.02% | 939 | $32K | Add +0.5% |
| ETN Eaton Corp. PLC | 0.02% | 84 | $31K | Reduce -1.2% |
| PGR Progressive Corp. | 0.02% | 126 | $31K | No change |
| PFE Pfizer Inc. | 0.02% | 1,221 | $31K | Reduce -0.1% |
| BSX Boston Scientific Corp. | 0.02% | 318 | $31K | No change |
| LOW Lowe's Cos Inc. | 0.02% | 121 | $30K | Reduce -0.8% |
| UNP Union Pacific Corp. | 0.02% | 128 | $30K | Reduce -1.5% |
| KLAC KLA Corp. | 0.02% | 28 | $30K | No change |
| GILD Gilead Sciences Inc. | 0.02% | 267 | $30K | Reduce -0.7% |
| COF Capital One Financial Corp. | 0.02% | 137 | $29K | No change |
| PANW Palo Alto Networks Inc. | 0.02% | 143 | $29K | No change |
| HON Honeywell International Inc. | 0.02% | 137 | $29K | Reduce -2.1% |
| SYK Stryker Corp. | 0.02% | 74 | $27K | No change |
| DHR Danaher Corp. | 0.02% | 137 | $27K | Reduce -0.7% |
| BX Blackstone Inc. | 0.02% | 158 | $27K | No change |
| ADI Analog Devices Inc. | 0.02% | 107 | $26K | No change |
| MDT Medtronic PLC | 0.02% | 276 | $26K | Reduce -0.4% |
| CRWD CrowdStrike Holdings Inc. Class A | 0.02% | 53 | $26K | No change |
| ADP Automatic Data Processing | 0.01% | 87 | $26K | No change |
| WELL Welltower Inc. | 0.01% | 143 | $25K | Add +9.2% |
| COP Conocophillips | 0.01% | 269 | $25K | Reduce -2.2% |
| CMCSA Comcast Corp. Class A | 0.01% | 791 | $25K | Reduce -3.2% |
| DE Deere & Co. | 0.01% | 54 | $25K | No change |
| TMUS T-Mobile US Inc. | 0.01% | 103 | $25K | No change |
| HOOD Robinhood Markets Inc. Class A | 0.01% | 166 | $24K | New |
| PLD Prologis Inc. | 0.01% | 200 | $23K | No change |
| CB Chubb Ltd. | 0.01% | 80 | $23K | No change |
Portfolio Sells Q2 2025 → Q3 2025
| SPY SS SPDR S&P 500 ETF Trust-US | Reduce -38.7% | 92.87% | −2.65 |
| HES Hess Corp. | Sold out | 0.00% | −0.00 |
| ANSS Ansys Inc. | Sold out | 0.00% | −0.00 |
| JNPR Juniper Networks Inc. | Sold out | 0.00% | −0.00 |
| MKTX Marketaxess Holdings Inc. | Sold out | 0.00% | −0.00 |
| PARAA Paramount Global Class B | Sold out | 0.00% | −0.00 |
| WBA Walgreens Boots Alliance Inc. | Sold out | 0.00% | −0.00 |
| CZR Caesars Entertainment Inc. | Sold out | 0.00% | −0.00 |
| RAL Ralliant Corp. | Sold out | 0.00% | −0.00 |
| ENPH Enphase Energy Inc. | Sold out | 0.00% | −0.00 |
| CNC Centene Corp. | Reduce -5.6% | 0.00% | −0.00 |
| CMG Chipotle Mexican Grill Inc. | Reduce -1.4% | 0.01% | +0.00 |
| DVA Davita Inc. | Reduce -11.1% | 0.00% | +0.00 |
| HSIC Henry Schein Inc. | Reduce -11.5% | 0.00% | +0.00 |
| BF.B Brown-Forman Corp. Class B | Reduce -2.6% | 0.00% | +0.00 |
| MGM MGM Resorts International | Reduce -8.3% | 0.00% | +0.00 |
| BALL Ball Corp. | Reduce -7.8% | 0.00% | +0.00 |
| STZ Constellation Brands Inc. Class A | Reduce -6.1% | 0.00% | +0.00 |
| RVTY Revvity Inc. | Reduce -3.9% | 0.00% | +0.00 |
| AKAM Akamai Technologies Inc. | Reduce -3.1% | 0.00% | +0.00 |
| MTCH Match Group Inc. | Reduce -3.7% | 0.00% | +0.00 |
| SWKS Skyworks Solutions Inc. | Reduce -5.9% | 0.00% | +0.00 |
| APA Apa Corp. | Reduce -2.5% | 0.00% | +0.00 |
| CF CF Industries Holdings Inc. | Reduce -5.4% | 0.00% | +0.00 |
| FISV Fiserv Inc. | Reduce -4.1% | 0.01% | +0.00 |
| HST Host Hotels & Resorts Inc. | Reduce -8.6% | 0.00% | +0.00 |
| IPG Interpublic Group of Cos Inc. | Reduce -1.3% | 0.00% | +0.00 |
| INVH Invitation Homes Inc. | Reduce -0.8% | 0.00% | +0.00 |
| KVUE Kenvue Inc. | Reduce -0.2% | 0.00% | +0.00 |
| KDP Keurig Dr Pepper Inc. | Reduce -0.3% | 0.00% | +0.00 |
| LUV Southwest Airlines Co. | Reduce -11.7% | 0.00% | +0.00 |
| DLTR Dollar Tree Inc. | Reduce -2.3% | 0.00% | +0.00 |
| DOC Healthpeak Properties Inc. | Reduce -0.7% | 0.00% | +0.00 |
| ON On Semiconductor | Reduce -3.3% | 0.00% | +0.00 |
| FIS Fidelity National Info Serv | Reduce -0.9% | 0.00% | +0.00 |
| FOXA Fox Corp. Class A | Reduce -2.1% | 0.00% | +0.00 |
| KEY Keycorp | Reduce -6.5% | 0.00% | +0.00 |
| PFG Principal Financial Group | Reduce -2.2% | 0.00% | +0.00 |
| WY Weyerhaeuser Co. | Reduce -0.6% | 0.00% | +0.00 |
| CTSH Cognizant Tech Solutions-A | Reduce -0.9% | 0.00% | +0.00 |
| LVS Las Vegas Sands Corp. | Reduce -9.5% | 0.00% | +0.00 |
| L Loews Corp. | Reduce -2.6% | 0.00% | +0.00 |
| PPG PPG Industries Inc. | Reduce -2.0% | 0.00% | +0.00 |
| CARR Carrier Global Corp. | Reduce -1.1% | 0.01% | +0.00 |
| GIS General Mills Inc. | Reduce -3.4% | 0.00% | +0.00 |
| IR Ingersoll-Rand Inc. | Reduce -10.3% | 0.00% | +0.00 |
| KHC The Kraft Heinz Co. | Reduce -2.1% | 0.00% | +0.00 |
| TRMB Trimble Inc. | Reduce -1.9% | 0.00% | +0.00 |
| DVN Devon Energy Corp. | Reduce -2.8% | 0.00% | +0.00 |
| APTV Aptiv PLC | Reduce -4.1% | 0.00% | +0.00 |
Portfolio Buys Q2 2025 → Q3 2025
| AMZN Amazon.com Inc. | Add +2.2% | 0.27% | +0.09 |
| TSLA Tesla Inc. | Add +0.2% | 0.16% | +0.08 |
| PLTR Palantir Technologies Inc. Class A | Add +10.7% | 0.05% | +0.03 |
| ORCL Oracle Corp. | Add +1.4% | 0.06% | +0.03 |
| APP AppLovin Corp. Class A | New | 0.02% | +0.02 |
| WMT Walmart Inc. | Add +0.5% | 0.06% | +0.02 |
| MA Mastercard Inc. Class A | Add +0.6% | 0.06% | +0.02 |
| BAC Bank of America Corp. | Add +2.2% | 0.04% | +0.02 |
| CVX Chevron Corp. | Add +14.7% | 0.04% | +0.02 |
| HOOD Robinhood Markets Inc. Class A | New | 0.01% | +0.01 |
| INTC Intel Corp. | Add +0.5% | 0.02% | +0.01 |
| IBM Intl Business Machines Corp. | Add +0.5% | 0.03% | +0.01 |
| APH Amphenol Corp. Class A | Add +0.4% | 0.02% | +0.01 |
| WELL Welltower Inc. | Add +9.2% | 0.01% | +0.01 |
| DDOG Datadog Inc. Class A | New | 0.01% | +0.01 |
| DASH DoorDash Inc. Class A | Add +8.2% | 0.01% | +0.01 |
| XYZ Block Inc. | New | 0.01% | +0.01 |
| GLW Corning Inc. | Add +0.6% | 0.01% | +0.00 |
| SNPS Synopsys Inc. | Add +18.2% | 0.01% | +0.00 |
| IBKR Interactive Brokers Gro Class A | New | 0.00% | +0.00 |
| WBD Warner Bros Discovery Inc. | Add +10.4% | 0.01% | +0.00 |
| RCL Royal Caribbean Cruises Ltd. | Add +1.9% | 0.01% | +0.00 |
| KKR KKR & Co. Inc. | Add +1.4% | 0.01% | +0.00 |
| SPG Simon Property Group Inc. | Add +6.1% | 0.01% | +0.00 |
| EME Emcor Group Inc. | New | 0.00% | +0.00 |
| SRE Sempra | Add +2.9% | 0.01% | +0.00 |
| COIN Coinbase Global Inc. Class A | Add +6.7% | 0.01% | +0.00 |
| COR Cencora Inc. | Add +10.8% | 0.01% | +0.00 |
| AJG Arthur J Gallagher & Co. | Add +1.9% | 0.01% | +0.00 |
| WM Waste Management Inc. | Add +1.3% | 0.01% | +0.00 |
| TTD Trade Desk Inc./the Class A | New | 0.00% | +0.00 |
| O Realty Income Corp. | Add +3.7% | 0.01% | +0.00 |
| XEL Xcel Energy Inc. | Add +2.4% | 0.01% | +0.00 |
| D Dominion Energy Inc. | Add +1.1% | 0.01% | +0.00 |
| SLB SLB Ltd. | Add +6.0% | 0.01% | +0.00 |
| MNST Monster Beverage Corp. | Add +1.3% | 0.01% | +0.00 |
| GRMN Garmin Ltd. | Add +6.1% | 0.01% | +0.00 |
| APO Apollo Global Management Inc. | Add +2.1% | 0.01% | +0.00 |
| ETR Entergy Corp. | Add +3.3% | 0.01% | +0.00 |
| KMI Kinder Morgan Inc. | Add +0.5% | 0.01% | +0.00 |
| TTWO Take-Two Interactive Softwre | Add +2.8% | 0.01% | +0.00 |
| DAL Delta Air Lines Inc. | Add +0.7% | 0.00% | +0.00 |
| NDAQ Nasdaq Inc. | Add +9.0% | 0.01% | +0.00 |
| AXON Axon Enterprise Inc. | Add +6.7% | 0.01% | +0.00 |
| OXY Occidental Petroleum Corp. | Add +5.5% | 0.00% | +0.00 |
| WEC WEC Energy Group Inc. | Add +1.5% | 0.00% | +0.00 |
| ED Consolidated Edison Inc. | Add +4.0% | 0.00% | +0.00 |
| VTR Ventas Inc. | Add +3.2% | 0.00% | +0.00 |
| CCL Carnival Corp. | Add +3.1% | 0.00% | +0.00 |
| OKE Oneok Inc. | Add +0.8% | 0.01% | +0.00 |
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 30 | $445.4M | NVDA, AAPL, GOOGL, MSFT, TSM |
| Q1 2026 | 31 | $415.8M | SPY, NVDA, AAPL, GOOGL, MSFT |
| Q4 2025 | 500 | $174.7M | SPY, NVDA, AAPL, MSFT, AMZN |
| Q3 2025 | 500 | $170.6M | SPY, NVDA, MSFT, AAPL, AMZN |
| Q2 2025 | 501 | $250.9M | SPY, NVDA, MSFT, AAPL, AMZN |
| Q1 2025 | 2 | $202.2M | SPY, BIOA |
| Q4 2024 | 2 | $568.4M | SPY, BIOA |
| Q3 2024 | 2 | $630.4M | SPY, BIOA |
| Q2 2024 | 1 | $466.2M | SPY |
| Q1 2024 | 2 | $332.9M | SPY, PCT |