Howard Hughes Medical Institute
In its 13F for Q4 2025 (holdings as of December 31, 2025, filed February 17, 2026), Howard Hughes Medical Institute reported 500 stock positions worth $174.7 million. Its top holding was SS SPDR S&P 500 ETF Trust-US (SPY) at 92.8% of the portfolio, followed by Nvidia (NVDA, 0.6%) and Apple (AAPL, 0.5%). Compared with Q3 2025, it opened 5 new positions, sold out of 6, added to 71 and reduced 84. The biggest buy was Eli Lilly (LLY, shares +1%) and the biggest sale Netflix (NFLX, shares −1%).
- Most Recent 13F
- Q2 2026
- Location
- Chevy Chase, MD
- CIK
- 0000810386
- Portfolio Value
- $174.7M (Q4 2025)
- SEC Filing
- 0001193125-26-052983 ↗ filed Feb 17, 2026
Holdings Value
Holdings 500 stocks · $174.7M
| SPY SS SPDR S&P 500 ETF Trust-US | 92.85% | 237,885 | $162.2M | No change |
| NVDA Nvidia Corp. | 0.56% | 5,221 | $974K | Reduce -0.4% |
| AAPL Apple Inc. | 0.50% | 3,184 | $866K | Reduce -0.1% |
| MSFT Microsoft Corp. | 0.44% | 1,600 | $774K | Add +0.2% |
| AMZN Amazon.com Inc. | 0.28% | 2,093 | $483K | Add +0.4% |
| GOOGL Alphabet Inc. Class A | 0.22% | 1,250 | $391K | No change |
| AVGO Broadcom Inc. | 0.20% | 1,016 | $352K | Add +0.5% |
| GOOG Alphabet Inc. Class C | 0.18% | 1,000 | $314K | Reduce -0.3% |
| META Meta Platforms Inc. Class A | 0.18% | 469 | $310K | Add +0.6% |
| TSLA Tesla Inc. | 0.16% | 603 | $271K | Add +0.2% |
| BRK.B Berkshire Hathaway Inc. Class B | 0.11% | 395 | $199K | Add +0.3% |
| JPM JPMorgan Chase & Co. | 0.11% | 588 | $189K | Reduce -0.5% |
| LLY Eli Lilly & Co. | 0.11% | 171 | $184K | Add +0.6% |
| V Visa Inc. Class A | 0.07% | 364 | $128K | Reduce -0.3% |
| XOM Exxon Mobil Corp. | 0.06% | 912 | $110K | Reduce -0.4% |
| JNJ Johnson & Johnson | 0.06% | 520 | $108K | Add +0.4% |
| WMT Walmart Inc. | 0.06% | 947 | $106K | Add +0.5% |
| MA Mastercard Inc. Class A | 0.06% | 177 | $101K | No change |
| PLTR Palantir Technologies Inc. Class A | 0.05% | 490 | $87K | Add +0.4% |
| ABBV Abbvie Inc. | 0.05% | 381 | $87K | Add +0.3% |
| NFLX Netflix Inc. | 0.05% | 913 | $86K | Reduce -0.8% |
| COST Costco Wholesale Corp. | 0.05% | 95 | $82K | No change |
| BAC Bank of America Corp. filed as BANK AMERICA CORP | 0.05% | 1,449 | $80K | Reduce -1.0% |
| AMD Advanced Micro Devices | 0.04% | 350 | $75K | Add +0.3% |
| HD Home Depot Inc. | 0.04% | 214 | $74K | No change |
| PG The Procter & Gamble Co. | 0.04% | 504 | $72K | No change |
| GE General Electric filed as GE AEROSPACE | 0.04% | 228 | $70K | No change |
| ORCL Oracle Corp. | 0.04% | 360 | $70K | Add +1.4% |
| MU Micron Technology Inc. | 0.04% | 241 | $69K | Add +0.4% |
| CSCO Cisco Systems Inc. | 0.04% | 850 | $65K | Reduce -0.1% |
| UNH Unitedhealth Group Inc. | 0.04% | 195 | $64K | No change |
| WFC Wells Fargo & Co. | 0.04% | 677 | $63K | Reduce -1.6% |
| CVX Chevron Corp. | 0.04% | 409 | $62K | Reduce -1.2% |
| IBM Intl Business Machines Corp. filed as INTERNATIONAL BUSINESS MACHS | 0.03% | 201 | $60K | Add +0.5% |
| KO The Coca-Cola Co. | 0.03% | 835 | $58K | Add +0.4% |
| CAT Caterpillar Inc. | 0.03% | 101 | $58K | No change |
| GS Goldman Sachs Group Inc. | 0.03% | 65 | $57K | Reduce -1.5% |
| MRK Merck & Co. Inc. | 0.03% | 534 | $56K | Reduce -0.6% |
| CRM Salesforce Inc. | 0.03% | 205 | $54K | Reduce -0.5% |
| RTX RTX Corp. | 0.03% | 288 | $53K | Add +0.3% |
| MCD McDonald's Corp. | 0.03% | 154 | $47K | No change |
| ABT Abbott Laboratories | 0.03% | 375 | $47K | Add +0.3% |
| TMO Thermo Fisher Scientific Inc. | 0.03% | 81 | $47K | Reduce -1.2% |
| MS Morgan Stanley | 0.03% | 261 | $46K | No change |
| LRCX Lam Research Corp. | 0.03% | 270 | $46K | Reduce -0.7% |
| C Citigroup Inc. | 0.03% | 386 | $45K | Reduce -2.5% |
| AMAT Applied Materials Inc. | 0.03% | 172 | $44K | Reduce -0.6% |
| DIS The Walt Disney Co. filed as DISNEY WALT CO | 0.03% | 385 | $44K | Reduce -0.5% |
| ISRG Intuitive Surgical Inc. | 0.03% | 77 | $44K | No change |
| LIN Linde PLC | 0.02% | 101 | $43K | No change |
| AXP American Express Co. | 0.02% | 116 | $43K | Reduce -0.8% |
| PEP Pepsico Inc. | 0.02% | 295 | $42K | No change |
| INTU Intuit Inc. | 0.02% | 60 | $40K | No change |
| QCOM Qualcomm Inc. | 0.02% | 232 | $40K | No change |
| APP AppLovin Corp. Class A | 0.02% | 58 | $39K | No change |
| GEV GE Vernova Inc. | 0.02% | 59 | $39K | No change |
| AMGN Amgen Inc. | 0.02% | 116 | $38K | No change |
| T AT&T Inc. | 0.02% | 1,527 | $38K | Reduce -0.6% |
| BKNG Booking Holdings Inc. | 0.02% | 7 | $37K | No change |
| VZ Verizon Communications Inc. | 0.02% | 908 | $37K | Add +0.2% |
| TJX TJX Companies Inc. filed as TJX COS INC NEW | 0.02% | 240 | $37K | No change |
| UBER Uber Technologies Inc. | 0.02% | 447 | $37K | Reduce -0.2% |
| BA The Boeing Co. | 0.02% | 168 | $36K | Add +3.7% |
| NEE Nextera Energy Inc. | 0.02% | 449 | $36K | Add +1.4% |
| SCHW Schwab (charles) Corp. | 0.02% | 360 | $36K | Reduce -1.9% |
| ACN Accenture PLC Class A | 0.02% | 134 | $36K | No change |
| INTC Intel Corp. | 0.02% | 965 | $36K | Add +2.8% |
| APH Amphenol Corp. Class A | 0.02% | 263 | $36K | Add +0.4% |
| SPGI S&P Global Inc. | 0.02% | 67 | $35K | Reduce -1.5% |
| KLAC KLA Corp. | 0.02% | 28 | $34K | No change |
| NOW ServiceNow Inc. | 0.02% | 222 | $34K | Add +0.9% |
| TXN Texas Instruments Inc. | 0.02% | 196 | $34K | No change |
| COF Capital One Financial Corp. | 0.02% | 137 | $33K | No change |
| BLK BlackRock Inc. | 0.02% | 31 | $33K | No change |
| GILD Gilead Sciences Inc. | 0.02% | 268 | $33K | Add +0.4% |
| ADBE Adobe Inc. | 0.02% | 91 | $32K | Reduce -1.1% |
| DHR Danaher Corp. | 0.02% | 136 | $31K | Reduce -0.7% |
| PFE Pfizer Inc. | 0.02% | 1,226 | $31K | Add +0.4% |
| BSX Boston Scientific Corp. | 0.02% | 319 | $30K | Add +0.3% |
| UNP Union Pacific Corp. | 0.02% | 128 | $30K | No change |
| LOW Lowe's Cos Inc. | 0.02% | 121 | $29K | No change |
| ANET Arista Networks Inc. | 0.02% | 222 | $29K | No change |
| ADI Analog Devices Inc. | 0.02% | 106 | $29K | Reduce -0.9% |
| PGR Progressive Corp. | 0.02% | 126 | $29K | No change |
| WELL Welltower Inc. | 0.02% | 147 | $27K | Add +2.8% |
| PANW Palo Alto Networks Inc. | 0.02% | 147 | $27K | Add +2.8% |
| ETN Eaton Corp. PLC | 0.02% | 84 | $27K | No change |
| HON Honeywell International Inc. | 0.02% | 137 | $27K | No change |
| MDT Medtronic PLC | 0.02% | 276 | $27K | No change |
| SYK Stryker Corp. | 0.01% | 74 | $26K | No change |
| PLD Prologis Inc. | 0.01% | 200 | $26K | No change |
| DE Deere & Co. | 0.01% | 54 | $25K | No change |
| COP Conocophillips | 0.01% | 267 | $25K | Reduce -0.7% |
| VRTX Vertex Pharmaceuticals Inc. | 0.01% | 55 | $25K | No change |
| CRWD CrowdStrike Holdings Inc. Class A | 0.01% | 53 | $25K | No change |
| CB Chubb Ltd. | 0.01% | 79 | $25K | Reduce -1.3% |
| BX Blackstone Inc. | 0.01% | 159 | $25K | Add +0.6% |
| PH Parker Hannifin Corp. | 0.01% | 27 | $24K | No change |
| CEG Constellation Energy | 0.01% | 67 | $24K | No change |
| BMY Bristol-Myers Squibb Co. | 0.01% | 438 | $24K | No change |
Portfolio Sells Q3 2025 → Q4 2025
| NFLX Netflix Inc. | Reduce -0.8% | 0.05% | −0.02 |
| NVDA Nvidia Corp. | Reduce -0.4% | 0.56% | −0.02 |
| UBER Uber Technologies Inc. | Reduce -0.2% | 0.02% | −0.00 |
| FISV Fiserv Inc. | Reduce -0.8% | 0.00% | −0.00 |
| T AT&T Inc. | Reduce -0.6% | 0.02% | −0.00 |
| K Kellanova | Sold out | 0.00% | −0.00 |
| CVX Chevron Corp. | Reduce -1.2% | 0.04% | −0.00 |
| MPC Marathon Petroleum Corp. | Reduce -1.5% | 0.01% | −0.00 |
| PYPL PayPal Holdings Inc. | Reduce -2.4% | 0.01% | −0.00 |
| ZTS Zoetis Inc. | Reduce -1.0% | 0.01% | −0.00 |
| IPG Interpublic Group of Cos Inc. | Sold out | 0.00% | −0.00 |
| CMCSA Comcast Corp. Class A | Reduce -1.0% | 0.01% | −0.00 |
| DHI D.R. Horton Inc. | Reduce -1.7% | 0.00% | −0.00 |
| CHTR Charter Communications Inc. Class A | Reduce -5.0% | 0.00% | −0.00 |
| LKQ LKQ Corp. | Sold out | 0.00% | −0.00 |
| LMT Lockheed Martin Corp. | Reduce -2.2% | 0.01% | −0.00 |
| KMX Carmax Inc. | Sold out | 0.00% | −0.00 |
| DIS The Walt Disney Co. | Reduce -0.5% | 0.03% | −0.00 |
| EMN Eastman Chemical Co. | Sold out | 0.00% | −0.00 |
| LEN Lennar Corp. Class A | Reduce -4.1% | 0.00% | −0.00 |
| ADBE Adobe Inc. | Reduce -1.1% | 0.02% | −0.00 |
| CARR Carrier Global Corp. | Reduce -0.6% | 0.01% | −0.00 |
| JPM JPMorgan Chase & Co. | Reduce -0.5% | 0.11% | −0.00 |
| MHK Mohawk Industries Inc. | Sold out | 0.00% | −0.00 |
| EOG EOG Resources Inc. | Reduce -0.8% | 0.01% | −0.00 |
| CMG Chipotle Mexican Grill Inc. | Reduce -1.4% | 0.01% | −0.00 |
| COP Conocophillips | Reduce -0.7% | 0.01% | −0.00 |
| FTNT Fortinet Inc. | Reduce -1.4% | 0.01% | −0.00 |
| XYZ Block Inc. | Reduce -0.8% | 0.00% | −0.00 |
| PHM Pultegroup Inc. | Reduce -2.3% | 0.00% | −0.00 |
| RJF Raymond James Financial Inc. | Reduce -2.6% | 0.00% | −0.00 |
| VLO Valero Energy Corp. | Reduce -1.5% | 0.01% | −0.00 |
| AFL Aflac Inc. | Reduce -1.9% | 0.01% | −0.00 |
| EBAY eBay Inc. | Reduce -1.0% | 0.00% | −0.00 |
| OTIS Otis Worldwide Corp. | Reduce -1.2% | 0.00% | −0.00 |
| CF CF Industries Holdings Inc. | Reduce -2.9% | 0.00% | −0.00 |
| GPN Global Payments Inc. | Reduce -3.8% | 0.00% | −0.00 |
| CHD Church & Dwight Co. Inc. | Reduce -1.9% | 0.00% | −0.00 |
| FIS Fidelity National Info Serv | Reduce -0.9% | 0.00% | −0.00 |
| MTCH Match Group Inc. | Reduce -1.9% | 0.00% | −0.00 |
| NTRS Northern Trust Corp. | Reduce -2.4% | 0.00% | −0.00 |
| BALL Ball Corp. | Reduce -1.7% | 0.00% | 0.00 |
| DVN Devon Energy Corp. | Reduce -0.7% | 0.00% | 0.00 |
| RF Regions Financial Corp. | Reduce -1.0% | 0.00% | 0.00 |
| TXT Textron Inc. | Reduce -2.6% | 0.00% | 0.00 |
| V Visa Inc. Class A | Reduce -0.3% | 0.07% | 0.00 |
| ACGL Arch Capital Group Ltd. | Reduce -2.5% | 0.00% | 0.00 |
| JCI Johnson Controls Internation | Reduce -6.4% | 0.01% | 0.00 |
| FTV Fortive Corp. | Reduce -5.5% | 0.00% | +0.00 |
| HSIC Henry Schein Inc. | Reduce -4.3% | 0.00% | +0.00 |
Portfolio Buys Q3 2025 → Q4 2025
| LLY Eli Lilly & Co. | Add +0.6% | 0.11% | +0.03 |
| MU Micron Technology Inc. | Add +0.4% | 0.04% | +0.02 |
| CRH CRH PLC | New | 0.01% | +0.01 |
| AMD Advanced Micro Devices | Add +0.3% | 0.04% | +0.01 |
| AMZN Amazon.com Inc. | Add +0.4% | 0.28% | +0.01 |
| CVNA Carvana Co. | New | 0.01% | +0.01 |
| AVGO Broadcom Inc. | Add +0.5% | 0.20% | +0.01 |
| JNJ Johnson & Johnson | Add +0.4% | 0.06% | +0.01 |
| ARES Ares Management Corp. Class A | New | 0.00% | +0.00 |
| SNDK Sandisk Corp. | New | 0.00% | +0.00 |
| FIX Comfort Systems USA Inc. | New | 0.00% | +0.00 |
| WMT Walmart Inc. | Add +0.5% | 0.06% | +0.00 |
| RTX RTX Corp. | Add +0.3% | 0.03% | +0.00 |
| INTC Intel Corp. | Add +2.8% | 0.02% | +0.00 |
| GILD Gilead Sciences Inc. | Add +0.4% | 0.02% | +0.00 |
| APH Amphenol Corp. Class A | Add +0.4% | 0.02% | +0.00 |
| UPS United Parcel Service Class B | Add +0.6% | 0.01% | +0.00 |
| OMC Omnicom Group | Add +64.3% | 0.00% | +0.00 |
| KO The Coca-Cola Co. | Add +0.4% | 0.03% | +0.00 |
| IBM Intl Business Machines Corp. | Add +0.5% | 0.03% | +0.00 |
| NEE Nextera Energy Inc. | Add +1.4% | 0.02% | +0.00 |
| STX Seagate Technology Holdings | Add +2.2% | 0.01% | +0.00 |
| VTRS Viatris Inc. | Add +19.8% | 0.00% | +0.00 |
| WELL Welltower Inc. | Add +2.8% | 0.02% | +0.00 |
| SLB SLB Ltd. | Add +0.6% | 0.01% | +0.00 |
| APO Apollo Global Management Inc. | Add +1.0% | 0.01% | +0.00 |
| EL Estee Lauder Companies Class A | Add +4.0% | 0.00% | +0.00 |
| VTR Ventas Inc. | Add +4.1% | 0.00% | +0.00 |
| BA The Boeing Co. | Add +3.7% | 0.02% | +0.00 |
| CVS CVS Health Corp. | Add +0.4% | 0.01% | +0.00 |
| F Ford Motor Co. | Add +0.4% | 0.01% | +0.00 |
| FOX Fox Corp. Class B | Add +10.7% | 0.00% | +0.00 |
| HBAN Huntington Bancshares Inc. | Add +8.0% | 0.00% | +0.00 |
| PCG P G & E Corp. | Add +0.4% | 0.00% | +0.00 |
| PWR Quanta Services Inc. | Add +3.2% | 0.01% | +0.00 |
| MRNA Moderna Inc. | Add +1.4% | 0.00% | +0.00 |
| ROL Rollins Inc. | Add +5.0% | 0.00% | +0.00 |
| DOW Dow Inc. | Add +0.7% | 0.00% | 0.00 |
| NWS News Corp. Class B | Add +8.3% | 0.00% | 0.00 |
| AMCR Amcor PLC | Add +0.4% | 0.00% | 0.00 |
| CMS CMS Energy Corp. | Add +1.6% | 0.00% | −0.00 |
| CNP Centerpoint Energy Inc. | Add +0.7% | 0.00% | −0.00 |
| ETR Entergy Corp. | Add +1.1% | 0.01% | −0.00 |
| NI Nisource Inc. | Add +2.0% | 0.00% | −0.00 |
| GEN Gen Digital Inc. | Add +0.8% | 0.00% | −0.00 |
| NCLH Norwegian Cruise Line Holdin | Add +1.0% | 0.00% | −0.00 |
| ES Eversource Energy | Add +1.3% | 0.00% | −0.00 |
| HPE Hewlett Packard Enterprise | Add +0.7% | 0.00% | −0.00 |
| KMI Kinder Morgan Inc. | Add +0.5% | 0.01% | −0.00 |
| ECL Ecolab Inc. | Add +1.9% | 0.01% | −0.00 |
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 30 | $445.4M | NVDA, AAPL, GOOGL, MSFT, TSM |
| Q1 2026 | 31 | $415.8M | SPY, NVDA, AAPL, GOOGL, MSFT |
| Q4 2025 | 500 | $174.7M | SPY, NVDA, AAPL, MSFT, AMZN |
| Q3 2025 | 500 | $170.6M | SPY, NVDA, MSFT, AAPL, AMZN |
| Q2 2025 | 501 | $250.9M | SPY, NVDA, MSFT, AAPL, AMZN |
| Q1 2025 | 2 | $202.2M | SPY, BIOA |
| Q4 2024 | 2 | $568.4M | SPY, BIOA |
| Q3 2024 | 2 | $630.4M | SPY, BIOA |
| Q2 2024 | 1 | $466.2M | SPY |
| Q1 2024 | 2 | $332.9M | SPY, PCT |