Kalehua Capital Management LLC
In its 13F for Q2 2026 (holdings as of June 30, 2026, filed August 19, 2026), Kalehua Capital Management LLC reported 26 stock positions worth $174.0 million. Its top holding was Alpha Architect 1-3 MNTH Box (BOXX) at 15.2% of the portfolio, followed by Veradermics (MANE, 10.3%) and X4 Pharmaceuticals (XFOR, 10.0%). Compared with Q1 2026, it opened 8 new positions, sold out of 7, added to 3 and reduced 2. The biggest buy was a new position in Karyopharm Therapeutics (KPTI) and the biggest sale an exit from Relay Therapeutics (RLAY).
- Most Recent 13F
- Q2 2026
- Location
- DALLAS, TX
- CIK
- 0002106181
- Portfolio Value
- $174.0M (Q2 2026)
- SEC Filing
- 0002106181-26-000008 ↗ filed Aug 19, 2026
Holdings Value
Holdings 26 stocks · $174.0M
| BOXX Alpha Architect 1-3 MNTH Box | 15.22% | 226,188 | $26.5M | Add +3.6% |
| MANE Veradermics Inc. | 10.30% | 145,695 | $17.9M | No change |
| XFOR X4 Pharmaceuticals Inc. | 9.99% | 3,722,840 | $17.4M | No change |
| CMPS Compass Pathways PLC | 6.67% | 819,692 | $11.6M | No change |
| SRZN Surrozen Inc. | 5.75% | 385,178 | $10.0M | No change |
| ACRS Aclaris Therapeutics Inc. | 5.57% | 1,832,365 | $9.7M | No change |
| SION Sionna Therapeutics Inc. | 4.98% | 197,072 | $8.7M | No change |
| IKT Inhibikase Therapeutics Inc. | 4.46% | 3,821,890 | $7.8M | No change |
| PHVS Pharvaris NV | 3.95% | 198,772 | $6.9M | No change |
| KPTI Karyopharm Therapeutics Inc. | 3.85% | 685,644 | $6.7M | New |
| SEPN Septerna Inc. | 3.75% | 194,544 | $6.5M | No change |
| IFRX Inflarx NV | 3.73% | 2,897,769 | $6.5M | New |
| CYCLERION THERAPEUTICS INC | 3.22% | 1,651,350 | $5.6M | New |
| KRRO Korro Bio Inc. | 3.07% | 405,040 | $5.3M | Add +270.3% |
| QURE Uniqure NV | 2.10% | 79,407 | $3.7M | Reduce -72.7% |
| LONA Leonabio Inc. | 2.08% | 393,701 | $3.6M | No change |
| DMRA Damora Therapeutics Inc. | 2.08% | 139,000 | $3.6M | No change |
| MLTX Moonlake Immunotherapeutics | 1.97% | 175,734 | $3.4M | No change |
| ANL Adlai Nortye Group Ltd. | 1.50% | 226,415 | $2.6M | New |
| TYRA Tyra Biosciences Inc. | 1.37% | 74,465 | $2.4M | No change |
| NVCT Nuvectis Pharma Inc. | 1.06% | 100,000 | $1.8M | New |
| GOSS Gossamer Bio Inc. | 1.05% | 11,149,363 | $1.8M | Add +8.9% |
| MIST Milestone Pharmaceuticals Inc. | 0.98% | 1,269,237 | $1.7M | New |
| ATYR Atyr Pharma Inc. | 0.61% | 1,788,167 | $1.1M | New |
| TIL Instil Bio Inc. | 0.44% | 99,600 | $766K | Reduce -45.6% |
| TCRX Tscan Therapeutics Inc. | 0.26% | 454,876 | $446K | New |
Portfolio Sells Q1 2026 → Q2 2026
| RLAY Relay Therapeutics Inc. | Sold out | 0.00% | −6.35 |
| ORKA Oruka Therapeutics Inc. | Sold out | 0.00% | −4.11 |
| QURE Uniqure NV | Reduce -72.7% | 2.10% | −1.26 |
| PEPG Pepgen Inc. | Sold out | 0.00% | −1.25 |
| TNYA Tenaya Therapeutics Inc. | Sold out | 0.00% | −0.98 |
| TIL Instil Bio Inc. | Reduce -45.6% | 0.44% | −0.63 |
| KLRS Kalaris Therapeutics Inc. | Sold out | 0.00% | −0.55 |
| DMAC Diamedica Therapeutics Inc. | Sold out | 0.00% | −0.30 |
| LOOP Loop Industries Inc. | Sold out | 0.00% | −0.26 |
Portfolio Buys Q1 2026 → Q2 2026
| KPTI Karyopharm Therapeutics Inc. | New | 3.85% | +3.85 |
| IFRX Inflarx NV | New | 3.73% | +3.73 |
| CYCLERION THERAPEUTICS INC | New | 3.22% | +3.22 |
| KRRO Korro Bio Inc. | Add +270.3% | 3.07% | +2.19 |
| ANL Adlai Nortye Group Ltd. | New | 1.50% | +1.50 |
| NVCT Nuvectis Pharma Inc. | New | 1.06% | +1.06 |
| MIST Milestone Pharmaceuticals Inc. | New | 0.98% | +0.98 |
| ATYR Atyr Pharma Inc. | New | 0.61% | +0.61 |
| TCRX Tscan Therapeutics Inc. | New | 0.26% | +0.26 |
| GOSS Gossamer Bio Inc. | Add +8.9% | 1.05% | −1.32 |
| BOXX Alpha Architect 1-3 MNTH Box | Add +3.6% | 15.22% | −2.73 |