Karyopharm TherapeuticsKPTI
13F holders, Q2 2026 (June 30)95holders +19
33new positions
14sold out
3famous investors
$9.77avg. 13F price*
At the end of Q2 2026, 95 institutions reported holding Karyopharm Therapeutics Inc. (KPTI) in their 13F filings, up 19 from Q1 2026. 33 opened new positions and 14 sold out. The largest holders were Ra Capital Management, L.P. ($18.7M), Adage Capital Partners Gp, L.L.C. ($14.9M) and Acorn Capital Advisors, LLC ($14.8M). 3 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Jim Simons / Peter Brown (0.0% of Renaissance Technologies's portfolio) and Ken Griffin (0.0% of Citadel Advisors's portfolio).
- Company
- Karyopharm Therapeutics Inc.
- CUSIP
- 48576U205
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2026 → Q2 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 33 | $26.5M |
| Exits | 14 | $19.5M |
All 13F filers, Q1 2026 → Q2 2026: 8,925,731 shares bought and 5,393,008 shares sold, net +3,532,723 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 95 holders
| Ra Capital Management, L.P. | 0.16% | No change | 1,917,354 | $18.7M |
| Adage Capital Partners Gp, L.L.C. | 0.02% | Reduce -15.8% | 1,521,322 | $14.9M |
| Acorn Capital Advisors, LLC | 4.05% | Add +427.4% | 1,518,113 | $14.8M |
| Goldman Sachs Group Inc. | 0.00% | Add +50.4% | 1,424,658 | $13.9M |
| BlackRock, Inc. | 0.00% | Add +479.3% | 1,418,799 | $13.9M |
| Vanguard Capital Management LLC | 0.00% | Add +29.6% | 958,979 | $9.4M |
| Catalio Capital Management, LP | 1.73% | Add +4.8% | 940,855 | $9.2M |
| Avidity Partners Management LP | 1.45% | Add +99.3% | 924,487 | $9.0M |
| T. Rowe Price Investment Management, Inc. | 0.01% | Reduce -49.0% | 786,309 | $7.7M |
| Two Sigma Investments, LP | 0.01% | Add +359.7% | 695,264 | $6.8M |
| Kalehua Capital Management LLC | 3.85% | New | 685,644 | $6.7M |
| NEA Management Company, LLC | 0.35% | New | 576,780 | $5.6M |
| Geode Capital Management, LLC | 0.00% | Add +157.7% | 531,231 | $5.2M |
| Ghisallo Capital Management LLC | 0.12% | New | 500,000 | $4.9M |
| Soleus Capital Management, L.P. | 0.15% | No change | 440,000 | $4.3M |
| UBS Group AG | 0.00% | Add +82.2% | 353,545 | $3.5M |
| State Street Corp. | 0.00% | Add +303.7% | 325,991 | $3.2M |
| Affinity Asset Advisors, LLC | 0.15% | Reduce -37.5% | 312,500 | $3.1M |
| Brevan Howard Capital Management LP | 0.04% | Add +45.9% | 309,817 | $3.0M |
| Millennium Management | 0.00% | Reduce -27.3% | 305,676 | $3.0M |
| Boxer Capital Management, LLC | 0.22% | No change | 302,536 | $3.0M |
| Davidson Kempner Capital Management LP | 0.07% | No change | 300,000 | $2.9M |
| Acadian Asset Management LLC | 0.00% | Add +20.1% | 298,997 | $2.9M |
| Silverarc Capital Management, LLC | 0.32% | New | 297,460 | $2.9M |
| Eversept Partners, LP | 0.15% | No change | 276,174 | $2.7M |
| JPMorgan Chase & Co. | 0.00% | Add +43978.3% | 207,609 | $2.1M |
| Morgan Stanley | 0.00% | Add +990.5% | 202,506 | $2.0M |
| Trexquant Investment LP | 0.01% | Reduce -27.0% | 188,368 | $1.8M |
| BNP Paribas Financial Markets | 0.00% | Add +223754.8% | 188,038 | $1.8M |
| Barclays PLC | 0.00% | Add +2134.7% | 165,904 | $1.6M |
| Northern Trust Corp. | 0.00% | Add +315.0% | 160,006 | $1.6M |
| Vanguard Fiduciary Trust Co. | 0.00% | Add +26.5% | 145,401 | $1.4M |
| Vanguard Portfolio Management LLC | 0.00% | New | 134,818 | $1.3M |
| Marshall Wace, LLP | 0.00% | No change | 128,451 | $1.3M |
| Renaissance Technologies | 0.00% | Add +2.7% | 108,214 | $1.1M |
| C WorldWide Group Holding A/S | 0.02% | No change | 100,000 | $977K |
| Jump Financial, LLC | 0.01% | Reduce -64.1% | 94,000 | $918K |
| Invesco Ltd. | 0.00% | Add +439.5% | 90,304 | $882K |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | Reduce -3.4% | 76,397 | $746K |
| Bridgeway Capital Management, LLC | 0.01% | No change | 71,873 | $702K |
| J. Goldman & Co LP | 0.02% | New | 67,500 | $659K |
| Squarepoint Ops LLC | 0.00% | New | 63,801 | $623K |
| Charles Schwab Investment Management Inc. | 0.00% | Add +361.3% | 61,943 | $605K |
| Royal Bank of Canada | 0.00% | Add +0.1% | 60,430 | $590K |
| Bank of New York Mellon Corp | 0.00% | Add +402.3% | 57,262 | $559K |
| Susquehanna Portfolio Strategies, LLC | 0.01% | Add +118.0% | 54,545 | $533K |
| XTX Topco Ltd | 0.01% | Reduce -67.6% | 53,272 | $520K |
| Citadel Advisors | 0.00% | New | 52,069 | $509K |
| Bank of America Corp. | 0.00% | Add +156.4% | 49,924 | $488K |
| Citigroup Inc. | 0.00% | Add +667.4% | 37,917 | $370K |
| Nuveen, LLC | 0.00% | New | 37,868 | $370K |
| Engineers Gate Manager LP | 0.00% | Reduce -69.8% | 33,966 | $332K |
| Nomura Asset Management International Inc. | 0.00% | New | 33,333 | $326K |
| Jane Street Group, LLC | 0.00% | Reduce -68.7% | 33,173 | $324K |
| Toronto Dominion Bank | 0.00% | New | 30,930 | $302K |
| Silverback Asset Management LLC | 1.10% | Reduce -53.9% | 30,000 | $293K |
| Baird Financial Group, Inc. | 0.00% | No change | 29,791 | $291K |
| T. Rowe Price Associates Inc. | 0.00% | Add +150.1% | 27,225 | $266K |
| ExodusPoint Capital Management, LP | 0.00% | New | 26,582 | $260K |
| China Universal Asset Management Co., Ltd. | 0.01% | Reduce -16.7% | 25,000 | $244K |
| Simplex Trading, LLC | 0.01% | New | 24,086 | $235K |
| Rhumbline Advisers | 0.00% | New | 23,467 | $229K |
| Susquehanna Fundamental Investments, LLC | 0.00% | New | 23,265 | $227K |
| Velan Capital Investment Management LP | 0.12% | Add +33.3% | 20,000 | $195K |
| Deutsche Bank AG | 0.00% | New | 19,425 | $190K |
| Wells Fargo & Company | 0.00% | New | 16,903 | $165K |
| Sei Investments Co. | 0.00% | New | 15,083 | $147K |
| HSBC Holdings PLC | 0.00% | Add +19.6% | 13,750 | $137K |
| Headlands Technologies LLC | 0.01% | New | 12,113 | $118K |
| MetLife Investment Management, LLC | 0.00% | New | 12,017 | $117K |
| Virtu Financial LLC | 0.00% | New | 10,728 | $105K |
| Y-Intercept (Hong Kong) Ltd | 0.00% | New | 10,375 | $101K |
| Quadrature Capital Ltd | 0.00% | New | 10,296 | $101K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | New | 9,171 | $90K |
| FMR LLC | 0.00% | Add +1243.8% | 8,936 | $87K |
| Vanguard Global Advisers, LLC | 0.00% | No change | 8,207 | $80K |
| Police & Firemen's Retirement System of New Jersey | 0.00% | New | 5,874 | $57K |
| New York State Common Retirement Fund | 0.00% | New | 5,600 | $55K |
| TD Waterhouse Canada Inc. | 0.00% | Add +78.2% | 5,707 | $55K |
| Legal & General Group Plc | 0.00% | New | 1,935 | $19K |
| Ameritas Investment Partners, Inc. | 0.00% | New | 1,808 | $18K |
| Russell Investments Group, Ltd. | 0.00% | New | 1,592 | $16K |
| Tower Research Capital LLC (TRC) | 0.00% | New | 1,259 | $12K |
| Osaic Holdings, Inc. | 0.00% | No change | 402 | $4K |
| Sterling Capital Management LLC | 0.00% | New | 352 | $3K |
| Harbour Investments, Inc. | 0.00% | No change | 285 | $3K |
| California State Teachers Retirement System | 0.00% | New | 274 | $3K |
| Quent Capital, LLC | 0.00% | Reduce -29.4% | 166 | $2K |
| Mb, Levis & Associates, LLC | 0.00% | No change | 100 | $977 |
| SBI Securities Co., Ltd. | 0.00% | No change | 67 | $655 |
| Activest Wealth Management | 0.00% | No change | 66 | $645 |
| Allworth Financial LP | 0.00% | No change | 26 | $255 |
| Caitong International Asset Management Co., Ltd | 0.00% | New | 14 | $137 |
| West Branch Capital LLC | 0.00% | No change | 3 | $30 |
| PlanVest Financial, Inc | 0.00% | No change | 1 | $10 |
"% of holder's portfolio" is KPTI's weight in each manager's 13F, not the share of Karyopharm Therapeutics Inc. the manager owns.