| CLDX Celldex Therapeutics Inc. | 11.75% | 6,100,729 | $157.8M | No change |
| SNDX Syndax Pharmaceuticals Inc. | 9.76% | 8,520,000 | $131.1M | No change |
| VERA Vera Therapeutics Inc. | 8.71% | 4,027,800 | $117.0M | Add +17.5% |
| COGT Cogent Biosciences Inc. | 8.43% | 7,886,172 | $113.2M | Reduce -7.1% |
| PCVX Vaxcyte Inc. | 8.24% | 3,071,588 | $110.6M | No change |
| VRDN Viridian Therapeutics Inc. | 7.11% | 4,427,927 | $95.6M | No change |
| CGON CG Oncology Inc. | 6.01% | 2,005,205 | $80.8M | Reduce -18.4% |
| BCRX Biocryst Pharmaceuticals Inc. | 5.31% | 9,390,270 | $71.3M | Add +10.9% |
| BEAM Beam Therapeutics Inc. | 4.55% | 2,517,647 | $61.1M | Add +4.1% |
| IMCR Immunocore Holdings PLC-ADR | 2.73% | 1,009,267 | $36.7M | Add +3.4% |
| MBX MBX Biosciences Inc. | 2.61% | 2,000,000 | $35.0M | New |
| ENGN Engene Holdings Inc. | 2.54% | 4,994,090 | $34.1M | No change |
| WVE Wave Life Sciences Ltd. | 2.49% | 4,560,053 | $33.4M | No change |
| TYRA Tyra Biosciences Inc. | 2.43% | 2,329,998 | $32.6M | No change |
| TVTX Travere Therapeutics Inc. | 1.69% | 949,727 | $22.7M | Reduce -38.4% |
| DVAX Dynavax Technologies Corp. | 1.59% | 2,145,319 | $21.3M | No change |
| NRIX Nurix Therapeutics Inc. | 1.49% | 2,168,605 | $20.0M | Add +84.8% |
| UTHR United Therapeutics Corp. | 1.49% | 67,588 | $20.0M | New |
| APLS Apellis Pharmaceuticals Inc. | 1.36% | 808,607 | $18.3M | New |
| PHVS Pharvaris NV | 1.25% | 675,000 | $16.8M | New |
| RLAY Relay Therapeutics Inc. | 1.12% | 2,887,014 | $15.1M | No change |
| CGEM Cullinan Therapeutics Inc. | 1.02% | 2,302,172 | $13.7M | Add +9.8% |
| CTMX Cytomx Therapeutics Inc. | 0.87% | 3,646,503 | $11.6M | Add +69.3% |
| AMRN Amarin Corp. PLC -ADR | 0.70% | 576,111 | $9.4M | No change |
| BNR Burning Rock Biotech Ltd.-ADR | 0.64% | 994,883 | $8.6M | No change |
| DSGN Design Therapeutics Inc. | 0.58% | 1,029,579 | $7.8M | No change |
| KALV Kalvista Pharmaceuticals Inc. | 0.55% | 606,171 | $7.4M | New |
| IRWD Ironwood Pharmaceuticals Inc. | 0.53% | 5,466,825 | $7.2M | No change |
| CRBU Caribou Biosciences Inc. | 0.53% | 3,067,774 | $7.1M | No change |
| URGN Urogen Pharma Ltd. | 0.52% | 282,412 | $6.9M | Reduce -57.0% |
| GERN Geron Corp. | 0.35% | 3,456,318 | $4.7M | No change |
| STRO Sutro Biopharma Inc. Com SHS | 0.33% | 5,088,099 | $4.4M | No change |
| EWTX Edgewise Therapeutics Inc. | 0.31% | 253,979 | $4.1M | No change |
| PRQR Proqr Therapeutics NV | 0.26% | 1,649,462 | $3.5M | No change |
| CLYM Climb Bio Inc. | 0.15% | 1,028,341 | $2.1M | No change |