Nantahala Capital Management, LLC

In its 13F for Q3 2025 (holdings as of September 30, 2025, filed November 14, 2025), Nantahala Capital Management, LLC reported 127 stock positions worth $1.6 billion. Its top holding was Establishment Labs (ESTA) at 5.0% of the portfolio, followed by Hilton Grand Vacations (HGV, 4.3%) and Bancorp (TBBK, 4.0%). Compared with Q2 2025, it opened 17 new positions, sold out of 23, added to 24 and reduced 31. The biggest buy was a new position in Fractyl Health (GUTS) and the biggest sale Soleno Therapeutics (SLNO, shares −14%).

Most Recent 13F
Q2 2026
Location
NEW CANAAN, CT
CIK
0001472322
Portfolio Value
$1.6B (Q3 2025)
SEC Filing
0001104659-25-112624 ↗ filed Nov 14, 2025

Holdings Value

0$500.0M$1.0B$1.5B$2.0B Q1 2024: $1.0B Q1 2024 Q2 2024: $994.2M Q2 2024 Q3 2024: $1.2B Q3 2024 Q4 2024: $1.4B Q4 2024 Q1 2025: $1.2B Q1 2025 Q2 2025: $1.4B Q2 2025 Q3 2025: $1.6B $1.6B Q3 2025 Q4 2025: $1.7B Q4 2025 Q1 2026: $1.6B Q1 2026 Q2 2026: $1.6B Q2 2026

Holdings 127 stocks · $1.6B

ESTA Establishment Labs Holdings 5.01% 1,973,492 $80.9M Add +11.2%
HGV Hilton Grand Vacations Inc. 4.32% 1,667,753 $69.7M Reduce -16.1%
TBBK The Bancorp Inc. 3.95% 852,334 $63.8M Reduce -12.0%
QURE Uniqure NV 3.64% 1,007,492 $58.8M Reduce -50.9%
SLNO Soleno Therapeutics Inc. 3.61% 863,763 $58.4M Reduce -13.7%
ABVX Abivax SA-ADR 2.93% 557,564 $47.3M Reduce -62.4%
XTNT Xtant Medical Holdings Inc. 2.75% 68,394,000 $44.4M No change
FULC Fulcrum Therapeutics Inc. 2.66% 4,670,784 $43.0M Add +8.9%
AMRX Amneal Pharmaceuticals Inc. 2.62% 4,224,564 $42.3M Reduce -3.3%
BVS Bioventus Inc. Class A 2.41% 5,810,662 $38.9M Add +10.0%
EOLS Evolus Inc. 2.18% 5,726,857 $35.2M Add +36.4%
PTON Peloton Interactive Inc. Class A 2.06% 3,697,700 $33.3M Add +13.2%
IMAX Imax Corp. 2.02% 996,150 $32.6M Reduce -12.2%
SVRA Savara Inc. 1.94% 8,775,375 $31.3M Add +5.4%
ETON Eton Pharmaceuticals Inc. 1.58% 1,175,951 $25.6M No change
ABEO Abeona Therapeutics Inc. 1.49% 4,564,665 $24.1M Add +4.5%
NKTR Nektar Therapeutics 1.47% 418,522 $23.8M Reduce -41.0%
COGT Cogent Biosciences Inc. 1.34% 1,506,989 $21.6M Reduce -9.0%
KROS Keros Therapeutics Inc. 1.21% 1,233,189 $19.5M Reduce -23.9%
GUTS Fractyl Health Inc. 1.19% 12,136,917 $19.3M New
SVC Service Pptys TR 1.18% 7,057,887 $19.1M Reduce -12.4%
IRON Disc Medicine Inc. 1.18% 287,800 $19.0M No change
CRMT America's Car-Mart Inc. 1.17% 644,686 $18.8M No change
ZVRA Zevra Therapeutics Inc. 1.16% 1,971,936 $18.8M Add +34.0%
TITN Titan Machinery Inc. 1.14% 1,096,232 $18.4M Reduce -3.5%
RMR RMR Group Inc./the - A 1.12% 1,147,902 $18.1M No change
FOXF Fox Factory Holding Corp. 1.10% 728,648 $17.7M No change
EB Eventbrite Inc. Class A 1.07% 6,831,395 $17.2M Add +7.0%
GMED Globus Medical Inc. Class A 1.06% 300,000 $17.2M New
RAPT Rapt Therapeutics Inc. 0.99% 623,282 $16.1M Reduce -34.5%
AVTX Avalo Therapeutics Inc. 0.97% 1,235,000 $15.7M Add +24.1%
PVLA Palvella Therapeutics Inc. 0.97% 250,062 $15.7M No change
FLWS 1-800-Flowers.com Inc. Class A 0.96% 3,368,065 $15.5M Add +68.4%
TNGX Tango Therapeutics Inc. 0.94% 1,809,948 $15.2M Reduce -47.4%
DNTH Dianthus Therapeutics Inc. 0.91% 375,000 $14.8M New
RDNW Ridenow Group Inc. 0.89% 3,272,845 $14.4M No change
AURA Aura Biosciences Inc. 0.81% 2,117,697 $13.1M No change
XNCR Xencor Inc. 0.80% 1,100,000 $12.9M Add +34.1%
AMLX Amylyx Pharmaceuticals Inc. 0.79% 935,684 $12.7M Reduce -68.1%
GERN Geron Corp. 0.77% 9,025,000 $12.4M New
JACK Jack in the Box Inc. 0.73% 600,000 $11.9M No change
BNTC Benitec Biopharma Inc. 0.73% 838,095 $11.8M No change
VSTM Verastem Inc. 0.71% 1,292,903 $11.4M Reduce -56.2%
UPB Upstream Bio Inc. 0.69% 594,971 $11.2M No change
LBRX LB Pharmaceuticals Inc. 0.66% 675,000 $10.7M New
SLDB Solid Biosciences Inc. 0.65% 1,699,258 $10.5M Reduce -0.2%
JCAP Jefferson Capital Inc. 0.64% 600,000 $10.4M No change
GPCR Structure Therapeutics Inc. 0.64% 368,553 $10.3M Add +118.7%
MDXG Mimedx Group Inc. 0.63% 1,466,566 $10.2M New
CMPS Compass Pathways PLC 0.61% 1,729,930 $9.9M Reduce -58.6%
CDXS Codexis Inc. 0.61% 4,030,619 $9.8M No change
CNTA Centessa Pharmaceuticals Ltd. 0.61% 404,803 $9.8M Reduce -27.0%
DRIO Dariohealth Corp. 0.60% 563,233 $9.8M Add +565.6%
ILPT Industrial Logistics Propert 0.60% 1,675,273 $9.8M Reduce -47.8%
FOSL Fossil Group Inc. 0.59% 3,741,157 $9.6M Reduce -26.5%
TLSI Trisalus Life Sciences Inc. 0.59% 2,040,245 $9.5M Add +2.0%
ADCT Adc Therapeutics SA 0.56% 2,266,289 $9.1M No change
DYN Dyne Therapeutics Inc. 0.55% 702,884 $8.9M Reduce -5.7%
AVR Anteris Technologies Global 0.53% 1,918,666 $8.6M Add +13.3%
RDVT Red Violet Inc. 0.53% 164,339 $8.6M Reduce -15.4%
CYTK Cytokinetics Inc. 0.51% 150,000 $8.2M New
NSPR Inspiremd Inc. 0.50% 3,376,484 $8.1M Add +45.7%
HLF Herbalife Ltd. 0.49% 942,431 $8.0M Add +14.6%
ATXS Astria Therapeutics Inc. 0.48% 1,069,530 $7.8M No change
ASSERTIO HOLDINGS INC 0.48% 8,810,073 $7.8M No change
RSVR Reservoir Media Inc. 0.48% 950,960 $7.7M Reduce -34.1%
XFOR X4 Pharmaceuticals Inc. 0.47% 2,228,350 $7.6M New
TELA Tela Bio Inc. 0.47% 5,111,588 $7.6M No change
EHTH Ehealth Inc. 0.47% 1,761,441 $7.6M Add +34.3%
ANEB Anebulo Pharmaceuticals Inc. 0.47% 3,036,325 $7.6M No change
DCTH Delcath Systems Inc. 0.44% 666,435 $7.2M New
APYX Apyx Medical Corp. 0.44% 3,338,048 $7.1M No change
VTGN Vistagen Therapeutics Inc. 0.43% 1,978,492 $7.0M No change
DSGR Distribution Solutions Group 0.43% 230,339 $6.9M Add +9.3%
ALTG Alta Equipment Group Inc. 0.42% 934,774 $6.8M Reduce -10.4%
DHX Dhi Group Inc. 0.41% 2,374,027 $6.6M No change
CMCO Columbus McKinnon Corp. 0.40% 450,000 $6.5M Add +121.0%
VMD Viemed Healthcare Inc. 0.39% 932,445 $6.3M No change
STKS One Group Hospitality Inc. filed as THE ONE GROUP HOSPITALITY IN 0.39% 2,121,084 $6.3M No change
MLYS Mineralys Therapeutics Inc. 0.37% 158,713 $6.0M Reduce -55.2%
DXLG Destination XL Group Inc. 0.37% 4,505,000 $5.9M Add +74.8%
IRD Opus Genetics Inc. 0.34% 3,345,923 $5.5M No change
AKBA Akebia Therapeutics Inc. 0.34% 2,000,000 $5.5M No change
GAIA Gaia Inc. 0.34% 914,618 $5.4M No change
SLN Silence Therapeutics PLC-ADR 0.33% 1,042,427 $5.4M No change
NNBR NN Inc. 0.31% 2,441,416 $5.0M No change
QUINCE THERAPEUTICS INC 0.31% 3,073,729 $5.0M Add +21.6%
SCPH Scpharmaceuticals Inc. 0.30% 861,277 $4.9M Reduce -13.5%
KOD Kodiak Sciences Inc. 0.29% 290,884 $4.8M Reduce -50.8%
HAIN Hain Celestial Group Inc. 0.29% 3,000,000 $4.7M No change
CGON CG Oncology Inc. 0.27% 109,449 $4.4M New
BRC INC-A 0.25% 2,630,517 $4.1M New
UNCY Unicycive Therapeutics Inc. 0.25% 939,202 $4.1M No change
AGIO Agios Pharmaceuticals Inc. 0.25% 100,000 $4.0M New
RYAM Rayonier Advanced Materials 0.23% 510,510 $3.7M New
IKT Inhibikase Therapeutics Inc. 0.22% 2,190,000 $3.5M No change
GRCE Grace Therapeutics Inc. 0.22% 1,178,203 $3.5M No change
AQST Aquestive Therapeutics Inc. 0.21% 600,000 $3.4M New
TLPH Talphera Inc. 0.19% 3,492,519 $3.1M Add +75.3%
NPCE Neuropace Inc. 0.19% 295,089 $3.0M No change
SRZN Surrozen Inc. 0.18% 229,527 $3.0M No change
ELDN Eledon Pharmaceuticals Inc. 0.18% 1,141,237 $3.0M No change
PAYO Payoneer Global Inc. 0.18% 483,836 $2.9M No change
NDLS Noodles & Co. 0.18% 4,505,489 $2.9M No change
KOS Kosmos Energy Ltd. 0.18% 1,716,593 $2.8M No change
ELUT Elutia Inc. 0.18% 3,184,947 $2.8M No change
RDI Reading International Inc. Class A 0.17% 1,921,088 $2.8M No change
CZR Caesars Entertainment Inc. 0.17% 98,879 $2.7M No change
MAZE Maze Therapeutics Inc. 0.15% 93,351 $2.4M New
SRL Scully Royalty Ltd. 0.14% 368,182 $2.2M No change
ACHV Achieve Life Sciences Inc. 0.13% 648,885 $2.0M Reduce -27.8%
AYTU Aytu Biopharma Inc. 0.13% 1,086,812 $2.0M No change
CNTX Context Therapeutics Inc. 0.10% 1,661,950 $1.6M Reduce -14.1%
EDSA Edesa Biotech Inc. 0.10% 625,000 $1.5M No change
BIOMX INC 0.08% 2,493,309 $1.3M No change
SNTI Senti Biosciences Inc. 0.08% 888,000 $1.3M No change
PERF Perfect Corp. 0.07% 583,925 $1.1M No change
KIDS Orthopediatrics Corp. 0.06% 49,449 $916K New
ACU Acme United Corp. filed as ACME UTD CORP 0.05% 20,427 $841K No change
SSKN Strata Skin Sciences Inc. 0.05% 403,917 $832K No change
EVOK Evoke Pharma Inc. 0.05% 148,153 $736K No change
SGRP Spar Group Inc. 0.04% 660,688 $681K No change
CASH Pathward Financial Inc. 0.04% 8,341 $617K No change
KPRX Kiora Pharmaceuticals Inc. 0.03% 156,427 $435K Reduce -25.9%
APRE Aprea Therapeutics Inc. 0.02% 205,760 $303K No change
ANIK Anika Therapeutics Inc. 0.01% 20,961 $197K New
LUCD Lucid Diagnostics Inc. 0.01% 94,541 $95K No change

Options reported separately and not counted above: IWM puts ($641.2M), EW puts ($140.0M), XBI puts ($70.1M), HLF calls ($57.4M), TEVA calls ($50.5M), VTRS calls ($49.5M), PTON calls ($40.5M), KRYS puts ($35.3M), CWH calls ($31.6M), HGV calls ($24.0M), REGN calls ($22.5M), LYV puts ($21.3M), and 10 more.

Other holdings (4): bonds, preferreds, convertibles and warrants · $3.2M (not counted above)
SecurityClassShares / PrincipalValueChange
ASPSW Altisource Portfolio - 30 *W EXP 04/30/203 2,477,312$1.7MNo change
ASPSZ Altisource Portfolio - 29C *W EXP 04/02/202 2,477,312$1.4MNo change
GFAIW Guardforce AI Co. Ltd. -CW26 *W EXP 10/01/202 154,205$29KNo change
PERFF Perfect Corp. *W EXP 10/28/202 16,075$348No change

Total filed on the 13F, all lines: $1.6B.

Portfolio Sells Q2 2025 → Q3 2025

SLNO Soleno Therapeutics Inc. Reduce -13.7% 3.61% −2.33
HGV Hilton Grand Vacations Inc. Reduce -16.1% 4.32% −1.54
THRD Third Harmonic Bio Inc. Sold out 0.00% −1.13
GOGO Gogo Inc. Sold out 0.00% −1.09
RZLT Rezolute Inc. Sold out 0.00% −0.72
TRML Tourmaline Bio Inc. Sold out 0.00% −0.63
DKS Dick's Sporting Goods Inc. Sold out 0.00% −0.56
AMLX Amylyx Pharmaceuticals Inc. Reduce -68.1% 0.79% −0.55
SNDX Syndax Pharmaceuticals Inc. Sold out 0.00% −0.50
TITN Titan Machinery Inc. Reduce -3.5% 1.14% −0.46
ILPT Industrial Logistics Propert Reduce -47.8% 0.60% −0.43
ITOS Iteos Therapeutics Inc. Sold out 0.00% −0.42
THTX Theratechnologies Inc. Sold out 0.00% −0.41
EYPT Eyepoint Inc. Sold out 0.00% −0.40
KROS Keros Therapeutics Inc. Reduce -23.9% 1.21% −0.33
CRGX Cargo Therapeutics Inc. Sold out 0.00% −0.32
TNGX Tango Therapeutics Inc. Reduce -47.4% 0.94% −0.31
RSVR Reservoir Media Inc. Reduce -34.1% 0.48% −0.30
VERV Verve Therapeutics Inc. Sold out 0.00% −0.26
IMAX Imax Corp. Reduce -12.2% 2.02% −0.23
CMPS Compass Pathways PLC Reduce -58.6% 0.61% −0.22
SVC Service Pptys TR Reduce -12.4% 1.18% −0.18
NVNO Envveno Medical Corporation Sold out 0.00% −0.17
VSTM Verastem Inc. Reduce -56.2% 0.71% −0.16
RDVT Red Violet Inc. Reduce -15.4% 0.53% −0.15
YMAB Y-Mabs Therapeutics Inc. Sold out 0.00% −0.11
ALTISOURCE PORTFOLIO SOLNS S Sold out 0.00% −0.08
OLPX Olaplex Holdings Inc. Sold out 0.00% −0.06
ALTG Alta Equipment Group Inc. Reduce -10.4% 0.42% −0.05
FBIO Fortress Biotech Inc. Sold out 0.00% −0.04
XGN Exagen Inc. Sold out 0.00% −0.03
LADR Ladder Capital Corp.-REIT Sold out 0.00% −0.02
PLCE The Children's Place Inc. Sold out 0.00% −0.02
ACHV Achieve Life Sciences Inc. Reduce -27.8% 0.13% −0.02
KPRX Kiora Pharmaceuticals Inc. Reduce -25.9% 0.03% −0.02
OKUR Onkure Therapeutics Inc. Class A Sold out 0.00% −0.01
URGN Urogen Pharma Ltd. Sold out 0.00% −0.01
TACT Transact Technologies Inc. Sold out 0.00% −0.00
BDSX Biodesix Inc. Sold out 0.00% −0.00
CNTX Context Therapeutics Inc. Reduce -14.1% 0.10% +0.01
MLYS Mineralys Therapeutics Inc. Reduce -55.2% 0.37% +0.03
SCPH Scpharmaceuticals Inc. Reduce -13.5% 0.30% +0.03
TBBK The Bancorp Inc. Reduce -12.0% 3.95% +0.04
DYN Dyne Therapeutics Inc. Reduce -5.7% 0.55% +0.05
SLDB Solid Biosciences Inc. Reduce -0.2% 0.65% +0.06
FOSL Fossil Group Inc. Reduce -26.5% 0.59% +0.06
CNTA Centessa Pharmaceuticals Ltd. Reduce -27.0% 0.61% +0.09
AMRX Amneal Pharmaceuticals Inc. Reduce -3.3% 2.62% +0.11
KOD Kodiak Sciences Inc. Reduce -50.8% 0.29% +0.14
NKTR Nektar Therapeutics Reduce -41.0% 1.47% +0.17

Portfolio Buys Q2 2025 → Q3 2025

GUTS Fractyl Health Inc. New 1.19% +1.19
GMED Globus Medical Inc. Class A New 1.06% +1.06
DNTH Dianthus Therapeutics Inc. New 0.91% +0.91
GERN Geron Corp. New 0.77% +0.77
LBRX LB Pharmaceuticals Inc. New 0.66% +0.66
MDXG Mimedx Group Inc. New 0.63% +0.63
AVTX Avalo Therapeutics Inc. Add +24.1% 0.97% +0.62
SVRA Savara Inc. Add +5.4% 1.94% +0.59
FULC Fulcrum Therapeutics Inc. Add +8.9% 2.66% +0.57
DRIO Dariohealth Corp. Add +565.6% 0.60% +0.52
CYTK Cytokinetics Inc. New 0.51% +0.51
XFOR X4 Pharmaceuticals Inc. New 0.47% +0.47
PTON Peloton Interactive Inc. Class A Add +13.2% 2.06% +0.45
DCTH Delcath Systems Inc. New 0.44% +0.44
GPCR Structure Therapeutics Inc. Add +118.7% 0.64% +0.39
XNCR Xencor Inc. Add +34.1% 0.80% +0.34
CGON CG Oncology Inc. New 0.27% +0.27
FLWS 1-800-Flowers.com Inc. Class A Add +68.4% 0.96% +0.26
BRC INC-A New 0.25% +0.25
AGIO Agios Pharmaceuticals Inc. New 0.25% +0.25
ZVRA Zevra Therapeutics Inc. Add +34.0% 1.16% +0.24
RYAM Rayonier Advanced Materials New 0.23% +0.23
AQST Aquestive Therapeutics Inc. New 0.21% +0.21
CMCO Columbus McKinnon Corp. Add +121.0% 0.40% +0.18
DXLG Destination XL Group Inc. Add +74.8% 0.37% +0.16
MAZE Maze Therapeutics Inc. New 0.15% +0.15
NSPR Inspiremd Inc. Add +45.7% 0.50% +0.13
TLPH Talphera Inc. Add +75.3% 0.19% +0.13
AVR Anteris Technologies Global Add +13.3% 0.53% +0.08
EHTH Ehealth Inc. Add +34.3% 0.47% +0.07
KIDS Orthopediatrics Corp. New 0.06% +0.06
DSGR Distribution Solutions Group Add +9.3% 0.43% +0.02
QUINCE THERAPEUTICS INC Add +21.6% 0.31% +0.01
ANIK Anika Therapeutics Inc. New 0.01% +0.01
HLF Herbalife Ltd. Add +14.6% 0.49% −0.01
BVS Bioventus Inc. Class A Add +10.0% 2.41% −0.07
EB Eventbrite Inc. Class A Add +7.0% 1.07% −0.12
TLSI Trisalus Life Sciences Inc. Add +2.0% 0.59% −0.19
ABEO Abeona Therapeutics Inc. Add +4.5% 1.49% −0.27
ESTA Establishment Labs Holdings Add +11.2% 5.01% −0.37
EOLS Evolus Inc. Add +36.4% 2.18% −0.56

Options Activity Q2 2025 → Q3 2025

IWM iShares Russell 2000 ETF put Reduce -26.4% 2,650,000 $641.2M
EW Edwards Lifesciences Corp. put New 1,800,000 $140.0M
XBI SS SPDR S&P Biotech ETF put Reduce -12.5% 700,000 $70.1M
HLF Herbalife Ltd. call Add +7.9% 6,800,000 $57.4M
TEVA Teva Pharmaceutical-SP ADR call Add +150.0% 2,500,000 $50.5M
PTON Peloton Interactive Inc. Class A call Add +50.0% 4,500,000 $40.5M
CWH Camping World Holdings Inc. Class A call Add +100.0% 2,000,000 $31.6M
REGN Regeneron Pharmaceuticals call New 40,000 $22.5M
GMED Globus Medical Inc. Class A call Sold out 300,000 $17.7Mbefore exit
HOOD Robinhood Markets Inc. Class A put New 100,000 $14.3M
URGN Urogen Pharma Ltd. call Sold out 1,000,000 $13.7Mbefore exit
ALGN Align Technology Inc. call New 100,000 $12.5M
SLNO Soleno Therapeutics Inc. call New 100,000 $6.8M
EOLS Evolus Inc. call Sold out 100,000 $921Kbefore exit

Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.

Notes & Other Activity Q2 2025 → Q3 2025

IMTXW Immatics NV -CW *W EXP 07/01/202 Sold out 248,506 $149before exit

Bonds, preferreds, convertibles and warrants; not part of the stock holdings or percentages above.

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026Amended 128$1.6BTBBK, BVS, HGV, SVRA, ETON
Q1 2026 125$1.6BTBBK, HGV, SLNO, BVS, PTON
Q4 2025 127$1.7BTBBK, ESTA, HGV, SLNO, XTNT
Q3 2025 127$1.6BESTA, HGV, TBBK, QURE, SLNO
Q2 2025 133$1.4BSLNO, HGV, ESTA, TBBK, XTNT
Q1 2025 126$1.2BSLNO, HGV, ESTA, EOLS, TBBK
Q4 2024 118$1.4BSLNO, ESTA, HGV, PTON, TBBK
Q3 2024 119$1.2BSLNO, ESTA, BVS, PTON, EOLS
Q2 2024Amended 113$994.2MSLNO, ESTA, PTON, EOLS, BVS
Q1 2024 107$1.0BSLNO, ESTA, CASH, EOLS, IMAX