Upstream BioUPB
13F holders, Q2 2026 (June 30)148holders +8
35new positions
29sold out
5famous investors
$6.92avg. 13F price*
At the end of Q2 2026, 148 institutions reported holding Upstream Bio Inc. (UPB) in their 13F filings, up 8 from Q1 2026. 35 opened new positions and 29 sold out. The largest holders were FMR LLC ($56.5M), Orbimed Advisors LLC ($39.4M) and Norges Bank ($26.1M). 5 famous investors held it, including Israel Englander (0.0% of Millennium Management's portfolio), Steve Cohen (0.0% of Point72 Asset Management's portfolio) and David E. Shaw (0.0% of D. E. Shaw & Co.'s portfolio).
- Company
- Upstream Bio Inc.
- CUSIP
- 91678A107
- Latest filing quarter
- Q2 2026
History
Number of 13F holders
Total Exit/New Position Q1 2026 → Q2 2026
| Institutions | Total Value | |
|---|---|---|
| New Positions | 35 | $13.3M |
| Exits | 29 | $28.1M |
All 13F filers, Q1 2026 → Q2 2026: 7,122,481 shares bought and 5,204,375 shares sold, net +1,918,106 shares. Counts holders who added, trimmed, opened or closed a position; split-adjusted.
Ownership 148 holders
| FMR LLC | 0.00% | Add +0.8% | 8,162,897 | $56.5M |
| Orbimed Advisors LLC | 0.75% | No change | 5,693,589 | $39.4M |
| Norges Bank | 0.00% | — | 3,768,619 | $26.1M |
| BlackRock, Inc. | 0.00% | Add +11.3% | 3,753,358 | $26.0M |
| Decheng Capital LLC | 2.58% | No change | 2,724,868 | $18.9M |
| Enavate Sciences Gp, LLC | 4.93% | No change | 2,459,703 | $17.0M |
| Vanguard Capital Management LLC | 0.00% | Add +0.2% | 1,876,734 | $13.0M |
| Millennium Management | 0.01% | Add +22.0% | 1,143,775 | $7.9M |
| D. E. Shaw & Co. | 0.00% | Add +26.3% | 1,036,044 | $7.2M |
| JPMorgan Chase & Co. | 0.00% | Add +118.6% | 1,012,044 | $7.0M |
| Qube Research & Technologies Ltd | 0.01% | Add +58.0% | 978,500 | $6.8M |
| Parkman Healthcare Partners LLC | 0.66% | Add +18.9% | 935,247 | $6.5M |
| Geode Capital Management, LLC | 0.00% | Reduce -2.0% | 931,261 | $6.4M |
| SEB Asset Management AB | 0.02% | No change | 878,473 | $6.1M |
| Woodline Partners LP | 0.02% | No change | 831,481 | $5.8M |
| State Street Corp. | 0.00% | Add +8.6% | 766,323 | $5.3M |
| Vanguard Portfolio Management LLC | 0.00% | Reduce -2.1% | 712,667 | $4.9M |
| Y-Intercept (Hong Kong) Ltd | 0.10% | Reduce -30.7% | 693,555 | $4.8M |
| Bain Capital Life Sciences Investors, LLC | 0.25% | Reduce -30.7% | 600,949 | $4.2M |
| AQR Capital Management | 0.00% | Add +655.0% | 544,869 | $3.8M |
| Morgan Stanley | 0.00% | Reduce -5.1% | 524,632 | $3.6M |
| BNP Paribas Financial Markets | 0.00% | Add +306.0% | 511,546 | $3.5M |
| Walleye Capital LLC | 0.02% | New | 498,490 | $3.4M |
| Trexquant Investment LP | 0.02% | Add +164.0% | 466,430 | $3.2M |
| Point72 Asset Management | 0.01% | Add +154.3% | 453,011 | $3.1M |
| Bank of America Corp. | 0.00% | Add +708.4% | 391,762 | $2.7M |
| Dimensional Fund Advisors LP | 0.00% | Add +377.0% | 381,613 | $2.6M |
| Altshuler Shaham Ltd | 0.03% | No change | 380,061 | $2.6M |
| Arrowstreet Capital, Limited Partnership | 0.00% | Add +93.3% | 357,756 | $2.5M |
| Samsara Biocapital, LLC | 0.20% | Reduce -51.9% | 353,717 | $2.4M |
| Propel Bio Management, LLC | 1.27% | Add +2.5% | 350,389 | $2.4M |
| Wellington Management Group LLP | 0.00% | No change | 342,353 | $2.4M |
| Northern Trust Corp. | 0.00% | Add +13.9% | 297,346 | $2.1M |
| Squarepoint Ops LLC | 0.00% | Add +551.9% | 290,904 | $2.0M |
| Voleon Capital Management LP | 0.04% | New | 285,234 | $2.0M |
| Charles Schwab Investment Management Inc. | 0.00% | Add +1.8% | 262,456 | $1.8M |
| Jacobs Levy Equity Management, Inc. | 0.01% | New | 253,092 | $1.8M |
| Goldman Sachs Group Inc. | 0.00% | Reduce -22.0% | 246,917 | $1.7M |
| XTX Topco Ltd | 0.02% | Add +15.8% | 242,346 | $1.7M |
| Deutsche Bank AG | 0.00% | Add +33.5% | 241,447 | $1.7M |
| Vanguard Fiduciary Trust Co. | 0.00% | Add +6.9% | 239,616 | $1.7M |
| UBS Group AG | 0.00% | Add +1.5% | 234,714 | $1.6M |
| Schonfeld Strategic Advisors LLC | 0.01% | Add +39.9% | 225,760 | $1.6M |
| Jump Financial, LLC | 0.02% | Reduce -30.1% | 223,223 | $1.5M |
| Sphera Funds Management LTD. | 0.22% | Reduce -38.6% | 219,700 | $1.5M |
| Acadian Asset Management LLC | 0.00% | New | 175,110 | $1.2M |
| HRT Financial LP | 0.00% | New | 170,590 | $1.2M |
| Boxer Capital Management, LLC | 0.08% | No change | 150,000 | $1.0M |
| Renaissance Technologies | 0.00% | Add +111.4% | 131,300 | $909K |
| EntryPoint Capital, LLC | 0.22% | Add +76.0% | 129,446 | $896K |
| Algert Global LLC | 0.01% | New | 118,630 | $821K |
| Bank of New York Mellon Corp | 0.00% | Add +5.4% | 85,747 | $593K |
| Nuveen, LLC | 0.00% | Add +12.2% | 84,770 | $587K |
| American Century Companies Inc. | 0.00% | Reduce -10.8% | 78,194 | $541K |
| Man Group plc | 0.00% | Add +249.0% | 73,823 | $511K |
| Gsa Capital Partners LLP | 0.03% | Add +76.8% | 69,348 | $480K |
| Alliancebernstein L.P. | 0.00% | Add +66.7% | 51,680 | $465K |
| Simplify Asset Management Inc. | 0.01% | Reduce -20.2% | 62,113 | $430K |
| Alps Advisors Inc. | 0.00% | Add +25.5% | 55,228 | $382K |
| Quantinno Capital Management LP | 0.00% | Add +11.0% | 54,838 | $379K |
| Virtus Investment Advisers, LLC | 0.09% | Add +433.9% | 53,638 | $371K |
| Invesco Ltd. | 0.00% | Add +31.8% | 53,397 | $370K |
| Brevan Howard Capital Management LP | 0.01% | New | 50,369 | $349K |
| Swiss National Bank | 0.00% | No change | 48,100 | $333K |
| Russell Investments Group, Ltd. | 0.00% | Add +1203.6% | 47,543 | $329K |
| Allspring Global Investments Holdings, LLC | 0.00% | New | 43,182 | $299K |
| Rhumbline Advisers | 0.00% | Add +2.9% | 42,384 | $293K |
| Two Sigma Investments, LP | 0.00% | New | 42,325 | $293K |
| ExodusPoint Capital Management, LP | 0.00% | Reduce -55.1% | 41,045 | $284K |
| Citigroup Inc. | 0.00% | Add +698.0% | 40,339 | $279K |
| California State Teachers Retirement System | 0.00% | Reduce -2.6% | 38,634 | $267K |
| Stonepine Capital Management, LLC | 0.18% | Reduce -4.5% | 33,432 | $231K |
| Mariner, LLC | 0.00% | Add +21.3% | 33,141 | $229K |
| Wells Fargo & Company | 0.00% | Add +60.3% | 29,497 | $204K |
| Barclays PLC | 0.00% | Add +18.2% | 29,208 | $202K |
| Creative Planning | 0.00% | Add +162.5% | 28,483 | $197K |
| T. Rowe Price Associates Inc. | 0.00% | Add +6.1% | 28,058 | $195K |
| Quantbot Technologies LP | 0.01% | Add +4150.1% | 28,178 | $195K |
| Axq Capital, LP | 0.02% | Reduce -1.6% | 27,068 | $187K |
| nVerses Capital, LLC | 0.26% | New | 24,029 | $166K |
| DNB Asset Management AS | 0.00% | Add +0.4% | 23,600 | $163K |
| VANGUARD ASSET MANAGEMENT, Ltd | 0.00% | Add +145.7% | 22,724 | $157K |
| Graham Capital Management, L.P. | 0.01% | New | 22,508 | $156K |
| Los Angeles Capital Management LLC | 0.00% | New | 22,385 | $155K |
| Verdad Advisers, LP | 0.14% | New | 21,810 | $151K |
| MetLife Investment Management, LLC | 0.00% | Add +7.6% | 20,852 | $144K |
| SG Americas Securities, LLC | 0.00% | New | 20,338 | $141K |
| Sei Investments Co. | 0.00% | New | 20,026 | $139K |
| WINTON GROUP Ltd | 0.00% | New | 19,800 | $137K |
| Ieq Capital, LLC | 0.00% | New | 19,535 | $135K |
| Diadema Partners LP | 0.05% | Reduce -11.6% | 19,093 | $132K |
| Shay Capital LLC | 0.01% | Add +80.0% | 18,000 | $125K |
| Quadrature Capital Ltd | 0.00% | New | 17,988 | $124K |
| Entropy Technologies, LP | 0.00% | Reduce -24.8% | 17,542 | $121K |
| State of Wisconsin Investment Board | 0.00% | Reduce -59.0% | 17,065 | $118K |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0.00% | Add +3.9% | 16,217 | $112K |
| Manufacturers Life Insurance Company, The | 0.00% | Add +2.6% | 15,735 | $109K |
| Jane Street Group, LLC | 0.00% | New | 15,594 | $108K |
| Mercer Global Advisors Inc. | 0.00% | New | 13,352 | $92K |
| Vanguard Global Advisers, LLC | 0.00% | No change | 13,059 | $90K |
"% of holder's portfolio" is UPB's weight in each manager's 13F, not the share of Upstream Bio Inc. the manager owns.