Omega Fund Management, LLC

In its 13F for Q3 2024 (holdings as of September 30, 2024, filed November 14, 2024), Omega Fund Management, LLC reported 11 stock positions worth $160.0 million. Its top holding was Bicara Therapeutics (BCAX) at 35.1% of the portfolio, followed by Nuvation Bio (NUVB, 18.7%) and Replimune (REPL, 16.9%). Compared with Q2 2024, it opened 1 new position, sold out of 1 and reduced 2. The biggest buy was a new position in Bicara Therapeutics (BCAX) and the biggest sale Nuvation Bio (NUVB, shares −2%).

Most Recent 13F
Q2 2026
Location
Boston, MA
CIK
0001637359
Portfolio Value
$160.0M (Q3 2024)
SEC Filing
0000950123-24-011486 ↗ filed Nov 14, 2024

Holdings Value

0$100.0M$200.0M$300.0M Q1 2024: $155.0M Q1 2024 Q2 2024: $135.0M Q2 2024 Q3 2024: $160.0M $160.0M Q3 2024 Q4 2024: $154.2M Q4 2024 Q1 2025: $169.5M Q1 2025 Q2 2025: $154.4M Q2 2025 Q3 2025: $222.4M Q3 2025 Q4 2025: $286.5M Q4 2025 Q1 2026: $163.1M Q1 2026 Q2 2026: $185.7M Q2 2026

Holdings 11 stocks · $160.0M
BCAX Bicara Therapeutics Inc. 35.09% 2,204,650 $56.2M New
NUVB Nuvation Bio Inc. 18.71% 13,072,340 $29.9M Reduce -1.5%
REPL Replimune Group Inc. 16.86% 2,461,319 $27.0M No change
LXEO Lexeo Therapeutics Inc. 13.31% 2,355,904 $21.3M No change
ENGN Engene Holdings Inc. 4.44% 1,076,357 $7.1M No change
ALMS Alumis Inc. 4.36% 653,223 $7.0M Reduce 0.0%
IKENA ONCOLOGY INC 2.43% 2,249,123 $3.9M No change
SANA Sana Biotechnology Inc. 2.19% 843,750 $3.5M No change
IMUX Immunic Inc. 1.84% 1,788,160 $3.0M No change
ENGENE HOLDINGS INC 0.42% 321,502 $675K No change
SYRS Syros Pharmaceuticals Inc. 0.34% 251,270 $540K No change

Portfolio Sells Q2 2024 → Q3 2024
NUVB Nuvation Bio Inc. Reduce -1.5% 18.71% −10.01
MORF Morphic Holding Inc. Sold out 0.00% −4.03
ALMS Alumis Inc. Reduce 0.0% 4.36% −2.08

Portfolio Buys Q2 2024 → Q3 2024
BCAX Bicara Therapeutics Inc. New 35.09% +35.09

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 10$185.7MBCAX, NUVB, KMTS, BBOT, BBNX
Q1 2026 10$163.1MBCAX, NUVB, BBOT, KMTS, BBNX
Q4 2025 11$286.5MNUVB, BBOT, BBNX, BCAX, KMTS
Q3 2025 12$222.4MKMTS, BBNX, BBOT, BCAX, NUVB
Q2 2025 13$154.4MBBNX, KMTS, UPB, NUVB, BCAX
Q1 2025 13$169.5MKMTS, BCAX, BBNX, NUVB, REPL
Q4 2024Amended 12$154.2MBCAX, NUVB, UPB, REPL, LXEO
Q3 2024 11$160.0MBCAX, NUVB, REPL, LXEO, ENGN
Q2 2024 11$135.0MNUVB, LXEO, REPL, ENGN, ALMS
Q1 2024 11$155.0MNUVB, LXEO, REPL, ENGN, SANA