Omega Fund Management, LLC
In its 13F for Q1 2025 (holdings as of March 31, 2025, filed May 15, 2025), Omega Fund Management, LLC reported 13 stock positions worth $169.5 million. Its top holding was Kestra Medical Technologies (KMTS) at 26.4% of the portfolio, followed by Bicara Therapeutics (BCAX, 17.0%) and Beta Bionics (BBNX, 14.4%). Compared with Q4 2024, it opened 2 new positions and sold out of 1. The biggest buy was a new position in Kestra Medical Technologies (KMTS) and the biggest sale an exit from Syros Pharmaceuticals (SYRS).
- Most Recent 13F
- Q2 2026
- Location
- Boston, MA
- CIK
- 0001637359
- Portfolio Value
- $169.5M (Q1 2025)
- SEC Filing
- 0000950123-25-005509 ↗ filed May 15, 2025
Holdings Value
Holdings 13 stocks · $169.5M
| KMTS Kestra Medical Technologies | 26.41% | 1,795,893 | $44.8M | New |
| BCAX Bicara Therapeutics Inc. | 16.95% | 2,204,650 | $28.7M | No change |
| BBNX Beta Bionics Inc. | 14.36% | 1,988,287 | $24.3M | New |
| NUVB Nuvation Bio Inc. | 13.58% | 13,072,340 | $23.0M | No change |
| REPL Replimune Group Inc. | 11.36% | 1,975,203 | $19.3M | No change |
| UPB Upstream Bio Inc. | 7.35% | 2,036,293 | $12.5M | No change |
| LXEO Lexeo Therapeutics Inc. | 2.43% | 1,184,636 | $4.1M | No change |
| ALMS Alumis Inc. | 2.37% | 653,223 | $4.0M | No change |
| IKENA ONCOLOGY INC | 1.70% | 2,249,123 | $2.9M | No change |
| ENGN Engene Holdings Inc. | 1.39% | 526,357 | $2.4M | No change |
| IMUX Immunic Inc. | 1.15% | 1,788,160 | $1.9M | No change |
| SANA Sana Biotechnology Inc. | 0.84% | 843,750 | $1.4M | No change |
| ENGENE HOLDINGS INC | 0.11% | 321,502 | $193K | No change |
Portfolio Sells Q4 2024 → Q1 2025
| SYRS Syros Pharmaceuticals Inc. | Sold out | 0.00% | −0.04 |
Portfolio Buys Q4 2024 → Q1 2025
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 10 | $185.7M | BCAX, NUVB, KMTS, BBOT, BBNX |
| Q1 2026 | 10 | $163.1M | BCAX, NUVB, BBOT, KMTS, BBNX |
| Q4 2025 | 11 | $286.5M | NUVB, BBOT, BBNX, BCAX, KMTS |
| Q3 2025 | 12 | $222.4M | KMTS, BBNX, BBOT, BCAX, NUVB |
| Q2 2025 | 13 | $154.4M | BBNX, KMTS, UPB, NUVB, BCAX |
| Q1 2025 | 13 | $169.5M | KMTS, BCAX, BBNX, NUVB, REPL |
| Q4 2024Amended | 12 | $154.2M | BCAX, NUVB, UPB, REPL, LXEO |
| Q3 2024 | 11 | $160.0M | BCAX, NUVB, REPL, LXEO, ENGN |
| Q2 2024 | 11 | $135.0M | NUVB, LXEO, REPL, ENGN, ALMS |
| Q1 2024 | 11 | $155.0M | NUVB, LXEO, REPL, ENGN, SANA |