Omega Fund Management, LLC
In its 13F for Q2 2025 (holdings as of June 30, 2025, filed August 14, 2025), Omega Fund Management, LLC reported 13 stock positions worth $154.4 million. Its top holding was Beta Bionics (BBNX) at 18.7% of the portfolio, followed by Kestra Medical Technologies (KMTS, 17.7%) and Upstream Bio (UPB, 14.5%). Compared with Q1 2025, it reduced 2. The biggest sale was Kestra Medical Technologies (KMTS, shares −8%).
- Most Recent 13F
- Q2 2026
- Location
- Boston, MA
- CIK
- 0001637359
- Portfolio Value
- $154.4M (Q2 2025)
- SEC Filing
- 0000950123-25-008066 ↗ filed Aug 14, 2025
Holdings Value
Holdings 13 stocks · $154.4M
| BBNX Beta Bionics Inc. | 18.75% | 1,988,287 | $28.9M | No change |
| KMTS Kestra Medical Technologies | 17.67% | 1,645,893 | $27.3M | Reduce -8.3% |
| UPB Upstream Bio Inc. | 14.48% | 2,036,293 | $22.4M | No change |
| NUVB Nuvation Bio Inc. | 13.94% | 11,042,728 | $21.5M | Reduce -15.5% |
| BCAX Bicara Therapeutics Inc. | 13.26% | 2,204,650 | $20.5M | No change |
| REPL Replimune Group Inc. | 11.88% | 1,975,203 | $18.3M | No change |
| LXEO Lexeo Therapeutics Inc. | 3.08% | 1,184,636 | $4.8M | No change |
| IKENA ONCOLOGY INC | 1.95% | 2,249,123 | $3.0M | No change |
| SANA Sana Biotechnology Inc. | 1.49% | 843,750 | $2.3M | No change |
| ALMS Alumis Inc. | 1.27% | 653,223 | $2.0M | No change |
| ENGN Engene Holdings Inc. | 1.24% | 526,357 | $1.9M | No change |
| IMUX Immunic Inc. | 0.81% | 1,788,160 | $1.2M | No change |
| ENGENE HOLDINGS INC | 0.18% | 321,502 | $273K | No change |
Portfolio Sells Q1 2025 → Q2 2025
Portfolio Buys Q1 2025 → Q2 2025
| None this quarter. | |||
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 10 | $185.7M | BCAX, NUVB, KMTS, BBOT, BBNX |
| Q1 2026 | 10 | $163.1M | BCAX, NUVB, BBOT, KMTS, BBNX |
| Q4 2025 | 11 | $286.5M | NUVB, BBOT, BBNX, BCAX, KMTS |
| Q3 2025 | 12 | $222.4M | KMTS, BBNX, BBOT, BCAX, NUVB |
| Q2 2025 | 13 | $154.4M | BBNX, KMTS, UPB, NUVB, BCAX |
| Q1 2025 | 13 | $169.5M | KMTS, BCAX, BBNX, NUVB, REPL |
| Q4 2024Amended | 12 | $154.2M | BCAX, NUVB, UPB, REPL, LXEO |
| Q3 2024 | 11 | $160.0M | BCAX, NUVB, REPL, LXEO, ENGN |
| Q2 2024 | 11 | $135.0M | NUVB, LXEO, REPL, ENGN, ALMS |
| Q1 2024 | 11 | $155.0M | NUVB, LXEO, REPL, ENGN, SANA |