Redmile Group, LLC

In its 13F for Q3 2024 (holdings as of September 30, 2024, filed November 14, 2024), Redmile Group, LLC reported 63 stock positions worth $1.7 billion. Its top holding was Krystal Biotech (KRYS) at 8.7% of the portfolio, followed by Nurix Therapeutics (NRIX, 5.7%) and Amicus Therapeutics (FOLD, 5.2%). Compared with Q2 2024, it opened 4 new positions, sold out of 4, added to 4 and reduced 32. The biggest buy was a new position in Biontech SE-ADR (BNTX) and the biggest sale Krystal Biotech (KRYS, shares −21%).

Most Recent 13F
Q2 2026
Location
LARKSPUR, CA
CIK
0001425738
Portfolio Value
$1.7B (Q3 2024)
SEC Filing
0001104659-24-118934 ↗ filed Nov 14, 2024

Holdings Value

0$1.0B$2.0B$3.0B Q1 2024: $2.7B Q1 2024 Q2 2024: $1.7B Q2 2024 Q3 2024: $1.7B $1.7B Q3 2024 Q4 2024: $1.4B Q4 2024 Q1 2025: $1.1B Q1 2025 Q2 2025: $939.6M Q2 2025 Q3 2025: $1.0B Q3 2025 Q4 2025: $1.4B Q4 2025 Q1 2026: $1.5B Q1 2026 Q2 2026: $1.5B Q2 2026

Holdings 63 stocks · $1.7B
KRYS Krystal Biotech Inc. 8.69% 810,245 $147.5M Reduce -20.6%
NRIX Nurix Therapeutics Inc. 5.67% 4,280,981 $96.2M Reduce -3.2%
FOLD Amicus Therapeutics Inc. 5.19% 8,246,592 $88.1M Reduce -22.2%
IMNM Immunome Inc. 4.21% 4,889,554 $71.5M No change
KYMR Kymera Therapeutics Inc. 3.88% 1,393,256 $65.9M Reduce -11.8%
ZYME Zymeworks Inc. 3.77% 5,101,911 $64.0M Reduce -2.1%
STOK Stoke Therapeutics Inc. 3.41% 4,713,509 $57.9M Reduce -0.2%
REPL Replimune Group Inc. 3.09% 4,781,183 $52.4M Reduce -14.0%
BHVN Biohaven Ltd. 3.04% 1,034,219 $51.7M Reduce -4.9%
RGNX Regenxbio Inc. 3.02% 4,892,902 $51.3M Add +7.1%
IGMS Igm Biosciences Inc. 2.99% 3,072,478 $50.8M No change
ADCT Adc Therapeutics SA 2.91% 15,669,217 $49.4M Add +2.6%
COGT Cogent Biosciences Inc. 2.85% 4,484,380 $48.4M Reduce -6.6%
FATE Fate Therapeutics Inc. 2.72% 13,169,057 $46.1M No change
LIVN Livanova PLC 2.71% 875,039 $46.0M Reduce -5.9%
SRRK Scholar Rock Holding Corp. 2.47% 5,238,837 $42.0M Reduce -3.9%
NGNE Neurogene Inc. 2.38% 964,347 $40.5M Reduce -4.9%
AKRO Akero Therapeutics Inc. 2.35% 1,387,479 $39.8M Reduce -14.1%
BEAM Beam Therapeutics Inc. 2.33% 1,611,013 $39.5M Reduce -5.4%
AUGX Augmedix Inc. 2.27% 16,380,327 $38.5M No change
ANNX Annexon Inc. 2.24% 6,427,462 $38.1M No change
CTLT Catalent Inc. 2.13% 595,570 $36.1M No change
PLRX Pliant Therapeutics Inc. 2.11% 3,197,491 $35.8M Reduce -0.4%
SLN Silence Therapeutics PLC-ADR 2.03% 1,899,317 $34.5M Reduce -5.7%
KROS Keros Therapeutics Inc. 1.89% 552,506 $32.1M No change
ABSI Absci Corp. 1.86% 8,253,316 $31.5M No change
BSX Boston Scientific Corp. 1.63% 330,873 $27.7M Reduce -15.2%
CLDX Celldex Therapeutics Inc. 1.32% 657,175 $22.3M Reduce -8.6%
IDYA Ideaya Biosciences Inc. 1.27% 681,150 $21.6M Reduce -10.3%
STTK Shattuck Labs Inc. 1.15% 5,615,489 $19.6M No change
BNTX Biontech SE-ADR 1.08% 154,456 $18.3M New
IMVT Immunovant Inc. 1.08% 642,229 $18.3M Reduce -10.8%
FDMT 4D Molecular Therapeutics Inc. 0.80% 1,262,090 $13.6M Add +17.6%
ISRG Intuitive Surgical Inc. 0.77% 26,698 $13.1M Reduce -33.0%
SYK Stryker Corp. 0.70% 32,741 $11.8M Reduce -17.1%
ETNB 89BIO Inc. 0.68% 1,569,850 $11.6M Reduce -10.1%
ARDX Ardelyx Inc. 0.67% 1,660,763 $11.4M Reduce -11.7%
ESTA Establishment Labs Holdings 0.67% 261,803 $11.3M Add +22.9%
ORKA Oruka Therapeutics Inc. 0.59% 411,728 $10.1M New
PRME Prime Medicine Inc. 0.47% 2,074,350 $8.0M No change
ALXO Alx Oncology Holdings Inc. 0.41% 3,836,576 $7.0M Reduce -5.0%
NUVB Nuvation Bio Inc. 0.41% 3,031,009 $6.9M No change
VERV Verve Therapeutics Inc. 0.39% 1,383,366 $6.7M Reduce -5.5%
RPTX Repare Therapeutics Inc. 0.39% 1,942,555 $6.7M No change
ACIU Ac Immune SA 0.38% 1,694,167 $6.4M Reduce -6.3%
CYTK Cytokinetics Inc. 0.30% 97,116 $5.1M Reduce -13.2%
VTYX Ventyx Biosciences Inc. 0.27% 2,107,215 $4.6M Reduce -2.6%
STXS Stereotaxis Inc. 0.25% 2,108,219 $4.3M No change
ATRA Atara Biotherapeutics Inc. 0.22% 452,270 $3.7M No change
BOLD Boundless Bio Inc. 0.21% 1,023,548 $3.6M Reduce -1.1%
LVTX Lava Therapeutics NV 0.20% 2,074,372 $3.4M No change
ATXS Astria Therapeutics Inc. 0.20% 310,884 $3.4M New
IVVD Invivyd Inc. 0.18% 3,065,714 $3.1M No change
XERS Xeris Biopharma Holdings Inc. 0.18% 1,046,587 $3.0M No change
GRITSTONE BIO INC 0.17% 4,920,178 $2.9M Reduce -3.7%
PEN Penumbra Inc. 0.16% 13,847 $2.7M New
CABA Cabaletta Bio Inc. 0.12% 442,826 $2.1M No change
ALLK Allakos LLC 0.12% 3,077,828 $2.0M No change
ACHL Achilles Therapeutics PL-ADR 0.10% 1,608,089 $1.6M No change
ALLOVIR INC 0.09% 1,907,969 $1.5M No change
RAPT THERAPEUTICS INC 0.06% 504,532 $1.0M Reduce -6.0%
ADAPY Adaptimmune Therapeutics-ADR 0.04% 715,607 $680K No change
HOOK Hookipa Pharma Inc. 0.03% 106,376 $457K No change

Portfolio Sells Q2 2024 → Q3 2024
KRYS Krystal Biotech Inc. Reduce -20.6% 8.69% −2.65
FOLD Amicus Therapeutics Inc. Reduce -22.2% 5.19% −1.17
ALXO Alx Oncology Holdings Inc. Reduce -5.0% 0.41% −1.06
BPMC Blueprint Medicines Corp. Sold out 0.00% −0.62
TRDA Entrada Therapeutics Inc. Sold out 0.00% −0.48
STOK Stoke Therapeutics Inc. Reduce -0.2% 3.41% −0.44
LIVN Livanova PLC Reduce -5.9% 2.71% −0.37
IDYA Ideaya Biosciences Inc. Reduce -10.3% 1.27% −0.34
ISRG Intuitive Surgical Inc. Reduce -33.0% 0.77% −0.30
CLDX Celldex Therapeutics Inc. Reduce -8.6% 1.32% −0.29
SLN Silence Therapeutics PLC-ADR Reduce -5.7% 2.03% −0.28
SRRK Scholar Rock Holding Corp. Reduce -3.9% 2.47% −0.27
BSX Boston Scientific Corp. Reduce -15.2% 1.63% −0.18
ARDX Ardelyx Inc. Reduce -11.7% 0.67% −0.17
ETNB 89BIO Inc. Reduce -10.1% 0.68% −0.16
SYK Stryker Corp. Reduce -17.1% 0.70% −0.12
BEAM Beam Therapeutics Inc. Reduce -5.4% 2.33% −0.09
IMVT Immunovant Inc. Reduce -10.8% 1.08% −0.07
CYTK Cytokinetics Inc. Reduce -13.2% 0.30% −0.06
ACIU Ac Immune SA Reduce -6.3% 0.38% −0.06
LAB Standard Biotools Inc. Sold out 0.00% −0.04
RAPT THERAPEUTICS INC Reduce -6.0% 0.06% −0.04
VERV Verve Therapeutics Inc. Reduce -5.5% 0.39% −0.04
BOLD Boundless Bio Inc. Reduce -1.1% 0.21% −0.03
VTYX Ventyx Biosciences Inc. Reduce -2.6% 0.27% −0.03
GRITSTONE BIO INC Reduce -3.7% 0.17% −0.02
TKNO Alpha Teknova Inc. Sold out 0.00% −0.01
PLRX Pliant Therapeutics Inc. Reduce -0.4% 2.11% +0.03
AKRO Akero Therapeutics Inc. Reduce -14.1% 2.35% +0.06
REPL Replimune Group Inc. Reduce -14.0% 3.09% +0.06
NRIX Nurix Therapeutics Inc. Reduce -3.2% 5.67% +0.09
NGNE Neurogene Inc. Reduce -4.9% 2.38% +0.15
COGT Cogent Biosciences Inc. Reduce -6.6% 2.85% +0.41
BHVN Biohaven Ltd. Reduce -4.9% 3.04% +0.76
KYMR Kymera Therapeutics Inc. Reduce -11.8% 3.88% +1.03
ZYME Zymeworks Inc. Reduce -2.1% 3.77% +1.09

Portfolio Buys Q2 2024 → Q3 2024
BNTX Biontech SE-ADR New 1.08% +1.08
ORKA Oruka Therapeutics Inc. New 0.59% +0.59
ATXS Astria Therapeutics Inc. New 0.20% +0.20
PEN Penumbra Inc. New 0.16% +0.16
ESTA Establishment Labs Holdings Add +22.9% 0.67% +0.08
ADCT Adc Therapeutics SA Add +2.6% 2.91% −0.01
RGNX Regenxbio Inc. Add +7.1% 3.02% −0.21
FDMT 4D Molecular Therapeutics Inc. Add +17.6% 0.80% −0.56

All Filings

QuarterPositions13F Reported ValueTop Holdings
Q2 2026 39$1.5BSRRK, KRYS, STOK, IMNM, NRIX
Q1 2026 35$1.5BSRRK, KRYS, STOK, IMNM, NRIX
Q4 2025 34$1.4BSRRK, KRYS, NRIX, STOK, IMNM
Q3 2025 40$1.0BSRRK, KRYS, STOK, ZYME, ADCT
Q2 2025 48$939.6MSRRK, KRYS, ZYME, STOK, IMNM
Q1 2025 56$1.1BSRRK, KRYS, FOLD, ZYME, NRIX
Q4 2024 62$1.4BSRRK, KRYS, NRIX, ZYME, FOLD
Q3 2024 63$1.7BKRYS, NRIX, FOLD, IMNM, KYMR
Q2 2024 63$1.7BKRYS, FOLD, NRIX, STOK, IMNM
Q1 2024 77$2.7BKRYS, FOLD, IMNM, SRRK, FATE