Sphera Funds Management LTD.
In its 13F for Q1 2024 (holdings as of March 31, 2024, filed May 15, 2024), Sphera Funds Management LTD. reported 92 stock positions worth $617.3 million. Its top holding was Teva Pharmaceutical-SP ADR (TEVA) at 4.3% of the portfolio, followed by Sanofi-ADR (SNY, 3.9%) and Nice Ltd. - Spon ADR (NICE, 3.6%). Compared with Q4 2023, it opened 23 new positions, sold out of 19, added to 23 and reduced 31. The biggest buy was a new position in Jasper Therapeutics (JSPR) and the biggest sale Nova (NVMI, shares −73%).
- Most Recent 13F
- Q2 2026
- Location
- TEL AVIV, L3
- CIK
- 0001496201
- Portfolio Value
- $617.3M (Q1 2024)
- SEC Filing
- 0001496201-24-000006 ↗ filed May 15, 2024
Holdings Value
Holdings 92 stocks · $617.3M
| TEVA Teva Pharmaceutical-SP ADR | 4.32% | 1,889,700 | $26.7M | Reduce -23.5% |
| SNY Sanofi-ADR | 3.93% | 499,515 | $24.3M | No change |
| NICE Nice Ltd. - Spon ADR | 3.63% | 85,881 | $22.4M | Add +26.8% |
| CYTK Cytokinetics Inc. | 3.20% | 281,671 | $19.7M | Add +25.9% |
| SNDX Syndax Pharmaceuticals Inc. | 3.13% | 812,964 | $19.3M | Add +5.2% |
| BBIO Bridgebio Pharma Inc. | 2.94% | 585,956 | $18.1M | Add +107.7% |
| BIIB Biogen Inc. | 2.47% | 70,646 | $15.2M | Add +52.4% |
| JSPR Jasper Therapeutics Inc. | 2.40% | 505,242 | $14.8M | New |
| CATX Perspective Therapeutics Inc. | 2.40% | 12,443,621 | $14.8M | Add +48373.5% |
| MRK Merck & Co. Inc. | 2.21% | 103,600 | $13.7M | Reduce -16.2% |
| KURA Kura Oncology Inc. | 2.11% | 610,826 | $13.0M | Reduce -13.2% |
| AZN Astrazeneca PLC-Spons ADR | 2.09% | 190,060 | $12.9M | Add +5.5% |
| S Sentinelone Inc. Class A | 2.08% | 550,818 | $12.8M | Add +158.1% |
| JNJ Johnson & Johnson | 2.05% | 79,831 | $12.6M | No change |
| META Meta Platforms Inc. Class A | 2.00% | 25,439 | $12.4M | Reduce -25.8% |
| CLDX Celldex Therapeutics Inc. | 1.88% | 276,996 | $11.6M | Reduce -12.2% |
| MSFT Microsoft Corp. | 1.88% | 27,548 | $11.6M | Add +15.5% |
| RARE Ultragenyx Pharmaceutical Inc. | 1.80% | 238,544 | $11.1M | Add +18.6% |
| LLY Eli Lilly & Co. | 1.79% | 14,190 | $11.0M | No change |
| PRAX Praxis Precision Medicines I | 1.75% | 177,139 | $10.8M | New |
| NVO Novo-Nordisk A/S-Spons ADR | 1.73% | 83,080 | $10.7M | Reduce -10.7% |
| CYBIN INC | 1.71% | 25,581,395 | $10.6M | New |
| INZY Inozyme Pharma Inc. | 1.70% | 1,372,907 | $10.5M | Reduce -12.2% |
| FROG Jfrog Ltd. | 1.61% | 224,381 | $9.9M | Add +104.2% |
| AMZN Amazon.com Inc. | 1.59% | 54,432 | $9.8M | Reduce -2.2% |
| FUSN Fusion Pharmaceuticals Inc. | 1.55% | 449,041 | $9.6M | Reduce -58.6% |
| PHVS Pharvaris NV | 1.47% | 392,877 | $9.1M | Add +60.4% |
| MLYS Mineralys Therapeutics Inc. | 1.38% | 658,803 | $8.5M | Reduce -11.4% |
| DAWN Day One Biopharmaceuticals I | 1.32% | 492,627 | $8.1M | Reduce -4.0% |
| GLBE Global-E Online Ltd. | 1.23% | 208,784 | $7.6M | Reduce -22.6% |
| WIX Wix.com Ltd. | 1.18% | 52,877 | $7.3M | Reduce -8.0% |
| SRPT Sarepta Therapeutics Inc. | 1.17% | 55,614 | $7.2M | Add +344.9% |
| IMTX Immatics NV | 1.13% | 666,111 | $7.0M | Add +7.3% |
| ABBV Abbvie Inc. | 1.12% | 38,000 | $6.9M | Reduce -17.4% |
| OTLK Outlook Therapeutics Inc. | 1.11% | 571,429 | $6.8M | New |
| MRUS Merus NV | 1.09% | 149,333 | $6.7M | Reduce -35.2% |
| AMAT Applied Materials Inc. | 1.07% | 32,000 | $6.6M | New |
| CAMT Camtek Ltd. | 1.02% | 74,909 | $6.3M | New |
| NVMI Nova Ltd. | 1.01% | 35,106 | $6.2M | Reduce -73.4% |
| TSEM Tower Semiconductor Ltd. | 0.97% | 179,600 | $6.0M | Reduce -66.0% |
| ETNB 89BIO Inc. | 0.97% | 515,882 | $6.0M | Add +26.2% |
| VIGL Vigil Neuroscience Inc. | 0.96% | 1,730,414 | $5.9M | Add +223.4% |
| ENPH Enphase Energy Inc. | 0.92% | 47,183 | $5.7M | Add +35.6% |
| VTYX Ventyx Biosciences Inc. | 0.88% | 992,749 | $5.5M | Add +451.5% |
| TBLA Taboola.com Ltd. | 0.86% | 1,191,070 | $5.3M | Reduce -30.9% |
| FDMT 4D Molecular Therapeutics Inc. | 0.84% | 162,161 | $5.2M | New |
| INCY Incyte Corp. | 0.83% | 89,556 | $5.1M | No change |
| RCKT Rocket Pharmaceuticals Inc. | 0.80% | 183,722 | $4.9M | Reduce -3.7% |
| NVS Novartis AG-Sponsored ADR | 0.78% | 50,000 | $4.8M | Reduce -16.7% |
| CPRX Catalyst Pharmaceuticals Inc. | 0.74% | 288,000 | $4.6M | New |
| GSK GSK PLC-Spon ADR | 0.69% | 100,000 | $4.3M | No change |
| VTGN Vistagen Therapeutics Inc. | 0.69% | 808,550 | $4.3M | No change |
| APLT Applied Therapeutics Inc. | 0.68% | 619,029 | $4.2M | New |
| HOWL Werewolf Therapeutics Inc. | 0.66% | 626,810 | $4.1M | No change |
| AKRO Akero Therapeutics Inc. | 0.66% | 160,445 | $4.1M | New |
| SHLT SHL Telemedicine Ltd.-ADR | 0.63% | 632,456 | $3.9M | No change |
| PLRX Pliant Therapeutics Inc. | 0.62% | 258,554 | $3.9M | Add +33.6% |
| PMN Promis Neurosciences Inc. | 0.57% | 1,834,047 | $3.5M | Add +0.0% |
| SWTX Springworks Therapeutics Inc. | 0.56% | 70,269 | $3.5M | Reduce -58.7% |
| ALEC Alector Inc. | 0.55% | 560,000 | $3.4M | New |
| IRON Disc Medicine Inc. | 0.49% | 48,886 | $3.0M | New |
| AAPL Apple Inc. | 0.49% | 17,500 | $3.0M | New |
| ENLT Enlight Renewable Energy Ltd. | 0.46% | 169,280 | $2.9M | No change |
| SEDG Solaredge Technologies Inc. | 0.46% | 40,175 | $2.9M | Reduce -16.3% |
| RZLT Rezolute Inc. | 0.41% | 996,710 | $2.5M | No change |
| QCOM Qualcomm Inc. | 0.41% | 15,000 | $2.5M | New |
| PFE Pfizer Inc. | 0.40% | 90,000 | $2.5M | No change |
| ACAD Acadia Pharmaceuticals Inc. | 0.37% | 125,000 | $2.3M | New |
| ELEV Elevation Oncology Inc. | 0.36% | 430,000 | $2.2M | Reduce -52.2% |
| ESTC Elastic NV | 0.32% | 20,000 | $2.0M | New |
| AMD Advanced Micro Devices | 0.32% | 11,000 | $2.0M | Reduce -78.2% |
| CGEN Compugen Ltd. | 0.32% | 769,239 | $2.0M | No change |
| NTR Nutrien Ltd. | 0.31% | 35,730 | $1.9M | New |
| KEZAR LIFE SCIENCES INC | 0.30% | 2,051,676 | $1.8M | No change |
| APRE Aprea Therapeutics Inc. | 0.29% | 270,000 | $1.8M | New |
| ALPN Alpine Immune Sciences Inc. | 0.29% | 44,841 | $1.8M | Reduce -80.9% |
| FIVN FIVE9 Inc. | 0.28% | 27,500 | $1.7M | Add +83.3% |
| CRGX Cargo Therapeutics Inc. | 0.27% | 75,000 | $1.7M | No change |
| ATXS Astria Therapeutics Inc. | 0.26% | 112,842 | $1.6M | Reduce -90.2% |
| PRME Prime Medicine Inc. | 0.23% | 205,242 | $1.4M | Add +177.4% |
| UPWK Upwork Inc. | 0.23% | 117,000 | $1.4M | Reduce -53.7% |
| CRBP Corbus Pharmaceuticals Holdi | 0.22% | 35,000 | $1.4M | New |
| AVGO Broadcom Inc. | 0.21% | 1,001 | $1.3M | Reduce -44.4% |
| GERN Geron Corp. | 0.21% | 384,356 | $1.3M | New |
| LVTX Lava Therapeutics NV | 0.20% | 367,582 | $1.2M | New |
| GOSS Gossamer Bio Inc. | 0.20% | 1,027,134 | $1.2M | Reduce -23.2% |
| VRNS Varonis Systems Inc. | 0.15% | 20,000 | $943K | New |
| AMLX Amylyx Pharmaceuticals Inc. | 0.12% | 267,250 | $759K | Add +45.5% |
| ICL Icl Group Ltd. | 0.11% | 130,475 | $702K | Reduce -68.9% |
| RNAC Cartesian Therapeutics Inc. | 0.08% | 25,071 | $489K | Reduce -96.7% |
| ANRO Alto Neuroscience Inc. | 0.08% | 30,500 | $468K | New |
| ARBE Arbe Robotics Ltd. | 0.01% | 43,165 | $90K | No change |
Options reported separately and not counted above: TEVA calls ($44.2M), XBI puts ($36.1M), ALNY calls ($3.0M), RARE calls ($2.6M), SEDG calls ($1.9M), ACAD calls ($1.8M), IRON calls ($1.6M), BBIO calls ($1.5M), INSM calls ($762K), AMLX calls ($682K), ANNX puts ($82K).
Other holdings (1): bonds, preferreds, convertibles and warrants · $270K (not counted above)
| Security | Class | Shares / Principal | Value | Change |
|---|---|---|---|---|
| IMTXW Immatics NV -CW | *W EXP 07/01/202 | 100,000 | $270K | No change |
Total filed on the 13F, all lines: $617.5M.
Portfolio Sells Q4 2023 → Q1 2024
| NVMI Nova Ltd. | Reduce -73.4% | 1.01% | −2.36 |
| TSEM Tower Semiconductor Ltd. | Reduce -66.0% | 0.97% | −2.02 |
| INHIBRX INC | Sold out | 0.00% | −1.60 |
| ATXS Astria Therapeutics Inc. | Reduce -90.2% | 0.26% | −1.38 |
| PRAX Praxis Precision Medicines I | Sold out | 0.00% | −1.36 |
| ALNY Alnylam Pharmaceuticals Inc. | Sold out | 0.00% | −1.29 |
| MDGL Madrigal Pharmaceuticals Inc. | Sold out | 0.00% | −1.19 |
| AMD Advanced Micro Devices | Reduce -78.2% | 0.32% | −1.06 |
| JSPR Jasper Therapeutics Inc. | Sold out | 0.00% | −1.05 |
| GRCL Gracell Biotechnologies-ADR | Sold out | 0.00% | −0.94 |
| PANW Palo Alto Networks Inc. | Sold out | 0.00% | −0.91 |
| ARWR Arrowhead Pharmaceuticals Inc. | Sold out | 0.00% | −0.82 |
| GLBE Global-E Online Ltd. | Reduce -22.6% | 1.23% | −0.76 |
| PTCT PTC Therapeutics Inc. | Sold out | 0.00% | −0.70 |
| SWTX Springworks Therapeutics Inc. | Reduce -58.7% | 0.56% | −0.59 |
| ALPN Alpine Immune Sciences Inc. | Reduce -80.9% | 0.29% | −0.54 |
| TBLA Taboola.com Ltd. | Reduce -30.9% | 0.86% | −0.53 |
| TEVA Teva Pharmaceutical-SP ADR | Reduce -23.5% | 4.32% | −0.47 |
| UPWK Upwork Inc. | Reduce -53.7% | 0.23% | −0.47 |
| CLDX Celldex Therapeutics Inc. | Reduce -12.2% | 1.88% | −0.44 |
| FUSN Fusion Pharmaceuticals Inc. | Reduce -58.6% | 1.55% | −0.39 |
| SEDG Solaredge Technologies Inc. | Reduce -16.3% | 0.46% | −0.37 |
| NVS Novartis AG-Sponsored ADR | Reduce -16.7% | 0.78% | −0.34 |
| RIGL Rigel Pharmaceuticals Inc. | Sold out | 0.00% | −0.33 |
| GILD Gilead Sciences Inc. | Sold out | 0.00% | −0.30 |
| MRK Merck & Co. Inc. | Reduce -16.2% | 2.21% | −0.29 |
| COGT Cogent Biosciences Inc. | Sold out | 0.00% | −0.28 |
| ICL Icl Group Ltd. | Reduce -68.9% | 0.11% | −0.28 |
| RCKT Rocket Pharmaceuticals Inc. | Reduce -3.7% | 0.80% | −0.26 |
| META Meta Platforms Inc. Class A | Reduce -25.8% | 2.00% | −0.25 |
| ORIC Oric Pharmaceuticals Inc. | Sold out | 0.00% | −0.22 |
| ABBV Abbvie Inc. | Reduce -17.4% | 1.12% | −0.20 |
| AVGO Broadcom Inc. | Reduce -44.4% | 0.21% | −0.16 |
| APGE Apogee Therapeutics Inc. | Sold out | 0.00% | −0.16 |
| WIX Wix.com Ltd. | Reduce -8.0% | 1.18% | −0.14 |
| MDWD Mediwound Ltd. | Sold out | 0.00% | −0.09 |
| MRUS Merus NV | Reduce -35.2% | 1.09% | −0.09 |
| MORF Morphic Holding Inc. | Sold out | 0.00% | −0.08 |
| DAWN Day One Biopharmaceuticals I | Reduce -4.0% | 1.32% | −0.07 |
| NVO Novo-Nordisk A/S-Spons ADR | Reduce -10.7% | 1.73% | −0.06 |
| GLUE Monte Rosa Therapeutics Inc. | Sold out | 0.00% | −0.05 |
| GOSS Gossamer Bio Inc. | Reduce -23.2% | 0.20% | −0.03 |
| REPL Replimune Group Inc. | Sold out | 0.00% | −0.03 |
| FRLN Freeline Therapeutics Holdin | Sold out | 0.00% | −0.02 |
| RNAC Cartesian Therapeutics Inc. | Reduce -96.7% | 0.08% | −0.02 |
| AMZN Amazon.com Inc. | Reduce -2.2% | 1.59% | +0.02 |
| MLYS Mineralys Therapeutics Inc. | Reduce -11.4% | 1.38% | +0.19 |
| KURA Kura Oncology Inc. | Reduce -13.2% | 2.11% | +0.23 |
| ELEV Elevation Oncology Inc. | Reduce -52.2% | 0.36% | +0.27 |
| INZY Inozyme Pharma Inc. | Reduce -12.2% | 1.70% | +0.47 |
Portfolio Buys Q4 2023 → Q1 2024
| JSPR Jasper Therapeutics Inc. | New | 2.40% | +2.40 |
| CATX Perspective Therapeutics Inc. | Add +48373.5% | 2.40% | +2.40 |
| PRAX Praxis Precision Medicines I | New | 1.75% | +1.75 |
| CYBIN INC | New | 1.71% | +1.71 |
| NICE Nice Ltd. - Spon ADR | Add +26.8% | 3.63% | +1.12 |
| OTLK Outlook Therapeutics Inc. | New | 1.11% | +1.11 |
| AMAT Applied Materials Inc. | New | 1.07% | +1.07 |
| CAMT Camtek Ltd. | New | 1.02% | +1.02 |
| S Sentinelone Inc. Class A | Add +158.1% | 2.08% | +0.99 |
| SRPT Sarepta Therapeutics Inc. | Add +344.9% | 1.17% | +0.94 |
| FROG Jfrog Ltd. | Add +104.2% | 1.61% | +0.90 |
| FDMT 4D Molecular Therapeutics Inc. | New | 0.84% | +0.84 |
| BBIO Bridgebio Pharma Inc. | Add +107.7% | 2.94% | +0.82 |
| VTYX Ventyx Biosciences Inc. | Add +451.5% | 0.88% | +0.80 |
| CPRX Catalyst Pharmaceuticals Inc. | New | 0.74% | +0.74 |
| APLT Applied Therapeutics Inc. | New | 0.68% | +0.68 |
| AKRO Akero Therapeutics Inc. | New | 0.66% | +0.66 |
| VIGL Vigil Neuroscience Inc. | Add +223.4% | 0.96% | +0.62 |
| ALEC Alector Inc. | New | 0.55% | +0.55 |
| IRON Disc Medicine Inc. | New | 0.49% | +0.49 |
| AAPL Apple Inc. | New | 0.49% | +0.49 |
| QCOM Qualcomm Inc. | New | 0.41% | +0.41 |
| ACAD Acadia Pharmaceuticals Inc. | New | 0.37% | +0.37 |
| ESTC Elastic NV | New | 0.32% | +0.32 |
| NTR Nutrien Ltd. | New | 0.31% | +0.31 |
| APRE Aprea Therapeutics Inc. | New | 0.29% | +0.29 |
| BIIB Biogen Inc. | Add +52.4% | 2.47% | +0.24 |
| CRBP Corbus Pharmaceuticals Holdi | New | 0.22% | +0.22 |
| MSFT Microsoft Corp. | Add +15.5% | 1.88% | +0.21 |
| GERN Geron Corp. | New | 0.21% | +0.21 |
| LVTX Lava Therapeutics NV | New | 0.20% | +0.20 |
| PHVS Pharvaris NV | Add +60.4% | 1.47% | +0.19 |
| PMN Promis Neurosciences Inc. | Add +0.0% | 0.57% | +0.18 |
| VRNS Varonis Systems Inc. | New | 0.15% | +0.15 |
| ETNB 89BIO Inc. | Add +26.2% | 0.97% | +0.12 |
| PRME Prime Medicine Inc. | Add +177.4% | 0.23% | +0.11 |
| ANRO Alto Neuroscience Inc. | New | 0.08% | +0.08 |
| ENPH Enphase Energy Inc. | Add +35.6% | 0.92% | +0.07 |
| FIVN FIVE9 Inc. | Add +83.3% | 0.28% | +0.06 |
| SNDX Syndax Pharmaceuticals Inc. | Add +5.2% | 3.13% | +0.03 |
| RARE Ultragenyx Pharmaceutical Inc. | Add +18.6% | 1.80% | +0.02 |
| PLRX Pliant Therapeutics Inc. | Add +33.6% | 0.62% | −0.03 |
| IMTX Immatics NV | Add +7.3% | 1.13% | −0.08 |
| AZN Astrazeneca PLC-Spons ADR | Add +5.5% | 2.09% | −0.17 |
| CYTK Cytokinetics Inc. | Add +25.9% | 3.20% | −0.27 |
| AMLX Amylyx Pharmaceuticals Inc. | Add +45.5% | 0.12% | −0.38 |
Options Activity Q4 2023 → Q1 2024
| TEVA Teva Pharmaceutical-SP ADR | call | Add +144.0% | 3,132,700 | $44.2M |
| XBI SS SPDR S&P Biotech ETF | put | Reduce -24.0% | 380,000 | $36.1M |
| CLDX Celldex Therapeutics Inc. | call | Sold out | 115,700 | $4.6Mbefore exit |
| ENPH Enphase Energy Inc. | call | Sold out | 32,100 | $4.2Mbefore exit |
| CYTK Cytokinetics Inc. | call | Sold out | 35,800 | $3.0Mbefore exit |
| RARE Ultragenyx Pharmaceutical Inc. | call | New | 55,000 | $2.6M |
| SRPT Sarepta Therapeutics Inc. | call | Sold out | 26,400 | $2.5Mbefore exit |
| PRTA Prothena Corp. PLC | call | Sold out | 68,200 | $2.5Mbefore exit |
| ACAD Acadia Pharmaceuticals Inc. | call | New | 100,000 | $1.8M |
| IRON Disc Medicine Inc. | call | New | 25,000 | $1.6M |
| BBIO Bridgebio Pharma Inc. | call | New | 50,000 | $1.5M |
| INSM Insmed Inc. | call | New | 28,100 | $762K |
| AMLX Amylyx Pharmaceuticals Inc. | call | Add +140.0% | 240,000 | $682K |
| ANNX Annexon Inc. | put | New | 11,400 | $82K |
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 97 | $698.8M | TEVA, MLYS, TSEM, SNDX, BIIB |
| Q1 2026 | 92 | $581.5M | MLYS, TEVA, TSEM, NVMI, BBIO |
| Q4 2025 | 94 | $478.5M | TEVA, BIIB, MLYS, SNDX, NVMI |
| Q3 2025 | 101 | $421.6M | TEVA, NICE, TSEM, NVMI, QQQ |
| Q2 2025 | 101 | $382.5M | TEVA, NVMI, SNDX, TSEM, CYTK |
| Q1 2025 | 111 | $405.5M | TEVA, SNDX, SNY, NVMI, AZN |
| Q4 2024 | 102 | $541.4M | TEVA, BBIO, SNY, SNDX, AZN |
| Q3 2024 | 107 | $611.0M | TEVA, SNY, BBIO, SNDX, AMZN |
| Q2 2024 | 109 | $613.3M | BBIO, SNY, CYTK, AMZN, SNDX |
| Q1 2024 | 92 | $617.3M | TEVA, SNY, NICE, CYTK, SNDX |