Sphera Funds Management LTD.
In its 13F for Q2 2024 (holdings as of June 30, 2024, filed August 14, 2024), Sphera Funds Management LTD. reported 109 stock positions worth $613.3 million. Its top holding was Bridgebio Pharma (BBIO) at 3.8% of the portfolio, followed by Sanofi-ADR (SNY, 3.6%) and Cytokinetics (CYTK, 3.4%). Compared with Q1 2024, it opened 30 new positions, sold out of 13, added to 29 and reduced 31. The biggest buy was a new position in Skye Bioscience (SKYE) and the biggest sale an exit from Perspective Therapeutics (CATX).
- Most Recent 13F
- Q2 2026
- Location
- TEL AVIV, L3
- CIK
- 0001496201
- Portfolio Value
- $613.3M (Q2 2024)
- SEC Filing
- 0001496201-24-000010 ↗ filed Aug 14, 2024
Holdings Value
Holdings 109 stocks · $613.3M
| BBIO Bridgebio Pharma Inc. | 3.76% | 910,070 | $23.1M | Add +55.3% |
| SNY Sanofi-ADR | 3.56% | 449,515 | $21.8M | Reduce -10.0% |
| CYTK Cytokinetics Inc. | 3.40% | 384,924 | $20.9M | Add +36.7% |
| AMZN Amazon.com Inc. | 3.20% | 101,432 | $19.6M | Add +86.3% |
| SNDX Syndax Pharmaceuticals Inc. | 2.75% | 822,047 | $16.9M | Add +1.1% |
| META Meta Platforms Inc. Class A | 2.75% | 33,439 | $16.9M | Add +31.4% |
| AZN Astrazeneca PLC-Spons ADR | 2.42% | 190,060 | $14.8M | No change |
| MSFT Microsoft Corp. | 2.40% | 32,927 | $14.7M | Add +19.5% |
| NICE Nice Ltd. - Spon ADR | 2.28% | 81,461 | $14.0M | Reduce -5.2% |
| SRPT Sarepta Therapeutics Inc. | 2.16% | 83,659 | $13.2M | Add +50.4% |
| AAPL Apple Inc. | 2.11% | 61,500 | $13.0M | Add +251.4% |
| TEVA Teva Pharmaceutical-SP ADR | 2.09% | 789,416 | $12.8M | Reduce -58.2% |
| KURA Kura Oncology Inc. | 2.05% | 610,826 | $12.6M | No change |
| RARE Ultragenyx Pharmaceutical Inc. | 1.97% | 293,832 | $12.1M | Add +23.2% |
| LLY Eli Lilly & Co. | 1.95% | 13,190 | $11.9M | Reduce -7.0% |
| PRAX Praxis Precision Medicines I | 1.91% | 283,424 | $11.7M | Add +60.0% |
| CLDX Celldex Therapeutics Inc. | 1.87% | 309,265 | $11.4M | Add +11.7% |
| NVO Novo-Nordisk A/S-Spons ADR | 1.82% | 78,080 | $11.1M | Reduce -6.0% |
| BIIB Biogen Inc. | 1.79% | 47,412 | $11.0M | Reduce -32.9% |
| SKYE Skye Bioscience Inc. | 1.70% | 1,298,312 | $10.4M | New |
| JSPR Jasper Therapeutics Inc. | 1.68% | 454,227 | $10.3M | Reduce -10.1% |
| JNJ Johnson & Johnson | 1.66% | 69,831 | $10.2M | Reduce -12.5% |
| ASML ASML Holding NV-NY Reg SHS | 1.65% | 9,901 | $10.1M | New |
| MRUS Merus NV | 1.42% | 147,633 | $8.7M | Reduce -1.1% |
| CRM Salesforce Inc. | 1.41% | 33,600 | $8.6M | New |
| IMTX Immatics NV | 1.39% | 731,111 | $8.5M | Add +9.8% |
| CATX Perspective Therapeutics Inc. | 1.28% | 786,909 | $7.8M | New |
| PHVS Pharvaris NV | 1.24% | 403,265 | $7.6M | Add +2.6% |
| MRK Merck & Co. Inc. | 1.20% | 59,600 | $7.4M | Reduce -42.5% |
| RZLT Rezolute Inc. | 1.20% | 1,707,999 | $7.3M | Add +71.4% |
| CYBIN INC | 1.13% | 25,581,395 | $6.9M | No change |
| VIGL Vigil Neuroscience Inc. | 1.10% | 1,692,166 | $6.8M | Reduce -2.2% |
| IONS Ionis Pharmaceuticals Inc. | 1.09% | 140,238 | $6.7M | New |
| INZY Inozyme Pharma Inc. | 1.06% | 1,462,724 | $6.5M | Add +6.5% |
| ABBV Abbvie Inc. | 1.06% | 38,000 | $6.5M | No change |
| PANW Palo Alto Networks Inc. | 0.99% | 18,000 | $6.1M | New |
| S Sentinelone Inc. Class A | 0.97% | 283,804 | $6.0M | Reduce -48.5% |
| TSEM Tower Semiconductor Ltd. | 0.96% | 149,600 | $5.9M | Reduce -16.7% |
| AMAT Applied Materials Inc. | 0.95% | 24,604 | $5.8M | Reduce -23.1% |
| ENPH Enphase Energy Inc. | 0.92% | 56,792 | $5.7M | Add +20.4% |
| NVS Novartis AG-Sponsored ADR | 0.87% | 50,000 | $5.3M | No change |
| ACAD Acadia Pharmaceuticals Inc. | 0.87% | 327,539 | $5.3M | Add +162.0% |
| MLYS Mineralys Therapeutics Inc. | 0.84% | 442,752 | $5.2M | Reduce -32.8% |
| FDMT 4D Molecular Therapeutics Inc. | 0.83% | 242,526 | $5.1M | Add +49.6% |
| MU Micron Technology Inc. | 0.79% | 37,000 | $4.9M | New |
| DAWN Day One Biopharmaceuticals I | 0.78% | 347,627 | $4.8M | Reduce -29.4% |
| CPRX Catalyst Pharmaceuticals Inc. | 0.73% | 288,000 | $4.5M | No change |
| RCKT Rocket Pharmaceuticals Inc. | 0.73% | 206,933 | $4.5M | Add +12.6% |
| FROG Jfrog Ltd. | 0.72% | 117,881 | $4.4M | Reduce -47.5% |
| ETNB 89BIO Inc. | 0.69% | 526,547 | $4.2M | Add +2.1% |
| OTLK Outlook Therapeutics Inc. | 0.69% | 571,428 | $4.2M | Reduce 0.0% |
| WIX Wix.com Ltd. | 0.65% | 25,177 | $4.0M | Reduce -52.4% |
| LRCX Lam Research Corp. | 0.64% | 3,700 | $3.9M | New |
| SVRA Savara Inc. | 0.63% | 962,687 | $3.9M | New |
| GSK GSK PLC-Spon ADR | 0.63% | 100,000 | $3.9M | No change |
| QCOM Qualcomm Inc. | 0.61% | 18,825 | $3.7M | Add +25.5% |
| ELDN Eledon Pharmaceuticals Inc. | 0.56% | 1,297,021 | $3.4M | New |
| AKRO Akero Therapeutics Inc. | 0.54% | 141,620 | $3.3M | Reduce -11.7% |
| SHLT SHL Telemedicine Ltd.-ADR | 0.53% | 632,456 | $3.2M | No change |
| APLT Applied Therapeutics Inc. | 0.51% | 674,268 | $3.1M | Add +8.9% |
| NTLA Intellia Therapeutics Inc. | 0.51% | 139,419 | $3.1M | New |
| AVGO Broadcom Inc. | 0.51% | 19,360 | $3.1M | Add +1834.1% |
| ADI Analog Devices Inc. | 0.48% | 13,000 | $3.0M | New |
| PTCT PTC Therapeutics Inc. | 0.47% | 94,318 | $2.9M | New |
| VTGN Vistagen Therapeutics Inc. | 0.46% | 808,550 | $2.8M | No change |
| PLRX Pliant Therapeutics Inc. | 0.45% | 258,554 | $2.8M | No change |
| ALEC Alector Inc. | 0.45% | 610,000 | $2.8M | Add +8.9% |
| ENLT Enlight Renewable Energy Ltd. | 0.45% | 169,280 | $2.7M | No change |
| PMN Promis Neurosciences Inc. | 0.44% | 1,814,213 | $2.7M | Reduce -1.1% |
| KLAC KLA Corp. | 0.44% | 3,300 | $2.7M | New |
| SWTX Springworks Therapeutics Inc. | 0.43% | 70,269 | $2.6M | No change |
| IRON Disc Medicine Inc. | 0.43% | 58,044 | $2.6M | Add +18.7% |
| CRGX Cargo Therapeutics Inc. | 0.42% | 155,506 | $2.6M | Add +107.3% |
| PFE Pfizer Inc. | 0.41% | 90,000 | $2.5M | No change |
| NVDA Nvidia Corp. | 0.40% | 20,000 | $2.5M | New |
| GLBE Global-E Online Ltd. | 0.40% | 66,884 | $2.4M | Reduce -68.0% |
| VTYX Ventyx Biosciences Inc. | 0.38% | 1,012,749 | $2.3M | Add +2.0% |
| TBLA Taboola.com Ltd. | 0.37% | 667,384 | $2.3M | Reduce -44.0% |
| LRMR Larimar Therapeutics Inc. | 0.37% | 312,469 | $2.3M | New |
| LHX L3HARRIS Technologies Inc. | 0.37% | 10,000 | $2.2M | New |
| ADCT Adc Therapeutics SA | 0.35% | 685,547 | $2.2M | New |
| NTR Nutrien Ltd. | 0.34% | 40,730 | $2.1M | Add +14.0% |
| PERI Perion Network Ltd. | 0.32% | 234,609 | $2.0M | New |
| KYTX Kyverna Therapeutics Inc. | 0.29% | 236,029 | $1.8M | New |
| ALMS Alumis Inc. | 0.27% | 125,000 | $1.7M | New |
| CLYM Climb Bio Inc. filed as ELIEM THERAPEUTICS INC | 0.25% | 215,179 | $1.5M | New |
| HOWL Werewolf Therapeutics Inc. | 0.25% | 626,810 | $1.5M | No change |
| ATXS Astria Therapeutics Inc. | 0.24% | 162,842 | $1.5M | Add +44.3% |
| VIR Vir Biotechnology Inc. | 0.24% | 162,051 | $1.4M | New |
| GLUE Monte Rosa Therapeutics Inc. | 0.23% | 375,000 | $1.4M | New |
| MRVL Marvell Technology Inc. | 0.23% | 20,000 | $1.4M | New |
| UPWK Upwork Inc. | 0.21% | 117,000 | $1.3M | No change |
| ARWR Arrowhead Pharmaceuticals Inc. | 0.20% | 48,175 | $1.3M | New |
| CGEN Compugen Ltd. | 0.20% | 739,239 | $1.2M | Reduce -3.9% |
| KEZAR LIFE SCIENCES INC | 0.20% | 2,051,676 | $1.2M | No change |
| INSM Insmed Inc. | 0.18% | 16,589 | $1.1M | New |
| APRE Aprea Therapeutics Inc. | 0.18% | 270,000 | $1.1M | No change |
| TSM Taiwan Semiconductor-SP ADR | 0.16% | 5,650 | $982K | New |
| ELEV Elevation Oncology Inc. | 0.15% | 330,000 | $891K | Reduce -23.3% |
| VRNS Varonis Systems Inc. | 0.13% | 16,000 | $768K | Reduce -20.0% |
Options reported separately and not counted above: TEVA calls ($53.1M), SMH puts ($39.1M), QQQ calls ($11.0M), NICE calls ($5.5M), BBIO calls ($5.2M), PRAX calls ($3.1M), SRPT calls ($2.4M), FULC puts ($366K).
Other holdings (1): bonds, preferreds, convertibles and warrants · $277K (not counted above)
| Security | Class | Shares / Principal | Value | Change |
|---|---|---|---|---|
| IMTXW Immatics NV -CW | *W EXP 07/01/202 | 100,000 | $277K | No change |
Total filed on the 13F, all lines: $613.6M.
Portfolio Sells Q1 2024 → Q2 2024
| CATX Perspective Therapeutics Inc. | Sold out | 0.00% | −2.40 |
| TEVA Teva Pharmaceutical-SP ADR | Reduce -58.2% | 2.09% | −2.23 |
| FUSN Fusion Pharmaceuticals Inc. | Sold out | 0.00% | −1.55 |
| NICE Nice Ltd. - Spon ADR | Reduce -5.2% | 2.28% | −1.34 |
| S Sentinelone Inc. Class A | Reduce -48.5% | 0.97% | −1.11 |
| MRK Merck & Co. Inc. | Reduce -42.5% | 1.20% | −1.01 |
| NVMI Nova Ltd. | Sold out | 0.00% | −1.01 |
| CAMT Camtek Ltd. | Reduce -97.4% | 0.04% | −0.98 |
| FROG Jfrog Ltd. | Reduce -47.5% | 0.72% | −0.89 |
| GLBE Global-E Online Ltd. | Reduce -68.0% | 0.40% | −0.83 |
| INCY Incyte Corp. | Sold out | 0.00% | −0.83 |
| JSPR Jasper Therapeutics Inc. | Reduce -10.1% | 1.68% | −0.72 |
| BIIB Biogen Inc. | Reduce -32.9% | 1.79% | −0.68 |
| DAWN Day One Biopharmaceuticals I | Reduce -29.4% | 0.78% | −0.54 |
| MLYS Mineralys Therapeutics Inc. | Reduce -32.8% | 0.84% | −0.53 |
| WIX Wix.com Ltd. | Reduce -52.4% | 0.65% | −0.52 |
| TBLA Taboola.com Ltd. | Reduce -44.0% | 0.37% | −0.48 |
| SEDG Solaredge Technologies Inc. | Sold out | 0.00% | −0.46 |
| OTLK Outlook Therapeutics Inc. | Reduce 0.0% | 0.69% | −0.42 |
| JNJ Johnson & Johnson | Reduce -12.5% | 1.66% | −0.38 |
| SNY Sanofi-ADR | Reduce -10.0% | 3.56% | −0.38 |
| ESTC Elastic NV | Sold out | 0.00% | −0.32 |
| AMD Advanced Micro Devices | Sold out | 0.00% | −0.32 |
| ALPN Alpine Immune Sciences Inc. | Sold out | 0.00% | −0.29 |
| FIVN FIVE9 Inc. | Sold out | 0.00% | −0.28 |
| CRBP Corbus Pharmaceuticals Holdi | Sold out | 0.00% | −0.22 |
| ELEV Elevation Oncology Inc. | Reduce -23.3% | 0.15% | −0.21 |
| GERN Geron Corp. | Sold out | 0.00% | −0.21 |
| GOSS Gossamer Bio Inc. | Reduce -78.4% | 0.03% | −0.16 |
| PRME Prime Medicine Inc. | Reduce -37.9% | 0.11% | −0.13 |
| PMN Promis Neurosciences Inc. | Reduce -1.1% | 0.44% | −0.12 |
| AMAT Applied Materials Inc. | Reduce -23.1% | 0.95% | −0.12 |
| CGEN Compugen Ltd. | Reduce -3.9% | 0.20% | −0.12 |
| AKRO Akero Therapeutics Inc. | Reduce -11.7% | 0.54% | −0.11 |
| AMLX Amylyx Pharmaceuticals Inc. | Reduce -86.5% | 0.01% | −0.11 |
| RNAC Cartesian Therapeutics Inc. | Sold out | 0.00% | −0.08 |
| ANRO Alto Neuroscience Inc. | Sold out | 0.00% | −0.08 |
| ICL Icl Group Ltd. | Reduce -17.8% | 0.07% | −0.04 |
| VRNS Varonis Systems Inc. | Reduce -20.0% | 0.13% | −0.03 |
| TSEM Tower Semiconductor Ltd. | Reduce -16.7% | 0.96% | −0.01 |
| NVO Novo-Nordisk A/S-Spons ADR | Reduce -6.0% | 1.82% | +0.09 |
| VIGL Vigil Neuroscience Inc. | Reduce -2.2% | 1.10% | +0.15 |
| LLY Eli Lilly & Co. | Reduce -7.0% | 1.95% | +0.16 |
| MRUS Merus NV | Reduce -1.1% | 1.42% | +0.34 |
Portfolio Buys Q1 2024 → Q2 2024
| SKYE Skye Bioscience Inc. | New | 1.70% | +1.70 |
| ASML ASML Holding NV-NY Reg SHS | New | 1.65% | +1.65 |
| AAPL Apple Inc. | Add +251.4% | 2.11% | +1.63 |
| AMZN Amazon.com Inc. | Add +86.3% | 3.20% | +1.61 |
| CRM Salesforce Inc. | New | 1.41% | +1.41 |
| CATX Perspective Therapeutics Inc. | New | 1.28% | +1.28 |
| IONS Ionis Pharmaceuticals Inc. | New | 1.09% | +1.09 |
| PANW Palo Alto Networks Inc. | New | 0.99% | +0.99 |
| SRPT Sarepta Therapeutics Inc. | Add +50.4% | 2.16% | +0.99 |
| BBIO Bridgebio Pharma Inc. | Add +55.3% | 3.76% | +0.82 |
| MU Micron Technology Inc. | New | 0.79% | +0.79 |
| RZLT Rezolute Inc. | Add +71.4% | 1.20% | +0.79 |
| META Meta Platforms Inc. Class A | Add +31.4% | 2.75% | +0.75 |
| LRCX Lam Research Corp. | New | 0.64% | +0.64 |
| SVRA Savara Inc. | New | 0.63% | +0.63 |
| ELDN Eledon Pharmaceuticals Inc. | New | 0.56% | +0.56 |
| MSFT Microsoft Corp. | Add +19.5% | 2.40% | +0.52 |
| NTLA Intellia Therapeutics Inc. | New | 0.51% | +0.51 |
| ACAD Acadia Pharmaceuticals Inc. | Add +162.0% | 0.87% | +0.49 |
| ADI Analog Devices Inc. | New | 0.48% | +0.48 |
| PTCT PTC Therapeutics Inc. | New | 0.47% | +0.47 |
| KLAC KLA Corp. | New | 0.44% | +0.44 |
| NVDA Nvidia Corp. | New | 0.40% | +0.40 |
| LRMR Larimar Therapeutics Inc. | New | 0.37% | +0.37 |
| LHX L3HARRIS Technologies Inc. | New | 0.37% | +0.37 |
| ADCT Adc Therapeutics SA | New | 0.35% | +0.35 |
| PERI Perion Network Ltd. | New | 0.32% | +0.32 |
| AVGO Broadcom Inc. | Add +1834.1% | 0.51% | +0.29 |
| KYTX Kyverna Therapeutics Inc. | New | 0.29% | +0.29 |
| ALMS Alumis Inc. | New | 0.27% | +0.27 |
| IMTX Immatics NV | Add +9.8% | 1.39% | +0.25 |
| CLYM Climb Bio Inc. | New | 0.25% | +0.25 |
| VIR Vir Biotechnology Inc. | New | 0.24% | +0.24 |
| GLUE Monte Rosa Therapeutics Inc. | New | 0.23% | +0.23 |
| MRVL Marvell Technology Inc. | New | 0.23% | +0.23 |
| ARWR Arrowhead Pharmaceuticals Inc. | New | 0.20% | +0.20 |
| CYTK Cytokinetics Inc. | Add +36.7% | 3.40% | +0.20 |
| QCOM Qualcomm Inc. | Add +25.5% | 0.61% | +0.20 |
| INSM Insmed Inc. | New | 0.18% | +0.18 |
| RARE Ultragenyx Pharmaceutical Inc. | Add +23.2% | 1.97% | +0.16 |
| PRAX Praxis Precision Medicines I | Add +60.0% | 1.91% | +0.16 |
| TSM Taiwan Semiconductor-SP ADR | New | 0.16% | +0.16 |
| CRGX Cargo Therapeutics Inc. | Add +107.3% | 0.42% | +0.15 |
| RNAC Cartesian Therapeutics Inc. | New | 0.11% | +0.11 |
| ARGX Argenx SE - ADR | New | 0.11% | +0.11 |
| NTR Nutrien Ltd. | Add +14.0% | 0.34% | +0.02 |
| ENPH Enphase Energy Inc. | Add +20.4% | 0.92% | −0.00 |
| FDMT 4D Molecular Therapeutics Inc. | Add +49.6% | 0.83% | −0.01 |
| ATXS Astria Therapeutics Inc. | Add +44.3% | 0.24% | −0.02 |
| CLDX Celldex Therapeutics Inc. | Add +11.7% | 1.87% | −0.02 |
Options Activity Q1 2024 → Q2 2024
| TEVA Teva Pharmaceutical-SP ADR | call | Add +4.3% | 3,268,900 | $53.1M |
| SMH Vaneck Semiconductor ETF | put | New | 149,800 | $39.1M |
| XBI SS SPDR S&P Biotech ETF | put | Sold out | 380,000 | $36.1Mbefore exit |
| QQQ Invesco QQQ Trust Series 1 | call | New | 22,900 | $11.0M |
| NICE Nice Ltd. - Spon ADR | call | New | 32,100 | $5.5M |
| BBIO Bridgebio Pharma Inc. | call | Add +309.2% | 204,600 | $5.2M |
| PRAX Praxis Precision Medicines I | call | New | 75,000 | $3.1M |
| ALNY Alnylam Pharmaceuticals Inc. | call | Sold out | 20,000 | $3.0Mbefore exit |
| RARE Ultragenyx Pharmaceutical Inc. | call | Sold out | 55,000 | $2.6Mbefore exit |
| SRPT Sarepta Therapeutics Inc. | call | New | 15,000 | $2.4M |
| SEDG Solaredge Technologies Inc. | call | Sold out | 26,800 | $1.9Mbefore exit |
| ACAD Acadia Pharmaceuticals Inc. | call | Sold out | 100,000 | $1.8Mbefore exit |
| IRON Disc Medicine Inc. | call | Sold out | 25,000 | $1.6Mbefore exit |
| INSM Insmed Inc. | call | Sold out | 28,100 | $762Kbefore exit |
| AMLX Amylyx Pharmaceuticals Inc. | call | Sold out | 240,000 | $682Kbefore exit |
| FULC Fulcrum Therapeutics Inc. | put | New | 59,000 | $366K |
| ANNX Annexon Inc. | put | Sold out | 11,400 | $82Kbefore exit |
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 97 | $698.8M | TEVA, MLYS, TSEM, SNDX, BIIB |
| Q1 2026 | 92 | $581.5M | MLYS, TEVA, TSEM, NVMI, BBIO |
| Q4 2025 | 94 | $478.5M | TEVA, BIIB, MLYS, SNDX, NVMI |
| Q3 2025 | 101 | $421.6M | TEVA, NICE, TSEM, NVMI, QQQ |
| Q2 2025 | 101 | $382.5M | TEVA, NVMI, SNDX, TSEM, CYTK |
| Q1 2025 | 111 | $405.5M | TEVA, SNDX, SNY, NVMI, AZN |
| Q4 2024 | 102 | $541.4M | TEVA, BBIO, SNY, SNDX, AZN |
| Q3 2024 | 107 | $611.0M | TEVA, SNY, BBIO, SNDX, AMZN |
| Q2 2024 | 109 | $613.3M | BBIO, SNY, CYTK, AMZN, SNDX |
| Q1 2024 | 92 | $617.3M | TEVA, SNY, NICE, CYTK, SNDX |