Sphera Funds Management LTD.
In its 13F for Q3 2024 (holdings as of September 30, 2024, filed November 14, 2024), Sphera Funds Management LTD. reported 107 stock positions worth $611.0 million. Its top holding was Teva Pharmaceutical-SP ADR (TEVA) at 6.3% of the portfolio, followed by Sanofi-ADR (SNY, 3.9%) and Bridgebio Pharma (BBIO, 3.5%). Compared with Q2 2024, it opened 19 new positions, sold out of 21, added to 28 and reduced 40. The biggest buy was Teva Pharmaceutical-SP ADR (TEVA, shares +170%) and the biggest sale Cytokinetics (CYTK, shares −42%).
- Most Recent 13F
- Q2 2026
- Location
- TEL AVIV, L3
- CIK
- 0001496201
- Portfolio Value
- $611.0M (Q3 2024)
- SEC Filing
- 0001496201-24-000017 ↗ filed Nov 14, 2024
Holdings Value
Holdings 107 stocks · $611.0M
| TEVA Teva Pharmaceutical-SP ADR | 6.28% | 2,130,216 | $38.4M | Add +169.8% |
| SNY Sanofi-ADR | 3.86% | 409,515 | $23.6M | Reduce -8.9% |
| BBIO Bridgebio Pharma Inc. | 3.51% | 842,644 | $21.5M | Reduce -7.4% |
| SNDX Syndax Pharmaceuticals Inc. | 3.26% | 1,034,846 | $19.9M | Add +25.9% |
| AMZN Amazon.com Inc. | 3.22% | 105,607 | $19.7M | Add +4.1% |
| META Meta Platforms Inc. Class A | 2.75% | 29,316 | $16.8M | Reduce -12.3% |
| SRPT Sarepta Therapeutics Inc. | 2.57% | 125,846 | $15.7M | Add +50.4% |
| AZN Astrazeneca PLC-Spons ADR | 2.42% | 190,060 | $14.8M | No change |
| MSFT Microsoft Corp. | 2.35% | 33,427 | $14.4M | Add +1.5% |
| CLDX Celldex Therapeutics Inc. | 2.33% | 419,103 | $14.2M | Add +35.5% |
| AAPL Apple Inc. | 2.32% | 60,847 | $14.2M | Reduce -1.1% |
| NICE Nice Ltd. - Spon ADR | 2.23% | 78,361 | $13.6M | Reduce -3.8% |
| KURA Kura Oncology Inc. | 1.95% | 610,087 | $11.9M | Reduce -0.1% |
| CYTK Cytokinetics Inc. | 1.94% | 225,021 | $11.9M | Reduce -41.5% |
| LLY Eli Lilly & Co. | 1.91% | 13,190 | $11.7M | No change |
| JNJ Johnson & Johnson | 1.85% | 69,831 | $11.3M | No change |
| RARE Ultragenyx Pharmaceutical Inc. | 1.78% | 195,349 | $10.9M | Reduce -33.5% |
| NVMI Nova Ltd. | 1.77% | 51,960 | $10.8M | New |
| NVO Novo-Nordisk A/S-Spons ADR | 1.52% | 78,080 | $9.3M | No change |
| TSEM Tower Semiconductor Ltd. | 1.52% | 209,441 | $9.3M | Add +40.0% |
| PRAX Praxis Precision Medicines I | 1.43% | 152,307 | $8.8M | Reduce -46.3% |
| VKTX Viking Therapeutics Inc. | 1.38% | 133,066 | $8.4M | New |
| HELP Cybin Inc. | 1.36% | 933,225 | $8.3M | Add +39.5% |
| IMTX Immatics NV | 1.35% | 721,111 | $8.2M | Reduce -1.4% |
| PHVS Pharvaris NV | 1.33% | 439,292 | $8.1M | Add +8.9% |
| CATX Perspective Therapeutics Inc. | 1.29% | 589,295 | $7.9M | Reduce -25.1% |
| CHKP Check Point Software Tech | 1.27% | 40,215 | $7.8M | New |
| ABBV Abbvie Inc. | 1.23% | 38,000 | $7.5M | No change |
| MRUS Merus NV | 1.21% | 147,633 | $7.4M | No change |
| ENPH Enphase Energy Inc. | 1.19% | 64,224 | $7.3M | Add +13.1% |
| MRK Merck & Co. Inc. | 1.11% | 59,600 | $6.8M | No change |
| BHVN Biohaven Ltd. | 1.09% | 133,323 | $6.7M | New |
| S Sentinelone Inc. Class A | 1.08% | 276,554 | $6.6M | Reduce -2.5% |
| MRVL Marvell Technology Inc. | 1.03% | 87,611 | $6.3M | Add +338.1% |
| INZY Inozyme Pharma Inc. | 1.02% | 1,191,140 | $6.2M | Reduce -18.6% |
| APLS Apellis Pharmaceuticals Inc. | 1.02% | 215,873 | $6.2M | New |
| SKYE Skye Bioscience Inc. | 1.00% | 1,563,522 | $6.1M | Add +20.4% |
| NTLA Intellia Therapeutics Inc. | 0.98% | 291,080 | $6.0M | Add +108.8% |
| RZLT Rezolute Inc. | 0.95% | 1,196,938 | $5.8M | Reduce -29.9% |
| NVS Novartis AG-Sponsored ADR | 0.94% | 50,000 | $5.8M | No change |
| WIX Wix.com Ltd. | 0.94% | 34,253 | $5.7M | Add +36.0% |
| VIGL Vigil Neuroscience Inc. | 0.92% | 1,647,604 | $5.6M | Reduce -2.6% |
| ORMAT TECHNOLOGIES INC (ORA 2.5 07/15/27 SEPT) | 0.86% | 5,037,000 | $5.3M | New |
| DAWN Day One Biopharmaceuticals I | 0.79% | 347,627 | $4.8M | No change |
| BIIB Biogen Inc. | 0.78% | 24,455 | $4.7M | Reduce -48.4% |
| PTCT PTC Therapeutics Inc. | 0.72% | 118,345 | $4.4M | Add +25.5% |
| RCKT Rocket Pharmaceuticals Inc. | 0.70% | 231,792 | $4.3M | Add +12.0% |
| GSK GSK PLC-Spon ADR | 0.67% | 100,000 | $4.1M | No change |
| ETNB 89BIO Inc. | 0.65% | 536,547 | $4.0M | Add +1.9% |
| ACAD Acadia Pharmaceuticals Inc. | 0.64% | 252,539 | $3.9M | Reduce -22.9% |
| JSPR Jasper Therapeutics Inc. | 0.58% | 189,270 | $3.6M | Reduce -58.3% |
| CRGX Cargo Therapeutics Inc. | 0.58% | 190,506 | $3.5M | Add +22.5% |
| FROG Jfrog Ltd. | 0.57% | 120,381 | $3.5M | Add +2.1% |
| PLRX Pliant Therapeutics Inc. | 0.55% | 297,362 | $3.3M | Add +15.0% |
| MLYS Mineralys Therapeutics Inc. | 0.54% | 272,472 | $3.3M | Reduce -38.5% |
| ELDN Eledon Pharmaceuticals Inc. | 0.53% | 1,297,321 | $3.2M | Add +0.0% |
| CGEM Cullinan Therapeutics Inc. | 0.51% | 185,871 | $3.1M | New |
| CRWD CrowdStrike Holdings Inc. Class A | 0.50% | 10,862 | $3.0M | New |
| ZURA Zura Bio Ltd. | 0.49% | 738,718 | $3.0M | New |
| NVDA Nvidia Corp. | 0.48% | 24,355 | $3.0M | Add +21.8% |
| AVGO Broadcom Inc. | 0.48% | 16,880 | $2.9M | Reduce -91.3% |
| CAMT Camtek Ltd. | 0.47% | 36,287 | $2.9M | Add +1770.5% |
| ALEC Alector Inc. | 0.47% | 620,000 | $2.9M | Add +1.6% |
| LRMR Larimar Therapeutics Inc. | 0.44% | 414,478 | $2.7M | Add +32.6% |
| APLT Applied Therapeutics Inc. | 0.43% | 311,572 | $2.6M | Reduce -53.8% |
| PFE Pfizer Inc. | 0.43% | 90,000 | $2.6M | No change |
| ENLT Enlight Renewable Energy Ltd. | 0.42% | 151,860 | $2.6M | Reduce -10.3% |
| IONS Ionis Pharmaceuticals Inc. | 0.42% | 63,821 | $2.6M | Reduce -54.5% |
| GLBE Global-E Online Ltd. | 0.41% | 64,384 | $2.5M | Reduce -3.7% |
| VTGN Vistagen Therapeutics Inc. | 0.40% | 808,550 | $2.4M | No change |
| PMN Promis Neurosciences Inc. | 0.39% | 1,929,297 | $2.4M | Add +6.3% |
| SVRA Savara Inc. | 0.39% | 563,107 | $2.4M | Reduce -41.5% |
| ASML ASML Holding NV-NY Reg SHS | 0.39% | 2,840 | $2.4M | Reduce -71.3% |
| OTLK Outlook Therapeutics Inc. | 0.36% | 413,545 | $2.2M | Reduce -27.6% |
| VTYX Ventyx Biosciences Inc. | 0.36% | 1,012,749 | $2.2M | No change |
| KLAC KLA Corp. | 0.35% | 2,775 | $2.1M | Reduce -15.9% |
| SHLT SHL Telemedicine Ltd.-ADR | 0.35% | 632,456 | $2.1M | No change |
| DYN Dyne Therapeutics Inc. | 0.33% | 56,504 | $2.0M | New |
| VRDN Viridian Therapeutics Inc. | 0.32% | 86,094 | $2.0M | New |
| NTR Nutrien Ltd. | 0.32% | 40,730 | $2.0M | No change |
| ALNY Alnylam Pharmaceuticals Inc. | 0.32% | 7,000 | $1.9M | New |
| CMMB Chemomab Therapeutics Ltd. | 0.31% | 1,214,575 | $1.9M | New |
| PERI Perion Network Ltd. | 0.30% | 234,609 | $1.8M | No change |
| WDAY Workday Inc. Class A | 0.30% | 7,500 | $1.8M | New |
| KEZAR LIFE SCIENCES INC | 0.26% | 205,168 | $1.6M | Reduce -90.0% |
| ADI Analog Devices Inc. | 0.25% | 6,660 | $1.5M | Reduce -48.8% |
| ATXS Astria Therapeutics Inc. | 0.25% | 136,582 | $1.5M | Reduce -16.1% |
| SRRK Scholar Rock Holding Corp. | 0.22% | 166,866 | $1.3M | New |
| ALMS Alumis Inc. | 0.22% | 125,000 | $1.3M | No change |
| HOWL Werewolf Therapeutics Inc. | 0.22% | 626,810 | $1.3M | No change |
| QCOM Qualcomm Inc. | 0.22% | 7,800 | $1.3M | Reduce -58.6% |
| ORIC Oric Pharmaceuticals Inc. | 0.22% | 128,396 | $1.3M | New |
| KYTX Kyverna Therapeutics Inc. | 0.20% | 248,651 | $1.2M | Add +5.3% |
| CAPR Capricor Therapeutics Inc. | 0.15% | 61,698 | $938K | New |
| CLYM Climb Bio Inc. filed as ELIEM THERAPEUTICS INC | 0.15% | 181,970 | $926K | Reduce -15.4% |
| APRE Aprea Therapeutics Inc. | 0.12% | 270,000 | $743K | No change |
| VIR Vir Biotechnology Inc. | 0.11% | 93,329 | $699K | Reduce -42.4% |
| ELEV Elevation Oncology Inc. | 0.11% | 1,079,762 | $648K | Add +227.2% |
| ADCT Adc Therapeutics SA | 0.11% | 205,036 | $646K | Reduce -70.1% |
| GLUE Monte Rosa Therapeutics Inc. | 0.10% | 118,103 | $626K | Reduce -68.5% |
| FDMT 4D Molecular Therapeutics Inc. | 0.09% | 48,702 | $526K | Reduce -79.9% |
| CGEN Compugen Ltd. | 0.07% | 227,094 | $411K | Reduce -69.3% |
| TNGX Tango Therapeutics Inc. | 0.06% | 50,000 | $385K | New |
| PRME Prime Medicine Inc. | 0.05% | 76,456 | $296K | Reduce -40.0% |
| LVTX Lava Therapeutics NV | 0.04% | 146,457 | $243K | Reduce -60.2% |
| TENX Tenax Therapeutics Inc. | 0.02% | 29,166 | $101K | New |
| ARBE Arbe Robotics Ltd. | 0.01% | 43,165 | $82K | No change |
Options reported separately and not counted above: NICE calls ($5.6M), PRAX puts ($3.0M), CYTK calls ($2.6M), TVTX calls ($2.4M), PRAX calls ($2.3M), JSPR calls ($1.1M), SRPT calls ($125K).
Other holdings (1): bonds, preferreds, convertibles and warrants · $230K (not counted above)
| Security | Class | Shares / Principal | Value | Change |
|---|---|---|---|---|
| IMTXW Immatics NV -CW | *W EXP 07/01/202 | 100,000 | $230K | No change |
Total filed on the 13F, all lines: $611.2M.
Portfolio Sells Q2 2024 → Q3 2024
| CYTK Cytokinetics Inc. | Reduce -41.5% | 1.94% | −1.46 |
| CRM Salesforce Inc. | Sold out | 0.00% | −1.41 |
| ASML ASML Holding NV-NY Reg SHS | Reduce -71.3% | 0.39% | −1.26 |
| JSPR Jasper Therapeutics Inc. | Reduce -58.3% | 0.58% | −1.10 |
| BIIB Biogen Inc. | Reduce -48.4% | 0.78% | −1.02 |
| PANW Palo Alto Networks Inc. | Sold out | 0.00% | −0.99 |
| AMAT Applied Materials Inc. | Sold out | 0.00% | −0.95 |
| MU Micron Technology Inc. | Sold out | 0.00% | −0.79 |
| FDMT 4D Molecular Therapeutics Inc. | Reduce -79.9% | 0.09% | −0.74 |
| CPRX Catalyst Pharmaceuticals Inc. | Sold out | 0.00% | −0.73 |
| IONS Ionis Pharmaceuticals Inc. | Reduce -54.5% | 0.42% | −0.67 |
| LRCX Lam Research Corp. | Sold out | 0.00% | −0.64 |
| AKRO Akero Therapeutics Inc. | Sold out | 0.00% | −0.54 |
| PRAX Praxis Precision Medicines I | Reduce -46.3% | 1.43% | −0.48 |
| SWTX Springworks Therapeutics Inc. | Sold out | 0.00% | −0.43 |
| IRON Disc Medicine Inc. | Sold out | 0.00% | −0.43 |
| QCOM Qualcomm Inc. | Reduce -58.6% | 0.22% | −0.39 |
| TBLA Taboola.com Ltd. | Sold out | 0.00% | −0.37 |
| LHX L3HARRIS Technologies Inc. | Sold out | 0.00% | −0.37 |
| OTLK Outlook Therapeutics Inc. | Reduce -27.6% | 0.36% | −0.33 |
| MLYS Mineralys Therapeutics Inc. | Reduce -38.5% | 0.54% | −0.30 |
| BBIO Bridgebio Pharma Inc. | Reduce -7.4% | 3.51% | −0.25 |
| ADCT Adc Therapeutics SA | Reduce -70.1% | 0.11% | −0.25 |
| RZLT Rezolute Inc. | Reduce -29.9% | 0.95% | −0.25 |
| SVRA Savara Inc. | Reduce -41.5% | 0.39% | −0.24 |
| ADI Analog Devices Inc. | Reduce -48.8% | 0.25% | −0.23 |
| ACAD Acadia Pharmaceuticals Inc. | Reduce -22.9% | 0.64% | −0.23 |
| UPWK Upwork Inc. | Sold out | 0.00% | −0.21 |
| ARWR Arrowhead Pharmaceuticals Inc. | Sold out | 0.00% | −0.20 |
| RARE Ultragenyx Pharmaceutical Inc. | Reduce -33.5% | 1.78% | −0.19 |
| VIGL Vigil Neuroscience Inc. | Reduce -2.6% | 0.92% | −0.19 |
| INSM Insmed Inc. | Sold out | 0.00% | −0.18 |
| TSM Taiwan Semiconductor-SP ADR | Sold out | 0.00% | −0.16 |
| CGEN Compugen Ltd. | Reduce -69.3% | 0.07% | −0.14 |
| GLUE Monte Rosa Therapeutics Inc. | Reduce -68.5% | 0.10% | −0.13 |
| VRNS Varonis Systems Inc. | Sold out | 0.00% | −0.13 |
| VIR Vir Biotechnology Inc. | Reduce -42.4% | 0.11% | −0.12 |
| RNAC Cartesian Therapeutics Inc. | Sold out | 0.00% | −0.11 |
| ARGX Argenx SE - ADR | Sold out | 0.00% | −0.11 |
| KURA Kura Oncology Inc. | Reduce -0.1% | 1.95% | −0.10 |
| CLYM Climb Bio Inc. | Reduce -15.4% | 0.15% | −0.10 |
| KLAC KLA Corp. | Reduce -15.9% | 0.35% | −0.09 |
| APLT Applied Therapeutics Inc. | Reduce -53.8% | 0.43% | −0.08 |
| ICL Icl Group Ltd. | Sold out | 0.00% | −0.07 |
| LVTX Lava Therapeutics NV | Reduce -60.2% | 0.04% | −0.07 |
| PRME Prime Medicine Inc. | Reduce -40.0% | 0.05% | −0.06 |
| NICE Nice Ltd. - Spon ADR | Reduce -3.8% | 2.23% | −0.06 |
| INZY Inozyme Pharma Inc. | Reduce -18.6% | 1.02% | −0.04 |
| IMTX Immatics NV | Reduce -1.4% | 1.35% | −0.04 |
| GOSS Gossamer Bio Inc. | Sold out | 0.00% | −0.03 |
Portfolio Buys Q2 2024 → Q3 2024
| TEVA Teva Pharmaceutical-SP ADR | Add +169.8% | 6.28% | +4.19 |
| NVMI Nova Ltd. | New | 1.77% | +1.77 |
| VKTX Viking Therapeutics Inc. | New | 1.38% | +1.38 |
| CHKP Check Point Software Tech | New | 1.27% | +1.27 |
| BHVN Biohaven Ltd. | New | 1.09% | +1.09 |
| APLS Apellis Pharmaceuticals Inc. | New | 1.02% | +1.02 |
| ORMAT TECHNOLOGIES INC (ORA 2.5 07/15/27 SEPT) | New | 0.86% | +0.86 |
| MRVL Marvell Technology Inc. | Add +338.1% | 1.03% | +0.81 |
| TSEM Tower Semiconductor Ltd. | Add +40.0% | 1.52% | +0.56 |
| CGEM Cullinan Therapeutics Inc. | New | 0.51% | +0.51 |
| SNDX Syndax Pharmaceuticals Inc. | Add +25.9% | 3.26% | +0.51 |
| CRWD CrowdStrike Holdings Inc. Class A | New | 0.50% | +0.50 |
| ZURA Zura Bio Ltd. | New | 0.49% | +0.49 |
| NTLA Intellia Therapeutics Inc. | Add +108.8% | 0.98% | +0.47 |
| CLDX Celldex Therapeutics Inc. | Add +35.5% | 2.33% | +0.47 |
| CAMT Camtek Ltd. | Add +1770.5% | 0.47% | +0.43 |
| SRPT Sarepta Therapeutics Inc. | Add +50.4% | 2.57% | +0.42 |
| DYN Dyne Therapeutics Inc. | New | 0.33% | +0.33 |
| VRDN Viridian Therapeutics Inc. | New | 0.32% | +0.32 |
| ALNY Alnylam Pharmaceuticals Inc. | New | 0.32% | +0.32 |
| CMMB Chemomab Therapeutics Ltd. | New | 0.31% | +0.31 |
| WDAY Workday Inc. Class A | New | 0.30% | +0.30 |
| WIX Wix.com Ltd. | Add +36.0% | 0.94% | +0.28 |
| ENPH Enphase Energy Inc. | Add +13.1% | 1.19% | +0.26 |
| PTCT PTC Therapeutics Inc. | Add +25.5% | 0.72% | +0.25 |
| HELP Cybin Inc. | Add +39.5% | 1.36% | +0.23 |
| SRRK Scholar Rock Holding Corp. | New | 0.22% | +0.22 |
| ORIC Oric Pharmaceuticals Inc. | New | 0.22% | +0.22 |
| CRGX Cargo Therapeutics Inc. | Add +22.5% | 0.58% | +0.16 |
| CAPR Capricor Therapeutics Inc. | New | 0.15% | +0.15 |
| PHVS Pharvaris NV | Add +8.9% | 1.33% | +0.10 |
| PLRX Pliant Therapeutics Inc. | Add +15.0% | 0.55% | +0.09 |
| NVDA Nvidia Corp. | Add +21.8% | 0.48% | +0.08 |
| LRMR Larimar Therapeutics Inc. | Add +32.6% | 0.44% | +0.07 |
| TNGX Tango Therapeutics Inc. | New | 0.06% | +0.06 |
| AMZN Amazon.com Inc. | Add +4.1% | 3.22% | +0.02 |
| ALEC Alector Inc. | Add +1.6% | 0.47% | +0.02 |
| TENX Tenax Therapeutics Inc. | New | 0.02% | +0.02 |
| RCKT Rocket Pharmaceuticals Inc. | Add +12.0% | 0.70% | −0.03 |
| ELDN Eledon Pharmaceuticals Inc. | Add +0.0% | 0.53% | −0.03 |
| ETNB 89BIO Inc. | Add +1.9% | 0.65% | −0.04 |
| ELEV Elevation Oncology Inc. | Add +227.2% | 0.11% | −0.04 |
| MSFT Microsoft Corp. | Add +1.5% | 2.35% | −0.05 |
| PMN Promis Neurosciences Inc. | Add +6.3% | 0.39% | −0.05 |
| KYTX Kyverna Therapeutics Inc. | Add +5.3% | 0.20% | −0.09 |
| FROG Jfrog Ltd. | Add +2.1% | 0.57% | −0.15 |
| SKYE Skye Bioscience Inc. | Add +20.4% | 1.00% | −0.70 |
Options Activity Q2 2024 → Q3 2024
| TEVA Teva Pharmaceutical-SP ADR | call | Sold out | 3,268,900 | $53.1Mbefore exit |
| SMH Vaneck Semiconductor ETF | put | Sold out | 149,800 | $39.1Mbefore exit |
| QQQ Invesco QQQ Trust Series 1 | call | Sold out | 22,900 | $11.0Mbefore exit |
| BBIO Bridgebio Pharma Inc. | call | Sold out | 204,600 | $5.2Mbefore exit |
| PRAX Praxis Precision Medicines I | put | New | 52,000 | $3.0M |
| CYTK Cytokinetics Inc. | call | New | 50,000 | $2.6M |
| TVTX Travere Therapeutics Inc. | call | New | 170,700 | $2.4M |
| PRAX Praxis Precision Medicines I | call | Reduce -46.7% | 40,000 | $2.3M |
| JSPR Jasper Therapeutics Inc. | call | New | 61,100 | $1.1M |
| FULC Fulcrum Therapeutics Inc. | put | Sold out | 59,000 | $366Kbefore exit |
| SRPT Sarepta Therapeutics Inc. | call | Reduce -93.3% | 1,000 | $125K |
Calls and puts are listed by the shares they cover; their value is not part of the stock holdings above.
All Filings
| Quarter | Positions | 13F Reported Value | Top Holdings |
|---|---|---|---|
| Q2 2026 | 97 | $698.8M | TEVA, MLYS, TSEM, SNDX, BIIB |
| Q1 2026 | 92 | $581.5M | MLYS, TEVA, TSEM, NVMI, BBIO |
| Q4 2025 | 94 | $478.5M | TEVA, BIIB, MLYS, SNDX, NVMI |
| Q3 2025 | 101 | $421.6M | TEVA, NICE, TSEM, NVMI, QQQ |
| Q2 2025 | 101 | $382.5M | TEVA, NVMI, SNDX, TSEM, CYTK |
| Q1 2025 | 111 | $405.5M | TEVA, SNDX, SNY, NVMI, AZN |
| Q4 2024 | 102 | $541.4M | TEVA, BBIO, SNY, SNDX, AZN |
| Q3 2024 | 107 | $611.0M | TEVA, SNY, BBIO, SNDX, AMZN |
| Q2 2024 | 109 | $613.3M | BBIO, SNY, CYTK, AMZN, SNDX |
| Q1 2024 | 92 | $617.3M | TEVA, SNY, NICE, CYTK, SNDX |