| EOLS Evolus Inc. | 5.61% | 4,847,399 | $78.5M | No change |
| TARS Tarsus Pharmaceuticals Inc. | 5.30% | 2,254,797 | $74.2M | No change |
| AUPH Aurinia Pharmaceuticals Inc. | 3.79% | 7,229,500 | $53.0M | Add +160.1% |
| VRDN Viridian Therapeutics Inc. | 3.65% | 2,242,925 | $51.0M | Add +61.0% |
| MIRM Mirum Pharmaceuticals Inc. | 3.59% | 1,287,107 | $50.2M | No change |
| KALV Kalvista Pharmaceuticals Inc. | 3.57% | 4,321,547 | $50.0M | Add +2.4% |
| ANAB Anaptysbio Inc. | 3.18% | 1,330,879 | $44.6M | No change |
| IMCR Immunocore Holdings PLC-ADR | 2.46% | 1,105,600 | $34.4M | Add +172.6% |
| PCVX Vaxcyte Inc. | 2.45% | 300,000 | $34.3M | No change |
| BNTX Biontech SE-ADR | 2.29% | 270,000 | $32.1M | New |
| ANIP Ani Pharmaceuticals Inc. | 1.92% | 450,000 | $26.8M | No change |
| PTCT PTC Therapeutics Inc. | 1.86% | 700,000 | $26.0M | No change |
| RLAY Relay Therapeutics Inc. | 1.80% | 3,568,058 | $25.3M | New |
| ITOS Iteos Therapeutics Inc. | 1.76% | 2,407,800 | $24.6M | New |
| APLT Applied Therapeutics Inc. | 1.66% | 2,730,000 | $23.2M | Add +17.2% |
| ACAD Acadia Pharmaceuticals Inc. | 1.65% | 1,500,000 | $23.1M | No change |
| ITCI Intra-Cellular Therapies Inc. | 1.57% | 300,000 | $22.0M | No change |
| DVAX Dynavax Technologies Corp. | 1.51% | 1,900,000 | $21.2M | Reduce -24.0% |
| LKFT Lakefront Biotherapeutic-ADR filed as GALAPAGOS NV | 1.44% | 700,000 | $20.2M | Add +1158.8% |
| GSK GSK PLC-Spon ADR | 1.31% | 450,000 | $18.4M | Add +12.5% |
| LENZ Lenz Therapeutics Inc. | 1.30% | 766,940 | $18.2M | Add +2.6% |
| NVDA Nvidia Corp. | 1.28% | 147,732 | $17.9M | Add +28.4% |
| NBIX Neurocrine Biosciences Inc. | 1.23% | 150,000 | $17.3M | New |
| ALT Altimmune Inc. | 1.21% | 2,750,000 | $16.9M | No change |
| AVDL Avadel Pharmaceuticals Ltd. | 1.15% | 1,230,000 | $16.1M | No change |
| KNSA Kiniksa Pharmaceuticals Inte | 1.12% | 628,609 | $15.7M | Add +0.5% |
| JAZZ Jazz Pharmaceuticals PLC | 1.11% | 140,000 | $15.6M | No change |
| AVIR Atea Pharmaceuticals Inc. | 1.10% | 4,607,060 | $15.4M | Add +2.9% |
| CGEM Cullinan Therapeutics Inc. | 1.10% | 921,138 | $15.4M | No change |
| META Meta Platforms Inc. Class A | 1.06% | 25,855 | $14.8M | Add +126.9% |
| RCKT Rocket Pharmaceuticals Inc. | 0.99% | 750,000 | $13.9M | No change |
| ZYME Zymeworks Inc. | 0.99% | 1,100,000 | $13.8M | No change |
| REPL Replimune Group Inc. | 0.94% | 1,200,000 | $13.2M | Add +49.0% |
| RVNC Revance Therapeutics Inc. | 0.93% | 2,500,000 | $13.0M | Add +525.0% |
| CRGX Cargo Therapeutics Inc. | 0.92% | 700,749 | $12.9M | Add +22.4% |
| TDOC Teladoc Health Inc. | 0.92% | 1,400,000 | $12.9M | Add +40.0% |
| NVAX Novavax Inc. | 0.90% | 1,000,000 | $12.6M | New |
| CRSP Crispr Therapeutics AG | 0.89% | 266,500 | $12.5M | Reduce -15.8% |
| CRBP Corbus Pharmaceuticals Holdi | 0.88% | 600,000 | $12.4M | New |
| ACET Adicet Bio Inc. | 0.85% | 8,216,960 | $11.8M | No change |
| AZN Astrazeneca PLC-Spons ADR | 0.83% | 150,000 | $11.7M | No change |
| HRMY Harmony Biosciences Holdings | 0.80% | 281,200 | $11.2M | No change |
| VNDA Vanda Pharmaceuticals Inc. | 0.79% | 2,353,307 | $11.0M | Add +9.3% |
| IMNM Immunome Inc. | 0.75% | 720,000 | $10.5M | No change |
| CTMX Cytomx Therapeutics Inc. | 0.66% | 7,811,760 | $9.2M | Add +0.3% |
| NUVB Nuvation Bio Inc. | 0.64% | 3,900,000 | $8.9M | Add +4.0% |
| ELAN Elanco Animal Health Inc. | 0.63% | 600,000 | $8.8M | New |
| HLVX Hillevax Inc. | 0.62% | 4,920,000 | $8.7M | New |
| OTLK Outlook Therapeutics Inc. | 0.59% | 1,559,560 | $8.3M | Reduce -3.7% |
| ONC Beone Medicines Ltd.-ADR filed as BEIGENE LTD | 0.59% | 37,000 | $8.3M | No change |
| MRNS Marinus Pharmaceuticals Inc. | 0.59% | 4,700,000 | $8.3M | Reduce -2.1% |
| LQDA Liquidia Corp. | 0.57% | 800,000 | $8.0M | Add +128.6% |
| DSGN Design Therapeutics Inc. | 0.57% | 1,480,975 | $8.0M | No change |
| ALXO Alx Oncology Holdings Inc. | 0.55% | 4,204,735 | $7.7M | New |
| VKTX Viking Therapeutics Inc. | 0.54% | 120,000 | $7.6M | No change |
| INSM Insmed Inc. | 0.52% | 100,000 | $7.3M | No change |
| DNTH Dianthus Therapeutics Inc. | 0.52% | 264,692 | $7.2M | No change |
| BHVN Biohaven Ltd. | 0.50% | 140,000 | $7.0M | No change |
| BIIB Biogen Inc. | 0.48% | 35,000 | $6.8M | No change |
| VTYX Ventyx Biosciences Inc. | 0.48% | 3,100,000 | $6.8M | No change |
| BLCO Bausch + Lomb Corp. | 0.48% | 350,000 | $6.8M | New |
| CNTA Centessa Pharmaceuticals Ltd. | 0.46% | 400,000 | $6.4M | New |
| GPCR Structure Therapeutics Inc. | 0.45% | 144,500 | $6.3M | No change |
| BCRX Biocryst Pharmaceuticals Inc. | 0.43% | 800,000 | $6.1M | No change |
| IONS Ionis Pharmaceuticals Inc. | 0.43% | 150,000 | $6.0M | No change |
| ABCL Abcellera Biologics Inc. | 0.43% | 2,300,000 | $6.0M | Add +398.2% |
| BDTX Black Diamond Therapeutics I | 0.43% | 1,370,209 | $6.0M | Reduce -14.5% |
| APGE Apogee Therapeutics Inc. | 0.42% | 100,000 | $5.9M | No change |
| OMIC Singular Genomics Systems Inc. | 0.42% | 372,000 | $5.8M | New |
| DTIL Precision Biosciences Inc. | 0.40% | 623,332 | $5.6M | No change |
| LNTH Lantheus Holdings Inc. | 0.39% | 50,000 | $5.5M | No change |
| CYTK Cytokinetics Inc. | 0.38% | 100,000 | $5.3M | No change |
| NUVL Nuvalent Inc. Class A | 0.37% | 50,000 | $5.1M | New |
| RENEO PHARMACEUTICALS INC | 0.36% | 2,946,260 | $5.0M | Reduce -1.7% |
| MRUS Merus NV | 0.36% | 100,000 | $5.0M | No change |
| ARE Alexandria Real Estate Equit | 0.34% | 40,000 | $4.8M | No change |
| IOVA Iovance Biotherapeutics Inc. | 0.34% | 500,000 | $4.7M | No change |
| ALMS Alumis Inc. | 0.33% | 426,594 | $4.6M | New |
| SEER Seer Inc. | 0.32% | 2,300,000 | $4.5M | No change |
| ARVN Arvinas Inc. | 0.32% | 180,000 | $4.4M | No change |
| BEAM Beam Therapeutics Inc. | 0.30% | 170,000 | $4.2M | Reduce -37.0% |
| SNY Sanofi-ADR | 0.29% | 70,000 | $4.0M | New |
| CCCC C4 Therapeutics Inc. | 0.28% | 700,000 | $4.0M | Add +250.0% |
| HRTX Heron Therapeutics Inc. | 0.26% | 1,850,000 | $3.7M | No change |
| HELP Cybin Inc. | 0.25% | 400,000 | $3.6M | New |
| TYRA Tyra Biosciences Inc. | 0.25% | 150,000 | $3.5M | Add +255.3% |
| CMPX Compass Therapeutics Inc. | 0.24% | 1,812,995 | $3.3M | New |
| NKTX Nkarta Inc. | 0.21% | 650,000 | $2.9M | Add +18.2% |
| ELEV Elevation Oncology Inc. | 0.20% | 4,760,000 | $2.9M | Add +55.6% |
| KEZAR LIFE SCIENCES INC | 0.20% | 3,640,300 | $2.8M | New |
| BOLT Bolt Biotherapeutics Inc. | 0.18% | 3,812,773 | $2.5M | No change |
| FATE Fate Therapeutics Inc. | 0.17% | 700,000 | $2.5M | No change |
| CHRS Coherus Oncology Inc. | 0.17% | 2,350,000 | $2.4M | Add +123.8% |
| GMAB Genmab A/S -SP ADR | 0.17% | 100,000 | $2.4M | No change |
| TECX Tectonic Therapeutic Inc. | 0.17% | 79,166 | $2.4M | No change |
| SWTX Springworks Therapeutics Inc. | 0.17% | 74,265 | $2.4M | New |
| TGTX TG Therapeutics Inc. | 0.17% | 100,000 | $2.3M | No change |
| TBPH Theravance Biopharma Inc. | 0.15% | 262,896 | $2.1M | New |
| KURA Kura Oncology Inc. | 0.14% | 100,000 | $2.0M | No change |
| IPSC Century Therapeutics Inc. | 0.11% | 900,000 | $1.5M | No change |
| BCAB Bioatla Inc. | 0.11% | 874,076 | $1.5M | Reduce -36.4% |
| ERAS Erasca Inc. | 0.10% | 502,915 | $1.4M | Reduce -8.6% |
| ENTA Enanta Pharmaceuticals Inc. | 0.09% | 126,655 | $1.3M | Reduce -57.8% |
| OABI Omniab Inc. | 0.09% | 300,000 | $1.3M | No change |
| ATYR Atyr Pharma Inc. | 0.08% | 671,134 | $1.2M | No change |
| ATXS Astria Therapeutics Inc. | 0.08% | 100,000 | $1.1M | No change |
| PASG Passage Bio Inc. | 0.07% | 1,500,000 | $1.1M | No change |
| WMT Walmart Inc. | 0.07% | 12,725 | $1.0M | Add +185.3% |
| JPM JPMorgan Chase & Co. | 0.07% | 4,673 | $985K | Add +158.0% |
| MSFT Microsoft Corp. | 0.07% | 2,250 | $968K | Add +176.4% |
| BRK.B Berkshire Hathaway Inc. Class B | 0.07% | 2,079 | $957K | Add +192.4% |
| HD Home Depot Inc. | 0.07% | 2,354 | $954K | Add +246.7% |
| PCRX Pacira Biosciences Inc. | 0.07% | 61,226 | $921K | New |
| VZ Verizon Communications Inc. | 0.07% | 20,401 | $916K | Add +284.3% |
| V Visa Inc. Class A | 0.07% | 3,318 | $912K | Add +216.3% |
| NXTC Nextcure Inc. | 0.06% | 652,386 | $894K | Add +8.2% |
| PG The Procter & Gamble Co. | 0.06% | 5,145 | $891K | Add +233.4% |
| KO The Coca-Cola Co. | 0.06% | 12,373 | $889K | Add +247.5% |
| TXN Texas Instruments Inc. | 0.06% | 4,202 | $868K | Add +249.0% |
| PYPL PayPal Holdings Inc. | 0.06% | 11,099 | $866K | New |
| INTC Intel Corp. | 0.06% | 36,572 | $858K | Add +397.3% |
| VTRS Viatris Inc. | 0.06% | 73,881 | $858K | Add +234.6% |
| DIS The Walt Disney Co. filed as DISNEY WALT CO | 0.06% | 8,834 | $850K | Add +335.4% |
| NKE Nike Inc. Class B | 0.06% | 9,539 | $843K | New |
| UNH Unitedhealth Group Inc. | 0.06% | 1,422 | $831K | New |
| XOM Exxon Mobil Corp. | 0.06% | 7,004 | $821K | Add +267.1% |
| JNJ Johnson & Johnson | 0.06% | 5,015 | $813K | New |
| VSTM Verastem Inc. | 0.06% | 270,000 | $807K | Reduce -50.1% |
| LAB Standard Biotools Inc. | 0.06% | 407,755 | $787K | New |
| PFE Pfizer Inc. | 0.05% | 25,738 | $745K | New |
| MGNX Macrogenics Inc. | 0.05% | 218,856 | $720K | No change |
| ATRA Atara Biotherapeutics Inc. | 0.04% | 75,196 | $611K | No change |
| PBYI Puma Biotechnology Inc. | 0.04% | 200,000 | $510K | No change |
| AFMDQ Affimed NV | 0.04% | 148,315 | $498K | New |
| PGEN Precigen Inc. | 0.03% | 500,000 | $474K | New |
| EGRX Eagle Pharmaceuticals Inc. | 0.03% | 118,857 | $443K | No change |
| IVVD Invivyd Inc. | 0.02% | 330,172 | $337K | Add +65.1% |
| AMLX Amylyx Pharmaceuticals Inc. | 0.02% | 100,000 | $324K | No change |
| NFLX Netflix Inc. | 0.02% | 427 | $303K | No change |
| AXP American Express Co. | 0.02% | 1,001 | $271K | No change |
| ATHIRA PHARMA INC | 0.02% | 600,000 | $268K | Reduce -43.0% |
| GE General Electric filed as GE AEROSPACE | 0.02% | 1,383 | $261K | No change |
| ALL Allstate Corp. | 0.02% | 1,260 | $239K | No change |
| SHW The Sherwin-Williams Co. | 0.02% | 612 | $234K | New |
| TMUS T-Mobile US Inc. | 0.02% | 1,071 | $221K | New |
| UAL United Airlines Holdings Inc. | 0.02% | 3,872 | $221K | New |
| AMZN Amazon.com Inc. | 0.02% | 1,164 | $217K | No change |
| CLX Clorox Company | 0.01% | 1,236 | $201K | New |
| MCRB Seres Therapeutics Inc. | 0.01% | 200,000 | $189K | Reduce -91.7% |
| RLMD Relmada Therapeutics Inc. | 0.01% | 50,825 | $165K | Reduce -78.6% |
| LXRX Lexicon Pharmaceuticals Inc. | 0.01% | 100,000 | $157K | New |
| F Ford Motor Co. filed as FORD MTR CO | 0.01% | 12,773 | $135K | No change |
| LVTX Lava Therapeutics NV | 0.01% | 53,101 | $88K | Add +939.4% |
| ALLK Allakos LLC | 0.00% | 45,262 | $30K | New |